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  1. Article ; Online: Gut Microbial Changes Following Fecal Microbiota Transplantation for D-Lactic Acidosis in Two Children.

    Busing, Jordan D / Fouladi, Farnaz / Bulik-Sullivan, Emily C / Carroll, Ian M / Fodor, Anthony A / Thomsen, Kelly F / Gulati, Ajay S / Nicholson, Maribeth R

    JPGN reports

    2023  Volume 4, Issue 3, Page(s) e319

    Abstract: D-lactic acidosis (D-LA) is an uncommon complication of short bowel syndrome characterized ... by elevated plasma D-lactate and encephalopathy. Treatments include rehydration ... been used in children to successfully treat D-LA. We compared the clinical course and then utilized ...

    Abstract D-lactic acidosis (D-LA) is an uncommon complication of short bowel syndrome characterized by elevated plasma D-lactate and encephalopathy. Treatments include rehydration, dietary carbohydrate restriction, and antibiotics to alter the gut microbiota. Fecal microbiota transplantation (FMT) has recently been used in children to successfully treat D-LA. We compared the clinical course and then utilized metagenomic shotgun sequencing to describe changes in the composition and function of the intestinal microbiome following FMT in 2 patients with recurrent D-LA. FMT altered the composition of the fecal microbiota in these 2 patients with recurrent D-LA, though not necessarily in a consistent manner. Importantly, microbial metabolic pathways were also impacted by FMT, which may be critical for achieving desired clinical outcomes. While sample size limits the generalizability of our results, these findings set the stage for further understanding of the role of microbes in the pathogenesis of recurrent D-LA.
    Language English
    Publishing date 2023-06-09
    Publishing country United States
    Document type Journal Article
    ISSN 2691-171X
    ISSN (online) 2691-171X
    DOI 10.1097/PG9.0000000000000319
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  2. Article ; Online: Adherence to Vitamin D Supplementation Recommendations for Breastfed Infants and Young Children: An Analysis of Canadian Community Health Survey Data Cycles From 2015 to 2018.

    Weiler, Hope A / Rana, Huma / McCrea, Jennifer / Loukine, Lidia / Bonvalot, Yvette / Nguyen, Loan / Hopperton, Kathryn / Cooper, Marcia / Bertinato, Jesse / Vercammen, Kelsey / Luo, Wei / Nicholson, Carley / Yuan, Jane / Brule, Shawn

    The Journal of nutrition

    2024  

    Abstract: ... recommendations, includes a daily vitamin D supplement of 10 μg (400 IU) for breastfed infants and young children ... to support adequate vitamin D status.: Objectives: This study aimed to report on adherence to vitamin D ... given a vitamin D supplement (yes/no) and the frequency (daily/almost every day, 1-2/wk, or <1/wk) were surveyed ...

    Abstract Background: In Canada, nutrition policy, as outlined in the Nutrition for Healthy Term Infants recommendations, includes a daily vitamin D supplement of 10 μg (400 IU) for breastfed infants and young children to support adequate vitamin D status.
    Objectives: This study aimed to report on adherence to vitamin D supplementation recommendations for breastfed infants (≤12 months); and for children breastfed >12 mo.
    Methods: Canadian Community Health Survey (paired-cycles 2015/2016 and 2017/2018) maternal experiences data for infants born 2012-2018 who received any breastmilk formed the sample (n = 7079). Whether the infant was given a vitamin D supplement (yes/no) and the frequency (daily/almost every day, 1-2/wk, or <1/wk) were surveyed. Weighted data (95% CI) were summarized according to breastfeeding history (exclusive to 6 mo and continuing; partial to 6 mo and continuing; and stopped ≤6 mo). Correlates of supplement adherence were explored using logistic regression.
    Results: Overall, 87.1% (95% CI: 85.9%, 88.3%) of participants reported giving their infant (≤12 mo) a vitamin D supplement, and of these, 83.3% (95% CI: 81.9%, 84.7%) did so daily/almost every day, 12.4% (95% CI: 11.1%, 13.7%) did so 1-2/wk, and 4.3% (95% CI: 3.6%, 5.0%) did so <1/wk. Lower adjusted odds of adherence were observed among participants reporting: stopped breastfeeding ≤6 mo, lower education or income, recent immigration, and overweight prepregnancy body mass index; higher odds of adherence were observed in the western provinces. Regarding mothers of children >12 mo and breastfed (n = 2312), 58.0% (95% CI: 54.9%, 61.1%) gave a vitamin D supplement daily/almost every day.
    Conclusions: Adherence to providing a vitamin D supplement to breastfed infants is high in Canada. Nonetheless, we estimate that ∼27% of mothers are nonadherent to daily/almost every day administration of a vitamin D supplement and that adherence declines in children breastfed >12 mo. Further promotion to support uptake of the current guidance may be necessary, particularly for parents of recent immigration or lower socioeconomic status.
    Language English
    Publishing date 2024-03-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218373-0
    ISSN 1541-6100 ; 0022-3166
    ISSN (online) 1541-6100
    ISSN 0022-3166
    DOI 10.1016/j.tjnut.2024.03.016
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  3. Article ; Online: Hepatitis B and D in the Pacific Islands of Kiribati.

    Jackson, Kathy / Tekoaua, Rosemary / Holgate, Thomas / Edwards, Ros / Yuen, Lilly / Lee, Alice / Nicholson, Suellen / Littlejohn, Margaret / Locarnini, Stephen / Tuneti, Kabiri

    Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology

    2020  Volume 129, Page(s) 104527

    Abstract: Background: Historical reports indicate that hepatitis B and hepatitis D are highly endemic ...

    Abstract Background: Historical reports indicate that hepatitis B and hepatitis D are highly endemic in the Pacific Island of Kiribati but current levels are unknown.
    Objectives: To determine current prevalence of HBV and HDV in Kiribati, characterize the strains in both mono-infection and co-infection and assess individuals for antiviral therapy.
    Study design: Sera obtained from 219 patients were screened for HBsAg, HBeAg, HBV DNA, anti-HD, and HDV RNA. 61 HBV isolates were sequenced for genotype, phylogenetic analysis and detection of pre-core and basal core promoter mutations. 82 HDV isolates were also sequenced.
    Results: 55.7 % HBsAg positive samples had antibodies to HDV and 73.2 % had detectable HDV RNA, indicating that 40.8 % HBsAg-positive individuals had current HBV/HDV co-infection. There were 42 co-infected males and 40 females; the youngest individual was a 4 year-old boy. HBV isolates were genotype D4, and HDV strains formed a distinct Pacific clade of genotype 1. Undetectable HBV DNA loads were statistically more frequent in the co-infected sub-population (p < 0.0001). Basal core promoter and pre-core mutations were present in both mono and co-infection.
    Conclusion: Kiribati has one of the highest HBV/HDV co-infection rates in the world. The epidemiology of co-infection in this population was unusual with males and females equally represented and the presence of co-infection in a 4 year old child suggesting neonatal or early horizontal transmission, which is extremely rare. Coinfection with HDV resulted in statistically significant suppression of HBV DNA levels. The HDV strain identified in Kiribati was unique to the Pacific Islands.
    MeSH term(s) Child, Preschool ; Coinfection ; Female ; Genotype ; Hepatitis B ; Hepatitis B Surface Antigens ; Hepatitis B virus ; Hepatitis D ; Hepatitis Delta Virus ; Humans ; Infant, Newborn ; Male ; Micronesia ; Pacific Islands ; Phylogeny
    Chemical Substances Hepatitis B Surface Antigens
    Language English
    Publishing date 2020-06-29
    Publishing country Netherlands
    Document type Case Reports ; Journal Article
    ZDB-ID 1446080-4
    ISSN 1873-5967 ; 1386-6532
    ISSN (online) 1873-5967
    ISSN 1386-6532
    DOI 10.1016/j.jcv.2020.104527
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  4. Article ; Online: Collaboration in times of crisis: A study on COVID-19 vaccine R&D partnerships.

    Druedahl, Louise C / Minssen, Timo / Price, W Nicholson

    Vaccine

    2021  Volume 39, Issue 42, Page(s) 6291–6295

    Abstract: Collaboration is central for initiatives and efforts in the race to fight COVID-19, with particular focus on fostering rapid development of safe and effective COVID-19 vaccines. We investigated the types of partnerships that have emerged during the ... ...

    Abstract Collaboration is central for initiatives and efforts in the race to fight COVID-19, with particular focus on fostering rapid development of safe and effective COVID-19 vaccines. We investigated the types of partnerships that have emerged during the pandemic to develop these products. Using the World Health Organization's list of COVID-19 vaccine developments, we found nearly one third of all vaccine candidates were developed by partnerships, which tended to use next-gen vaccine platforms more than solo efforts. These partnerships vary substantially between materials-transfer partnerships and knowledge-sharing partnerships. The difference is important: The type of sharing between partners not only shapes the collaboration, but also bears implications for knowledge and technology development in the field and more broadly. Policies promoting fair and effective collaboration and knowledge-sharing are key for public health to avoid stumbling blocks for vaccine development, deployment, and equitable access, both for COVID-19 and expected future pandemics.
    MeSH term(s) Biomedical Research ; COVID-19 ; COVID-19 Vaccines ; Humans ; Policy ; SARS-CoV-2
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2021-09-02
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2021.08.101
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    Zs.MO 458: Show issues

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  5. Article ; Online: Is D-dimer a Reliable Serum Marker for Shoulder Periprosthetic Joint Infection?

    Zmistowski, Benjamin / Chang, Michael / Shahi, Alisina / Nicholson, Thema / Abboud, Joseph / Lazarus, Mark / Williams, Gerald / Parvizi, Javad / Namdari, Surena

    Clinical orthopaedics and related research

    2021  Volume 479, Issue 7, Page(s) 1447–1454

    Abstract: ... with confidence. Serum D-dimer has proven to be effective as a screening tool for periprosthetic joint infection ... Questions/purposes: (1) Is D-dimer elevated in patients with probable or definite periprosthetic shoulder ... infections? (2) What is the diagnostic accuracy of D-dimer for periprosthetic shoulder infections? (3 ...

    Abstract Background: The diagnosis of periprosthetic shoulder infection continues to be difficult to make with confidence. Serum D-dimer has proven to be effective as a screening tool for periprosthetic joint infection in other major joints; however, it has yet to be evaluated for use in periprosthetic shoulder infection.
    Questions/purposes: (1) Is D-dimer elevated in patients with probable or definite periprosthetic shoulder infections? (2) What is the diagnostic accuracy of D-dimer for periprosthetic shoulder infections? (3) What are the diagnostic accuracies of serum tests (erythrocyte sedimentation rate [ESR], C-reactive protein [CRP], and D-dimer), singly and in combination?
    Methods: Between March 2016 and March 2020, 94 patients undergoing revision total shoulder arthroplasty (anatomic or reverse) at a single institution had preoperative serum testing with CRP, ESR, and D-dimer. These 94 patients were a subset of 189 revision shoulder arthroplasties performed at this institution during the study period who met inclusion criteria and consented to participate. Included patients had a mean ± SD age of 69 ± 8 years, and 56% (53 of 94) were men. Patient records were reviewed to classify patients as definitely having infection, probably having infection, possibly having infection, or unlikely to have an infection, according to the International Consensus Meeting (ICM) definition of periprosthetic shoulder infection. Statistical analyses, including a receiver operating characteristic curve analysis, were performed to quantify the diagnostic value of D-dimer for periprosthetic shoulder infection. Based on the ICM definition, 4% (4 of 94), 15% (14 of 94), 14% (13 of 94), and 67% (63 of 94) of patients had definite, probable, possible, or unlikely periprosthetic shoulder infections.
    Results: D-dimer was elevated in patients with definite or probable infections (median [range] 661 ng/mL [150 to 8205]) compared with those with possible infections or those who were unlikely to have an infection (263 ng/mL [150 to 3060]; median difference 143 ng/mL [95% CI 40 to 503]; p = 0.01). In the receiver operating characteristic curve analysis, D-dimer had an area under the curve of 0.71 (0.50-0.92), demonstrating weak diagnostic value. A D-dimer level of 598 ng/mL provided a sensitivity and specificity of 61% (95% CI 36% to 82%) and 74% (95% CI 62% to 83%), respectively, for diagnosing a definite or probable infection according to the ICM definitions. The specificity of detecting periprosthetic joint infection (88% [95% CI 79% to 94%]) was high when three positive serum markers (ESR, CRP, and D-dimer) were required, at the expense of sensitivity (28% [95% CI 10% to 53%]).
    Conclusion: In periprosthetic shoulder infection, D-dimer is elevated. However, similar to other serum tests, it has limited diagnostic utility in identifying patients with periprosthetic shoulder infection. Further work is needed to understand the process by which D-dimer is associated with active infection.
    Level of evidence: Level III, diagnostic study.
    MeSH term(s) Aged ; Arthroplasty, Replacement, Shoulder/adverse effects ; Biomarkers/blood ; Blood Sedimentation ; C-Reactive Protein/analysis ; Female ; Fibrin Fibrinogen Degradation Products/analysis ; Humans ; Male ; Middle Aged ; Postoperative Period ; Preoperative Period ; Prosthesis-Related Infections/diagnosis ; Prosthesis-Related Infections/etiology ; ROC Curve ; Reoperation/adverse effects ; Reproducibility of Results ; Sensitivity and Specificity ; Shoulder Prosthesis/adverse effects
    Chemical Substances Biomarkers ; Fibrin Fibrinogen Degradation Products ; fibrin fragment D ; C-Reactive Protein (9007-41-4)
    Language English
    Publishing date 2021-05-16
    Publishing country United States
    Document type Evaluation Study ; Journal Article
    ZDB-ID 80301-7
    ISSN 1528-1132 ; 0009-921X
    ISSN (online) 1528-1132
    ISSN 0009-921X
    DOI 10.1097/CORR.0000000000001774
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  6. Article ; Online: Comparative study of antibacterial activity and stability of D-enantiomeric and L-enantiomeric bovine NK-lysin peptide NK2A.

    Dassanayake, Rohana P / Porter, Tracy J / Samorodnitsky, Daniel / Falkenberg, Shollie M / Nicholson, Eric M / Tatum, Fred M / Briggs, Robert E / Palmer, Mitchell V / Casas, Eduardo

    Biochemical and biophysical research communications

    2022  Volume 595, Page(s) 76–81

    Abstract: L-enantiomers of antimicrobial peptides (AMPs) are sensitive to proteolytic degradation; however, D ... antibacterial activity of L-enantiomeric bovine NK2A (L-NK2A) and its D-enantiomeric NK2A (D-NK2A ... Circular dichroism spectroscopy of D-NK2A and L-NK2A in anionic liposomes showed α-helical structures and the α ...

    Abstract L-enantiomers of antimicrobial peptides (AMPs) are sensitive to proteolytic degradation; however, D-enantiomers of AMPs are expected to provide improved proteolytic resistance. The present study aimed to comparatively investigate the in vitro antibacterial activity, trypsin and serum stability, toxicity, and in vivo antibacterial activity of L-enantiomeric bovine NK2A (L-NK2A) and its D-enantiomeric NK2A (D-NK2A). Circular dichroism spectroscopy of D-NK2A and L-NK2A in anionic liposomes showed α-helical structures and the α-helical conformation of D-NK2A was a mirror image of L-NK2A. Both D-NK2A and L-NK2A displayed minimal in vitro and in vivo toxicities. RP-HPLC and mass spectrometry analyses revealed that D-NK2A, but not L-NK2A, was resistant to trypsin digestion. D-NK2A and L-NK2A showed similar in vitro bacterial killing activities against Histophilus somni. Slightly reduced antibacterial activity was observed when D-NK2A and L-NK2A were pre-incubated with serum. Confocal and transmission electron microscopic findings confirmed that both peptides induced disruption of bacterial inner- and outer-membranes. Improved survivals with D-NK2A treatment were observed when compared to L-NK2A in a murine model of acute H. somni septicemia. We conclude that antibacterial activity and mode of action of NK2A are not chiral specific. With further optimization, D-NK2A may be a viable AMP candidate to combat bacterial infections.
    MeSH term(s) Animals ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Antimicrobial Peptides/chemistry ; Antimicrobial Peptides/pharmacology ; Cattle ; Circular Dichroism ; Kaplan-Meier Estimate ; Mice ; Microscopy, Electron, Transmission ; Pasteurellaceae/drug effects ; Pasteurellaceae/physiology ; Pasteurellaceae/ultrastructure ; Pasteurellaceae Infections/microbiology ; Pasteurellaceae Infections/prevention & control ; Protein Stability ; Protein Structure, Secondary ; Proteolipids/chemistry ; Proteolipids/pharmacology ; Stereoisomerism
    Chemical Substances Anti-Bacterial Agents ; Antimicrobial Peptides ; NK-lysin ; Proteolipids
    Language English
    Publishing date 2022-01-22
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2022.01.071
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    Zs.A 116: Show issues Location:
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  7. Article ; Online: Selective and interactive effects of D

    Isherwood, Sarah N / Robbins, Trevor W / Nicholson, Janet R / Dalley, Jeffrey W / Pekcec, Anton

    Neuropharmacology

    2017  Volume 123, Page(s) 249–260

    Abstract: Background: Metabotropic glutamate receptor 4 (mGluR4) and dopamine D: Methods: Rats were ... in conjunction with D ...

    Abstract Background: Metabotropic glutamate receptor 4 (mGluR4) and dopamine D
    Methods: Rats were trained on the five-choice serial reaction time task (5-CSRTT) of sustained visual attention and segregated according to low, mid, and high levels of motor impulsivity (LI, MI and HI, respectively), with unscreened rats used as an additional control group. A separate group of rats was trained on a delay discounting task (DDT) to assess choice impulsivity.
    Results: Systemic administration of Cpd11 dose-dependently increased motor impulsivity and impaired attentional accuracy on the 5-CSRTT in all groups tested. Eticlopride selectively attenuated the increase in impulsivity induced by Cpd11, but not the accompanying attentional impairment, at doses that had no significant effect on behavioural performance when administered alone. Cpd11 also decreased choice impulsivity on the DDT (i.e. increased preference for the large, delayed reward) and decreased locomotor activity.
    Conclusions: These findings demonstrate that mGluR4s, in conjunction with D
    MeSH term(s) Animals ; Attention/drug effects ; Attention/physiology ; Cyclic AMP/metabolism ; Delay Discounting/drug effects ; Delay Discounting/physiology ; Dopamine D2 Receptor Antagonists/blood ; Dopamine D2 Receptor Antagonists/pharmacology ; Dose-Response Relationship, Drug ; Excitatory Amino Acid Agonists/blood ; Excitatory Amino Acid Agonists/cerebrospinal fluid ; Excitatory Amino Acid Agonists/pharmacology ; Impulsive Behavior/drug effects ; Impulsive Behavior/physiology ; Male ; Motor Activity/drug effects ; Motor Activity/physiology ; Psychotropic Drugs/pharmacology ; Pyrimidines/blood ; Pyrimidines/cerebrospinal fluid ; Pyrimidines/pharmacology ; Rats ; Receptors, Dopamine D2/metabolism ; Receptors, Metabotropic Glutamate/agonists ; Receptors, Metabotropic Glutamate/metabolism ; Salicylamides/blood ; Salicylamides/pharmacology ; Styrenes/blood ; Styrenes/cerebrospinal fluid ; Styrenes/pharmacology ; Visual Perception/drug effects ; Visual Perception/physiology
    Chemical Substances 4-styrylpyrimidin-2-ylamine ; DRD2 protein, rat ; Dopamine D2 Receptor Antagonists ; Excitatory Amino Acid Agonists ; Psychotropic Drugs ; Pyrimidines ; Receptors, Dopamine D2 ; Receptors, Metabotropic Glutamate ; Salicylamides ; Styrenes ; Cyclic AMP (E0399OZS9N) ; eticlopride (J8M468HBH4) ; metabotropic glutamate receptor 4 (YZN9W7P1BX)
    Language English
    Publishing date 2017-05-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 218272-5
    ISSN 1873-7064 ; 0028-3908
    ISSN (online) 1873-7064
    ISSN 0028-3908
    DOI 10.1016/j.neuropharm.2017.05.006
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  8. Article: Measurement of CP-violating asymmetries in B0-->D*(+/-)D(-/+).

    Aubert, B / Bona, M / Boutigny, D / Karyotakis, Y / Lees, J P / Poireau, V / Prudent, X / Tisserand, V / Zghiche, A / Garra Tico, J / Grauges, E / Lopez, L / Palano, A / Eigen, G / Stugu, B / Sun, L / Abrams, G S / Battaglia, M / Brown, D N /
    Button-Shafer, J / Cahn, R N / Groysman, Y / Jacobsen, R G / Kadyk, J A / Kerth, L T / Kolomensky, Yu G / Kukartsev, G / Lopes Pegna, D / Lynch, G / Mir, L M / Orimoto, T J / Ronan, M T / Tackmann, K / Wenzel, W A / del Amo Sanchez, P / Hawkes, C M / Watson, A T / Held, T / Koch, H / Lewandowski, B / Pelizaeus, M / Schroeder, T / Steinke, M / Walker, D / Asgeirsson, D J / Cuhadar-Donszelmann, T / Fulsom, B G / Hearty, C / Mattison, T S / McKenna, J A / Khan, A / Saleem, M / Teodorescu, L / Blinov, V E / Bukin, A D / Druzhinin, V P / Golubev, V B / Onuchin, A P / Serednyakov, S I / Skovpen, Yu I / Solodov, E P / Todyshev, K Yu / Bondioli, M / Curry, S / Eschrich, I / Kirkby, D / Lankford, A J / Lund, P / Mandelkern, M / Martin, E C / Stoker, D P / Abachi, S / Buchanan, C / Foulkes, S D / Gary, J W / Liu, F / Long, O / Shen, B C / Zhang, L / Paar, H P / Rahatlou, S / Sharma, V / Berryhill, J W / Campagnari, C / Cunha, A / Dahmes, B / Hong, T M / Kovalskyi, D / Richman, J D / Beck, T W / Eisner, A M / Flacco, C J / Heusch, C A / Kroseberg, J / Lockman, W S / Schalk, T / Schumm, B A / Seiden, A / Williams, D C / Wilson, M G / Winstrom, L O / Chen, E / Cheng, C H / Fang, F / Hitlin, D G / Narsky, I / Piatenko, T / Porter, F C / Andreassen, R / Mancinelli, G / Meadows, B T / Mishra, K / Sokoloff, M D / Blanc, F / Bloom, P C / Chen, S / Ford, W T / Hirschauer, J F / Kreisel, A / Nagel, M / Nauenberg, U / Olivas, A / Smith, J G / Ulmer, K A / Wagner, S R / Zhang, J / Gabareen, A M / Soffer, A / Toki, W H / Wilson, R J / Winklmeier, F / Zeng, Q / Altenburg, D D / Feltresi, E / Hauke, A / Jasper, H / Merkel, J / Petzold, A / Spaan, B / Wacker, K / Brandt, T / Klose, V / Kobel, M J / Lacker, H M / Mader, W F / Nogowski, R / Schubert, J / Schubert, K R / Schwierz, R / Sundermann, J E / Volk, A / Bernard, D / Bonneaud, G R / Latour, E / Lombardo, V / Thiebaux, Ch / Verderi, M / Clark, P J / Gradl, W / Muheim, F / Playfer, S / Robertson, A I / Xie, Y / Andreotti, M / Bettoni, D / Bozzi, C / Calabrese, R / Cecchi, A / Cibinetto, G / Franchini, P / Luppi, E / Negrini, M / Petrella, A / Piemontese, L / Prencipe, E / Santoro, V / Anulli, F / Baldini-Ferroli, R / Calcaterra, A / de Sangro, R / Finocchiaro, G / Pacetti, S / Patteri, P / Peruzzi, I M / Piccolo, M / Rama, M / Zallo, A / Buzzo, A / Contri, R / Lo Vetere, M / Macri, M M / Monge, M R / Passaggio, S / Patrignani, C / Robutti, E / Santroni, A / Tosi, S / Chaisanguanthum, K S / Morii, M / Wu, J / Dubitzky, R S / Marks, J / Schenk, S / Uwer, U / Bard, D J / Dauncey, P D / Flack, R L / Nash, J A / Nikolich, M B / Panduro Vazquez, W / Tibbetts, M / Behera, P K / Chai, X / Charles, M J / Mallik, U / Meyer, N T / Ziegler, V / Cochran, J / Crawley, H B / Dong, L / Eyges, V / Meyer, W T / Prell, S / Rosenberg, E I / Rubin, A E / Gritsan, A V / Guo, Z J / Lae, C K / Denig, A G / Fritsch, M / Schott, G / Arnaud, N / Béquilleux, J / Davier, M / Grosdidier, G / Höcker, A / Lepeltier, V / Le Diberder, F / Lutz, A M 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    Physical review letters

    2007  Volume 99, Issue 7, Page(s) 71801

    Abstract: We present updated measurements of CP-violating asymmetries in the decays B0-->D*(+/-)D(-/+) and B0 ... We determine the time-integrated CP asymmetry A(D*(+/-)D(-/+))=0.12+/-0.06+/-0.02, and the time-dependent ... asymmetry parameters to be C(D*+D-)=0.18+/-0.15+/-0.04, S(D*+D-)=-0.79+/-0.21+/-0.06, C(D*-D+)=0.23+/-0.15+ ...

    Abstract We present updated measurements of CP-violating asymmetries in the decays B0-->D*(+/-)D(-/+) and B0-->D+D- using (383+/-4) x 10(6)B(B) pairs collected by the BABAR detector at the SLAC PEP-II B factory. We determine the time-integrated CP asymmetry A(D*(+/-)D(-/+))=0.12+/-0.06+/-0.02, and the time-dependent asymmetry parameters to be C(D*+D-)=0.18+/-0.15+/-0.04, S(D*+D-)=-0.79+/-0.21+/-0.06, C(D*-D+)=0.23+/-0.15+/-0.04, S(D*-D+)=-0.44+/-0.22+/-0.06, C(D+D-)=0.11+/-0.22+/-0.07, and S(D+D-)=-0.54+/-0.34+/-0.06, where the first uncertainty is statistical and the second is systematic.
    Language English
    Publishing date 2007-08-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.99.071801
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  9. Article: Collaboration in times of crisis: A study on COVID-19 vaccine R&D partnerships

    Druedahl, Louise C. / Minssen, Timo / Price, W. Nicholson

    Vaccine. 2021 Oct. 08, v. 39, no. 42

    2021  

    Abstract: Collaboration is central for initiatives and efforts in the race to fight COVID-19, with particular focus on fostering rapid development of safe and effective COVID-19 vaccines. We investigated the types of partnerships that have emerged during the ... ...

    Abstract Collaboration is central for initiatives and efforts in the race to fight COVID-19, with particular focus on fostering rapid development of safe and effective COVID-19 vaccines. We investigated the types of partnerships that have emerged during the pandemic to develop these products. Using the World Health Organization’s list of COVID-19 vaccine developments, we found nearly one third of all vaccine candidates were developed by partnerships, which tended to use next-gen vaccine platforms more than solo efforts. These partnerships vary substantially between materials-transfer partnerships and knowledge-sharing partnerships. The difference is important: The type of sharing between partners not only shapes the collaboration, but also bears implications for knowledge and technology development in the field and more broadly. Policies promoting fair and effective collaboration and knowledge-sharing are key for public health to avoid stumbling blocks for vaccine development, deployment, and equitable access, both for COVID-19 and expected future pandemics.
    Keywords COVID-19 infection ; World Health Organization ; pandemic ; public health ; vaccine development ; vaccines
    Language English
    Dates of publication 2021-1008
    Size p. 6291-6295.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2021.08.101
    Database NAL-Catalogue (AGRICOLA)

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  10. Article: Study of B-->D(*)sJ +-D(*) decays.

    Aubert, B / Barate, R / Boutigny, D / Couderc, F / Gaillard, J-M / Hicheur, A / Karyotakis, Y / Lees, J P / Tisserand, V / Zghiche, A / Palano, A / Pompili, A / Chen, J C / Qi, N D / Rong, G / Wang, P / Zhu, Y S / Eigen, G / Ofte, I /
    Stugu, B / Abrams, G S / Borgland, A W / Breon, A B / Brown, D N / Button-Shafer, J / Cahn, R N / Charles, E / Day, C T / Gill, M S / Gritsan, A V / Groysman, Y / Jacobsen, R G / Kadel, R W / Kadyk, J / Kerth, L T / Kolomensky, Yu G / Kukartsev, G / Lynch, G / Mir, L M / Oddone, P J / Orimoto, T J / Pripstein, M / Roe, N A / Ronan, M T / Shelkov, V G / Wenzel, W A / Barrett, M / Ford, K E / Harrison, T J / Hart, A J / Hawkes, C M / Morgan, S E / Watson, A T / Fritsch, M / Goetzen, K / Held, T / Koch, H / Lewandowski, B / Pelizaeus, M / Steinke, M / Boyd, J T / Chevalier, N / Cottingham, W N / Kelly, M P / Latham, T E / Wilson, F F / Cuhadar-Donszelmann, T / Hearty, C / Knecht, N S / Mattison, T S / McKenna, J A / Thiessen, D / Khan, A / Kyberd, P / Teodorescu, L / Blinov, A E / Blinov, V E / Druzhinin, V P / Golubev, V B / Ivanchenko, V N / Kravchenko, E A / Onuchin, A P / Serednyakov, S I / Skovpen, Yu I / Solodov, E P / Yushkov, A N / Best, D / Bruinsma, M / Chao, M / Eschrich, I / Kirkby, D / Lankford, A J / Mandelkern, M / Mommsen, R K / Roethel, W / Stoker, D P / Buchanan, C / Hartfiel, B L / Foulkes, S D / Gary, J W / Shen, B C / Wang, K / del Re, D / Hadavand, H K / Hill, E J / MacFarlane, D B / Paar, H P / Rahatlou, Sh / Sharma, V / Berryhill, J W / Campagnari, C / Dahmes, B / Long, O / Lu, A / Mazur, M A / Richman, J D / Verkerke, W / Beck, T W / Eisner, A M / Heusch, C A / Kroseberg, J / Lockman, W S / Nesom, G / Schalk, T / Schumm, B A / Seiden, A / Spradlin, P / Williams, D C / Wilson, M G / Albert, J / Chen, E / Dubois-Felsmann, G P / Dvoretskii, A / Hitlin, D G / Narsky, I / Piatenko, T / Porter, F C / Ryd, A / Samuel, A / Yang, S / Jayatilleke, S / Mancinelli, G / Meadows, B T / Sokoloff, M D / Abe, T / Blanc, F / Bloom, P / Chen, S / Ford, W T / Nauenberg, U / Olivas, A / Rankin, P / Smith, J G / Zhang, J / Zhang, L / Chen, A / Harton, J L / Soffer, A / Toki, W H / Wilson, R J / Zeng, Q / Altenburg, D / Brandt, T / Brose, J / Dickopp, M / Feltresi, E / Hauke, A / Lacker, H M / Müller-Pfefferkorn, R / Nogowski, R / Otto, S / Petzold, A / Schubert, J / Schubert, K R / Schwierz, R / Spaan, B / Sundermann, J E / Bernard, D / Bonneaud, G R / Brochard, F / Grenier, P / Schrenk, S / Thiebaux, Ch / Vasileiadis, G / Verderi, M / Bard, D J / Clark, P J / Lavin, D / Muheim, F / Playfer, S / Xie, Y / Andreotti, M / Azzolini, V / Bettoni, D / Bozzi, C / Calabrese, R / Cibinetto, G / Luppi, E / Negrini, M / Piemontese, L / Sarti, A / Treadwell, E / Anulli, F / Baldini-Ferroli, R / Calcaterra, A / de Sangro, R / Finocchiaro, G / Patteri, P / Peruzzi, I M / Piccolo, M / Zallo, A / Buzzo, A / Capra, R / Contri, R / Crosetti, G / Lo Vetere, M / Macri, M / Monge, M R / Passaggio, S / Patrignani, C / Robutti, E / Santroni, A / Tosi, S / Bailey, S / Brandenburg, G / Chaisanguanthum, K S / Morii, M / Won, E / Dubitzky, R S / Langenegger, U / Bhimji, W / Bowerman, D A / Dauncey, P D / Egede, U / Gaillard, J R / Morton, G W / Nash, J A / Nikolich, M B / Taylor, G P / Charles, M J / Grenier, G J / Mallik, U / Cochran, J / Crawley, H B / Lamsa, J / Meyer, W T / Prell, S / Rosenberg, E I / Rubin, A E / Yi, J / Biasini, M / Covarelli, R / Pioppi, M / Davier, M / Giroux, X / Grosdidier, G / Höcker, A / Laplace, S / Le Diberder, F / Lepeltier, V / Lutz, A M / Petersen, T C / Plaszczynski, S / Schune, M H / Tantot, L / Wormser, G / Cheng, C H / Lange, D J / Simani, M C / Wright, D M / Bevan, A J / Chavez, C A / Coleman, J P / Forster, I J / Fry, J R / Gabathuler, E / Gamet, R / Hutchcroft, D E / Parry, R J / Payne, D J / Sloane, R J / Touramanis, C / Back, J J / Cormack, C M / Harrison, P F / Di Lodovico, F / Mohanty, G B / Brown, C L / Cowan, G / Flack, R L / Flaecher, H U / Green, M G / Jackson, P S / McMahon, T R / Ricciardi, S / Salvatore, F / Winter, M A / Brown, D / Davis, C L / Allison, J / Barlow, N R / Barlow, R J / Hart, P A / Hodgkinson, M C / Lafferty, G D / Lyon, A J / Williams, J C / Farbin, A / Hulsbergen, W D / Jawahery, A / Kovalskyi, D / Lae, C K / Lillard, V / Roberts, D A / Blaylock, G / Dallapiccola, C / Flood, K T / Hertzbach, S S / Kofler, R / Koptchev, V B / Moore, T B / Saremi, S / Staengle, H / Willocq, S / Cowan, R / Sciolla, G / Sekula, S J / Taylor, F / Yamamoto, R K / Mangeol, D J J / Patel, P M / Robertson, S H / Lazzaro, A / Lombardo, V / Palombo, F / Bauer, J M / Cremaldi, L / Eschenburg, V / Godang, R / Kroeger, R / Reidy, J / Sanders, D A / Summers, D J / Zhao, H W / Brunet, S / Côté, D / Taras, P / Nicholson, H / Cavallo, N / Fabozzi, F / Gatto, C / Lista, L / Monorchio, D / Paolucci, P / Piccolo, D / Sciacca, C / Baak, M / Bulten, H / Raven, G / Snoek, H L / Wilden, L / Jessop, C P / LoSecco, J M / Allmendinger, T / Gan, K K / Honscheid, K / Hufnagel, D / Kagan, H / Kass, R / Pulliam, T / Rahimi, A M / Ter-Antonyan, R / Wong, Q K / Brau, J / Frey, R / Igonkina, O / Potter, C T / Sinev, N B / Strom, D / Torrence, E / Colecchia, F / Dorigo, A / Galeazzi, F / Margoni, M / 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N / Franek, B / Geddes, N I / Gopal, G P / Olaiya, E O / Aleksan, R / Emery, S / Gaidot, A / Ganzhur, S F / Giraud, P-F / Hamel de Monchenault, G / Kozanecki, W / Legendre, M / London, G W / Mayer, B / Schott, G / Vasseur, G / Yèche, Ch / Zito, M / Purohit, M V / Weidemann, A W / Wilson, J R / Yumiceva, F X / Aston, D / Bartoldus, R / Berger, N / Boyarski, A M / Buchmueller, O L / Claus, R / Convery, M R / Cristinziani, M / De Nardo, G / Dong, D / Dorfan, J / Dujmic, D / Dunwoodie, W / Elsen, E E / Fan, S / Field, R C / Glanzman, T / Gowdy, S J / Hadig, T / Halyo, V / Hast, C / Hryn'ova, T / Innes, W R / Kelsey, M H / Kim, P / Kocian, M L / Leith, D W G S / Libby, J / Luitz, S / Luth, V / Lynch, H L / Marsiske, H / Messner, R / Muller, D R / O'Grady, C P / Ozcan, V E / Perazzo, A / Perl, M / Petrak, S / Ratcliff, B N / Roodman, A / Salnikov, A A / Schindler, R H / Schwiening, J / Simi, G / Snyder, A / Soha, A / Stelzer, J / Su, D / Sullivan, M K / Va'vra, J / Wagner, S R / Weaver, M / 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    Physical review letters

    2004  Volume 93, Issue 18, Page(s) 181801

    Abstract: We report a study of D(*)(sJ)(2317)(+) and D(sJ)(2460)(+) meson production in B decays. We observe ... the decays B+-->D((*)+)(sJ)D ((*)0) and B0-->D((*)+)(sJ)D((*)-) with the subsequent decays D(*)(sJ)(2317 ... D(+)(s)pi(0), D(sJ)(2460)(+)-->D(+)(s)gamma, and D(sJ)(2460)(+)-->D(*+)(s)pi(0). Based on a data ...

    Abstract We report a study of D(*)(sJ)(2317)(+) and D(sJ)(2460)(+) meson production in B decays. We observe the decays B+-->D((*)+)(sJ)D ((*)0) and B0-->D((*)+)(sJ)D((*)-) with the subsequent decays D(*)(sJ)(2317)(+)-->D(+)(s)pi(0), D(sJ)(2460)(+)-->D(+)(s)gamma, and D(sJ)(2460)(+)-->D(*+)(s)pi(0). Based on a data sample of 122.1 x 10(6) BB pairs collected with the BABAR detector at the PEP-II B factory, we obtain branching fractions for these modes, including the previously unseen decays B-->D((*)+)(sJ)D(*). In addition, we perform an angular analysis of D(sJ)(2460)(+)-->D(+)(s)gamma decays to test the different D(sJ)(2460)(+) spin hypotheses.
    Language English
    Publishing date 2004-10-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.93.181801
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