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Article: Helium Recovery by Membrane Gas Separation Using Poly(o-acyloxyamide)s

DiÌez, Blanca / Cuadrado PurificacioÌn / HernaÌndez Antonio / Lozano AÌngel E / Marcos-FernaÌndez AÌngel / Palacio Laura / PraÌdanos Pedro / Tena Alberto

Industrial & Engineering Chemistry Research. 2014 Aug. 13, v. 53, no. 32

2014

Abstract: Poly(o-acyloxyamide)s (PORAs) derived from a poly(o-hydroxyamide) from 2,2â²-bis(3-amino-4 ... as gas separation materials. PORAs were synthesized from poly(o-hydroxyamide)s by derivatization of the free OH ... good mechanical properties. The poly(o-acyloxyamide)s synthesized have shown good permselectivities ...

Abstract	Poly(o-acyloxyamide)s (PORAs) derived from a poly(o-hydroxyamide) from 2,2â²-bis(3-amino-4-hydroxyphenyl)hexafluoropropane (APAF) diamine, APAFâPOHA, have been synthesized and evaluated as gas separation materials. PORAs were synthesized from poly(o-hydroxyamide)s by derivatization of the free OH group with an aliphatic acid dichloride or dianhydride that allowed the introduction of acetyl or pivaloyl groups on their structure. All of them showed lowâmedium thermal stability due to a degradation of the amide moieties, and most of them (those synthesized from isophthaloyl dichloride (IPC), 2,2â²-bis(4-carboxyphenyl) hexafluoropropane dichloride (6FC), and 4,4â²-dicarboxydiphenylsulfone dichloride (DPSC)) showed good mechanical properties. The poly(o-acyloxyamide)s synthesized have shown good permselectivities for He/Nâ and He/CHâ separations and very good permeabilityâselectivity balance for He/COâ separation. The acetyl PORAs showed better permeability versus selectivity balances than the pivaloyl ones. Moreover, selectivity increased while permeability decreased in the sequence 6F-APAF > IP-APAF > DPS-APAF. Intersegmental distances, d-spacing, were shown to decrease along this sequence, obtaining a nice correlation between permeability and d-spacing. For the He/Nâ and the He/CHâ pairs of gases, the best permeabilityâselectivity values are obtained for 6F-APAF-Ac with a He permeability of 33 barrer and selectivities of 84 and 106, respectively. DPS-APAF-Ac gives a He permeability of 13 barrer and a selectivity of 21 for the He/COâ separation.
Keywords	derivatization ; engineering ; gases ; helium ; mechanical properties ; moieties ; permeability ; thermal stability
Language	English
Dates of publication	2014-0813
Size	p. 12809-12818.
Publishing place	American Chemical Society
Document type	Article
ZDB-ID	1484436-9
ISSN	1520-5045 ; 0888-5885
ISSN (online)	1520-5045
ISSN	0888-5885
DOI	10.1021%2Fie501649b
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Antisense oligonucleotides for therapeutic interventions in neuromuscular diseases.

Danos, Olivier

Human gene therapy

2013 Volume 24, Issue 5, Page(s) 470–471

MeSH term(s)	Humans ; Neuromuscular Diseases/genetics ; Neuromuscular Diseases/therapy ; Oligonucleotides, Antisense/genetics ; Oligonucleotides, Antisense/therapeutic use ; Research
Chemical Substances	Oligonucleotides, Antisense
Language	English
Publishing date	2013-05
Publishing country	United States
Document type	Editorial
ZDB-ID	1028152-6
ISSN	1557-7422 ; 1043-0342
ISSN (online)	1557-7422
ISSN	1043-0342
DOI	10.1089/hum.2013.2504
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Article ; Online: The presence of CpGs in AAV gene therapy vectors induces a plasmacytoid dendritic cell-like population very early after administration.

Glenn, Justin D / Negash, Henos / Henry, William / Qian, Randolph / Liu, Ye / Danos, Olivier / Bruder, Joseph T / Karumuthil-Melethil, Subha

Cellular immunology

2024 Volume 399-400, Page(s) 104823

Abstract: AAV-mediated gene transfer is a promising platform still plagued by potential host-derived, antagonistic immune responses to therapeutic components. CpG-mediated TLR9 stimulation activates innate immune cells and leads to cognate T cell activation and ... ...

Abstract	AAV-mediated gene transfer is a promising platform still plagued by potential host-derived, antagonistic immune responses to therapeutic components. CpG-mediated TLR9 stimulation activates innate immune cells and leads to cognate T cell activation and suppression of transgene expression. Here, we demonstrate that CpG depletion increased expression of an antibody transgene product by 2-3-fold as early as 24 h post-vector administration in mice. No significant differences were noted in anti-transgene product/ anti-AAV capsid antibody production or cytotoxic gene induction. Instead, CpG depletion significantly reduced the presence of a pDC-like myeloid cell population, which was able to directly bind the antibody transgene product via Fc-FcγR interactions. Thus, we extend the mechanisms of TLR9-mediated antagonism of transgene expression in AAV gene therapy to include the actions of a previously unreported pDC-like cell population.
Language	English
Publishing date	2024-03-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	80094-6
ISSN	1090-2163 ; 0008-8749
ISSN (online)	1090-2163
ISSN	0008-8749
DOI	10.1016/j.cellimm.2024.104823
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Article ; Online: AAV vectors for RNA-based modulation of gene expression.

Danos, O

Gene therapy

2008 Volume 15, Issue 11, Page(s) 864–869

Abstract: At the post-transcriptional level, gene expression is largely regulated through a network of molecular machines that regulate pre-mRNA maturation integrity, transport, translation and degradation. These processes are based on the formation of ... ...

Abstract	At the post-transcriptional level, gene expression is largely regulated through a network of molecular machines that regulate pre-mRNA maturation integrity, transport, translation and degradation. These processes are based on the formation of nucleoprotein complexes and require the recognition of sequence motifs on the RNA. By masking these targets with complementary RNA sequences forming Watson-Crick base pairing, it is possible to efficiently and specifically impact on the cell phenotype, or to compensate the deleterious effect of mutations. Here we review how the adeno-associated virus technology is being exploited for expressing non-coding RNAs in tissues such as the brain, muscle or liver, in functional genomic studies as well as for the development of novel therapeutic strategies.
MeSH term(s)	Animals ; Dependovirus/genetics ; Gene Silencing ; Gene Transfer Techniques ; Genetic Therapy/methods ; Genetic Vectors/administration & dosage ; Genetic Vectors/genetics ; Humans ; RNA Interference ; RNA, Untranslated
Chemical Substances	RNA, Untranslated
Language	English
Publishing date	2008-06
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1191036-7
ISSN	1476-5462 ; 0969-7128
ISSN (online)	1476-5462
ISSN	0969-7128
DOI	10.1038/gt.2008.69
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Article ; Online: Microdystrophin Expression as a Surrogate Endpoint for Duchenne Muscular Dystrophy Clinical Trials.

Chamberlain, Jeffrey S / Robb, Melissa / Braun, Serge / Brown, Kristy J / Danos, Olivier / Ganot, Annie / Gonzalez-Alegre, Pedro / Hunter, Nina / McDonald, Craig / Morris, Carl / Tobolowsky, Mark / Wagner, Kathryn R / Ziolkowski, Olivia / Duan, Dongsheng

Human gene therapy

2023 Volume 34, Issue 9-10, Page(s) 404–415

Abstract: Duchenne muscular dystrophy (DMD) is a serious, rare genetic disease, affecting primarily boys. It is caused by mutations in ... ...

Abstract	Duchenne muscular dystrophy (DMD) is a serious, rare genetic disease, affecting primarily boys. It is caused by mutations in the
MeSH term(s)	Male ; Humans ; Muscular Dystrophy, Duchenne/genetics ; Muscle, Skeletal/metabolism ; Genetic Therapy/methods ; Gene Transfer Techniques ; Biomarkers/metabolism
Chemical Substances	Biomarkers
Language	English
Publishing date	2023-03-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	1028152-6
ISSN	1557-7422 ; 1043-0342
ISSN (online)	1557-7422
ISSN	1043-0342
DOI	10.1089/hum.2022.190
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Article ; Online: Racial Disparities in Triple Negative Breast Cancer: A Review of the Role of Biologic and Non-biologic Factors.

Prakash, Om / Hossain, Fokhrul / Danos, Denise / Lassak, Adam / Scribner, Richard / Miele, Lucio

Frontiers in public health

2020 Volume 8, Page(s) 576964

Abstract: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer that lacks expression of the estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor (HER2). TNBC constitutes about 15-30 percent of all ...

Abstract	Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer that lacks expression of the estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor (HER2). TNBC constitutes about 15-30 percent of all diagnosed invasive breast cancer cases in the United States. African-American (AA) women have high prevalence of TNBC with worse clinical outcomes than European-American (EA) women. The contributing factors underlying racial disparities have been divided into two major categories based on whether they are related to lifestyle (non-biologic) or unrelated to lifestyle (biologic). Our objective in the present review article was to understand the potential interactions by which these risk factors intersect to drive the initiation and development of the disparities resulting in the aggressive TNBC subtypes in AA women more likely than in EA women. To reach our goal, we conducted literature searches using MEDLINE/PubMed to identify relevant articles published from 2005 to 2019 addressing breast cancer disparities primarily among AA and EA women in the United States. We found that disparities in TNBC may be attributed to racial differences in biological factors, such as tumor heterogeneity, population genetics, somatic genomic mutations, and increased expression of genes in AA breast tumors which have direct link to breast cancer. In addition, a large number of non-biologic factors, including socioeconomic deprivation adversities associated with poverty, social stress, unsafe neighborhoods, lack of healthcare access and pattern of reproductive factors, can promote comorbid diseases such as obesity and diabetes which may adversely contribute to the aggression of TNBC biology in AA women. Further, the biological risk factors directly linked to TNBC in AA women may potentially interact with non-biologic factors to promote a higher prevalence of TNBC, more aggressive biology, and poor survival. The relative contributions of the biologic and non-biologic factors and their potential interactions is essential to our understanding of disproportionately high burden and poor survival rates of AA women with TNBC.
MeSH term(s)	African Americans ; Biological Products ; European Continental Ancestry Group ; Female ; Humans ; Receptors, Estrogen/genetics ; Triple Negative Breast Neoplasms/epidemiology ; United States/epidemiology
Chemical Substances	Biological Products ; Receptors, Estrogen
Language	English
Publishing date	2020-12-22
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2020.576964
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Article ; Online: Gene therapy ameliorates spontaneous seizures associated with cortical neuron loss in a Cln2R207X mouse model.

Takahashi, Keigo / Eultgen, Elizabeth M / Wang, Sophie H / Rensing, Nicholas R / Nelvagal, Hemanth R / Dearborn, Joshua T / Danos, Olivier / Buss, Nicholas / Sands, Mark S / Wong, Michael / Cooper, Jonathan D

The Journal of clinical investigation

2023 Volume 133, Issue 12

Abstract: Although a disease-modifying therapy for classic late infantile neuronal ceroid lipofuscinosis (CLN2 disease) exists, poor understanding of cellular pathophysiology has hampered the development of more effective and persistent therapies. Here, we ... ...

Abstract	Although a disease-modifying therapy for classic late infantile neuronal ceroid lipofuscinosis (CLN2 disease) exists, poor understanding of cellular pathophysiology has hampered the development of more effective and persistent therapies. Here, we investigated the nature and progression of neurological and underlying neuropathological changes in Cln2R207X mice, which carry one of the most common pathogenic mutations in human patients but are yet to be fully characterized. Long-term electroencephalography recordings revealed progressive epileptiform abnormalities, including spontaneous seizures, providing a robust, quantifiable, and clinically relevant phenotype. These seizures were accompanied by the loss of multiple cortical neuron populations, including those stained for interneuron markers. Further histological analysis revealed early localized microglial activation months before neuron loss started in the thalamocortical system and spinal cord, which was accompanied by astrogliosis. This pathology was more pronounced and occurred in the cortex before the thalamus or spinal cord and differed markedly from the staging seen in mouse models of other forms of neuronal ceroid lipofuscinosis. Neonatal administration of adeno-associated virus serotype 9-mediated gene therapy ameliorated the seizure and gait phenotypes and prolonged the life span of Cln2R207X mice, attenuating most pathological changes. Our findings highlight the importance of clinically relevant outcome measures for judging preclinical efficacy of therapeutic interventions for CLN2 disease.
MeSH term(s)	Animals ; Humans ; Mice ; Neurons/pathology ; Seizures/genetics ; Seizures/therapy ; Seizures/pathology ; Gliosis/pathology ; Interneurons/pathology ; Thalamus/pathology ; Disease Models, Animal
Language	English
Publishing date	2023-06-15
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	3067-3
ISSN	1558-8238 ; 0021-9738
ISSN (online)	1558-8238
ISSN	0021-9738
DOI	10.1172/JCI165908
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Article: Transfert de gènes.

Danos, O

Bulletin de l'Academie nationale de medecine

2000 Volume 184, Issue 6, Page(s) 1169–77; discussion 1177–9

Abstract: Mammalian cells in culture can be modified by gene transfer and these procedures are routinely used in experimental biology. Yet, efficient approaches to modify certain complex cell populations, stem cells or cells organized within a tissue are still ... ...

Title translation	Gene transfer.
Abstract	Mammalian cells in culture can be modified by gene transfer and these procedures are routinely used in experimental biology. Yet, efficient approaches to modify certain complex cell populations, stem cells or cells organized within a tissue are still lacking. The hurdles to gene transfer can be listed by describing the pathway of a nucleic acid molecule, from the external medium towards the cell nucleus where its encoded information will be expressed. The requirements include the necessity to compact the size of the macromolecule, to overcome electrostatic repulsion, to cross a series of membranes and to establish itself permanently. Viruses have evolved to achieve these goals and understanding their strategies for cell invasion allows to design vectors for gene transfer. Chemicals or biochemicals able to bind DNA, as well as physical methods inducing changes in the structure of membranes can also be useful for gene transfer. The outcome of gene transfer technologies and their improvement pave the way to inovative medical applications and provide powerful tools for exploring the living world.
MeSH term(s)	Animals ; Gene Transfer Techniques ; Nucleic Acids/physiology ; Viruses
Chemical Substances	Nucleic Acids
Language	French
Publishing date	2000
Publishing country	Netherlands
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	213227-8
ISSN	0001-4079
ISSN	0001-4079
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Article ; Online: Meganuclease-Mediated COL7A1 Gene Correction for Recessive Dystrophic Epidermolysis Bullosa.

Izmiryan, Araksya / Danos, Olivier / Hovnanian, Alain

The Journal of investigative dermatology

2016 Volume 136, Issue 4, Page(s) 872–875

MeSH term(s)	Base Sequence ; Collagen Type VII/genetics ; DNA Breaks, Double-Stranded ; DNA Repair ; Deoxyribonucleases/metabolism ; Epidermolysis Bullosa Dystrophica/genetics ; Exons ; Fibroblasts/metabolism ; Genes, Dominant ; Genes, Recessive ; Genetic Vectors ; HEK293 Cells ; Humans ; Introns ; Keratinocytes/metabolism ; Lentivirus/genetics ; Microscopy, Fluorescence ; Molecular Sequence Data ; Mutation ; Sequence Homology, Nucleic Acid
Chemical Substances	COL7A1 protein, human ; Collagen Type VII ; Deoxyribonucleases (EC 3.1.-)
Language	English
Publishing date	2016-02-17
Publishing country	United States
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	80136-7
ISSN	1523-1747 ; 0022-202X
ISSN (online)	1523-1747
ISSN	0022-202X
DOI	10.1016/j.jid.2015.11.028
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Article ; Online: Promoter hypermethylation of RARB and GSTP1 genes in plasma cell-free DNA as breast cancer biomarkers in Peruvian women.

Danos, Pierina / Giannoni-Luza, Stefano / Murillo Carrasco, Alexis Germán / Acosta, Oscar / Guevara-Fujita, Maria Luisa / Cotrina Concha, José Manuel / Guerra Miller, Henry / Pinto Oblitas, Joseph / Aguilar Cartagena, Alfredo / Araujo, Jhajaira M / Fujita, Ricardo / Buleje Sono, José Luis

Molecular genetics & genomic medicine

2023 Volume 11, Issue 12, Page(s) e2260

Abstract: Background: Promoter hypermethylation is one of the enabling mechanisms of hallmarks of cancer. Tumor suppressor genes like RARB and GSTP1 have been reported as hypermethylated in breast cancer tumors compared with normal tissues in several populations. ...

Abstract	Background: Promoter hypermethylation is one of the enabling mechanisms of hallmarks of cancer. Tumor suppressor genes like RARB and GSTP1 have been reported as hypermethylated in breast cancer tumors compared with normal tissues in several populations. This case-control study aimed to determine the association between the promoter methylation ratio (PMR) of RARB and GSTP1 genes (separately and as a group) with breast cancer and its clinical-pathological variables in Peruvian patients, using a liquid biopsy approach. Methods: A total of 58 breast cancer patients and 58 healthy controls, matched by age, participated in the study. We exacted cell-free DNA (cfDNA) from blood plasma and converted it by bisulfite salts. Methylight PCR was performed to obtain the PMR value of the studied genes. We determined the association between PMR and breast cancer, in addition to other clinicopathological variables. The sensitivity and specificity of the PMR of these genes were obtained. Results: A significant association was not found between breast cancer and the RARB PMR (OR = 1.90; 95% CI [0.62-6.18]; p = 0.210) or the GSTP1 PMR (OR = 6.57; 95% CI [0.75-307.66]; p = 0.114). The combination of the RARB + GSTP1 PMR was associated with breast cancer (OR = 2.81; 95% CI [1.02-8.22]; p = 0.026), controls under 50 years old (p = 0.048), patients older than 50 (p = 0.007), and postmenopausal (p = 0.034). The PMR of both genes showed a specificity of 86.21% and a sensitivity of 31.03%. Conclusion: Promoter hypermethylation of RARB + GSTP1 genes is associated with breast cancer, older age, and postmenopausal Peruvian patients. The methylated promoter of the RARB + GSTP1 genes needs further validation to be used as a biomarker for liquid biopsy and as a recommendation criterion for additional tests in asymptomatic women younger than 50 years.
MeSH term(s)	Female ; Humans ; Middle Aged ; Biomarkers, Tumor/genetics ; Breast/pathology ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Case-Control Studies ; DNA Methylation ; Glutathione S-Transferase pi/genetics ; Peru
Chemical Substances	Biomarkers, Tumor ; Glutathione S-Transferase pi (EC 2.5.1.18) ; GSTP1 protein, human (EC 2.5.1.18) ; retinoic acid receptor beta
Language	English
Publishing date	2023-08-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2734884-2
ISSN	2324-9269 ; 2324-9269
ISSN (online)	2324-9269
ISSN	2324-9269
DOI	10.1002/mgg3.2260
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