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  1. Article: Cases Demonstrated at the M.R.C.P. Class.

    Elkington, J S

    Postgraduate medical journal

    2011  Volume 9, Issue 95, Page(s) 347–349

    Language English
    Publishing date 2011-01-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 80325-x
    ISSN 1469-0756 ; 0032-5473
    ISSN (online) 1469-0756
    ISSN 0032-5473
    DOI 10.1136/pgmj.9.95.347
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: NEW PERSPECTIVES IN OPHTHALMOLOGY : PROC. OF A MEETING HELD AT THE ... STRATFORD-UPON-AVON, 12TH JULY, 1982/ED.: A. R. ELKINGTON

    ELKINGTON, A. R.

    1982  

    Title variant NEW PERSPECTIVES IN OPHTHALMOLOGY
    Keywords OPHTHALMOLOGY / CONGRESSES
    Document type Article
    Note IN: RESEARCH AND CLINICAL FORUMS 4,5. 1982, S. 1-129
    HBZ-ID HT002637113
    Database Catalogue ZB MED Medicine, Health

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  3. Article ; Online: Highly lubricious SPMK-g-PEEK implant surfaces to facilitate rehydration of articular cartilage.

    Elkington, Robert J / Hall, Richard M / Beadling, Andrew R / Pandit, Hemant / Bryant, Michael G

    Journal of the mechanical behavior of biomedical materials

    2023  Volume 147, Page(s) 106084

    Abstract: To enable long lasting osteochondral defect repairs which preserve the native function of synovial joint counter-face, it is essential to develop surfaces which are optimised to support healthy cartilage function by providing a hydrated, low friction and ...

    Abstract To enable long lasting osteochondral defect repairs which preserve the native function of synovial joint counter-face, it is essential to develop surfaces which are optimised to support healthy cartilage function by providing a hydrated, low friction and compliant sliding interface. PEEK surfaces were modified using a biocompatible 3-sulfopropyl methacrylate potassium salt (SPMK) through UV photo-polymerisation, resulting in a ∼350 nm thick hydrophilic coating rich in hydrophilic anionic sulfonic acid groups. Characterisation was done through Fourier Transformed Infrared Spectroscopy, Focused Ion Beam Scanning Electron Microscopy, and Water Contact Angle measurements. Using a Bruker UMT TriboLab, bovine cartilage sliding tests were conducted with real-time strain and shear force measurements, comparing untreated PEEK, SPMK functionalised PEEK (SPMK-g-PEEK), and Cobalt Chrome Molybdenum alloy. Tribological tests over 2.5 h at physiological loads (0.75 MPa) revealed that SPMK-g-PEEK maintains low friction (μ< 0.024) and minimises equilibrium strain, significantly reducing forces on the cartilage interface. Post-test analysis showed no notable damage to the cartilage interfacing against the SPMK functionalised surfaces. The application of a constitutive biphasic cartilage model to the experimental strain data reveals that SPMK surfaces increase the interfacial permeability of cartilage in sliding, facilitating fluid and strain recovery. Unlike previous demonstrations of sliding-induced tribological rehydration requiring specific hydrodynamic conditions, the SPMK-g-PEEK introduces a novel mode of tribological rehydration operating at low speeds and in a stationary contact area. SPMK-g-PEEK surfaces provide an enhanced cartilage counter-surface, which provides a highly hydrated and lubricious boundary layer along with supporting biphasic lubrication. Soft polymer surface functionalisation of orthopaedic implant surfaces are a promising approach for minimally invasive synovial joint repair with an enhanced bioinspired polyelectrolyte interface for sliding against cartilage. These hydrophilic surface coatings offer an enabling technology for the next generation of focal cartilage repair and hemiarthroplasty implant surfaces.
    Language English
    Publishing date 2023-08-25
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2378381-3
    ISSN 1878-0180 ; 1751-6161
    ISSN (online) 1878-0180
    ISSN 1751-6161
    DOI 10.1016/j.jmbbm.2023.106084
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The rising cost of falls - Health researchers are calling for action.

    Delbaere, Kim / Elkington, Jane / Lord, Stephen R / Batchelor, Frances / Sturnieks, Daina L / Sherrington, Catherine

    Australasian journal on ageing

    2022  Volume 41, Issue 4, Page(s) 487–489

    Language English
    Publishing date 2022-12-12
    Publishing country Australia
    Document type Editorial
    ZDB-ID 1457406-8
    ISSN 1741-6612 ; 0726-4240 ; 1440-6381
    ISSN (online) 1741-6612
    ISSN 0726-4240 ; 1440-6381
    DOI 10.1111/ajag.13157
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The changing role of pre-admission work experience (clinical visits) in therapeutic radiography, diagnostic radiography and operating department practice: Academic perspectives (part 2).

    Ibbotson, R / Ali, N / Cadman, V / Burke, G / Shute, E / Elkington, M / Nightingale, J

    Radiography (London, England : 1995)

    2022  Volume 28 Suppl 1, Page(s) S84–S92

    Abstract: Introduction: A clinical visit (work experience) provides an opportunity for prospective students, prior to registration, to visit a clinical department to observe health professionals in practice. The Covid-19 pandemic interrupted access to clinical ... ...

    Abstract Introduction: A clinical visit (work experience) provides an opportunity for prospective students, prior to registration, to visit a clinical department to observe health professionals in practice. The Covid-19 pandemic interrupted access to clinical visits; this article explores the value of clinical visits and the alternatives implemented as a response to Covid-19 restrictions from an academic perspective.
    Methods: This article reports the quantitative phase of a three-phase mixed methods study. A survey was distributed to Higher Education Institution (HEI) education leaders for onward distribution to academics supporting recruitment for diagnostic radiography, therapeutic radiography and operating department practice programmes. Qualtrics online survey software was used to administer the survey which was launched in October 2020. Descriptive statistics summarised the data.
    Results: Representing 37.7% (n = 18/49) of eligible universities, 34 responses from 18 HEIs across England and Wales were received Seventy-eight percent of respondents strongly agreed that they are vital in confirming career choices. Prior to the Covid-19 pandemic, 64% of respondents' programmes had a clinical visit requirement, yet with improvements in simulation and online learning alternatives, 48% agreed that in the longer-term clinical visits will become obsolete.
    Conclusion: Requirements for clinical visits vary between professions and HEIs; academics welcome an opportunity to standardise work experience. Regardless of prospective student background and selected profession/university, all should have equitable and easily available access to high quality resources to support career decision-making.
    Implications for practice: The enforced withdrawal of clinical visits may impact upon subsequent attrition associated with 'misinformed career choice'. Alternatives to clinical visits, while less onerous for students, admissions staff and clinical colleagues alike, need to be carefully evaluated to ensure they offer prospective students a realistic understanding of the profession.
    MeSH term(s) COVID-19/epidemiology ; COVID-19 Testing ; Career Choice ; Humans ; Pandemics ; Radiography ; Surveys and Questionnaires
    Language English
    Publishing date 2022-08-26
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1289102-2
    ISSN 1532-2831 ; 1078-8174
    ISSN (online) 1532-2831
    ISSN 1078-8174
    DOI 10.1016/j.radi.2022.08.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Referral to and engagement in substance use disorder treatment within opioid intervention courts in New York: a qualitative study of implementation barriers and facilitators.

    O'Grady, Megan A / Elkington, Katherine S / Robson, Gail / Achebe, Ikenna Y / Williams, Arthur Robin / Cohall, Alwyn T / Cohall, Renee / Christofferson, Monica / Garcia, Alejandra / Ramsey, Kelly S / Lincourt, Pat / Tross, Susan

    Substance abuse treatment, prevention, and policy

    2024  Volume 19, Issue 1, Page(s) 12

    Abstract: Background: People with opioid use disorder (OUD) are frequently in contact with the court system and have markedly higher rates of fatal opioid overdose. Opioid intervention courts (OIC) were developed to address increasing rates of opioid overdose ... ...

    Abstract Background: People with opioid use disorder (OUD) are frequently in contact with the court system and have markedly higher rates of fatal opioid overdose. Opioid intervention courts (OIC) were developed to address increasing rates of opioid overdose among court defendants by engaging court staff in identification of treatment need and referral for opioid-related services and building collaborations between the court and OUD treatment systems. The study goal was to understand implementation barriers and facilitators in referring and engaging OIC clients in OUD treatment.
    Methods: Semi-structured interviews were conducted with OIC stakeholders (n = 46) in 10 New York counties in the United States, including court coordinators, court case managers, and substance use disorder treatment clinic counselors, administrators, and peers. Interviews were recorded and transcribed and thematic analysis was conducted, guided by the Exploration, Preparation, Implementation, Sustainment (EPIS) framework, employing both inductive and deductive coding.
    Results: Results were conceptualized using EPIS inner (i.e., courts) and outer (i.e., OUD treatment providers) implementation contexts and bridging factors that impacted referral and engagement to OUD treatment from the OIC. Inner factors that facilitated OIC implementation included OIC philosophy (e.g., non-punitive, access-oriented), court organizational structure (e.g., strong court staff connectedness), and OIC court staff and client characteristics (e.g., positive medications for OUD [MOUD] attitudes). The latter two also served as barriers (e.g., lack of formalized procedures; stigma toward MOUD). Two outer context entities impacted OIC implementation as both barriers and facilitators: substance use disorder treatment programs (e.g., attitudes toward the OIC and MOUD; operational characteristics) and community environments (e.g., attitudes toward the opioid epidemic). The COVID-19 pandemic and bail reform were macro-outer context factors that negatively impacted OIC implementation. Facilitating bridging factors included staffing practices that bridged court and treatment systems (e.g., peers); barriers included communication and cultural differences between systems (e.g., differing expectations about OIC client success).
    Conclusions: This study identified key barriers and facilitators that OICs may consider as this model expands in the United States. Referral to and engagement in OUD treatment within the OIC context requires ongoing efforts to bridge the treatment and court systems, and reduce stigma around MOUD.
    MeSH term(s) Humans ; New York ; Analgesics, Opioid/therapeutic use ; Opiate Overdose ; Pandemics ; Opioid-Related Disorders/drug therapy ; Buprenorphine ; Opiate Substitution Treatment
    Chemical Substances Analgesics, Opioid ; Buprenorphine (40D3SCR4GZ)
    Language English
    Publishing date 2024-01-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2222956-5
    ISSN 1747-597X ; 1747-597X
    ISSN (online) 1747-597X
    ISSN 1747-597X
    DOI 10.1186/s13011-024-00593-y
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  7. Article: Elevated plasma matrix metalloproteinases associate with

    Walker, N F / Schutz, C / Ward, A / Barr, D / Opondo, C / Shey, M / Elkington, P T / Wilkinson, K A / Wilkinson, R J / Meintjes, G

    medRxiv : the preprint server for health sciences

    2023  

    Abstract: Mortality from HIV-associated tuberculosis (HIV-TB) is high, particularly among hospitalised patients. In 433 people living with HIV admitted to hospital with symptoms of TB, we investigated plasma matrix metalloproteinases (MMP) and matrix-derived ... ...

    Abstract Mortality from HIV-associated tuberculosis (HIV-TB) is high, particularly among hospitalised patients. In 433 people living with HIV admitted to hospital with symptoms of TB, we investigated plasma matrix metalloproteinases (MMP) and matrix-derived biomarkers in relation to TB diagnosis, mortality and
    Language English
    Publishing date 2023-12-13
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.12.12.23299845
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Readiness to change among justice-involved young adults in an alternative sentencing program who screened positive for alcohol or drug risk.

    O'Grady, Megan A / Tross, Susan / Cohall, Alwyn / Wilson, Patrick / Cohall, Renee / Campos, Stephanie / Lee, Sin / Dolezal, Curtis / Elkington, Katherine S

    Addictive behaviors reports

    2022  Volume 16, Page(s) 100456

    Abstract: Introduction: Readiness to change is a key component of substance use behavioral change; yet little is known about readiness to change among justice-involved young adults. This study 1) describes readiness to change alcohol and drug use and 2) examines ... ...

    Abstract Introduction: Readiness to change is a key component of substance use behavioral change; yet little is known about readiness to change among justice-involved young adults. This study 1) describes readiness to change alcohol and drug use and 2) examines predictors of readiness to change alcohol and drug use among justice-involved young adults.
    Method: Justice-involved young adults (18-24 years; n = 137) who were positive on a validated alcohol and/or drug screening tool completed an interview assessing substance use, readiness to change, and reasons to quit. A multivariable linear regression model examined whether reasons to change and substance use severity, and interactions between these, predicted readiness.
    Results: More than half of participants were contemplating or had decided to quit/cut down substance use. Personal reasons to quit were positively related to readiness to change; interpersonal reasons were negatively associated.
    Conclusions: This study contributes information needed to design motivational interventions for substance use among justice-involved young adults. Personal reasons to quit using drugs are a potential intervention target.
    Language English
    Publishing date 2022-09-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2831558-3
    ISSN 2352-8532 ; 2352-8532
    ISSN (online) 2352-8532
    ISSN 2352-8532
    DOI 10.1016/j.abrep.2022.100456
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  9. Article ; Online: Psychometric Properties of a New Decision-Making Capacity Assessment Tool for People with Substance Use Disorder: The CAT-CAT.

    Kumar, Rishika / Berry, Jamie / Koning, Ashley / Rossell, Steve / Jain, Harshali / Elkington, Selina / Nagaraj, Sagar / Batchelor, Jennifer

    Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists

    2022  Volume 37, Issue 5, Page(s) 994–1034

    Abstract: Individuals with substance use disorder (SUD) often present with cognitive impairments, which may impede their ability to make decisions for themselves, including treatment-related decisions. It is therefore important to assess whether individuals with ... ...

    Abstract Individuals with substance use disorder (SUD) often present with cognitive impairments, which may impede their ability to make decisions for themselves, including treatment-related decisions. It is therefore important to assess whether individuals with SUD have adequate decision-making capacity. Indeed, there have not been any capacity assessment tools tailored for use with SUD populations that demonstrate adequate psychometric properties or that have the strong ethical foundation that is required of capacity assessment tools. The Compulsory Assessment and Treatment-Capacity Assessment Tool (CAT-CAT) was designed to fill this gap in the literature. Therefore, the aim of this study was to establish the interrater and test-retest reliability, and discriminative validity of the CAT-CAT. The first of this two-part study recruited healthcare professionals in New Zealand and asked them to conduct a capacity assessment on two hypothetical clients. Generally, excellent interrater reliability (ρ = .998 overall) and test-retest reliability (ρ = .996 overall) was found. The CAT-CAT has exhibited reliability that was at least comparable to widely used capacity assessment tools for other pathologies. The second part of this study involved cognitively normal individuals undergoing capacity assessments to investigate the hypothesis that individuals that do not lack capacity will obtain scores significantly higher than 50% in each section of the CAT-CAT. This hypothesis was met with highly significant results. To conclude, preliminary data suggest that the CAT-CAT has excellent reliability and correctly classifies those with capacity.
    MeSH term(s) Health Personnel ; Humans ; Neuropsychological Tests ; Psychometrics ; Reproducibility of Results ; Substance-Related Disorders/complications ; Substance-Related Disorders/diagnosis
    Language English
    Publishing date 2022-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632972-x
    ISSN 1873-5843 ; 0887-6177
    ISSN (online) 1873-5843
    ISSN 0887-6177
    DOI 10.1093/arclin/acac010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The changing role of pre-admission work experience (clinical visits) in Therapeutic Radiography, Diagnostic Radiography and Operating Department Practice: Student perspectives (Part 1).

    Ali, N / Saunders, J / Ibbotson, R / Shute, E / Burke, G / Cadman, V / Elkington, M / Nightingale, J

    Radiography (London, England : 1995)

    2022  Volume 28 Suppl 1, Page(s) S77–S83

    Abstract: Introduction: Clinical visits (work experience opportunities) are a recommended part of admissions processes for many diagnostic and therapeutic radiography courses but not for operating department practice (ODP) where observational visits are ... ...

    Abstract Introduction: Clinical visits (work experience opportunities) are a recommended part of admissions processes for many diagnostic and therapeutic radiography courses but not for operating department practice (ODP) where observational visits are challenging for applicants to obtain. The Covid-19 pandemic interrupted access to visits for all prospective students; this study presents a review of the value of clinical visits and alternatives.
    Methods: This article reports the initial qualitative phase of a three-phase mixed methods study. Using a critical realist approach, focus groups explored first year student experiences of the 'ideal' pre-admission clinical visit and alternative resources. A structured review of Online Prospectus (OLP) entries was undertaken by two student researchers to ascertain the requirements for clinical visits for the three professions.
    Results: Four focus groups included 25 first year students interviewed prior to their first clinical placement (14 therapeutic radiography, 5 diagnostic radiography and 6 ODP students). Three themes were constructed, namely: informing career choices, the clinical visit experience, and the value of clinical visits. Clinical visits affirmed rather than inspired career choices. The best timing for a visit was before admission interviews and optimal duration was a full day. Interacting with current students was the most valued aspect. Videos and simulations provided in-depth information about the professional role and allowed replay, but some participants found the videos uninspiring. OLP entries present a confusing picture for applicants who may be researching several Universities and professions.
    Conclusion: Clinical visits were deemed 'vital' to radiography student career choices, yet ODPs who could not access visits were comfortable with videos. Simulated visits are a safe option amidst the pandemic but must capture the dynamic and patient-centred nature of practice to accurately inform career choices.
    MeSH term(s) COVID-19 ; COVID-19 Testing ; Career Choice ; Humans ; Pandemics ; Radiography ; Students
    Language English
    Publishing date 2022-08-27
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1289102-2
    ISSN 1532-2831 ; 1078-8174
    ISSN (online) 1532-2831
    ISSN 1078-8174
    DOI 10.1016/j.radi.2022.08.001
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