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  1. Article ; Online: The best offense is a good beta-defensin.

    Dhariwala, Miqdad O / Scharschmidt, Tiffany C

    Immunity

    2022  Volume 55, Issue 9, Page(s) 1586–1588

    Abstract: The full range of receptors through which antimicrobial peptides exert their immunologic effects remains incompletely explored. Dong and colleagues identify Mgrpra2 as a G-coupled protein receptor on neutrophils, for which keratinocyte-derived Beta- ... ...

    Abstract The full range of receptors through which antimicrobial peptides exert their immunologic effects remains incompletely explored. Dong and colleagues identify Mgrpra2 as a G-coupled protein receptor on neutrophils, for which keratinocyte-derived Beta-defensins serve as key ligands. Binding of Mgrpra2 leads to release of neutrophil granules and Il-1β, which helps shape skin microbiome composition and augments cutaneous defense against bacterial infection.
    MeSH term(s) Carrier Proteins ; Keratinocytes/metabolism ; Neutrophils/metabolism ; Skin/metabolism ; beta-Defensins/chemistry ; beta-Defensins/metabolism
    Chemical Substances Carrier Proteins ; beta-Defensins
    Language English
    Publishing date 2022-09-06
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2022.08.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4227: Show issues Location:
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  2. Article ; Online: Antibiotics for Acne-A Pilot Study of Collateral Damage to the Skin Microbiome.

    Scharschmidt, Tiffany C

    JAMA dermatology

    2019  Volume 155, Issue 4, Page(s) 419–421

    MeSH term(s) Acne Vulgaris ; Anti-Bacterial Agents ; Humans ; Microbiota ; Pilot Projects ; Skin
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2019-03-25
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2701761-8
    ISSN 2168-6084 ; 2168-6068
    ISSN (online) 2168-6084
    ISSN 2168-6068
    DOI 10.1001/jamadermatol.2018.5146
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Early life host-microbe interactions in skin.

    Dwyer, Laura R / Scharschmidt, Tiffany C

    Cell host & microbe

    2022  Volume 30, Issue 5, Page(s) 684–695

    Abstract: Our skin is the interface through which we mediate lifelong interactions with our surrounding environment. Initial development of the skin's epidermis, adnexal structures, and barrier function is necessary for normal cutaneous microbial colonization, ... ...

    Abstract Our skin is the interface through which we mediate lifelong interactions with our surrounding environment. Initial development of the skin's epidermis, adnexal structures, and barrier function is necessary for normal cutaneous microbial colonization, immune development, and prevention of disease. Early life microbial exposures can have unique and long-lasting impacts on skin health. The identity of neonatal skin microbes and the context in which they are first encountered, i.e., through a compromised skin barrier or in conjunction with cutaneous inflammation, can have additional short- and long-term health consequences. Here, we discuss key attributes of infant skin and endogenous and exogenous factors that shape its relationship to the early life cutaneous microbiome, with a focus on their clinical implications.
    MeSH term(s) Dermatitis ; Host Microbial Interactions ; Humans ; Infant ; Infant, Newborn ; Microbiota ; Skin
    Language English
    Publishing date 2022-05-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2278004-X
    ISSN 1934-6069 ; 1931-3128
    ISSN (online) 1934-6069
    ISSN 1931-3128
    DOI 10.1016/j.chom.2022.02.016
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  4. Article ; Online: Preclinical Atopic Dermatitis Skin in Infants: An Emerging Research Area.

    Paller, Amy S / Scharschmidt, Tiffany C / Kezic, Sanja / Irvine, Alan D

    The Journal of investigative dermatology

    2024  Volume 144, Issue 5, Page(s) 1001–1009

    Abstract: Whereas clinically apparent atopic dermatitis (AD) can be confirmed by validated diagnostic criteria, the preclinical phenotype of infants who eventually develop AD is less well-characterized. Analogous to unaffected or nonlesional skin in established AD, ...

    Abstract Whereas clinically apparent atopic dermatitis (AD) can be confirmed by validated diagnostic criteria, the preclinical phenotype of infants who eventually develop AD is less well-characterized. Analogous to unaffected or nonlesional skin in established AD, clinically normal-appearing skin in infants who will develop clinical AD has distinct changes. Prospective studies have revealed insights into this preclinical AD phenotype. In this study, we review the structural, immunologic, and microbiome nature of the preclinical AD phenotype. Determination of markers that predict the development of AD will facilitate targeting of interventions to prevent the development or reduce the severity of AD in infants.
    MeSH term(s) Dermatitis, Atopic/immunology ; Dermatitis, Atopic/microbiology ; Dermatitis, Atopic/diagnosis ; Humans ; Infant ; Skin/microbiology ; Skin/immunology ; Skin/pathology ; Phenotype ; Microbiota/immunology ; Biomarkers/analysis ; Infant, Newborn ; Severity of Illness Index
    Chemical Substances Biomarkers
    Language English
    Publishing date 2024-04-03
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2024.02.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Baby's skin bacteria: first impressions are long-lasting.

    Dhariwala, Miqdad O / Scharschmidt, Tiffany C

    Trends in immunology

    2021  Volume 42, Issue 12, Page(s) 1088–1099

    Abstract: Early life is a dynamic period for skin microbial colonization and immune development. We postulate that microbial exposures in this period durably alter the skin immune trajectory and later disease susceptibility. Bacteria contribute to infant skin ... ...

    Abstract Early life is a dynamic period for skin microbial colonization and immune development. We postulate that microbial exposures in this period durably alter the skin immune trajectory and later disease susceptibility. Bacteria contribute to infant skin immune imprinting via interactions with microbes as well as with cutaneous epithelial and immune cells. Excellent research is underway at the skin microbiome-immune interface, both in deciphering basic mechanisms and implementing their therapeutic applications. As emphasized herein, focusing on the unique opportunities and challenges presented by microbial immune modulation in early life will be important. In our view, only through dedicated study of skin-microbe crosstalk in this developmental window can we elucidate the molecular underpinnings of pivotal events that contribute to sustained host-microbe symbiosis.
    MeSH term(s) Bacteria ; Humans ; Infant ; Microbiota ; Skin/microbiology ; Symbiosis
    Language English
    Publishing date 2021-11-04
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2036831-8
    ISSN 1471-4981 ; 1471-4906
    ISSN (online) 1471-4981
    ISSN 1471-4906
    DOI 10.1016/j.it.2021.10.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MG 2: Show issues

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  6. Article ; Online: Measuring inflammation in IBD with an OSM-ostat.

    Scharschmidt, Tiffany C

    Science translational medicine

    2017  Volume 9, Issue 388

    Abstract: Oncostatin M is elevated in inflammatory bowel disease, wherein it may promote intestinal stroma cell inflammation and predict nonresponsiveness to anti-TNF therapy. ...

    Abstract Oncostatin M is elevated in inflammatory bowel disease, wherein it may promote intestinal stroma cell inflammation and predict nonresponsiveness to anti-TNF therapy.
    Language English
    Publishing date 2017-05-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2518854-9
    ISSN 1946-6242 ; 1946-6234
    ISSN (online) 1946-6242
    ISSN 1946-6234
    DOI 10.1126/scitranslmed.aan3777
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6941: Show issues Location:
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  7. Article ; Online: A vitamin to D-crease sunburn.

    Scharschmidt, Tiffany C

    Science translational medicine

    2017  Volume 9, Issue 394

    Abstract: High doses of oral vitamin ... ...

    Abstract High doses of oral vitamin D
    MeSH term(s) Humans ; Inflammation ; Research ; Sunburn ; Vitamin D ; Vitamins
    Chemical Substances Vitamins ; Vitamin D (1406-16-2)
    Language English
    Publishing date 2017-06-14
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2518854-9
    ISSN 1946-6242 ; 1946-6234
    ISSN (online) 1946-6242
    ISSN 1946-6234
    DOI 10.1126/scitranslmed.aan5233
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    Zs.A 6941: Show issues Location:
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  8. Article ; Online: When TLRs fail, IgG has your back.

    Scharschmidt, Tiffany C

    Science translational medicine

    2017  Volume 9, Issue 382

    Abstract: Inherited TIRAP deficiency confers susceptibility to staphylococcal disease via impaired TLR2 and TLR4 responses, which can be rescued by bacteria-specific antibodies. ...

    Abstract Inherited TIRAP deficiency confers susceptibility to staphylococcal disease via impaired TLR2 and TLR4 responses, which can be rescued by bacteria-specific antibodies.
    MeSH term(s) Adaptive Immunity ; Humans ; Immunity, Innate ; Immunoglobulin G ; Toll-Like Receptor 2 ; Toll-Like Receptor 4
    Chemical Substances Immunoglobulin G ; Toll-Like Receptor 2 ; Toll-Like Receptor 4
    Language English
    Publishing date 2017-03-15
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2518854-9
    ISSN 1946-6242 ; 1946-6234
    ISSN (online) 1946-6242
    ISSN 1946-6234
    DOI 10.1126/scitranslmed.aan0768
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    Zs.A 6941: Show issues Location:
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  9. Article ; Online: Skin Dysbiosis Goes "Off-Leish".

    Scharschmidt, Tiffany C

    Cell host & microbe

    2017  Volume 22, Issue 1, Page(s) 1–3

    Abstract: There is increasing interest in the contribution of microbes to skin disease. In this issue of Cell Host & Microbe, Gimblet et al. (2017) demonstrate that cutaneous leishmaniasis alters the human skin microbiota. In mice, this dysbiosis is transferable ... ...

    Abstract There is increasing interest in the contribution of microbes to skin disease. In this issue of Cell Host & Microbe, Gimblet et al. (2017) demonstrate that cutaneous leishmaniasis alters the human skin microbiota. In mice, this dysbiosis is transferable to naive animals, where it augments skin inflammation and disease severity.
    MeSH term(s) Animals ; Bacteria/classification ; Bacterial Physiological Phenomena/immunology ; Dysbiosis/immunology ; Dysbiosis/microbiology ; Dysbiosis/parasitology ; Host-Pathogen Interactions/immunology ; Humans ; Inflammation/immunology ; Inflammation/microbiology ; Leishmaniasis, Cutaneous/immunology ; Leishmaniasis, Cutaneous/microbiology ; Mice ; Mice, Inbred C57BL ; Microbiota/immunology ; Models, Animal ; Skin/immunology ; Skin/microbiology ; Skin/parasitology ; Skin Diseases/immunology ; Skin Diseases/microbiology ; Skin Diseases/parasitology
    Language English
    Publishing date 2017-07-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2278004-X
    ISSN 1934-6069 ; 1931-3128
    ISSN (online) 1934-6069
    ISSN 1931-3128
    DOI 10.1016/j.chom.2017.06.017
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  10. Article ; Online: Establishing Tolerance to Commensal Skin Bacteria: Timing Is Everything.

    Scharschmidt, Tiffany C

    Dermatologic clinics

    2017  Volume 35, Issue 1, Page(s) 1–9

    Abstract: Commensal bacteria live intimately and in constant dialogue with skin immune cells. Regulating our immune response to these bacteria is critical for skin homeostasis. Using a new murine model to track Staphylococcus epidermidis-specific T cells, we found ...

    Abstract Commensal bacteria live intimately and in constant dialogue with skin immune cells. Regulating our immune response to these bacteria is critical for skin homeostasis. Using a new murine model to track Staphylococcus epidermidis-specific T cells, we found that colonization during neonatal but not adult life led to S.epidermidis-specific immune tolerance. This tolerance protected against skin inflammation and was mediated by a wave of regulatory T cells entering neonatal skin. These findings provide new insight into how we establish a healthy symbiosis with commensal microbes and highlight avenues for future research to identify novel therapies for inflammatory skin disease.
    MeSH term(s) Animals ; Antigens, Bacterial/immunology ; Humans ; Immune Tolerance/immunology ; Immunity, Innate/immunology ; Mice ; Microbiota/immunology ; Propionibacterium acnes/immunology ; Skin/immunology ; Skin/microbiology ; Staphylococcus epidermidis/immunology ; Symbiosis/immunology ; T-Lymphocytes, Regulatory/immunology ; Time Factors
    Chemical Substances Antigens, Bacterial
    Language English
    Publishing date 2017-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 82798-8
    ISSN 1558-0520 ; 0733-8635
    ISSN (online) 1558-0520
    ISSN 0733-8635
    DOI 10.1016/j.det.2016.07.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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