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  1. Article ; Online: Vitamin B12 deficiency-induced megaloblastic anemia in a pediatric patient with autism spectrum disorder with a chronically unbalanced diet.

    Sawada, Yuri / Sakamoto, Kenichi / Tsukamura, Atsushi / Sawai, Chihiro

    International journal of hematology

    2024  

    Abstract: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by a lack of behavioral flexibility and stereotyped language. Food selectivity is common among children with ASD because of their persnickety nature. A prolonged unbalanced ... ...

    Abstract Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by a lack of behavioral flexibility and stereotyped language. Food selectivity is common among children with ASD because of their persnickety nature. A prolonged unbalanced diet results in an increased risk of several diseases, such as iron deficiency anemia, scurvy, rickets, dry eye, and Wernicke encephalopathy. However, no cases of megaloblastic anemia have been reported to date. We report the case of an 11-year-old boy with ASD who developed megaloblastic anemia due to vitamin B12 deficiency. He had a prolonged history of selective eating for more than 10 years. His nutritional status on admission was poor, and he had low weight and short stature. His food selectivity was so strong that intervention to expand diet variety was unsuccessful. A developmental-behavioral pediatrician found that the patient had visual dominance and could take some medications when suffering from a minor illness. Nutritional supplements were selected after consultation with a nutritionist. Although compulsory treatment was necessary during the acute phase, the therapy was continued at home. With multidisciplinary intervention tailored to the patient and his parents' characteristics, his nutritional status improved in a few months.
    Language English
    Publishing date 2024-03-25
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1076875-0
    ISSN 1865-3774 ; 0917-1258 ; 0925-5710
    ISSN (online) 1865-3774
    ISSN 0917-1258 ; 0925-5710
    DOI 10.1007/s12185-024-03759-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 269: Show issues Location:
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  2. Article ; Online: Giant progressive mitral vegetation in a case of infective endocarditis caused by Streptococcus agalactiae.

    Susukida, Gyo / Sakamoto, Atsushi / Iguchi, Keisuke / Fujihiro, Mayu / Ohtani, Hayato / Shiiya, Norihiko / Maekawa, Yuichiro

    Journal of echocardiography

    2024  

    Language English
    Publishing date 2024-01-17
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2209473-8
    ISSN 1880-344X ; 1349-0222
    ISSN (online) 1880-344X
    ISSN 1349-0222
    DOI 10.1007/s12574-023-00633-9
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  3. Article ; Online: Conduction disturbance followed by progressive ventricular wall thickening as an initial manifestation of light-chain cardiac amyloidosis.

    Ikoma, Takenori / Sakamoto, Atsushi / Iguchi, Keisuke / Ohtani, Hayato / Tominaga, Hiromutsu / Baba, Satoshi / Maekawa, Yuichiro

    Journal of echocardiography

    2024  

    Language English
    Publishing date 2024-02-03
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2209473-8
    ISSN 1880-344X ; 1349-0222
    ISSN (online) 1880-344X
    ISSN 1349-0222
    DOI 10.1007/s12574-023-00639-3
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  4. Article ; Online: Sellimonas catena

    Hisatomi, Atsushi / Ohkuma, Moriya / Sakamoto, Mitsuo

    International journal of systematic and evolutionary microbiology

    2023  Volume 73, Issue 4

    Abstract: Obligately anaerobic, Gram-stain-positive, small-chain coccobacilli, strains ... ...

    Abstract Obligately anaerobic, Gram-stain-positive, small-chain coccobacilli, strains 12EGH17
    MeSH term(s) Humans ; RNA, Ribosomal, 16S/genetics ; Fatty Acids/chemistry ; Phylogeny ; DNA, Bacterial/genetics ; Bacterial Typing Techniques ; Sequence Analysis, DNA ; Base Composition ; Feces ; Nucleic Acid Hybridization
    Chemical Substances RNA, Ribosomal, 16S ; Fatty Acids ; DNA, Bacterial
    Language English
    Publishing date 2023-04-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2002336-4
    ISSN 1466-5034 ; 1466-5026
    ISSN (online) 1466-5034
    ISSN 1466-5026
    DOI 10.1099/ijsem.0.005853
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 409: Show issues Location:
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  5. Article: Osteoradionecrosis of the occipitocervical junction: A rare case of C1 anterior arch disruption.

    Sakamoto, Masaki / Shimizu, Takayoshi / Suehiro, Atsushi / Matsuda, Shuichi

    Journal of craniovertebral junction & spine

    2023  Volume 14, Issue 1, Page(s) 93–96

    Abstract: We report the case of a 57-year-old man who developed osteoradionecrosis (ORN) at the occipitocervical (OC) junction after radiation therapy for nasopharyngeal carcinoma. During soft-tissue debridement using a nasopharyngeal endoscope, the anterior arch ... ...

    Abstract We report the case of a 57-year-old man who developed osteoradionecrosis (ORN) at the occipitocervical (OC) junction after radiation therapy for nasopharyngeal carcinoma. During soft-tissue debridement using a nasopharyngeal endoscope, the anterior arch of the atlas (AAA) was spontaneously disrupted, which was later spat out. Radiographic examination revealed complete disruption of the AAA that caused OC instability. We performed posterior OC fixation. The patient experienced successful postoperative pain relief. AAA disruption secondary to ORN at OC junction can cause severe instability. Posterior OC fixation alone may be an effective procedure if the necrotic pharyngeal region is mild and endoscopically controllable.
    Language English
    Publishing date 2023-03-13
    Publishing country India
    Document type Case Reports
    ZDB-ID 2573344-8
    ISSN 0976-9285 ; 0974-8237
    ISSN (online) 0976-9285
    ISSN 0974-8237
    DOI 10.4103/jcvjs.jcvjs_145_22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A case of nonpigmented fixed-drug eruption with eosinophilic intraepidermal vesicle formation.

    Sakamoto, Keiko / Fujihiro, Mayu / Sakamoto, Atsushi / Yamada, Chika / Nagao, Keisuke / Honda, Tetsuya

    The Journal of dermatology

    2023  Volume 51, Issue 4, Page(s) e120–e122

    MeSH term(s) Humans ; Drug Eruptions/diagnosis ; Drug Eruptions/etiology
    Language English
    Publishing date 2023-11-10
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 800103-0
    ISSN 1346-8138 ; 0385-2407
    ISSN (online) 1346-8138
    ISSN 0385-2407
    DOI 10.1111/1346-8138.17022
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    In stock of ZB MED Cologne/Königswinter

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  7. Article ; Online: Increased extracellular release of microRNAs from dorsal root ganglion cells in a rat model of neuropathic pain caused by peripheral nerve injury.

    Ikuma, Yuko / Sakai, Atsushi / Sakamoto, Atsuhiro / Suzuki, Hidenori

    PloS one

    2023  Volume 18, Issue 1, Page(s) e0280425

    Abstract: microRNAs (miRNAs) are extracellularly released by cells for intercellular communication, while intracellularly, they inhibit the expression of specific genes. An increasing number of studies suggest that extracellular miRNAs have great potential as both ...

    Abstract microRNAs (miRNAs) are extracellularly released by cells for intercellular communication, while intracellularly, they inhibit the expression of specific genes. An increasing number of studies suggest that extracellular miRNAs have great potential as both therapeutic targets and disease-specific biomarkers in a variety of diseases, including pain disorders. However, little is known about miRNA release from dorsal root ganglion (DRG) neurons in neuropathic pain caused by peripheral nerve injury. In this study, we investigated the changes in the extracellular release of miRNAs from DRG neurons in a rat model of neuropathic pain induced by chronic constriction injury of the sciatic nerve. We found increased release of six miRNAs (let-7d, miR-21, miR-142-3p, miR-146b, miR-203-3p and miR-221) from primary cultured DRG neurons prepared from rats 7 days after nerve injury. Among these, miR-221 was also increased in serum from days 7 to 28 after nerve injury. In contrast, serum miR-221 levels and its release from DRG neurons were unchanged in an inflammatory pain model produced by intraplantar injection of complete Freund's adjuvant. These results suggest that the increased release of specific miRNAs by DRG neurons may be involved in the pathophysiology of neuropathic pain through extracellular as well as intracellular mechanisms. Furthermore, serum miR-221 may be useful as a biomarker of neuropathic pain caused by peripheral nerve injury.
    MeSH term(s) Rats ; Animals ; Ganglia, Spinal/metabolism ; Peripheral Nerve Injuries/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Neuralgia/etiology ; Sciatic Nerve/injuries
    Chemical Substances MicroRNAs ; MIRN203 microRNA, rat ; mirn21 microRNA, rat
    Language English
    Publishing date 2023-01-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0280425
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  8. Article ; Online: Actin cytoskeletal reorganization is involved in hyperosmotic stress-induced autophagy in tubular epithelial cells.

    Miyano, Takashi / Suzuki, Atsushi / Sakamoto, Naoya

    Biochemical and biophysical research communications

    2023  Volume 663, Page(s) 1–7

    Abstract: Tubular epithelial cells are routinely exposed to severe changes in osmolarity. Although the autophagic activity of cells is an indispensable process to maintain cellular homeostasis and respond to stressors, the effect of hyperosmotic stress on ... ...

    Abstract Tubular epithelial cells are routinely exposed to severe changes in osmolarity. Although the autophagic activity of cells is an indispensable process to maintain cellular homeostasis and respond to stressors, the effect of hyperosmotic stress on autophagic activity in tubular epithelial cells remains unknown. The aim of this study was to determine the effect of hyperosmotic stress on autophagy in rat kidney tubular epithelial cells focusing on the role of actin and microtubule cytoskeletons. Normal rat kidney (NRK)-52E cells exposed to mannitol-induced hyperosmotic stress. As a result, NRK-52E cells showed elevated protein levels of the autophagosome marker LC3-II, indicating enhancement of the autophagic flux. Hyperosmotic stress also transiently decreased cell volume and caused the reorganization of actin and microtubule cytoskeletal structures in NRK-52E cells. The inhibition of the actin cytoskeleton reorganization by cytochalasin D impaired the increase in the levels of LC3-II; however, disassembly of the microtubules following treatment with nocodazole did not affect the increase. These results indicate that hyperosmotic stress can induce autophagy mediated by the reorganization of the actin cytoskeleton in tubular epithelial cells.
    MeSH term(s) Rats ; Animals ; Actins/metabolism ; Epithelial Cells/metabolism ; Autophagy ; Cytoskeleton ; Microtubules
    Chemical Substances Actins
    Language English
    Publishing date 2023-04-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2023.04.070
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 116: Show issues Location:
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  9. Article ; Online: Bernard-Soulier syndrome caused by a novel GP1BB variant and 22q11.2 deletion.

    Nagoshi, Rintaro / Sakamoto, Atsushi / Imai, Tsuyoshi / Uchiyama, Toru / Kaname, Tadashi / Kunishima, Shinji / Ishiguro, Akira

    International journal of hematology

    2024  

    Abstract: Bernard-Soulier syndrome (BSS) is caused by defects in GP1BA, GP1BB, or GP9 genes. Patients with 22q11.2 deletion syndrome (22q11.2DS) are obligate carriers of BSS because GP1BB resides on chromosome 22q11.2. A 15-month-old girl without bleeding symptoms ...

    Abstract Bernard-Soulier syndrome (BSS) is caused by defects in GP1BA, GP1BB, or GP9 genes. Patients with 22q11.2 deletion syndrome (22q11.2DS) are obligate carriers of BSS because GP1BB resides on chromosome 22q11.2. A 15-month-old girl without bleeding symptoms had giant platelets and thrombocytopenia. Physical findings and macrothrombocytopenia suggested 22q11.2DS, which was confirmed by fluorescence in situ hybridization. Flow cytometry showed decreased GPIbα on the platelets. Gene panel testing revealed a novel variant in GP1BB, p.(Val169_Leu172del). These findings confirmed that the patient had BSS. This case suggests that any patient with 22q11.2DS and macrothrombocytopenia should be further tested for BSS.
    Language English
    Publishing date 2024-04-16
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1076875-0
    ISSN 1865-3774 ; 0917-1258 ; 0925-5710
    ISSN (online) 1865-3774
    ISSN 0917-1258 ; 0925-5710
    DOI 10.1007/s12185-024-03768-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  10. Article ; Online: Case report: Immunological characteristics of

    Morita, Atsushi / Imagawa, Kazuo / Tagawa, Manabu / Sakamoto, Noriaki / Takada, Hidetoshi

    Frontiers in immunology

    2023  Volume 14, Page(s) 1107808

    Abstract: The pathological mechanisms ... ...

    Abstract The pathological mechanisms of
    MeSH term(s) Humans ; Child ; Female ; Colitis, Ulcerative ; COVID-19 ; CD8-Positive T-Lymphocytes ; SARS-CoV-2 ; Inflammatory Bowel Diseases ; Antibodies, Viral ; Receptors, Antigen, T-Cell
    Chemical Substances spike protein, SARS-CoV-2 ; Antibodies, Viral ; Receptors, Antigen, T-Cell
    Language English
    Publishing date 2023-02-16
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1107808
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