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  1. Article ; Online: Comment on "Physiological and functional impact of an unsupervised but supported exercise programme for claudicants", Roberts AJ, Roberts EB, Sykes K, deCossart L, Edwards P, Cotterell D. Eur J Vasc Endovasc Surg 2008;36:319-24.

    Beard, J D

    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

    2009  Volume 37, Issue 3, Page(s) 370; author reply 370–1

    MeSH term(s) Exercise Therapy ; Humans ; Intermittent Claudication/physiopathology ; Intermittent Claudication/therapy ; Journal Impact Factor
    Language English
    Publishing date 2009-03
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 1225869-6
    ISSN 1532-2165 ; 1078-5884
    ISSN (online) 1532-2165
    ISSN 1078-5884
    DOI 10.1016/j.ejvs.2008.09.022
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    Zs.A 2283: Show issues Location:
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  2. Article: V(D)J recombination is not activated by demethylation of the kappa locus.

    Cherry, S R / Beard, C / Jaenisch, R / Baltimore, D

    Proceedings of the National Academy of Sciences of the United States of America

    2000  Volume 97, Issue 15, Page(s) 8467–8472

    Abstract: V(D)J recombination is thought to be regulated by changes in the accessibility of target sites ...

    Abstract V(D)J recombination is thought to be regulated by changes in the accessibility of target sites, such as modulation of methylation. To test whether demethylation of the kappa locus can activate recombination, we generated two recombinationally active B cell lines in which the gene for maintenance of genomic DNA methylation, Dnmt1, was flanked with loxP sites. Transduction with a retrovirus expressing both the cre recombinase and green fluorescent protein allowed us to purify recombinationally active cells devoid of methylation. Loss of methylation of the kappa locus was not sufficient to activate recombination, although transcription was activated in one line. It appears that demethylation of the kappa locus is not the rate-limiting step for altering accessibility and thus regulated demethylation does not generate specificity of recombination.
    MeSH term(s) Animals ; B-Lymphocytes ; Cell Line, Transformed ; DNA (Cytosine-5-)-Methyltransferase 1 ; DNA (Cytosine-5-)-Methyltransferases/genetics ; DNA Methylation ; DNA Nucleotidyltransferases/metabolism ; Gene Rearrangement, B-Lymphocyte, Light Chain ; Genes, Immunoglobulin ; Immunoglobulin kappa-Chains/genetics ; Integrases ; Mice ; Recombination, Genetic ; Transcriptional Activation ; VDJ Recombinases ; Viral Proteins
    Chemical Substances Immunoglobulin kappa-Chains ; Viral Proteins ; DNA (Cytosine-5-)-Methyltransferase 1 (EC 2.1.1.37) ; DNA (Cytosine-5-)-Methyltransferases (EC 2.1.1.37) ; Dnmt1 protein, mouse (EC 2.1.1.37) ; Cre recombinase (EC 2.7.7.-) ; DNA Nucleotidyltransferases (EC 2.7.7.-) ; Integrases (EC 2.7.7.-) ; VDJ Recombinases (EC 2.7.7.-)
    Language English
    Publishing date 2000-07-18
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.150218497
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    Zs.A 1148: Show issues Location:
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  3. Article ; Online: A revision of the genus Extenuipalpus Reck, 1959 (Trombidiformes: Tetranychoidea: Tenuipalpidae), with description of a new species.

    Beard, Jennifer J / Ueckermann, Edward A / Castro, Elizeu B / Seeman, Owen D

    Zootaxa

    2024  Volume 5417, Issue 1, Page(s) 1–62

    Abstract: ... a new species, E. situngu Beard & Ueckermann sp. nov. from glossy forest grape, Rhoicissus rhomboidea (E. Mey ex ...

    Abstract Extenuipalpus is reviewed, covering its taxonomic history, a new genus diagnosis, body and leg chaetotaxy, and redescriptions of the three previously known species E. niekerkae (Meyer, 1979), E. quadrisetosus (Lawrence, 1940) and E. sagittus (Meyer, 1993) based on type material. We also describe a new species, E. situngu Beard & Ueckermann sp. nov. from glossy forest grape, Rhoicissus rhomboidea (E. Mey ex Harv.) Planch. (Vitaceae), and provide a key to species of Extenuipalpus.
    MeSH term(s) Animals ; Mites ; Forests
    Language English
    Publishing date 2024-02-26
    Publishing country New Zealand
    Document type Journal Article
    ISSN 1175-5334
    ISSN (online) 1175-5334
    DOI 10.11646/zootaxa.5417.1.1
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  4. Article ; Online: Therapist factors associated with intent to use exposure therapy: a systematic review and meta-analysis.

    Langthorne, Diane / Beard, Jessica / Waller, Glenn

    Cognitive behaviour therapy

    2023  Volume 52, Issue 4, Page(s) 347–379

    Abstract: Exposure therapy is effective but widely underused. Numerous studies indicate therapist factors that might explain this pattern of underuse. This systematic review and meta-analysis synthesised those previous research findings, to identify which ... ...

    Abstract Exposure therapy is effective but widely underused. Numerous studies indicate therapist factors that might explain this pattern of underuse. This systematic review and meta-analysis synthesised those previous research findings, to identify which therapist factors are clearly associated with their intent to use exposure therapy. A systematic review and six random-effects meta-analyses synthesised studies identified in three databases (Scopus, PsychINFO, Web of Science) and through reference lists and citation searches. Most studies relied on a survey design, resulting in weak quality of research. Twenty-six eligible studies were included in the narrative synthesis, (including 5557 participants), while 21 studies yielded sufficient data to enter the meta-analysis. Medium to large pooled effect sizes indicated that therapists with more positive beliefs, a CBT orientation, and training in exposure therapy were significantly more likely to use exposure. Small pooled effect sizes indicated that older and more anxious therapists were less likely to use exposure. Therapist years of experience was not significantly associated with exposure use. There was no evidence of publication bias. Therapist characteristics clearly play a role in the use of exposure therapy, and future clinical and research work is required to address this limitation in the delivery of this effective therapy.
    MeSH term(s) Humans ; Implosive Therapy ; Anxiety ; Narration
    Language English
    Publishing date 2023-03-28
    Publishing country England
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 2076060-7
    ISSN 1651-2316 ; 1650-6073
    ISSN (online) 1651-2316
    ISSN 1650-6073
    DOI 10.1080/16506073.2023.2191824
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  5. Article ; Online: Consensus Recommendations for the Safe Conduct of Nonoperating Room Anesthesia: A Meeting Report From the 2022 Stoelting Conference of the Anesthesia Patient Safety Foundation.

    Beard, John / Methangkool, Emily / Angus, Shane / Urman, Richard D / Cole, Daniel J

    Anesthesia and analgesia

    2023  Volume 137, Issue 2, Page(s) e8–e11

    MeSH term(s) Humans ; Patient Safety ; Consensus ; Anesthesiology ; Anesthesia/adverse effects
    Language English
    Publishing date 2023-07-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    DOI 10.1213/ANE.0000000000006539
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    Zs.MO 149: Show issues

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  6. Article ; Online: Digital and robotic MSK surgery: is this the moment?

    Plastow, R / Beard, D J / Haddad, F S

    Annals of the Royal College of Surgeons of England

    2021  Volume 104, Issue 1, Page(s) 2–4

    MeSH term(s) Humans ; Musculoskeletal Diseases/surgery ; Musculoskeletal System/surgery ; Robotic Surgical Procedures/methods ; Surgery, Computer-Assisted/methods
    Language English
    Publishing date 2021-12-23
    Publishing country England
    Document type Editorial
    ZDB-ID 80044-2
    ISSN 1478-7083 ; 0035-8843
    ISSN (online) 1478-7083
    ISSN 0035-8843
    DOI 10.1308/rcsann.2021.0131
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  7. Article ; Online: Editorial

    Daniel J. Beard / Lucy A. Murtha / Damian D. McLeod

    Frontiers in Stroke, Vol

    Intracranial pressure regulation in stroke

    2023  Volume 2

    Keywords acute ischemic stroke ; intracranial hemorrhage ; intracranial pressure elevation ; collateral failure ; stroke progression ; early neurological deterioration (END) ; Medicine ; R
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Government Program Celebrates 25 Years of Commitment to Environmental Justice Movement.

    Beard, Sharon / Freeman, Kenda / Richards, David / Lee Pearson, Joy

    New solutions : a journal of environmental and occupational health policy : NS

    2023  Volume 32, Issue 4, Page(s) 277–287

    Abstract: For over 25 years, the National Institute of Environmental Health Sciences (NIEHS) Environmental Career Worker Training Program (ECWTP) has advanced principles of environmental justice by funding nonprofit organizations, or grantees, to deliver health, ... ...

    Abstract For over 25 years, the National Institute of Environmental Health Sciences (NIEHS) Environmental Career Worker Training Program (ECWTP) has advanced principles of environmental justice by funding nonprofit organizations, or grantees, to deliver health, safety, and job training for individuals from disadvantaged communities. This article provides a brief background of the environmental justice movement and examines the efforts of grantees to demonstrate how the ECWTP model can serve as a pathway for advancing environmental justice in disadvantaged and underserved communities.
    MeSH term(s) United States ; Humans ; Environmental Health ; Environmental Justice ; Inservice Training ; National Institute of Environmental Health Sciences (U.S.) ; Government Programs ; Social Justice
    Language English
    Publishing date 2023-01-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1236515-4
    ISSN 1541-3772 ; 1048-2911
    ISSN (online) 1541-3772
    ISSN 1048-2911
    DOI 10.1177/10482911221150832
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    Zs.A 4297: Show issues Location:
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  9. Article ; Online: Comparison of Two Bandage Splint Constructs in an Ex Vivo Equine Metacarpal Fracture Model.

    Granello, M E / Weatherall, K M / Lutter, J D / Beard, W L

    Veterinary and comparative orthopaedics and traumatology : V.C.O.T

    2022  Volume 36, Issue 2, Page(s) 82–86

    Abstract: Objectives:  The aim of this study was to compare the deflection distance, deflection angle and pre-loading sub-bandage pressure of a transverse, mid-metacarpal fracture in an equine cadaver limb when loaded in bending while stabilized with either a ... ...

    Abstract Objectives:  The aim of this study was to compare the deflection distance, deflection angle and pre-loading sub-bandage pressure of a transverse, mid-metacarpal fracture in an equine cadaver limb when loaded in bending while stabilized with either a Robert Jones Bandage (RJB) or a single-stack bandage (SS), each containing two orthogonal splints.
    Study design:  In an ex vivo experimental study, forelimb pairs from eight horses were collected, and one forelimb from each pair was assigned to either the SS or RJB groups. A transverse osteotomy was performed at the midpoint of the metacarpus. After bandaging, the limbs were loaded in bending. Pre-loading sub-bandage pressure, pre- and post-loading radiographs and post-loading deflection distance measurements were taken. Dorsopalmar radiographs were used to measure the loaded deflection angle.
    Results:  There was no significant difference between RJB and SS constructs in change in deflection angle (10.7 ± 3.0 degrees vs. 9.8 ± 2.6 degrees;
    Conclusion:  The SS splint construct resists bending forces similarly to the RJB splint construct in an
    MeSH term(s) Animals ; Bandages/standards ; Bandages/veterinary ; Biomechanical Phenomena ; Forelimb/injuries ; Fractures, Bone/therapy ; Fractures, Bone/veterinary ; Horses/injuries ; Metacarpal Bones/injuries ; Splints/standards ; Splints/veterinary
    Language English
    Publishing date 2022-12-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 286750-3
    ISSN 2567-6911 ; 0932-0814
    ISSN (online) 2567-6911
    ISSN 0932-0814
    DOI 10.1055/s-0042-1759867
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    Zs.A 2352: Show issues Location:
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  10. Article ; Online: Trial Forge Guidance 4: a guideline for reporting the results of randomised Studies Within A Trial (SWATs).

    Arundel, C E / Clark, L K / Parker, A / Beard, D / Coleman, E / Cooper, C / Devane, D / Eldridge, S / Galvin, S / Gillies, K / Hewitt, C E / Sutton, C / Torgerson, D J / Treweek, S

    Trials

    2024  Volume 25, Issue 1, Page(s) 183

    Abstract: Background: Evidence to support decisions on trial processes is minimal. One way to generate this evidence is to use a Study Within A Trial (SWAT) to test trial processes or explore methodological uncertainties. SWAT evidence relies on replication to ... ...

    Abstract Background: Evidence to support decisions on trial processes is minimal. One way to generate this evidence is to use a Study Within A Trial (SWAT) to test trial processes or explore methodological uncertainties. SWAT evidence relies on replication to ensure sufficient power and broad applicability of findings. Prompt reporting is therefore essential; however, SWAT publications are often the first to be abandoned in the face of other time pressures. Reporting guidance for embedded methodology trials does exist but is not widely used. We sought therefore to build on these guidelines to develop a straightforward, concise reporting standard, which remains adherent to the CONSORT guideline.
    Methods: An iterative process was used to develop the guideline. This included initial meetings with key stakeholders, development of an initial guideline, pilot testing of draft guidelines, further iteration and pilot testing, and finalisation of the guideline.
    Results: We developed a reporting guideline applicable to randomised SWATs, including replications of previous evaluations. The guideline follows the Consolidated Standards for Reporting Trials (CONSORT) statement and provides example text to ensure ease and clarity of reporting across all domains.
    Conclusions: The SWAT reporting guideline will aid authors, reviewers, and journal editors to produce and review clear, structured reports of randomised SWATs, whilst also adhering to the CONSORT guideline.
    Trial registration: EQUATOR Network - Guidelines Under Development ( https://www.equator-network.org/library/reporting-guidelines-under-development/reporting-guidelines-under-development-for-clinical-trials/#SWAT ). Registered on 25 March 2021.
    MeSH term(s) Humans ; Randomized Controlled Trials as Topic ; Guidelines as Topic
    Language English
    Publishing date 2024-03-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2040523-6
    ISSN 1745-6215 ; 1468-6694 ; 1745-6215
    ISSN (online) 1745-6215
    ISSN 1468-6694 ; 1745-6215
    DOI 10.1186/s13063-024-08004-0
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