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  1. Book: The metabolic syndrome

    Byrne, Christopher D. / Wild, Sarah H.

    2011  

    Author's details ed. by Christopher D. Byrne ; Sarah H. Wild
    Keywords Metabolic Syndrome ; Metabolism--Disorders
    Subject code 616.39
    Language English
    Size XIV, 366 S. : Ill., graph. Darst.
    Edition 2. ed.
    Publisher Wiley-Blackwell
    Publishing place Oxford u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT016915866
    ISBN 978-1-4443-3658-0 ; 1-4443-3658-4
    Database Catalogue ZB MED Medicine, Health

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  2. Article: Severe depression and all-cause and cause-specific mortality in Scotland: 20 year national cohort study.

    Alotaibi, Raied / Halbesma, Nynke / Wild, Sarah H / Jackson, Caroline A

    BJPsych open

    2024  Volume 10, Issue 1, Page(s) e28

    Abstract: Background: Understanding cause of death in people with depression could inform approaches to reducing premature mortality.: Aim: To describe all-cause and cause-specific mortality for people with severe depression in Scotland, by sex, relative to ... ...

    Abstract Background: Understanding cause of death in people with depression could inform approaches to reducing premature mortality.
    Aim: To describe all-cause and cause-specific mortality for people with severe depression in Scotland, by sex, relative to the general population.
    Method: We performed a retrospective cohort study, using psychiatric hospital admission data linked to death data, to identify adults (≥18 years old) with severe depression and ascertain cause-specific deaths, during 2000-2019. We estimated relative all-cause and cause-specific mortality for people with severe depression using standardised mortality ratios (SMRs), stratified by sex using the whole Scottish population as the standard.
    Results: Of 28 808 people with severe depression, 7903 (27.4%) died during a median follow-up of 8.7 years. All-cause relative mortality was over three times higher than expected (SMR, both sexes combined: 3.26, 95% CI 3.19-3.34). Circulatory disease was the leading cause of death, and, among natural causes of death, excess relative mortality was highest for circulatory diseases (SMR 2.51, 2.40-2.66), respiratory diseases (SMR 3.79, 3.56-4.01) and 'other' causes (SMR 4.10, 3.89-4.30). Among circulatory disease subtypes, excess death was highest for cerebrovascular disease. Both males and females with severe depression had higher all-cause and cause-specific mortality than the general population. Suicide had the highest SMR among both males (SMR 12.44, 95% CI 11.33-13.54) and females (22.86, 95% CI 20.35-25.36).
    Conclusion: People with severe depression have markedly higher all-cause mortality than the general population in Scotland, with relative mortality varying by cause of death. Effective interventions are needed to reduce premature mortality for people with severe depression.
    Language English
    Publishing date 2024-01-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2829557-2
    ISSN 2056-4724
    ISSN 2056-4724
    DOI 10.1192/bjo.2023.633
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  3. Article ; Online: Marked and widening socioeconomic inequalities in type 2 diabetes prevalence in Scotland.

    Wang, Jack / Wild, Sarah H

    Journal of epidemiology and community health

    2021  

    Abstract: Background: This study investigated the association between socioeconomic status and type 2 diabetes (T2D) prevalence in Scotland in 2021 and tested the null hypothesis that inequalities had not changed since they were last described for 2001-2007.: ... ...

    Abstract Background: This study investigated the association between socioeconomic status and type 2 diabetes (T2D) prevalence in Scotland in 2021 and tested the null hypothesis that inequalities had not changed since they were last described for 2001-2007.
    Methods: Data from a national population-based diabetes database for 35-to-84-year-olds in Scotland for 2021 and mid-year population estimates for 2019 stratified by sex and fifths of the Scottish Index of Multiple Deprivation were used to calculate age-specific prevalence of T2D. Age-standardised prevalence was estimated using the European Standard Population with relative risks (RRs) compared between the most (Q1) and least (Q5) deprived fifths for each sex, and compared against similar estimates from 2001 to 2007.
    Results: Complete data were available for 255 764 people (98.9%) with T2D. Age-standardised prevalence was lowest for women in Q5 (3.4%) and highest for men in Q1 (11.6%). RRs have increased from 2.00 (95% CI 1.52 to 2.62) in 2001-2007 to 2.48 (95% CI 2.43 to 2.53) in 2021 for women and from 1.58 (95% CI 1.20 to 2.07) in 2007 to 1.89 (95% CI 1.86 to 1.92) in 2021 for men.
    Conclusions: Socioeconomic inequalities in T2D prevalence have widened between 2001-2007 and 2021. Further research is required to investigate potential medium-term effects of the COVID-19 pandemic.
    Language English
    Publishing date 2021-10-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 391868-3
    ISSN 1470-2738 ; 0142-467X ; 0141-7681 ; 0143-005X
    ISSN (online) 1470-2738
    ISSN 0142-467X ; 0141-7681 ; 0143-005X
    DOI 10.1136/jech-2021-217747
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  4. Article ; Online: Baseline and change in serum uric acid level over time and resolution of nonalcoholic fatty liver disease in young adults: The Kangbuk Samsung Health Study.

    Cho, Yoosun / Chang, Yoosoo / Ryu, Seungho / Wild, Sarah H / Byrne, Christopher D

    Diabetes, obesity & metabolism

    2024  Volume 26, Issue 5, Page(s) 1644–1657

    Abstract: Aims: To determine the association between: (i) baseline serum uric acid (SUA) level and (ii) SUA changes over time, and nonalcoholic fatty liver disease (NAFLD) resolution.: Materials and methods: A retrospective cohort study, comprising 38 483 ... ...

    Abstract Aims: To determine the association between: (i) baseline serum uric acid (SUA) level and (ii) SUA changes over time, and nonalcoholic fatty liver disease (NAFLD) resolution.
    Materials and methods: A retrospective cohort study, comprising 38 483 subjects aged <40 years with pre-existing NAFLD, was undertaken. The effects of SUA changes over time were studied in 25 266 subjects. Participants underwent a health examination between 2011 and 2019, and at least one follow-up liver ultrasonography scan up to December 2020. Exposures included baseline SUA level and SUA changes between baseline and subsequent visits, categorized into quintiles. The reference group was the third quintile (Q3) containing zero change. The primary endpoint was resolution of NAFLD.
    Results: During a median follow-up of 4 years, low baseline SUA level and decreases in SUA levels over time were independently associated with NAFLD resolution (p for trend <0.001). Using SUA as a continuous variable, the likelihood of NAFLD resolution was increased by 10% and 13% in men and women, respectively, per 1-mg/dL decrease in SUA. In a time-dependent model with changes in SUA treated as a time-varying covariate, adjusted hazard ratios (95% confidence intervals) for NAFLD resolution comparing Q1 (highest decrease) and Q2 (slight decrease) to Q3 (reference) were 1.63 (1.49-1.78) and 1.23 (1.11-1.35) in men and 1.78 (1.49-2.12) and 1.18 (0.95-1.46) in women, respectively.
    Conclusions: Low baseline SUA levels and a decrease in SUA levels over time were both associated with NAFLD resolution in young adults.
    MeSH term(s) Male ; Humans ; Female ; Young Adult ; Non-alcoholic Fatty Liver Disease/diagnosis ; Uric Acid ; Retrospective Studies ; Risk Factors ; Ultrasonography
    Chemical Substances Uric Acid (268B43MJ25)
    Language English
    Publishing date 2024-02-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 1454944-x
    ISSN 1463-1326 ; 1462-8902
    ISSN (online) 1463-1326
    ISSN 1462-8902
    DOI 10.1111/dom.15466
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  5. Article ; Online: Prevention of premature cardiovascular death worldwide.

    Read, Stephanie H / Wild, Sarah H

    Lancet (London, England)

    2019  Volume 395, Issue 10226, Page(s) 758–760

    MeSH term(s) Cardiovascular Diseases ; Cause of Death ; Humans ; Mortality, Premature ; Prospective Studies ; Risk Factors
    Language English
    Publishing date 2019-09-03
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(19)32034-3
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  6. Article ; Online: The individual and combined associations of depression and socioeconomic status with risk of major cardiovascular events: A prospective cohort study.

    Prigge, Regina / Wild, Sarah H / Jackson, Caroline A

    Journal of psychosomatic research

    2022  Volume 160, Page(s) 110978

    Abstract: Objective: We aimed to investigate the individual and combined associations of depression and low socioeconomic status (SES) with risk of major cardiovascular events (MCVE), defined as first-ever fatal or non-fatal stroke or myocardial infarction, in a ... ...

    Abstract Objective: We aimed to investigate the individual and combined associations of depression and low socioeconomic status (SES) with risk of major cardiovascular events (MCVE), defined as first-ever fatal or non-fatal stroke or myocardial infarction, in a large prospective cohort study.
    Methods: We used data from 466,238 UK Biobank participants, aged 40-69 years without cardiovascular disease, bipolar disorder or schizophrenia at baseline. We performed Cox proportional hazard models to estimate adjusted hazard ratios (HR) and 95% confidence intervals (CI) for the individual and combined associations of depression and each of educational attainment, area-based deprivation and income with risk of MCVE. We assessed effect modification and explored interaction on the additive and multiplicative scale.
    Results: Depression, low education, high area-based deprivation and low income were individually associated with increased risks of MCVE (adjusted HR, 95% CI: 1.28, 1.19-1.38; 1.20, 1.14-1.27; 1.17, 1.11-1.23; and 1.22, 1.16-1.29, respectively). Depression was associated with increased risks of MCVE among individuals with high and low SES. Individuals with depression and each of low education, high area-based deprivation and low income were at particularly high risk of MCVE (HR, 95% CI: 1.50, 1.38-1.63; 1.63, 1.46-1.82; 1.31, 1.23-1.40, respectively). There was interaction between depression and area-based deprivation on multiplicative and additive scales but no interaction with education or income.
    Conclusion: Depression was associated with increased risks of MCVE among individuals with high and low SES, with particularly high risks among those living in areas of high deprivation.
    MeSH term(s) Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Depression/epidemiology ; Humans ; Myocardial Infarction/complications ; Prospective Studies ; Risk Factors ; Social Class
    Language English
    Publishing date 2022-06-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80166-5
    ISSN 1879-1360 ; 0022-3999
    ISSN (online) 1879-1360
    ISSN 0022-3999
    DOI 10.1016/j.jpsychores.2022.110978
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  7. Article ; Online: Depression, diabetes, comorbid depression and diabetes and risk of all-cause and cause-specific mortality: a prospective cohort study.

    Prigge, Regina / Wild, Sarah H / Jackson, Caroline A

    Diabetologia

    2022  Volume 65, Issue 9, Page(s) 1450–1460

    Abstract: Aims/hypothesis: The aim of this study was to investigate the risks of all-cause and cause-specific mortality among participants with neither, one or both of diabetes and depression in a large prospective cohort study in the UK.: Methods: Our study ... ...

    Abstract Aims/hypothesis: The aim of this study was to investigate the risks of all-cause and cause-specific mortality among participants with neither, one or both of diabetes and depression in a large prospective cohort study in the UK.
    Methods: Our study population included 499,830 UK Biobank participants without schizophrenia and bipolar disorder at baseline. Type 1 and type 2 diabetes and depression were identified using self-reported diagnoses, prescribed medication and hospital records. Mortality was identified from death records using the primary cause of death to define cause-specific mortality. We performed Cox proportional hazards models to estimate the risk of all-cause mortality and mortality from cancer, circulatory disease and causes of death other than circulatory disease or cancer among participants with either depression (n=41,791) or diabetes (n=22,677) alone and with comorbid diabetes and depression (n=3597) compared with the group with neither condition (n=431,765), adjusting for sociodemographic and lifestyle factors, comorbidities and history of CVD or cancer. We also investigated the interaction between diabetes and depression.
    Results: During a median of 6.8 (IQR 6.1-7.5) years of follow-up, there were 13,724 deaths (cancer, n=7976; circulatory disease, n=2827; other causes, n=2921). Adjusted HRs of all-cause mortality and mortality from cancer, circulatory disease and other causes were highest among people with comorbid depression and diabetes (HRs 2.16 [95% CI 1.94, 2.42]; 1.62 [95% CI 1.35, 1.93]; 2.22 [95% CI 1.80, 2.73]; and 3.60 [95% CI 2.93, 4.42], respectively). The risks of all-cause, cancer and other mortality among those with comorbid depression and diabetes exceeded the sum of the risks due to diabetes and depression alone.
    Conclusions/interpretation: We confirmed that depression and diabetes individually are associated with an increased mortality risk and also identified that comorbid depression and diabetes have synergistic effects on the risk of all-cause mortality that are largely driven by deaths from cancer and causes other than circulatory disease and cancer.
    MeSH term(s) Cardiovascular Diseases/epidemiology ; Cause of Death ; Depression/complications ; Depression/diagnosis ; Depression/epidemiology ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/epidemiology ; Humans ; Neoplasms/epidemiology ; Proportional Hazards Models ; Prospective Studies ; Risk Factors
    Language English
    Publishing date 2022-05-27
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1694-9
    ISSN 1432-0428 ; 0012-186X
    ISSN (online) 1432-0428
    ISSN 0012-186X
    DOI 10.1007/s00125-022-05723-4
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  8. Article ; Online: Reply: NAFLD improves risk prediction of type 2 diabetes-With effect modification by sex and menopausal status.

    Kim, Yejin / Chang, Yoosoo / Ryu, Seungho / Wild, Sarah H / Byrne, Christopher D

    Hepatology (Baltimore, Md.)

    2023  Volume 79, Issue 2, Page(s) E20–E21

    MeSH term(s) Humans ; Non-alcoholic Fatty Liver Disease/epidemiology ; Diabetes Mellitus, Type 2/epidemiology ; Risk Factors ; Menopause
    Language English
    Publishing date 2023-09-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1097/HEP.0000000000000610
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  9. Article ; Online: Variation in colorectal cancer treatment and outcomes in Scotland: real world evidence from national linked administrative health data.

    Lemmon, Elizabeth / Hanna, Catherine / Diernberger, Katharina / Paterson, Hugh M / Wild, Sarah H / Ennis, Holly / Hall, Peter S

    International journal of population data science

    2024  Volume 9, Issue 1, Page(s) 2179

    Abstract: Background: Colorectal cancer (CRC) is the fourth most common type of cancer in the United Kingdom and the second leading cause of cancer death. Despite improvements in CRC survival over time, Scotland lags behind its UK and European counterparts. In ... ...

    Abstract Background: Colorectal cancer (CRC) is the fourth most common type of cancer in the United Kingdom and the second leading cause of cancer death. Despite improvements in CRC survival over time, Scotland lags behind its UK and European counterparts. In this study, we carry out an exploratory analysis which aims to provide contemporary, population level evidence on CRC treatment and survival in Scotland.
    Methods: We conducted a retrospective population-based analysis of adults with incident CRC registered on the Scottish Cancer Registry (Scottish Morbidity Record 06 (SMR06)) between January 2006 and December 2018. The CRC cohort was linked to hospital inpatient (SMR01) and National Records of Scotland (NRS) deaths records allowing a description of their demographic, diagnostic and treatment characteristics. Cox proportional hazards regression models were used to explore the demographic and clinical factors associated with all-cause mortality and CRC specific mortality after adjusting for patient and tumour characteristics among people identified as early-stage and treated with surgery.
    Results: Overall, 32,691 (73%) and 12,184 (27%) patients had a diagnosis of colon and rectal cancer respectively, of whom 55% and 53% were early-stage and treated with surgery. Five year overall survival (CRC specific survival) within this cohort was 72% (82%) and 76% (84%) for patients with colon and rectal cancer respectively. Cox proportional hazards models revealed significant variation in mortality by sex, area-based deprivation and geographic location.
    Conclusions: In a Scottish population of patients with early-stage CRC treated with surgery, there was significant variation in risk of death, even after accounting for clinical factors and patient characteristics.
    MeSH term(s) Adult ; Humans ; Retrospective Studies ; Colorectal Neoplasms/drug therapy ; Scotland/epidemiology ; Rectal Neoplasms ; Treatment Outcome
    Language English
    Publishing date 2024-02-20
    Publishing country Wales
    Document type Journal Article
    ISSN 2399-4908
    ISSN (online) 2399-4908
    DOI 10.23889/ijpds.v6i1.2179
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  10. Article ; Online: Cardiovascular risk management among individuals with type 2 diabetes and severe mental illness: a cohort study.

    Ter Braake, Jonne G / Fleetwood, Kelly J / Vos, Rimke C / Blackbourn, Luke / McGurnaghan, Stuart J / Wild, Sarah H / Jackson, Caroline A

    Diabetologia

    2024  Volume 67, Issue 6, Page(s) 1029–1039

    Abstract: Aims/hypothesis: The aim of this study was to compare cardiovascular risk management among people with type 2 diabetes according to severe mental illness (SMI) status.: Methods: We used linked electronic data to perform a retrospective cohort study ... ...

    Abstract Aims/hypothesis: The aim of this study was to compare cardiovascular risk management among people with type 2 diabetes according to severe mental illness (SMI) status.
    Methods: We used linked electronic data to perform a retrospective cohort study of adults diagnosed with type 2 diabetes in Scotland between 2004 and 2020, ascertaining their history of SMI from hospital admission records. We compared total cholesterol, systolic BP and HbA
    Results: We included 291,644 individuals with type 2 diabetes, of whom 1.0% had schizophrenia, 0.5% had bipolar disorder and 3.3% had major depression. People with SMI were less likely to achieve cholesterol targets, although this difference did not reach statistical significance for all disorders. However, people with SMI were more likely to achieve systolic BP targets compared to those without SMI, with effect estimates being largest for schizophrenia (men: adjusted OR 1.72; 95% CI 1.49, 1.98; women: OR 1.64; 95% CI 1.38, 1.96). HbA
    Conclusions/interpretation: We found disparities in cholesterol target achievement and statin prescribing by SMI status. This reinforces the importance of clinical review of statin prescribing for secondary prevention of CVD, particularly among people with SMI.
    MeSH term(s) Humans ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/drug therapy ; Male ; Female ; Middle Aged ; Retrospective Studies ; Cardiovascular Diseases/epidemiology ; Aged ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Adult ; Mental Disorders/epidemiology ; Glycated Hemoglobin/metabolism ; Scotland/epidemiology ; Blood Pressure/physiology ; Schizophrenia/epidemiology ; Schizophrenia/drug therapy ; Cholesterol/blood ; Bipolar Disorder/epidemiology ; Bipolar Disorder/drug therapy ; Bipolar Disorder/complications ; Heart Disease Risk Factors
    Chemical Substances Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Glycated Hemoglobin ; Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 2024-02-26
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1694-9
    ISSN 1432-0428 ; 0012-186X
    ISSN (online) 1432-0428
    ISSN 0012-186X
    DOI 10.1007/s00125-024-06111-w
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