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  1. Article: Interview with Peter J Barnes.

    Barnes, Peter J

    Therapeutic delivery

    2013  Volume 4, Issue 8, Page(s) 901–903

    MeSH term(s) Drug Delivery Systems ; Humans ; Pulmonary Disease, Chronic Obstructive/drug therapy
    Language English
    Publishing date 2013-08
    Publishing country England
    Document type Interview
    ISSN 2041-5990
    ISSN 2041-5990
    DOI 10.4155/tde.13.65
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Betablocker bei Asthma? Interview mit Professor Peter J. Barnes, Direktor des British National Heart and Lung Institute

    Barnes, Peter J.

    Ars medici

    2009  Volume 99, Issue Sonderh. Nov. Pneumologie, Page(s) 6

    Language German
    Document type Article
    ZDB-ID 124118-7
    ISSN 0004-2897
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 69: Show issues Location:
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  3. Book ; Conference proceedings ; Online: Interstitial water chemistry of ODP Leg 110 holes, supplementary data to: Gieskes, Joris M; Blanc, Gérard; Vrolijk, Peter J; Elderfield, Harry; Barnes, Ross (1990): Interstitial water chemistry - major constituents. In: Moore, JC; Mascle, A; et al. (eds.), Proceedings of the Ocean Drilling Program, Scientific Results, College Station, TX (Ocean Drilling Program), 110, 155-178

    Gieskes, Joris M / Barnes, Ross / Blanc, Gérard / Elderfield, Harry / Vrolijk, Peter J

    1990  

    Abstract: Major-element compositions (Cl-, SO4[2-], Ca2+, Mg2+ , Li+ , K+, Na+ , Sr2+) of interstitial waters obtained from sediment cores along the ODP Leg 110 transect across the Northern Barbados accretionary prism have shown that a complex set of geochemical ... ...

    Abstract Major-element compositions (Cl-, SO4[2-], Ca2+, Mg2+ , Li+ , K+, Na+ , Sr2+) of interstitial waters obtained from sediment cores along the ODP Leg 110 transect across the Northern Barbados accretionary prism have shown that a complex set of geochemical processes are of importance in this area. In the volcanic ash-rich Pleistocene-Pliocene sediments, alteration reactions involving volcanic ash lead to depletions of Mg2+ and K+. This process is confirmed by the much lower than contemporaneous seawater values of the 87Sr/86Sr ratios of dissolved strontium. In the deeper sediments recovered below the zone of decollement (Sites 671 and 672) large increases in Ca2+ and gradual decreases in Mg2+ , Na+, and d18O (H2O) indicate a potential contribution to the interstitial water chemistry by exchange with underlying basement rocks. This process has been hard to confirm because the drill holes were terminated well short of reaching basement. However, the concentration gradient pattern is consistent with observations in a large number of DSDP drill holes. Finally, but most importantly, low Cl- concentrations in the decollement zone and underlying sand layers, as well as in fault zones at Sites 673 and 674, indicate dilution of interstitial waters. The potential origins of the low Cl- concentrations are discussed, though we are not able to distinguish any mechanism in particular. Our evidence supports the concept of water migration along the decollement and through the underlying sandstones as well as along recent fault zones in the accretionary complex. Interstitial water concentration depth profiles are affected by faulting, thrusting, and overturn processes in the accretionary prism. These processes have caused a diminished diffusive exchange with the overlying ocean, thus explaining increased depletions in Mg2+ and SO4[2-] in sites farther onto the accretionary prism.
    Language English
    Dates of publication 1990-9999
    Size Online-Ressource
    Publisher PANGAEA - Data Publisher for Earth & Environmental Science
    Publishing place Bremen/Bremerhaven
    Document type Book ; Conference proceedings ; Online
    Note This dataset is supplement to doi:10.2973/odp.proc.sr.110.170.1990
    DOI 10.1594/PANGAEA.747729
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  4. Book ; Online ; E-Book: Pocket prescriber pulmonary medicine

    Batista, Craig / Singer, Donald Rj / Barnes, Peter J.

    (Pocket Prescriber Series)

    2024  

    Abstract: Pocket Prescriber Pulmonary Medicine is a concise, up-to-date prescribing guide containing all the 'must-have' information that clinical professionals treating patients with respiratory conditions need to know. ...

    Author's details Craig Batista, Donald Rj Singer, and Peter J. Barnes
    Series title Pocket Prescriber Series
    Abstract Pocket Prescriber Pulmonary Medicine is a concise, up-to-date prescribing guide containing all the 'must-have' information that clinical professionals treating patients with respiratory conditions need to know.
    Keywords Drug abuse
    Subject code 613.8
    Language English
    Size 1 online resource (329 pages)
    Publisher CRC Press
    Publishing place Boca Raton, FL
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 1-315-15181-2 ; 1-4987-4441-9 ; 9781498744409 ; 978-1-315-15181-6 ; 978-1-4987-4441-6 ; 1498744400
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Book: Chronic obstructive pulmonary disease

    Barnes, Peter J.

    (Clinics in chest medicine ; 35,1)

    2014  

    Author's details ed. Peter J. Barnes
    Series title Clinics in chest medicine ; 35,1
    Collection
    Language English
    Size XII, 278 S. : Ill., graph. Darst.
    Publisher Elsevier
    Publishing place Philadelphia, Pa
    Publishing country United States
    Document type Book
    HBZ-ID HT018232484
    ISBN 978-0-323-26090-9 ; 0-323-26090-X
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 805 -35,1- verfügbar in Königswinter Königswinter

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  6. Article ; Online: Senotherapy for lung diseases.

    Barnes, Peter J

    Advances in pharmacology (San Diego, Calif.)

    2023  Volume 98, Page(s) 249–271

    Abstract: Increasing evidence suggests that there is acceleration of lung ageing in chronic lung diseases, such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF), with the accumulation of senescent cells in the lung. Senescent ...

    Abstract Increasing evidence suggests that there is acceleration of lung ageing in chronic lung diseases, such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF), with the accumulation of senescent cells in the lung. Senescent cells fail to repair tissue damage and release an array of inflammatory proteins, known as the senescence-associated secretory phenotype, which drive further senescence and disease progression. This suggests that targeting cellular senescence with senotherapies may treat the underlying disease process in COPD and IPF and thus reduce disease progression and mortality. Several existing or future drugs may inhibit the development of cellular senescence which is driven by chronic oxidative stress (senostatics), including inhibitors of PI3K-mTOR signalling pathways, antagomirs of critical microRNAs and novel antioxidants. Other drugs (senolytics) selectively remove senescent cells by promoting apoptosis. Clinical studies with senotherapies are already underway in chronic lung diseases.
    MeSH term(s) Humans ; Lung Diseases/drug therapy ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Cellular Senescence/genetics ; Aging ; Idiopathic Pulmonary Fibrosis/drug therapy ; Disease Progression
    Language English
    Publishing date 2023-04-20
    Publishing country United States
    Document type Journal Article
    ISSN 1557-8925
    ISSN (online) 1557-8925
    DOI 10.1016/bs.apha.2023.04.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Chemokine receptor CCR1: new target for asthma therapy.

    Barnes, Peter J

    Trends in pharmacological sciences

    2022  Volume 43, Issue 7, Page(s) 539–541

    Abstract: A recent study shows that chemokine receptor 1 (CCR1) plays a role in eosinophilic inflammation and that its ligand CCL15 is increased in asthmatic eosinophils (Du et al.). A companion study reports that N-truncated forms of CCL15 generated by tissue ... ...

    Abstract A recent study shows that chemokine receptor 1 (CCR1) plays a role in eosinophilic inflammation and that its ligand CCL15 is increased in asthmatic eosinophils (Du et al.). A companion study reports that N-truncated forms of CCL15 generated by tissue proteases induce biased CCR1 signaling (Shao et al.). These insights may provide the basis for the generation of more effective CCR antagonists as an oral therapy for asthma.
    MeSH term(s) Asthma/drug therapy ; Eosinophils ; Humans ; Ligands ; Receptors, CCR1 ; Signal Transduction
    Chemical Substances CCR1 protein, human ; Ligands ; Receptors, CCR1
    Language English
    Publishing date 2022-03-02
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 282846-7
    ISSN 1873-3735 ; 0165-6147
    ISSN (online) 1873-3735
    ISSN 0165-6147
    DOI 10.1016/j.tips.2022.02.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1513: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
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  8. Book: Pharmacology and therapeutics of Asthma and COPD

    Page, Clive P. / Barnes, Peter J.

    (Handbook of experimental pharmacology ; 237)

    2017  

    Series title Handbook of experimental pharmacology ; 237
    Collection
    Keywords Airway inflammatory diseases ; Asthma ; COPD ; Pulmonary pharmacology ; Respiratory diseases
    Language English
    Size x, 285 Seiten, Illustrationen
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT019260469
    ISBN 978-3-319-52173-2 ; 3-319-52173-X
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2017 A 455 available for loan (reading room) Lesesaal EG

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  9. Article: Oxidative Stress in Chronic Obstructive Pulmonary Disease.

    Barnes, Peter J

    Antioxidants (Basel, Switzerland)

    2022  Volume 11, Issue 5

    Abstract: There is a marked increase in oxidative stress in the lungs of patients with COPD, as measured by increased exhaled 8-isoprostane, ethane, and hydrogen peroxide in the breath. The lung may be exposed to exogenous oxidative stress from cigarette smoking ... ...

    Abstract There is a marked increase in oxidative stress in the lungs of patients with COPD, as measured by increased exhaled 8-isoprostane, ethane, and hydrogen peroxide in the breath. The lung may be exposed to exogenous oxidative stress from cigarette smoking and indoor or outdoor air pollution and to endogenous oxidative stress from reactive oxygen species released from activated inflammatory cells, particularly neutrophils and macrophages, in the lungs. Oxidative stress in COPD may be amplified by a reduction in endogenous antioxidants and poor intake of dietary antioxidants. Oxidative stress is a major driving mechanism of COPD through the induction of chronic inflammation, induction of cellular senescence and impaired autophagy, reduced DNA repair, increased autoimmunity, increased mucus secretion, and impaired anti-inflammatory response to corticosteroids. Oxidative stress, therefore, drives the pathology of COPD and may increase disease progression, amplify exacerbations, and increase comorbidities through systemic oxidative stress. This suggests that antioxidants may be effective as disease-modifying treatments. Unfortunately, thiol-based antioxidants, such as N-acetylcysteine, have been poorly effective, as they are inactivated by oxidative stress in the lungs, so there is a search for more effective and safer antioxidants. New antioxidants in development include mitochondria-targeted antioxidants, NOX inhibitors, and activators of the transcription factor Nrf2, which regulates several antioxidant genes.
    Language English
    Publishing date 2022-05-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox11050965
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Endogenous inhibitory mechanisms in asthma.

    Chiarella, Sergio E / Barnes, Peter J

    The journal of allergy and clinical immunology. Global

    2023  Volume 2, Issue 4, Page(s) 100135

    Abstract: Endogenous inhibitory mechanisms promote resolution of inflammation, enhance tissue repair and integrity, and promote homeostasis in the lung. These mechanisms include steroid hormones, regulatory T cells, IL-10, prostaglandin ... ...

    Abstract Endogenous inhibitory mechanisms promote resolution of inflammation, enhance tissue repair and integrity, and promote homeostasis in the lung. These mechanisms include steroid hormones, regulatory T cells, IL-10, prostaglandin E
    Language English
    Publishing date 2023-07-05
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2772-8293
    ISSN (online) 2772-8293
    DOI 10.1016/j.jacig.2023.100135
    Database MEDical Literature Analysis and Retrieval System OnLINE

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