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  1. Book: Adenosine receptors

    Haskó, György

    therapeutic aspects for inflammatory and immune diseases

    2007  

    Author's details ed. by György Haskó
    Keywords Receptors, Purinergic P1 / therapeutic use ; Adenosine / immunology ; Immune System Diseases / drug therapy
    Language English
    Size [6] Bl., 363 S. : Ill., graph. Darst., 25 cm
    Publisher CRC Taylor & Francis
    Publishing place Boca Raton u.a.
    Publishing country United States
    Document type Book
    Note Literaturangaben
    HBZ-ID HT014860779
    ISBN 0-8493-3999-5 ; 978-0-8493-3999-8
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2007 A 273 order for loan Magazin

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  2. Article ; Online: May be adenosine an immuno-quorum-sensing signal?

    Antonioli, Luca / Haskó, György

    Purinergic signalling

    2022  Volume 18, Issue 2, Page(s) 205–209

    Abstract: Quorum sensing indicates a communication process between bacteria based on a coordinate variation in gene expression aimed at coordinating a collective comportment related to the bacterial population density. Increasing pieces of evidence pointed out ... ...

    Abstract Quorum sensing indicates a communication process between bacteria based on a coordinate variation in gene expression aimed at coordinating a collective comportment related to the bacterial population density. Increasing pieces of evidence pointed out that a quorum-sensing system can be a regulatory program also used in the immune field to organize the density of the various immune cell populations and to calibrate their responses. In particular, such equilibrium is achieved by the ability of immune cells to perceive the density of their own populations or those of other cells in their environment, through the release of several mediators able to finely shape the cell density via coordinated changes in gene expression and protein signaling. In this regard, adenosine displays the typical characteristics of a mediator involved in the regulation of quorum sensing, thus suggesting a putative role of this nucleoside in shaping the balance between diverse immune cell populations.
    MeSH term(s) Adenosine ; Quorum Sensing ; Signal Transduction
    Chemical Substances Adenosine (K72T3FS567)
    Language English
    Publishing date 2022-04-30
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2172143-9
    ISSN 1573-9546 ; 1573-9538
    ISSN (online) 1573-9546
    ISSN 1573-9538
    DOI 10.1007/s11302-022-09866-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Adenosine signaling as target in cardiovascular pharmacology.

    Antonioli, Luca / Fornai, Matteo / Pellegrini, Carolina / Pacher, Pál / Haskó, György

    Current opinion in pharmacology

    2023  Volume 71, Page(s) 102393

    Abstract: Increasing evidence demonstrated the relevance of adenosine system in the onset and development of cardiovascular diseases, such as hypertension, myocardial infarct, ischemia, hypertension, heart failure, and atherosclerosis. In this regard, intense ... ...

    Abstract Increasing evidence demonstrated the relevance of adenosine system in the onset and development of cardiovascular diseases, such as hypertension, myocardial infarct, ischemia, hypertension, heart failure, and atherosclerosis. In this regard, intense research efforts are being focused on the characterization of the pathophysiological significance of adenosine, acting at its membrane receptors named A
    MeSH term(s) Humans ; Adenosine/pharmacology ; Cardiovascular Diseases/drug therapy ; Hypertension ; Receptor, Adenosine A2A ; Receptor, Adenosine A2B/metabolism
    Chemical Substances Adenosine (K72T3FS567) ; Receptor, Adenosine A2A ; Receptor, Adenosine A2B
    Language English
    Publishing date 2023-07-12
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2037057-X
    ISSN 1471-4973 ; 1471-4892
    ISSN (online) 1471-4973
    ISSN 1471-4892
    DOI 10.1016/j.coph.2023.102393
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Caffeine and Bones: If Less Is Good, More May Not Be Better.

    Antonioli, Luca / Haskó, György

    Journal of caffeine and adenosine research

    2019  Volume 9, Issue 2, Page(s) 38–39

    Language English
    Publishing date 2019-06-19
    Publishing country United States
    Document type Editorial
    ZDB-ID 2928613-X
    ISSN 2573-3400 ; 2573-3397
    ISSN (online) 2573-3400
    ISSN 2573-3397
    DOI 10.1089/caff.2019.29011.ah
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  5. Article ; Online: Pharmacological modulation of P2X4 in inflammatory bowel diseases: the way towards novel therapeutics?

    D'Antongiovanni, Vanessa / Pellegrini, Carolina / Fornai, Matteo / Nemeth, Zoltan H / Haskó, György / Antonioli, Luca

    Journal of drug targeting

    2023  Volume 31, Issue 7, Page(s) 693–699

    Abstract: Inflammatory bowel diseases (IBDs) are a group of idiopathic, chronic, relapsing, inflammatory conditions, which include ulcerative colitis (UC) and Crohn's disease (CD). These disorders are characterised by intestinal symptoms associated with chronic ... ...

    Abstract Inflammatory bowel diseases (IBDs) are a group of idiopathic, chronic, relapsing, inflammatory conditions, which include ulcerative colitis (UC) and Crohn's disease (CD). These disorders are characterised by intestinal symptoms associated with chronic inflammation of the intestinal mucosa, such as gut dysmotility and visceral pain. Currently, the pharmacological management of IBD patients is far from satisfactory in terms of efficacy and safety, thus spurring the interest of the scientific community to identify novel molecular targets for the management of these disorders. According to recent research, it appears that P2 purinergic receptors, which can regulate the host's response to inflammation, have been identified as potential targets for the treatment of IBDs. In particular, among P2 receptors, the P2X4 receptor subtype has recently captured the attention of the research community owing to its role in shaping immune/inflammatory responses. Based on this evidence, the present review has been conceived to provide a critical appraisal of the available knowledge about the role of P2X4R subtype in the pathophysiological mechanisms underlying IBDs, pointing out its potential as therapeutic target to develop innovative therapeutic strategies aimed at counteracting the inflammatory process, gut dysmotility and visceral hypersensitivity associated with these disorders.
    MeSH term(s) Humans ; Inflammatory Bowel Diseases/drug therapy ; Colitis, Ulcerative/diagnosis ; Colitis, Ulcerative/therapy ; Crohn Disease/diagnosis ; Crohn Disease/therapy ; Intestines ; Inflammation
    Language English
    Publishing date 2023-07-20
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1187110-6
    ISSN 1029-2330 ; 1061-186X
    ISSN (online) 1029-2330
    ISSN 1061-186X
    DOI 10.1080/1061186X.2023.2235092
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Role of Macrophages in the Endocrine System.

    Rehman, Abdul / Pacher, Pál / Haskó, György

    Trends in endocrinology and metabolism: TEM

    2021  Volume 32, Issue 4, Page(s) 238–256

    Abstract: Macrophages are cells of the innate immune system that play myriad roles in the body. Macrophages are known to reside in endocrine glands, and a body of evidence now suggests that these cells interact closely with endocrine cells. Immune-endocrine ... ...

    Abstract Macrophages are cells of the innate immune system that play myriad roles in the body. Macrophages are known to reside in endocrine glands, and a body of evidence now suggests that these cells interact closely with endocrine cells. Immune-endocrine interactions are important in the development of endocrine glands and their functioning during physiological states, and also become key players in pathophysiological states. Through gene expression profiling, diverse subpopulations of tissue macrophages have been discovered within endocrine organs; this has important implications for disease pathogenesis and potential pharmacotherapy. The molecular basis for the crosstalk between macrophages and endocrine cells is being unraveled, and allows the identification of multiple points for pharmacologic intervention. Macrophages in adipose tissue and pancreatic islets are key players in the process of metaflammation (metabolic inflammation) that underlies the development of insulin resistance, metabolic syndrome, diabetes mellitus, and non-alcoholic fatty liver disease. In the ovary, they play important roles in ovarian folliculogenesis and ovulation, whereas in the male reproductive tract they regulate spermatogenesis through the regulation of steroidogenesis by Leydig cells. We summarize the diverse roles played by macrophages in the endocrine system and identify potential targets for pharmacotherapy in endocrine disorders.
    MeSH term(s) Endocrine System/immunology ; Endocrine System/metabolism ; Humans ; Insulin Resistance ; Macrophages/metabolism ; Metabolic Syndrome ; Non-alcoholic Fatty Liver Disease
    Language English
    Publishing date 2021-01-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1042384-9
    ISSN 1879-3061 ; 1043-2760
    ISSN (online) 1879-3061
    ISSN 1043-2760
    DOI 10.1016/j.tem.2020.12.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Adenosine and inflammation: it's time to (re)solve the problem.

    Antonioli, Luca / Pacher, Pál / Haskó, György

    Trends in pharmacological sciences

    2021  Volume 43, Issue 1, Page(s) 43–55

    Abstract: Resolution of inflammation requires proresolving molecular pathways triggered as part of the host response during the inflammatory phase. Adenosine and its receptors, which are collectively called the adenosine system, shape inflammatory cell activity ... ...

    Abstract Resolution of inflammation requires proresolving molecular pathways triggered as part of the host response during the inflammatory phase. Adenosine and its receptors, which are collectively called the adenosine system, shape inflammatory cell activity during the active phase of inflammation, leading these immune cells toward a functional repolarization, thus contributing to the onset of resolution. Strategies based on the resolution of inflammation have shaped a new area of pharmacology referred to as 'resolution pharmacology' and in this regard, the adenosine system represents an interesting target to design novel pharmacological tools to 'resolve' the inflammatory process. In this review, we outline the role of the adenosine system in driving the events required for an effective transition from the proinflammatory phase to the onset and establishment of resolution.
    MeSH term(s) Adenosine ; Humans ; Inflammation ; Inflammation Mediators/metabolism
    Chemical Substances Inflammation Mediators ; Adenosine (K72T3FS567)
    Language English
    Publishing date 2021-11-12
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 282846-7
    ISSN 1873-3735 ; 0165-6147
    ISSN (online) 1873-3735
    ISSN 0165-6147
    DOI 10.1016/j.tips.2021.10.010
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  8. Article ; Online: Early Events Triggering the Initiation of a Type 2 Immune Response.

    El-Naccache, Darine W / Haskó, György / Gause, William C

    Trends in immunology

    2020  Volume 42, Issue 2, Page(s) 151–164

    Abstract: Type 2 immune responses are typically associated with protection against helminth infections and also with harmful inflammation in response to allergens. Recent advances have revealed that type 2 immunity also contributes to sterile inflammation, cancer, ...

    Abstract Type 2 immune responses are typically associated with protection against helminth infections and also with harmful inflammation in response to allergens. Recent advances have revealed that type 2 immunity also contributes to sterile inflammation, cancer, and microbial infections. However, the early events that initiate type 2 immune responses remain poorly defined. New insights reveal major contributions from danger-associated molecular patterns (DAMPs) in the initiation of type 2 immune responses. In this review, we examine the molecules released by the host and pathogens and the role they play in mediating the initiation of mammalian innate type 2 immune responses under a variety of conditions.
    MeSH term(s) Alarmins ; Allergens ; Animals ; Helminthiasis ; Humans ; Immunity, Innate ; Inflammation
    Chemical Substances Alarmins ; Allergens
    Language English
    Publishing date 2020-12-29
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2036831-8
    ISSN 1471-4981 ; 1471-4906
    ISSN (online) 1471-4981
    ISSN 1471-4906
    DOI 10.1016/j.it.2020.11.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A

    Lovászi, Marianna / Németh, Zoltán H / Pacher, Pál / Gause, William C / Wagener, Gebhard / Haskó, György

    Purinergic signalling

    2022  Volume 18, Issue 3, Page(s) 345–358

    Abstract: Extracellular adenosine is a biologically active signaling molecule that accumulates at sites of metabolic stress in sepsis. Extracellular adenosine has potent immunosuppressive effects by binding to and activating G protein-coupled ... ...

    Abstract Extracellular adenosine is a biologically active signaling molecule that accumulates at sites of metabolic stress in sepsis. Extracellular adenosine has potent immunosuppressive effects by binding to and activating G protein-coupled A
    MeSH term(s) Adenosine ; Aging ; Animals ; Humans ; Mice ; Mice, Knockout ; Neutrophils/metabolism ; Phenotype ; Receptor, Adenosine A2A/metabolism ; Sepsis
    Chemical Substances Receptor, Adenosine A2A ; Adenosine (K72T3FS567)
    Language English
    Publishing date 2022-07-15
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2172143-9
    ISSN 1573-9546 ; 1573-9538
    ISSN (online) 1573-9546
    ISSN 1573-9538
    DOI 10.1007/s11302-022-09884-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Ectonucleotidases in Inflammation, Immunity, and Cancer.

    Haas, Clarissa Branco / Lovászi, Marianna / Braganhol, Elizandra / Pacher, Pál / Haskó, György

    Journal of immunology (Baltimore, Md. : 1950)

    2022  Volume 206, Issue 9, Page(s) 1983–1990

    Abstract: Nucleoside triphosphate diphosphohydrolases (NTPDases) are a family of enzymes that hydrolyze nucleotides such as ATP, UTP, ADP, and UDP to monophosphates derivates such as AMP and UMP. The NTPDase family consists of eight enzymes, of which NTPDases 1, 2, ...

    Abstract Nucleoside triphosphate diphosphohydrolases (NTPDases) are a family of enzymes that hydrolyze nucleotides such as ATP, UTP, ADP, and UDP to monophosphates derivates such as AMP and UMP. The NTPDase family consists of eight enzymes, of which NTPDases 1, 2, 3, and 8 are expressed on cell membranes thereby hydrolyzing extracellular nucleotides. Cell membrane NTPDases are expressed in all tissues, in which they regulate essential physiological tissue functions such as development, blood flow, hormone secretion, and neurotransmitter release. They do so by modulating nucleotide-mediated purinergic signaling through P2 purinergic receptors. NTPDases 1, 2, 3, and 8 also play a key role during infection, inflammation, injury, and cancer. Under these conditions, NTPDases can contribute and control the pathophysiology of infectious, inflammatory diseases and cancer. In this review, we discuss the role of NTPDases, focusing on the less understood NTPDases 2-8, in regulating inflammation and immunity during infectious, inflammatory diseases, and cancer.
    MeSH term(s) Adenosine Triphosphatases/genetics ; Adenosine Triphosphatases/metabolism ; Animals ; Gene Expression Regulation, Enzymologic ; Humans ; Immunity/genetics ; Inflammation/enzymology ; Inflammation/genetics ; Isoenzymes/genetics ; Isoenzymes/metabolism ; Multigene Family ; Neoplasms/enzymology ; Neoplasms/genetics ; Nucleotides/metabolism
    Chemical Substances Isoenzymes ; Nucleotides ; Adenosine Triphosphatases (EC 3.6.1.-)
    Language English
    Publishing date 2022-04-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.2001342
    Database MEDical Literature Analysis and Retrieval System OnLINE

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