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  1. Article ; Online: Factors to take into account when interpreting 25-hydroxy-vitamin D serum levels.

    Delanghe, Joris R / Speeckaert, Marijn M / Maenhout, Thomas

    Acta clinica Belgica

    2024  , Page(s) 1–6

    Abstract: Background: Assessing vitamin D status, typically evaluated using serum or plasma 25-hydroxy vitamin D [25(OH)D] concentration, is complex because of various influencing factors.: Methods: Seasonality significantly affects intra-individual ... ...

    Abstract Background: Assessing vitamin D status, typically evaluated using serum or plasma 25-hydroxy vitamin D [25(OH)D] concentration, is complex because of various influencing factors.
    Methods: Seasonality significantly affects intra-individual variability in 25(OH)D levels. This variation can be addressed by employing cosinor functions that are tailored to the geographical location of the patient to correct for seasonal effects. In addition to seasonality, genetic factors, such as DBP polymorphism and body composition, particularly adiposity, play crucial roles. Dialysis patients with DBP 2-2 phenotype exhibit higher vitamin D requirements. Genotyping/phenotyping of DBP allows for better tailored vitamin D supplementation. The lipid-soluble nature of vitamin D also interacts with plasma components such as serum triglycerides, which can influence vitamin D measurements. Adiposity, which is negatively correlated with vitamin D concentration, necessitates body mass-based mathematical adjustments for accurate vitamin D assessment in subjects with extreme BMI values.
    Conclusions: Accordingly, vitamin D replacement therapy must be personalized, taking into account factors such as body size and seasonal variations, to effectively reach the target serum 25(OH)D concentrations.
    Language English
    Publishing date 2024-03-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 390201-8
    ISSN 2295-3337 ; 0001-5512 ; 1784-3286
    ISSN (online) 2295-3337
    ISSN 0001-5512 ; 1784-3286
    DOI 10.1080/17843286.2024.2327218
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Commentary: Vitamin D Status in Relation to the Clinical Outcome of Hospitalized COVID-19 Patients.

    Speeckaert, Marijn M / Delanghe, Joris R

    Frontiers in medicine

    2022  Volume 9, Page(s) 922820

    Language English
    Publishing date 2022-06-16
    Publishing country Switzerland
    Document type Journal Article ; Comment
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2022.922820
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  3. Article: Commentary: Serum Vitamin D Levels Are Associated With Increased COVID-19 Severity and Mortality Independent of Whole-Body and Visceral Adiposity.

    Speeckaert, Marijn M / Delanghe, Joris R

    Frontiers in nutrition

    2022  Volume 9, Page(s) 885204

    Language English
    Publishing date 2022-03-28
    Publishing country Switzerland
    Document type Journal Article ; Comment
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2022.885204
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Association of Vitamin D Status and COVID-19-Related Hospitalization and Mortality.

    Speeckaert, Marijn M / Delanghe, Joris R

    Journal of general internal medicine

    2022  Volume 37, Issue 13, Page(s) 3491–3492

    MeSH term(s) COVID-19 ; Hospitalization ; Humans ; Vitamin D ; Vitamins
    Chemical Substances Vitamins ; Vitamin D (1406-16-2)
    Language English
    Publishing date 2022-05-17
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 639008-0
    ISSN 1525-1497 ; 0884-8734
    ISSN (online) 1525-1497
    ISSN 0884-8734
    DOI 10.1007/s11606-022-07658-3
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  5. Article ; Online: Commentary: Is There a Crucial Link Between Vitamin D Status and Inflammatory Response in Patients With COVID-19?

    Speeckaert, Marijn M / Delanghe, Joris R

    Frontiers in immunology

    2022  Volume 13, Page(s) 875973

    MeSH term(s) COVID-19 ; Humans ; Vitamin D ; Vitamin D Deficiency/complications ; Vitamins
    Chemical Substances Vitamins ; Vitamin D (1406-16-2)
    Language English
    Publishing date 2022-03-22
    Publishing country Switzerland
    Document type Journal Article ; Comment
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.875973
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  6. Article: Vitamin D Binding Protein Polymorphism: a Potential Determinant of the Prevalence and Outcome of COVID-19.

    Speeckaert, Marijn M / Delanghe, Joris R

    Clinical laboratory

    2022  Volume 68, Issue 4

    MeSH term(s) COVID-19/epidemiology ; Humans ; Prevalence ; Vitamin D ; Vitamin D Deficiency/epidemiology ; Vitamin D Deficiency/genetics ; Vitamin D-Binding Protein/genetics ; Vitamin D-Binding Protein/metabolism
    Chemical Substances GC protein, human ; Vitamin D-Binding Protein ; Vitamin D (1406-16-2)
    Language English
    Publishing date 2022-04-17
    Publishing country Germany
    Document type Letter
    ZDB-ID 1307629-2
    ISSN 1433-6510 ; 0941-2131
    ISSN 1433-6510 ; 0941-2131
    DOI 10.7754/Clin.Lab.2021.210809
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Influence of the vitamin D binding protein polymorphisms on the relationship between vitamin D status and the severity of COVID-19 in pregnant women.

    Speeckaert, Marijn M / Delanghe, Joris R

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

    2022  Volume 35, Issue 25, Page(s) 9294–9295

    MeSH term(s) Female ; Pregnancy ; Humans ; Vitamin D-Binding Protein/genetics ; Vitamin D ; Pregnant Women ; COVID-19 ; Vitamins ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/genetics
    Chemical Substances Vitamin D-Binding Protein ; Vitamin D (1406-16-2) ; Vitamins
    Language English
    Publishing date 2022-01-25
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2077261-0
    ISSN 1476-4954 ; 1057-0802 ; 1476-7058
    ISSN (online) 1476-4954
    ISSN 1057-0802 ; 1476-7058
    DOI 10.1080/14767058.2022.2028771
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Sodium and risk assessment of osmotic demyelination syndrome: the method matters!

    Stove, Veronique V / Oyaert, Matthijs / Delanghe, Joris R

    Clinical chemistry and laboratory medicine

    2023  Volume 62, Issue 1, Page(s) e22–e23

    MeSH term(s) Humans ; Sodium ; Demyelinating Diseases/diagnosis ; Hyponatremia/diagnosis ; Risk Assessment
    Chemical Substances Sodium (9NEZ333N27)
    Language English
    Publishing date 2023-07-27
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 1418007-8
    ISSN 1437-4331 ; 1434-6621 ; 1437-8523
    ISSN (online) 1437-4331
    ISSN 1434-6621 ; 1437-8523
    DOI 10.1515/cclm-2023-0667
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    Zs.A 121: Show issues Location:
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  9. Article ; Online: The potential role of vitamin D binding protein in kidney disease: a comprehensive review.

    Delanghe, Joris R / Delrue, Charlotte / Speeckaert, Reinhart / Speeckaert, Marijn M

    Acta clinica Belgica

    2024  , Page(s) 1–13

    Abstract: Chronic kidney disease (CKD) is a growing health concern with a complex etiological landscape. Among the numerous factors implicated, vitamin D binding protein (VDBP) has emerged as a focal point of scientific studies because of its critical role in ... ...

    Abstract Chronic kidney disease (CKD) is a growing health concern with a complex etiological landscape. Among the numerous factors implicated, vitamin D binding protein (VDBP) has emerged as a focal point of scientific studies because of its critical role in vitamin D metabolism and immune modulation. The relationship between VDBP and CKD reveals a complex web of molecular and biochemical details that have great potential for improving diagnostic understanding and treatment strategies for CKD. This review summarizes the multifaceted roles of VDBP, including its molecular dynamics, interactions with vitamin D, and subsequent implications for kidney function. The main focus of the discussion is how VDBP affects bone mineral homeostasis, highlighted by the dysregulation of calcium and phosphorus metabolism, which is a part of the pathophysiology of CKD. The discussion also touches on the immunomodulatory scope of VDBP and how it may reduce the chronic inflammatory environment that accompanies CKD. The diagnostic potential of VDBP as a biomarker for CKD has been rigorously examined, highlighting its capacity to improve early detection and prognostic assessment. Modification of VDBP activity has the potential to slow the course of CKD and improve patient outcomes. Furthermore, a detailed examination of the genetic polymorphisms of
    Language English
    Publishing date 2024-01-03
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 390201-8
    ISSN 2295-3337 ; 0001-5512 ; 1784-3286
    ISSN (online) 2295-3337
    ISSN 0001-5512 ; 1784-3286
    DOI 10.1080/17843286.2023.2301278
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The role of sRAGE in cardiovascular diseases.

    Delrue, Charlotte / Delanghe, Joris R / Speeckaert, Marijn M

    Advances in clinical chemistry

    2023  Volume 117, Page(s) 53–102

    Abstract: Advanced glycation end products (AGEs), by-products of glucose metabolism, have been linked to the emergence of cardiovascular disorders (CVD). AGEs can cause tissue damage in four different ways: (1) by altering protein function, (2) by crosslinking ... ...

    Abstract Advanced glycation end products (AGEs), by-products of glucose metabolism, have been linked to the emergence of cardiovascular disorders (CVD). AGEs can cause tissue damage in four different ways: (1) by altering protein function, (2) by crosslinking proteins, which makes tissue stiffer, (3) by causing the generation of free radicals, and (4) by activating an inflammatory response after binding particular AGE receptors, such as the receptor for advanced glycation end products (RAGE). It is suggested that the soluble form of RAGE (sRAGE) blocks ligand-mediated pro-inflammatory and oxidant activities by serving as a decoy. Therefore, several studies have investigated the possible anti-inflammatory and anti-oxidant characteristics of sRAGE, which may help lower the risk of CVD. According to the results of various studies, the relationship between circulating sRAGE, cRAGE, and esRAGE and CVD is inconsistent. To establish the potential function of sRAGE as a therapeutic target in the treatment of cardiovascular illnesses, additional studies are required to better understand the relationship between sRAGE and CVD. In this review, we explored the potential function of sRAGE in different CVD, highlighting unanswered concerns and outlining the possibilities for further investigation.
    MeSH term(s) Humans ; Cardiovascular Diseases/metabolism ; Glycation End Products, Advanced/metabolism ; Receptor for Advanced Glycation End Products/metabolism
    Chemical Substances Glycation End Products, Advanced ; Receptor for Advanced Glycation End Products
    Language English
    Publishing date 2023-09-19
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 210505-6
    ISSN 2162-9471 ; 0065-2423
    ISSN (online) 2162-9471
    ISSN 0065-2423
    DOI 10.1016/bs.acc.2023.08.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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