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  1. Article ; Online: Pill related oesophagitis due to tenofovir disproxil fumarate/emtricitabine (Truvada) HIV pre-exposure prophylaxis.

    Bonnichsen, Mark H / Tschuchnigg, Mark / Post, Jeffrey J / Bye, William

    Internal medicine journal

    2022  Volume 52, Issue 6, Page(s) 1099–1100

    MeSH term(s) Emtricitabine/adverse effects ; Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination/adverse effects ; Esophagitis ; Fumarates/therapeutic use ; HIV Infections/drug therapy ; HIV Infections/prevention & control ; Humans ; Pre-Exposure Prophylaxis ; Tenofovir/adverse effects
    Chemical Substances Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination ; Fumarates ; Tenofovir (99YXE507IL) ; Emtricitabine (G70B4ETF4S)
    Language English
    Publishing date 2022-06-06
    Publishing country Australia
    Document type Letter
    ZDB-ID 2045436-3
    ISSN 1445-5994 ; 1444-0903
    ISSN (online) 1445-5994
    ISSN 1444-0903
    DOI 10.1111/imj.15807
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  2. Article ; Online: Preservation of recipient plasma sphingosine-1-phosphate levels reduces transfusion-related acute lung injury.

    Hsing, Vanessa / Zhao, Han Qi / Post, Martin / Devine, Dana / McVey, Mark J

    American journal of physiology. Lung cellular and molecular physiology

    2024  Volume 326, Issue 5, Page(s) L589–L595

    Abstract: Cold-stored (CS) platelets are once again being reintroduced for clinical use. Transfused CS platelets offer benefits over room temperature-stored (RTS) platelets such as increased hemostatic effects and prolongation of shelf-life. Despite these ... ...

    Abstract Cold-stored (CS) platelets are once again being reintroduced for clinical use. Transfused CS platelets offer benefits over room temperature-stored (RTS) platelets such as increased hemostatic effects and prolongation of shelf-life. Despite these advantages little is known about their association with transfusion-related acute lung injury (TRALI). TRALI is associated with prolonged storage of RTS platelets and has a mortality of >15%. Determining the safety of CS platelets is important considering their proposed use in TRALI-vulnerable populations with inflammation such as surgical patients or patients with trauma. Donor platelet-derived ceramide causes TRALI, whereas donor platelet sphingosine-1-phosphate (S1P) is barrier protective. Females have higher plasma levels of S1P than males. Cold temperatures increase S1P levels in cells. Therefore, we hypothesized that female (donors or recipients) and/or CS platelets would decrease TRALI. To test this, we compared how male and female donor and recipient allogeneic platelet transfusions of CS (4°C) versus RTS (23°C) platelets stored for 5 days influence murine TRALI. Transfusion of CS platelets significantly reduced recipient lung tissue wet-to-dry ratios, bronchoalveolar lavage total protein, lung tissue myeloperoxidase enzyme activity, histological lung injury scores, and increased plasma sphingosine-1-phosphate (S1P) levels compared with RTS platelet transfusions. Female as opposed to male recipients had less TRALI and higher plasma S1P levels. Female donor mouse platelets had higher S1P levels than males. Mouse and human CS platelets had increased S1P levels compared with RTS platelets. Higher recipient plasma S1P levels appear protective considering females, and males receiving platelets from females or male CS platelets had less TRALI.
    MeSH term(s) Lysophospholipids/blood ; Lysophospholipids/metabolism ; Sphingosine/analogs & derivatives ; Sphingosine/blood ; Animals ; Female ; Male ; Mice ; Blood Preservation/methods ; Transfusion-Related Acute Lung Injury/blood ; Platelet Transfusion ; Mice, Inbred C57BL ; Blood Platelets/metabolism ; Humans ; Acute Lung Injury/blood ; Acute Lung Injury/etiology ; Acute Lung Injury/prevention & control
    Chemical Substances Lysophospholipids ; sphingosine 1-phosphate (26993-30-6) ; Sphingosine (NGZ37HRE42)
    Language English
    Publishing date 2024-02-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1013184-x
    ISSN 1522-1504 ; 1040-0605
    ISSN (online) 1522-1504
    ISSN 1040-0605
    DOI 10.1152/ajplung.00388.2023
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  3. Article ; Online: Protocol for differentiation of bovine adipogenic progenitor cells embedded in alginate sheets.

    Caponi, Joseph J / Shmushkis, Jane / Geissler, Hanna / Post, Mark J / Jackisch, Laura / Mall, Eva M

    STAR protocols

    2023  Volume 4, Issue 2, Page(s) 102143

    Abstract: Here, we present a cost-effective protocol to differentiate bovine fibro-adipogenic progenitors in a thin hydrogel sheet adherent to 96-well plates. We describe steps for the embedding and culturing of cells in alginate sheets, culture maintenance, and ... ...

    Abstract Here, we present a cost-effective protocol to differentiate bovine fibro-adipogenic progenitors in a thin hydrogel sheet adherent to 96-well plates. We describe steps for the embedding and culturing of cells in alginate sheets, culture maintenance, and analysis. Compared to alternative three-dimensional (3D) models such as hydrogel-based microfibers, this approach simplifies automation while retaining efficient maturation of adipocytes. Embedded cells are still subjected to a 3D environment, but the sheets can be handled and analyzed like two-dimensional cultures.
    Language English
    Publishing date 2023-03-09
    Publishing country United States
    Document type Journal Article
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2023.102143
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  4. Article: Development of a Chemically Defined Medium for

    Kolkmann, Anna M / Van Essen, Anon / Post, Mark J / Moutsatsou, Panagiota

    Frontiers in bioengineering and biotechnology

    2022  Volume 10, Page(s) 895289

    Abstract: The use of fetal bovine serum (FBS) in animal cell culture media is widely spread since it provides a broad spectrum of molecules that are known to support cell attachment and growth. However, the harvest and collection procedures of FBS raise ethical ... ...

    Abstract The use of fetal bovine serum (FBS) in animal cell culture media is widely spread since it provides a broad spectrum of molecules that are known to support cell attachment and growth. However, the harvest and collection procedures of FBS raise ethical concerns and serum is an ill-defined and expensive component. This is especially problematic when it comes to regulatory approval for food applications like cultured meat. The aim of this study is to develop a chemically defined, cost efficient serum-free and animal-free medium that supports the attachment and expansion of bovine myoblasts while maintaining their differentiation capacity. Bovine satellite cells were harvested and isolated from a fresh sample of skeletal muscle tissue and cultured in planar systems. The efficacy of the tested formulations was assessed with metabolic assays and cell counting techniques. Optical microscopy was used to observe cellular morphology and statistical analysis was applied. Based on a comprehensive literature analysis, a defined serum-free medium (SFM) composition was developed consisting of DMEM/F12 as basal medium, supplemented with L-ascorbic acid 2-phosphate, fibronectin, hydrocortisone, GlutaMAX
    Language English
    Publishing date 2022-08-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2022.895289
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  5. Article ; Online: Extracellular vesicles: effectors of transfusion-related acute lung injury.

    Kuebler, Wolfgang M / William, Nishaka / Post, Martin / Acker, Jason P / McVey, Mark J

    American journal of physiology. Lung cellular and molecular physiology

    2023  Volume 325, Issue 3, Page(s) L327–L341

    Abstract: Respiratory transfusion reactions represent some of the most severe adverse reactions related to receiving blood products. Of those, transfusion-related acute lung injury (TRALI) is associated with elevated morbidity and mortality. TRALI is characterized ...

    Abstract Respiratory transfusion reactions represent some of the most severe adverse reactions related to receiving blood products. Of those, transfusion-related acute lung injury (TRALI) is associated with elevated morbidity and mortality. TRALI is characterized by severe lung injury associated with inflammation, pulmonary neutrophil infiltration, lung barrier leak, and increased interstitial and airspace edema that cause respiratory failure. Presently, there are few means of detecting TRALI beyond clinical definitions based on physical examination and vital signs or preventing/treating TRALI beyond supportive care with oxygen and positive pressure ventilation. Mechanistically, TRALI is thought to be mediated by the culmination of two successive proinflammatory hits, which typically comprise a recipient factor (1st hit-e.g., systemic inflammatory conditions) and a donor factor (2nd hit-e.g., blood products containing pathogenic antibodies or bioactive lipids). An emerging concept in TRALI research is the contribution of extracellular vesicles (EVs) in mediating the first and/or second hit in TRALI. EVs are small, subcellular, membrane-bound vesicles that circulate in donor and recipient blood. Injurious EVs may be released by immune or vascular cells during inflammation, by infectious bacteria, or in blood products during storage, and can target the lung upon systemic dissemination. This review assesses emerging concepts such as how EVs:
    MeSH term(s) Humans ; Transfusion-Related Acute Lung Injury/etiology ; Transfusion Reaction ; Lung ; Lung Injury ; Antibodies ; Inflammation
    Chemical Substances Antibodies
    Language English
    Publishing date 2023-06-13
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1013184-x
    ISSN 1522-1504 ; 1040-0605
    ISSN (online) 1522-1504
    ISSN 1040-0605
    DOI 10.1152/ajplung.00040.2023
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  6. Article: Towards resource- and cost- efficient cultured meat

    Hubalek, Sophie / Post, Mark J. / Moutsatsou, Panagiota

    Current opinion in food science. 2022 June 18,

    2022  

    Abstract: Cultured meat is a bearer of hope for sustainable meat production, aiming at ensuring global food security while preserving environmental resources. Being a nascent industry, there are still many hurdles to overcome, some of which are cost reduction and ... ...

    Abstract Cultured meat is a bearer of hope for sustainable meat production, aiming at ensuring global food security while preserving environmental resources. Being a nascent industry, there are still many hurdles to overcome, some of which are cost reduction and ensuring a sustainable supply chain. This review focuses on the current state of the industry, identifies medium related costs as one of the main cost-drivers for scalable cultured meat production and discusses the latest findings on potential cost-effective nutrient replacements for cell propagation and differentiation, based on hydrolysates. Opportunities for medium recyclability with a focus on algae are also explored.
    Keywords cost effectiveness ; cultured meat ; food science ; food security ; industry ; meat production ; supply chain
    Language English
    Dates of publication 2022-0618
    Publishing place Elsevier Ltd
    Document type Article
    Note Pre-press version
    ZDB-ID 2797683-X
    ISSN 2214-7993
    ISSN 2214-7993
    DOI 10.1016/j.cofs.2022.100885
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Correction: The effect of information content on acceptance of cultured meat in a tasting context.

    Rolland, Nathalie C M / Markus, C Rob / Post, Mark J

    PloS one

    2020  Volume 15, Issue 10, Page(s) e0240630

    Abstract: This corrects the article DOI: 10.1371/journal.pone.0231176.]. ...

    Abstract [This corrects the article DOI: 10.1371/journal.pone.0231176.].
    Language English
    Publishing date 2020-10-07
    Publishing country United States
    Document type Published Erratum
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0240630
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  8. Article: Single-cell analysis of bovine muscle-derived cell types for cultured meat production.

    Messmer, Tobias / Dohmen, Richard G J / Schaeken, Lieke / Melzener, Lea / Hueber, Rui / Godec, Mary / Didoss, Carin / Post, Mark J / Flack, Joshua E

    Frontiers in nutrition

    2023  Volume 10, Page(s) 1212196

    Abstract: Cultured meat technologies leverage the proliferation and differentiation of animal-derived stem ... ...

    Abstract Cultured meat technologies leverage the proliferation and differentiation of animal-derived stem cells
    Language English
    Publishing date 2023-09-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2023.1212196
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  9. Article ; Online: Cultured beef: medical technology to produce food.

    Post, Mark J

    Journal of the science of food and agriculture

    2014  Volume 94, Issue 6, Page(s) 1039–1041

    MeSH term(s) Animals ; Cattle ; Cells, Cultured ; Diet ; Food Technology ; Humans ; Meat ; Muscles ; Tissue Engineering
    Language English
    Publishing date 2014-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 184116-6
    ISSN 1097-0010 ; 0022-5142
    ISSN (online) 1097-0010
    ISSN 0022-5142
    DOI 10.1002/jsfa.6474
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  10. Article ; Online: An alternative animal protein source: cultured beef.

    Post, Mark J

    Annals of the New York Academy of Sciences

    2014  Volume 1328, Page(s) 29–33

    Abstract: Alternative sources of animal proteins are needed that can be produced efficiently, thereby providing food security with diminished ecological burden. It is feasible to culture beef from bovine skeletal muscle stem cells, but the technology is still ... ...

    Abstract Alternative sources of animal proteins are needed that can be produced efficiently, thereby providing food security with diminished ecological burden. It is feasible to culture beef from bovine skeletal muscle stem cells, but the technology is still under development. The aim is to create a beef mimic with equivalent taste, texture, and appearance and with the same nutritional value as livestock-produced beef. More specifically, there is a need for optimization of protein content and fat content. In addition, scalability of production requires modification of current small-scale bioreactors to the largest possible scale. The necessary steps and current progress suggest that this aim is achievable, but formal evidence is still required. Similarly, we can be optimistic about consumer acceptance based on initial data, but detailed studies are needed to gain more insight into potential psychological obstacles that could lead to rejection. These challenges are formidable but likely surmountable. The severity of upcoming food-security threats warrants serious research and development efforts to address the challenges that come with bringing cultured beef to the market.
    MeSH term(s) Animals ; Bioreactors ; Cattle ; Conservation of Natural Resources ; Dietary Proteins/supply & distribution ; Humans ; Meat/supply & distribution ; Public Opinion ; Tissue Culture Techniques
    Chemical Substances Dietary Proteins
    Language English
    Publishing date 2014-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 211003-9
    ISSN 1749-6632 ; 0077-8923
    ISSN (online) 1749-6632
    ISSN 0077-8923
    DOI 10.1111/nyas.12569
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