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Article: Adapted suicide safety plans to address self-harm, suicidal ideation, and suicide behaviours in autistic adults: protocol for a pilot randomised controlled trial.

Rodgers, Jacqui / Goodwin, Jane / Nielsen, Emma / Bhattarai, Nawaraj / Heslop, Phil / Kharatikoopaei, Ehsan / O'Connor, Rory C / Ogundimu, Emmanuel / Ramsay, Sheena E / Steele, Katie / Townsend, Ellen / Vale, Luke / Walton, Emily / Wilson, Colin / Cassidy, Sarah

Pilot and feasibility studies

2023 Volume 9, Issue 1, Page(s) 31

Abstract: Background: Suicide prevention is a national priority for the UK government. Autistic people are at greater risk of experiencing self-harm and suicidal thoughts and behaviours than the general population. Safety plans are widely used in suicide ... ...

Abstract	Background: Suicide prevention is a national priority for the UK government. Autistic people are at greater risk of experiencing self-harm and suicidal thoughts and behaviours than the general population. Safety plans are widely used in suicide prevention but have not yet been designed with and for autistic people. We developed the first safety plan specifically targeting suicidality in autistic adults: the Autism Adapted Safety Plan (AASP). It consists of a prioritised list of hierarchical steps that can be used prior to or during a crisis to mitigate risk of self-harm and suicidal behaviour. This is a pilot study that aims to assess the feasibility and acceptability of the AASPs and the research processes, including the response rates, potential barriers and reach of AASPs, methods of recruitment, what comprises usual care, and economic evaluation methods/tools. Methods: This is an external pilot randomised controlled trial of a suicide prevention tool aimed at mitigating the risk of self-harm and suicidal behaviour in autistic adults: AASPs. Participants will be assessed at baseline and followed up 1 month and 6 months later. Assessments include questions about self-harm, suicidality, service use, and their experience of the AASP/taking part in the study. Autistic adults who have a clinical autism diagnosis and self-reported history of self-harm, suicidal thoughts, or suicidal behaviours within the last 6 months will be invited to take part in the study. Informed consent will be obtained. Participants will be recruited via community and third sector services (including community settings, autism charities, and mental health charities). They may also "self-refer" into the study through social media recruitment and word of mouth. Ninety participants will be randomised to either develop an AASP or receive their usual care in a 1:1 ratio. Discussion: The present study will provide an evaluation of the suitability of the processes that would be undertaken in a larger definitive study, including recruitment, randomisation, methods, questionnaires, outcome measures, treatment, and follow-up assessments. Trial registration: ISRCTN70594445, Protocol v4: 8/2/22.
Language	English
Publishing date	2023-02-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2809935-7
ISSN	2055-5784
ISSN	2055-5784
DOI	10.1186/s40814-023-01264-8
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Article ; Online: Express Yourself: Quantitative Real-Time PCR Assays for Rapid Chromosomal Antimicrobial Resistance Detection in Pseudomonas aeruginosa.

Madden, Danielle E / Olagoke, Olusola / Baird, Timothy / Neill, Jane / Ramsay, Kay A / Fraser, Tamieka A / Bell, Scott C / Sarovich, Derek S / Price, Erin P

Antimicrobial agents and chemotherapy

2022 Volume 66, Issue 5, Page(s) e0020422

Abstract: The rise of antimicrobial-resistant (AMR) bacteria is a global health emergency. One critical facet of tackling this epidemic is more rapid AMR diagnosis in serious multidrug-resistant pathogens like Pseudomonas aeruginosa. Here, we designed and then ... ...

Abstract	The rise of antimicrobial-resistant (AMR) bacteria is a global health emergency. One critical facet of tackling this epidemic is more rapid AMR diagnosis in serious multidrug-resistant pathogens like Pseudomonas aeruginosa. Here, we designed and then validated two multiplex quantitative real-time PCR (qPCR) assays to simultaneously detect differential expression of the resistance-nodulation-division efflux pumps MexAB-OprM, MexCD-OprJ, MexEF-OprN, and MexXY-OprM, the AmpC β-lactamase, and the porin OprD, which are commonly associated with chromosomally encoded AMR. Next, qPCRs were tested on 15 sputa from 11 participants with P. aeruginosa respiratory infections to determine AMR profiles
MeSH term(s)	Anti-Bacterial Agents/therapeutic use ; Bacterial Outer Membrane Proteins/genetics ; Bacterial Proteins/metabolism ; Carbapenems/therapeutic use ; Cystic Fibrosis/complications ; Drug Resistance, Bacterial ; Humans ; Membrane Transport Proteins/genetics ; Microbial Sensitivity Tests ; Pseudomonas Infections/microbiology ; Pseudomonas aeruginosa ; Real-Time Polymerase Chain Reaction
Chemical Substances	Anti-Bacterial Agents ; Bacterial Outer Membrane Proteins ; Bacterial Proteins ; Carbapenems ; Membrane Transport Proteins
Language	English
Publishing date	2022-04-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	217602-6
ISSN	1098-6596 ; 0066-4804
ISSN (online)	1098-6596
ISSN	0066-4804
DOI	10.1128/aac.00204-22
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Zs.A 809: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: γ-Glutamyl-β-phenylethylamine, a novel

Ogbole, Omonike O / Noleto-Dias, Clarice / Kamdem, Ramsay S T / Akinleye, Toluwanimi E / Nkumah, Abraham / Ward, Jane L / Beale, Michael H

Natural product research

2021 Volume 36, Issue 18, Page(s) 4681–4691

Abstract: ... ...

Abstract	Termitomyces
MeSH term(s)	Agaricales/metabolism ; Glycoside Hydrolase Inhibitors/chemistry ; Glycoside Hydrolase Inhibitors/pharmacology ; Nigeria ; Phenethylamines ; Plant Extracts/chemistry ; Termitomyces/metabolism ; alpha-Amylases ; alpha-Glucosidases/metabolism
Chemical Substances	Glycoside Hydrolase Inhibitors ; Phenethylamines ; Plant Extracts ; phenethylamine (327C7L2BXQ) ; alpha-Amylases (EC 3.2.1.1) ; alpha-Glucosidases (EC 3.2.1.20)
Language	English
Publishing date	2021-12-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2021.2012774
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Article ; Online: Rapid fluoroquinolone resistance detection in

Madden, Danielle E / McCarthy, Kate L / Bell, Scott C / Olagoke, Olusola / Baird, Timothy / Neill, Jane / Ramsay, Kay A / Kidd, Timothy J / Stewart, Adam G / Subedi, Shradha / Choong, Keat / Fraser, Tamieka A / Sarovich, Derek S / Price, Erin P

Journal of medical microbiology

2022 Volume 71, Issue 10

Abstract: Background. ...

Abstract	Background.
MeSH term(s)	Fluoroquinolones/pharmacology ; Pseudomonas aeruginosa ; DNA Gyrase/genetics ; Drug Resistance, Bacterial/genetics ; Real-Time Polymerase Chain Reaction ; Microbial Sensitivity Tests ; Anti-Bacterial Agents/pharmacology ; Australia ; Mutation
Chemical Substances	Fluoroquinolones ; DNA Gyrase (EC 5.99.1.3) ; Anti-Bacterial Agents
Language	English
Publishing date	2022-10-27
Publishing country	England
Document type	Journal Article
ZDB-ID	218356-0
ISSN	1473-5644 ; 0022-2615
ISSN (online)	1473-5644
ISSN	0022-2615
DOI	10.1099/jmm.0.001593
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Zs.A 634: Show issues

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Article ; Online: Translin facilitates RNA polymerase II dissociation and suppresses genome instability during RNase H2- and Dicer-deficiency.

Gomez-Escobar, Natalia / Alsaiari, Ahad A A / Alahamadi, Hanadi A S / Alzahrani, Othman / Vernon, Ellen / Althagafi, Hussam A E / Almobadel, Nasser S / Pryce, David W / Wakeman, Jane A / McFarlane, Ramsay J

PLoS genetics

2022 Volume 18, Issue 6, Page(s) e1010267

Abstract: The conserved nucleic acid binding protein Translin contributes to numerous facets of mammalian biology and genetic diseases. It was first identified as a binder of cancer-associated chromosomal translocation breakpoint junctions leading to the ... ...

Abstract	The conserved nucleic acid binding protein Translin contributes to numerous facets of mammalian biology and genetic diseases. It was first identified as a binder of cancer-associated chromosomal translocation breakpoint junctions leading to the suggestion that it was involved in genetic recombination. With a paralogous partner protein, Trax, Translin has subsequently been found to form a hetero-octomeric RNase complex that drives some of its functions, including passenger strand removal in RNA interference (RNAi). The Translin-Trax complex also degrades the precursors to tumour suppressing microRNAs in cancers deficient for the RNase III Dicer. This oncogenic activity has resulted in the Translin-Trax complex being explored as a therapeutic target. Additionally, Translin and Trax have been implicated in a wider range of biological functions ranging from sleep regulation to telomere transcript control. Here we reveal a Trax- and RNAi-independent function for Translin in dissociating RNA polymerase II from its genomic template, with loss of Translin function resulting in increased transcription-associated recombination and elevated genome instability. This provides genetic insight into the longstanding question of how Translin might influence chromosomal rearrangements in human genetic diseases and provides important functional understanding of an oncological therapeutic target.
MeSH term(s)	Animals ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Genomic Instability/genetics ; Humans ; Mammals/metabolism ; RNA Polymerase II/genetics ; RNA Polymerase II/metabolism ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Ribonuclease III/genetics ; Ribonuclease III/metabolism
Chemical Substances	DNA-Binding Proteins ; RNA-Binding Proteins ; RNA Polymerase II (EC 2.7.7.-) ; Ribonuclease III (EC 3.1.26.3)
Language	English
Publishing date	2022-06-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2186725-2
ISSN	1553-7404 ; 1553-7390
ISSN (online)	1553-7404
ISSN	1553-7390
DOI	10.1371/journal.pgen.1010267
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Article ; Online: Obstetric management of obesity in pregnancy.

Jarvie, Eleanor / Ramsay, Jane E

Seminars in fetal & neonatal medicine

2010 Volume 15, Issue 2, Page(s) 83–88

Abstract: Rates of obesity among the pregnant population have increased substantially and adiposity has a damaging effect on every aspect of female reproductive life. This review summarises epidemiological data concerning obesity-related complications of pregnancy. ...

Abstract	Rates of obesity among the pregnant population have increased substantially and adiposity has a damaging effect on every aspect of female reproductive life. This review summarises epidemiological data concerning obesity-related complications of pregnancy. Obesity is linked to a number of adverse obstetric outcomes as well as increased maternal and neonatal morbidity and mortality. These complications include miscarriage, congenital abnormalities, pre-eclampsia, gestational diabetes mellitus, iatrogenic preterm delivery, postdates pregnancy with increased rates of induction of labour, caesarean section, postpartum haemorrhage, shoulder dystocia, infection, venous thromboembolism, and increased hospital stay. It is important to consider obese pregnant women as a high risk group with a linear increase in risk of complications associated with their degree of obesity. Their obstetric management should be consultant-led and involve a multidisciplinary team approach to improve outcome.
MeSH term(s)	Body Mass Index ; Congenital Abnormalities/etiology ; Female ; Fetal Macrosomia/etiology ; Humans ; Obesity/complications ; Obesity/mortality ; Obesity/therapy ; Postnatal Care ; Pregnancy ; Pregnancy Complications/mortality ; Pregnancy Complications/therapy ; Prenatal Care ; Venous Thromboembolism/complications ; Venous Thromboembolism/mortality
Language	English
Publishing date	2010-04
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2174416-6
ISSN	1878-0946 ; 1744-165X
ISSN (online)	1878-0946
ISSN	1744-165X
DOI	10.1016/j.siny.2009.10.001
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Zs.A 4798: Show issues

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Article ; Online: Maternal Adipose Tissue Expansion, A Missing Link in the Prediction of Birth Weight Centile.

Jarvie, Eleanor M / Stewart, Frances M / Ramsay, Jane E / Brown, E Ann / Meyer, Barbara J / Olivecrona, Gunilla / Griffin, Bruce A / Freeman, Dilys J

The Journal of clinical endocrinology and metabolism

2019 Volume 105, Issue 3

Abstract: Context: Maternal body mass index (BMI) is associated with increased birth weight but does not explain all the variance in fetal adiposity.: Objective: To assess the contribution of maternal body fat distribution to offspring birth weight and ... ...

Abstract	Context: Maternal body mass index (BMI) is associated with increased birth weight but does not explain all the variance in fetal adiposity. Objective: To assess the contribution of maternal body fat distribution to offspring birth weight and adiposity. Design: Longitudinal study throughout gestation and at delivery. Setting: Women recruited at 12 weeks of gestation and followed up at 26 and 36 weeks. Cord blood was collected at delivery. Patients: Pregnant women (n = 45) with BMI 18.0 to 46.3 kg/m2 and healthy pregnancy outcome. Methods: Maternal first trimester abdominal subcutaneous and visceral adipose tissue thickness (SAT and VAT) was assessed by ultrasound. Main outcome measures: Maternal body fat distribution, maternal and cord plasma glucose and lipid concentrations, placental weight, birth weight, and fetal adiposity assessed by cord blood leptin. Results: VAT was the only anthropometric measure independently associated with birth weight centile (r2 adjusted 15.8%, P = .002). BMI was associated with trimester 2 and trimesters 1 through 3 area under the curve (AUC) glucose and insulin resistance (Homeostatic Model Assessment). SAT alone predicted trimester 2 lipoprotein lipase (LPL) mass (a marker of adipocyte insulin sensitivity) (11.3%, P = .017). VAT was associated with fetal triglyceride (9.3%, P = .047). Placental weight was the only independent predictor of fetal adiposity (48%, P < .001). Maternal trimester 2 and AUC LPL were inversely associated with fetal adiposity (r = -0.69, P = .001 and r = -0.58, P = .006, respectively). Conclusions: Maternal VAT provides additional information to BMI for prediction of birth weight. VAT may be a marker of reduced SAT expansion and increased availability of maternal fatty acids for placental transport.
MeSH term(s)	Adiposity/physiology ; Adult ; Area Under Curve ; Birth Weight/physiology ; Blood Glucose/metabolism ; Body Fat Distribution ; Body Mass Index ; Female ; Fetus/physiology ; Humans ; Infant, Newborn ; Insulin Resistance ; Intra-Abdominal Fat/diagnostic imaging ; Intra-Abdominal Fat/physiology ; Longitudinal Studies ; Pregnancy ; Pregnancy Trimesters/physiology ; Ultrasonography, Prenatal
Chemical Substances	Blood Glucose
Language	English
Publishing date	2019-12-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3029-6
ISSN	1945-7197 ; 0021-972X
ISSN (online)	1945-7197
ISSN	0021-972X
DOI	10.1210/clinem/dgz248
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Article: γ-Glutamyl-β-phenylethylamine, a novel α-glucosidase and α-amylase inhibitory compound from Termitomyces robustus, an edible Nigerian mushroom

Ogbole, Omonike O. / Noleto-Dias, Clarice / Kamdem, Ramsay S. T. / Akinleye, Toluwanimi E. / Nkumah, Abraham / Ward, Jane L. / Beale, Michael H.

Natural product research. 2021 Nov. 30, v. 36, no. 18

2021

Abstract: Termitomyces species are known edible mushrooms in Nigeria, believed to have exceptional culinary and nutraceutical properties. Methanol extract from fruiting bodies of Termitomyces robustus was evaluated for antidiabetic activity using in vitro α- ... ...

Abstract	Termitomyces species are known edible mushrooms in Nigeria, believed to have exceptional culinary and nutraceutical properties. Methanol extract from fruiting bodies of Termitomyces robustus was evaluated for antidiabetic activity using in vitro α-amylase and α-glucosidase assays. The isolation and structural elucidation of metabolites from the T. robustus extract afforded five compounds including a new natural product γ-glutamyl-β-phenylethylamine 3 and four known phenyl derivatives: tryptophan 1, 4-hydroxyphenylacetic acid 2, 4-hydroxyphenylpropionic acid 4, and phenyllactic acid 5. Structures were elucidated from analyses of spectroscopic data (1 D and 2 D NMR, HRESIMS) and all isolated compounds were tested for α-amylase and α-glycosidase inhibitory activity. The in vitro assay established crude extract to possess α- amylase and α-glucosidase inhibition with IC₅₀ of 78.05 µg/mL and 86.10 µg/mL, respectively. The isolated compounds compared favourably with the standard drug, acarbose with IC₅₀ ranging from 6.18-15.08 µg/mL and 18.28-44.63 µg/mL for α-amylase and glucosidase, respectively.
Keywords	Termitomyces ; acarbose ; alpha-amylase ; dietary supplements ; drugs ; glycemic effect ; metabolites ; methanol ; mushrooms ; phenyllactic acid ; research ; spectral analysis ; tryptophan ; Nigeria
Language	English
Dates of publication	2021-1130
Size	p. 4675-4685.
Publishing place	Taylor & Francis
Document type	Article
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2021.2012774
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Article ; Online: Invasive pneumococcal disease 3 years after introduction of a reduced 1 + 1 infant 13-valent pneumococcal conjugate vaccine immunisation schedule in England: a prospective national observational surveillance study.

Bertran, Marta / D'Aeth, Joshua C / Abdullahi, Fariyo / Eletu, Seyi / Andrews, Nick J / Ramsay, Mary E / Litt, David J / Ladhani, Shamez N

The Lancet. Infectious diseases

2024

Abstract: ... valent pneumococcal conjugate vaccine (PCV13) on Jan 1, 2020, coincided with the start of the COVID-19 ...

Abstract	Background: The UK transition from a 2 + 1 to a 1 + 1 infant immunisation schedule with the 13-valent pneumococcal conjugate vaccine (PCV13) on Jan 1, 2020, coincided with the start of the COVID-19 pandemic. We describe the epidemiology of invasive pneumococcal disease (IPD) in England over 6 financial years (April 1 to March 31) between 2017-18 and 2022-23. Methods: We used prospective national surveillance data, including serotyping and whole-genome sequencing of invasive isolates, to analyse IPD trends in England by age and financial year. We compared breakthrough infections and vaccine failure rates in 2022-23 among children eligible for the 1 + 1 schedule with rates in cohorts of children eligible for the 2 + 1 schedule between 2017-18 and 2019-20. We assessed genomic changes over time by comparing Global Pneumococcal Sequencing Clusters and multilocus sequence types among PCV13 serotypes causing IPD. Findings: There were 4598 laboratory-confirmed IPD cases in 2022-23, 3025 in 2021-22, 1240 in 2020-21, and 5316 in 2019-20. IPD incidence in 2022-23 was 14% lower than in 2019-20 (incidence rate ratio [IRR] 0·86, 95% CI 0·81-0·91; p<0·001). IPD incidence in 2022-23 compared with 2019-20 was 34% higher in children (aged <15 years) (378 cases vs 292 cases; IRR 1·34, 95% CI 1·08-1·68; p=0·009) and 17% lower in adults (aged 15 years and older; 4220 vs 5024; 0·83, 0·78-0·88; p<0·001). The proportion of PCV13-type IPD increased from 19·4% (95% CI 18·2-20·4; 957 of 4947) in 2019-20 to 29·7% (28·3-31·0; 1283 of 4326) in 2022-23, mainly due to serotype 3, but also serotypes 19F, 19A, and 4, alongside a decrease in non-PCV13 serotypes 8, 12F, and 9N. The increase in IPD incidence due to serotypes 3, 19A, and 19F was driven by clonal expansion of previously circulating strains, whereas serotype 4 expansion was driven by newer strains (ie, sequence types 801 and 15603). Breakthrough infections and vaccine failure rates were similar in children eligible for the 1 + 1 (1·07 per 100 000 person-years) and 2 + 1 (0·76 per 100 000 person-years; IRR 1·42, 95% CI 0·78-2·49; p=0·20) PCV13 schedules. Interpretation: Overall, IPD incidence in England was lower in 2022-23, 2 years after removal of pandemic restrictions, than in 2019-20. Breakthrough and vaccine failure rates were not significantly different between children who received the 1 + 1 compared with the 2 + 1 PCV13 immunisation schedule. The post-pandemic increase in childhood IPD incidence and especially PCV13-type IPD will require close monitoring. Funding: None.
Language	English
Publishing date	2024-02-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2061641-7
ISSN	1474-4457 ; 1473-3099
ISSN (online)	1474-4457
ISSN	1473-3099
DOI	10.1016/S1473-3099(23)00706-5
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Zs.A 5743: Show issues

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Article ; Online: B Part of It School Leaver Study: A Repeat Cross-Sectional Study to Assess the Impact of Increasing Coverage With Meningococcal B (4CMenB) Vaccine on Carriage of Neisseria meningitidis.

McMillan, Mark / Koehler, Ann P / Lawrence, Andrew / Sullivan, Thomas R / Bednarz, Jana / MacLennan, Jenny M / Maiden, Martin C J / Ladhani, Shamez N / Ramsay, Mary E / Trotter, Caroline / Borrow, Ray / Finn, Adam / Kahler, Charlene M / Whelan, Jane / Vadivelu, Kumaran / Richmond, Peter C / Marshall, Helen S

The Journal of infectious diseases

2021 Volume 225, Issue 4, Page(s) 637–649

Abstract: Background: Recombinant protein-based vaccines targeting serogroup B meningococci protect against invasive disease but impacts on carriage are uncertain. This study assessed carriage prevalence of disease-associated meningococci in 2018-2020 as the ... ...

Abstract	Background: Recombinant protein-based vaccines targeting serogroup B meningococci protect against invasive disease but impacts on carriage are uncertain. This study assessed carriage prevalence of disease-associated meningococci in 2018-2020 as the proportion of vaccinated adolescents increased following introduction of a school-based 4CMenB immunization program. Methods: Eligible participants who completed high school (aged 17-25) in South Australia in the previous year had an oropharyngeal swab taken and completed a risk factor questionnaire. Disease-associated meningococci (genogroups A, B, C, W, X, Y) were detected by meningococcal and genogroup-specific polymerase chain reaction. Results: The analysis included 4104 participants in 2018, 2690 in 2019, and 1338 in 2020. The proportion vaccinated with 4CMenB increased from 43% in 2018, to 78% in 2019, and 76% in 2020. Carriage prevalence of disease-associated meningococci in 2018 was 225/4104 (5.5%). There was little difference between carriage prevalence in 2019 (134/2690, 5.0%; adjusted odds ratio [aOR], 0.82; 95% confidence interval [CI], .64-1.05) and 2020 (68/1338, 5.1%; aOR, 0.82; 95% CI, .57-1.17) compared to 2018. Conclusions: Increased 4CMenB uptake in adolescents was not associated with decline in carriage of disease-associated meningococci. 4CMenB immunization programs should focus on direct (individual) protection for groups at greatest risk of disease. Clinical trials registration: NCT03419533.
MeSH term(s)	Adolescent ; Cross-Sectional Studies ; Humans ; Meningococcal Infections/epidemiology ; Meningococcal Infections/prevention & control ; Meningococcal Vaccines ; Neisseria meningitidis ; Neisseria meningitidis, Serogroup B
Chemical Substances	Meningococcal Vaccines
Language	English
Publishing date	2021-09-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3019-3
ISSN	1537-6613 ; 0022-1899
ISSN (online)	1537-6613
ISSN	0022-1899
DOI	10.1093/infdis/jiab444
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