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  1. Article ; Online: Child Language Difficulties and Internalizing and Externalizing Symptoms: A Meta-Analysis.

    Hentges, Rochelle F / Devereux, Chloe / Graham, Susan A / Madigan, Sheri

    Child development

    2021  Volume 92, Issue 4, Page(s) e691–e715

    Abstract: This study conducted two meta-analyses to synthesize the association between children's language skills and two broad-band dimensions of psychopathology: internalizing and externalizing. Pooled estimates across 139 samples (externalizing k = 105; ... ...

    Abstract This study conducted two meta-analyses to synthesize the association between children's language skills and two broad-band dimensions of psychopathology: internalizing and externalizing. Pooled estimates across 139 samples (externalizing k = 105; internalizing k = 90) and 147,305 participants (age range: 2-17 years old; mean % males: 53.75; mean % White participants: 55.59; mean % minority participants: 43.12) indicated small but significant associations between child language skills and externalizing problems (Hedges' g = .22) and between language skills and internalizing problems (Hedges' g = .23). The association between language difficulties and externalizing problems was stronger amongst males and in children with low versus high sociodemographic risk. Implications of the results for theory and practice are discussed.
    MeSH term(s) Adolescent ; Child ; Child Language ; Child, Preschool ; Female ; Humans ; Male ; Parent-Child Relations
    Language English
    Publishing date 2021-01-25
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't
    ZDB-ID 215602-7
    ISSN 1467-8624 ; 0009-3920
    ISSN (online) 1467-8624
    ISSN 0009-3920
    DOI 10.1111/cdev.13540
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The Fetus or the Infant: Which Is the Father of the Man? (Both).

    Turner, Steve / Devereux, Graham

    American journal of respiratory and critical care medicine

    2017  Volume 197, Issue 2, Page(s) 147–148

    MeSH term(s) Asthma ; Female ; Fetus ; Humans ; Infant ; Pregnancy ; Prenatal Care
    Language English
    Publishing date 2017-10-16
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.201709-1947ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: CMV pneumonitis in a patient with Crohn's disease taking azathioprine.

    Hawthorne, Timothy Zef / Shellien, Rachel / Chambers, Lucy / Devereux, Graham

    BMJ case reports

    2021  Volume 14, Issue 4

    Abstract: This case report discusses the rare presentation of cytomegalovirus (CMV) pneumonitis in a young patient with moderately severe Crohn's disease managed with low dose azathioprine. CMV pneumonitis was initially suspected on CT chest images and confirmed ... ...

    Abstract This case report discusses the rare presentation of cytomegalovirus (CMV) pneumonitis in a young patient with moderately severe Crohn's disease managed with low dose azathioprine. CMV pneumonitis was initially suspected on CT chest images and confirmed by PCR for CMV. She was treated with intravenous ganciclovir and later stepped down to oral valganciclovir. Although this patient had a prolonged and complicated hospital admission, a good clinical outcome was achieved. CMV infection was raised as an early differential and antiviral treatment was started without delay. This case study, therefore, makes the case for increased awareness of the possibility of, and recognition of CMV pneumonitis among healthcare professionals as a way of preventing significant morbidity and mortality. It also raises awareness of checking for slow metabolisers of azathioprine before initiation to look for individuals who may be at increased risk of azathioprine's adverse effects.
    MeSH term(s) Antiviral Agents/adverse effects ; Azathioprine/adverse effects ; Crohn Disease/drug therapy ; Cytomegalovirus Infections/complications ; Cytomegalovirus Infections/diagnosis ; Cytomegalovirus Infections/drug therapy ; Female ; Ganciclovir/therapeutic use ; Humans ; Pneumonia/chemically induced ; Pneumonia/drug therapy
    Chemical Substances Antiviral Agents ; Azathioprine (MRK240IY2L) ; Ganciclovir (P9G3CKZ4P5)
    Language English
    Publishing date 2021-04-23
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2020-241256
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Obstructive and restrictive spirometry from school age to adulthood

    Anhar Ullah / Raquel Granell / Sadia Haider / Lesley Lowe / Sara Fontanella / Hasan Arshad / Clare S. Murray / Steve Turner / John W. Holloway / Angela Simpson / Graham Roberts / Adnan Custovic / John Ainsworth / Philip Couch / Paul Cullinan / Graham Devereux / Ashley Woodcock

    EClinicalMedicine, Vol 67, Iss , Pp 102355- (2024)

    three birth cohort studiesResearch in context

    1481  

    Abstract: Summary: Background: Spirometric obstruction and restriction are two patterns of impaired lung function which are predictive of poor health. We investigated the development of these phenotypes and their transitions through childhood to early adulthood. ... ...

    Abstract Summary: Background: Spirometric obstruction and restriction are two patterns of impaired lung function which are predictive of poor health. We investigated the development of these phenotypes and their transitions through childhood to early adulthood. Methods: In this study, we analysed pooled data from three UK population−based birth cohorts established between 1989 and 1995. We applied descriptive statistics, regression modelling and data-driven modelling to data from three population−based birth cohorts with at least three spirometry measures from childhood to adulthood (mid-school: 8–10 years, n = 8404; adolescence: 15–18, n = 5764; and early adulthood: 20–26, n = 4680). Participants were assigned to normal, restrictive, and obstructive spirometry based on adjusted regression residuals. We considered two transitions: from 8–10 to 15–18 and from 15–18 to 20–26 years. Findings: Obstructive phenotype was observed in ∼10%, and restrictive in ∼9%. A substantial proportion of children with impaired lung function in school age (between one third in obstructive and a half in restricted phenotype) improved and achieved normal and stable lung function to early adulthood. Of those with normal lung function in school-age, <5% declined to adulthood. Underweight restrictive and obese obstructive participants were less likely to transit to normal. Maternal smoking during pregnancy and current asthma diagnosis increased the risk of persistent obstruction and worsening. Significant associate of worsening in restrictive phenotypes was lower BMI at the first lung function assessment. Data-driven methodologies identified similar risk factors for obstructive and restrictive clusters. Interpretation: The worsening and improvement in obstructive and restrictive spirometry were observed at all ages. Maintaining optimal weight during childhood and reducing maternal smoking during pregnancy may reduce spirometry obstruction and restriction and improve lung function. Funding: MRC Grant MR/S025340/1.
    Keywords Lung function ; Obstruction ; Restriction ; Worsening ; Improvement ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Testing a proactive approach to frailty identification: the electronic frailty index.

    Devereux, Nathan / Ellis, Graham / Dobie, Laura / Baughan, Paul / Monaghan, Thomas

    BMJ open quality

    2019  Volume 8, Issue 3, Page(s) e000682

    Language English
    Publishing date 2019-08-24
    Publishing country England
    Document type Journal Article
    ISSN 2399-6641
    ISSN (online) 2399-6641
    DOI 10.1136/bmjoq-2019-000682
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Session 1: Allergic disease: Nutrition as a potential determinant of asthma.

    Devereux, Graham

    The Proceedings of the Nutrition Society

    2010  Volume 69, Issue 1, Page(s) 1–10

    Abstract: Asthma is characterised by chronic lung airway inflammation, increased airway responsiveness and variable airflow obstruction. In Westernised countries asthma is a public health concern because of its prevalence, associated ill health and high societal ... ...

    Abstract Asthma is characterised by chronic lung airway inflammation, increased airway responsiveness and variable airflow obstruction. In Westernised countries asthma is a public health concern because of its prevalence, associated ill health and high societal and healthcare costs. In recent decades there has been a marked increase in asthma prevalence, particularly in Westernised countries. It has been proposed that changing diet has contributed to the increase in asthma. Several dietary hypotheses exist; the first relates the increase in asthma to declining dietary antioxidant intake, the second to decreased intake of long-chain n-3 PUFA and increasing intake of n-6 PUFA. Vitamin D supplementation and deficiency have also been hypothesised to have contributed to the increase in asthma. Observational studies have reported associations between asthma and dietary antioxidants (vitamin E, vitamin C, carotenoids, Se, flavonoids, fruit), lipids (PUFA, butter, margarine, fish) and vitamin D. However, supplementing the diets of adults with asthma with antioxidants and lipids has minimal, if any, clinical benefit. There is growing interest in the possibility that childhood asthma is influenced by maternal diet during pregnancy, with studies highlighting associations between childhood asthma and maternal intake of some nutrients (vitamin E, vitamin D, Se, PUFA) during pregnancy. It has been suggested that maternal diet during pregnancy influences fetal airway and/or immune development. Further intervention studies are needed to establish whether modification of maternal nutrient intake during pregnancy can be used as a healthy low-cost public health measure to reduce the prevalence of childhood asthma.
    MeSH term(s) Adult ; Antioxidants/administration & dosage ; Asthma/epidemiology ; Asthma/etiology ; Asthma/prevention & control ; Child ; Diet ; Dietary Fats, Unsaturated/administration & dosage ; Dietary Supplements ; Fatty Acids, Unsaturated/administration & dosage ; Female ; Fetal Development ; Humans ; Hypersensitivity ; Maternal Nutritional Physiological Phenomena ; Micronutrients/deficiency ; Pregnancy ; Prenatal Exposure Delayed Effects ; Prevalence
    Chemical Substances Antioxidants ; Dietary Fats, Unsaturated ; Fatty Acids, Unsaturated ; Micronutrients
    Language English
    Publishing date 2010-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 391142-1
    ISSN 1475-2719 ; 0029-6651
    ISSN (online) 1475-2719
    ISSN 0029-6651
    DOI 10.1017/S0029665109991753
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Modeling Wheezing Spells Identifies Phenotypes with Different Outcomes and Genetic Associates.

    Haider, Sadia / Granell, Raquel / Curtin, John / Fontanella, Sara / Cucco, Alex / Turner, Stephen / Simpson, Angela / Roberts, Graham / Murray, Clare S / Holloway, John W / Devereux, Graham / Cullinan, Paul / Arshad, Syed Hasan / Custovic, Adnan

    American journal of respiratory and critical care medicine

    2022  Volume 205, Issue 8, Page(s) 883–893

    Abstract: Rationale: ...

    Abstract Rationale:
    MeSH term(s) Adult ; Asthma ; Cadherin Related Proteins ; Cadherins/genetics ; Humans ; Infant ; Latent Class Analysis ; Membrane Proteins/genetics ; Phenotype ; Respiratory Function Tests ; Respiratory Sounds/genetics ; Risk Factors
    Chemical Substances CDHR3 protein, human ; Cadherin Related Proteins ; Cadherins ; Membrane Proteins
    Language English
    Publishing date 2022-01-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202108-1821OC
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Maternal diet during pregnancy: an emerging risk factor for childhood asthma.

    Devereux, Graham

    Expert review of clinical immunology

    2008  Volume 4, Issue 6, Page(s) 663–668

    Abstract: Evaluation of: Willers SM, Wijga AH, Brunekreef B et al. Maternal food consumption during pregnancy and the longitudinal development of childhood asthma. Am. J. Respir. Crit. Care Med. 178, 124-131 (2008). It has been hypothesized that the recent marked ... ...

    Abstract Evaluation of: Willers SM, Wijga AH, Brunekreef B et al. Maternal food consumption during pregnancy and the longitudinal development of childhood asthma. Am. J. Respir. Crit. Care Med. 178, 124-131 (2008). It has been hypothesized that the recent marked increase in the prevalence of asthma may, in part, be a consequence of changing diet. There is increasing interest in the possibility that childhood asthma may be influenced by maternal diet during pregnancy and an increasing number of studies have highlighted associations between childhood asthma and maternal intake of certain foods (e.g., fish, fruits and vegetables) and nutrients (e.g., vitamin E, vitamin D, zinc and polyunsaturated fatty acids) during pregnancy. Maternal diet during pregnancy has the potential to influence fetal immune and airway development during a critical period of life with long-term irreversible consequences, such as childhood asthma. Further research, particularly intervention studies, needs to be carried out to establish whether dietary intervention during pregnancy can be used as a healthy, low-cost, public-health measure to reduce the prevalence of childhood asthma.
    Language English
    Publishing date 2008-11
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 2274260-8
    ISSN 1744-8409 ; 1744-666X
    ISSN (online) 1744-8409
    ISSN 1744-666X
    DOI 10.1586/1744666X.4.6.663
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Women and girls in resource poor countries experience much greater exposure to household air pollutants than men: Results from Uganda and Ethiopia.

    Okello, Gabriel / Devereux, Graham / Semple, Sean

    Environment international

    2018  Volume 119, Page(s) 429–437

    Abstract: Household Air Pollution (HAP) from burning biomass fuels is a major cause of mortality and morbidity in low-income settings worldwide. Little is known about the differences in objective personal HAP exposure by age and gender. We measured personal ... ...

    Abstract Household Air Pollution (HAP) from burning biomass fuels is a major cause of mortality and morbidity in low-income settings worldwide. Little is known about the differences in objective personal HAP exposure by age and gender. We measured personal exposure to HAP across six groups defined by age and gender (young children, young males, young females, adult males, adult females, and elderly) in rural households in two sub-Saharan African countries. Data on 24-hour personal exposure to HAP were collected from 215 participants from 85 households in Uganda and Ethiopia. HAP exposure was assessed by measuring carbon monoxide (CO) and/or fine particulate matter (PM
    MeSH term(s) Adolescent ; Adult ; Air Pollutants/analysis ; Air Pollution, Indoor/analysis ; Biomass ; Carbon Monoxide/analysis ; Child ; Child, Preschool ; Cooking ; Environmental Exposure/analysis ; Ethiopia ; Family Characteristics ; Female ; Humans ; Male ; Middle Aged ; Particulate Matter/analysis ; Poverty ; Rural Population ; Sex Factors ; Uganda ; Young Adult
    Chemical Substances Air Pollutants ; Particulate Matter ; Carbon Monoxide (7U1EE4V452)
    Language English
    Publishing date 2018-07-20
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 554791-x
    ISSN 1873-6750 ; 0160-4120
    ISSN (online) 1873-6750
    ISSN 0160-4120
    DOI 10.1016/j.envint.2018.07.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Household food insecurity, maternal nutrition, environmental risks and infants' health outcomes: protocol of the IMPALA birth cohort study in Uganda.

    Terfa, Zelalem G / Nantanda, Rebecca / Lesosky, Maia / Devereux, Graham / Obasi, Angela / Mortimer, Kevin / Khan, Jahangir / Rylance, Jamie / Niessen, Louis Wihelmus

    BMJ open

    2022  Volume 12, Issue 3, Page(s) e050729

    Abstract: Introduction: In low- and middle-income countries (LMICs), food insecurity and undernutrition disproportionately affect women of reproductive age, infants and young children. The disease burden from undernutrition in these vulnerable sections of ... ...

    Abstract Introduction: In low- and middle-income countries (LMICs), food insecurity and undernutrition disproportionately affect women of reproductive age, infants and young children. The disease burden from undernutrition in these vulnerable sections of societies remains a major concern in LMICs. Biomass fuel use for cooking is also common in LMICs. Empirical evidence from high-income countries indicates that early life nutritional and environmental exposures and their effect on infant lung function are important; however, data from sub-Saharan Africa are scarce.
    Aim: To estimate the association between infant lung function and household food insecurity, energy poverty and maternal dietary diversity.
    Methods and analysis: Pregnant women will be recruited in an existing Health and Demographic Surveillance Site in South-West Uganda. Household food insecurity, sources and uses of energy, economic measures and maternal dietary diversity will be collected during pregnancy and after birth. Primary health outcomes will be infant lung function determined by tidal breath flow and volume analysis at 6-10 weeks of age. Infant weight and length will also be collected.A household Food Consumption Score and Minimum Dietary Diversity for Women (MDD-W) indicator will be constructed. The involved cost of dietary diversity will be estimated based on MDD-W. The association between household level and mothers' food access indicators and infant lung function will be evaluated using regression models. The Multidimensional Energy Poverty Index (MEPI) will be estimated and used as an indicator of households' environmental exposures. The association between household MEPI and infant lung function will be assessed using econometric models.
    Ethics and dissemination: Ethical approvals have been obtained from Liverpool School of Tropical Medicine (18-059), the Uganda Virus Research Institute Ethics Committee (097/2018) and Uganda National Council for Science and Technology (SS 4846). Study results will be shared with participants, policy-makers, other stakeholders and published in peer-reviewed journals.
    MeSH term(s) Birth Cohort ; Child ; Child, Preschool ; Cohort Studies ; Female ; Food Insecurity ; Food Supply ; Humans ; Infant ; Pregnancy ; Uganda/epidemiology
    Language English
    Publishing date 2022-03-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2021-050729
    Database MEDical Literature Analysis and Retrieval System OnLINE

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