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  1. Article ; Online: Decline in seasonal predictability potentially destabilized Classic Maya societies.

    Braun, Tobias / Breitenbach, Sebastian F M / Skiba, Vanessa / Lechleitner, Franziska A / Ray, Erin E / Baldini, Lisa M / Polyak, Victor J / Baldini, James U L / Kennett, Douglas J / Prufer, Keith M / Marwan, Norbert

    Communications earth & environment

    2023  Volume 4, Issue 1, Page(s) 82

    Abstract: Classic Maya populations living in peri-urban states were highly dependent on seasonally ... of decadal to centennial-scale climatic changes on the demise of Classic Maya sociopolitical institutions ... at seasonal scale over the past 1600 years. We find that the initial disintegration of Maya ...

    Abstract Classic Maya populations living in peri-urban states were highly dependent on seasonally distributed rainfall for reliable surplus crop yields. Despite intense study of the potential impact of decadal to centennial-scale climatic changes on the demise of Classic Maya sociopolitical institutions (750-950 CE), its direct importance remains debated. We provide a detailed analysis of a precisely dated speleothem record from Yok Balum cave, Belize, that reflects local hydroclimatic changes at seasonal scale over the past 1600 years. We find that the initial disintegration of Maya sociopolitical institutions and population decline occurred in the context of a pronounced decrease in the predictability of seasonal rainfall and severe drought between 700 and 800 CE. The failure of Classic Maya societies to successfully adapt to volatile seasonal rainfall dynamics likely contributed to gradual but widespread processes of sociopolitical disintegration. We propose that the complex abandonment of Classic Maya population centres was not solely driven by protracted drought but also aggravated by year-to-year decreases in rainfall predictability, potentially caused by a regional reduction in coherent Intertropical Convergence Zone-driven rainfall.
    Language English
    Publishing date 2023-03-17
    Publishing country England
    Document type Journal Article
    ISSN 2662-4435
    ISSN (online) 2662-4435
    DOI 10.1038/s43247-023-00717-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Hyperhidrosis and Hypermobility Spectrum Disorders Among Adolescents.

    Zloof, Yair / Derazne, Estela / Braun, Maya / Friedland, Rivka / Scheuerman, Oded / Shlaifer, Amir / Goldberg, Lotem

    JAMA dermatology

    2024  

    Language English
    Publishing date 2024-03-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701761-8
    ISSN 2168-6084 ; 2168-6068
    ISSN (online) 2168-6084
    ISSN 2168-6068
    DOI 10.1001/jamadermatol.2024.0100
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  3. Article: Transcriptome changes in DM1 patients' tissues are governed by the RNA interference pathway.

    Braun, Maya / Shoshani, Shachar / Tabach, Yuval

    Frontiers in molecular biosciences

    2022  Volume 9, Page(s) 955753

    Abstract: Myotonic dystrophy type 1 (DM1) is a multisystemic disease caused by pathogenic expansions of CTG repeats. The expanded repeats are transcribed to long RNA and induce cellular toxicity. Recent studies suggest that the CUG repeats are processed by the RNA ...

    Abstract Myotonic dystrophy type 1 (DM1) is a multisystemic disease caused by pathogenic expansions of CTG repeats. The expanded repeats are transcribed to long RNA and induce cellular toxicity. Recent studies suggest that the CUG repeats are processed by the RNA interference (RNAi) pathway to generate small interfering repeated RNA (siRNA). However, the effects of the CTG repeat-derived siRNAs remain unclear. We hypothesize that the RNAi machinery in DM1 patients generates distinct gene expression patterns that determine the disease phenotype in the individual patient. The abundance of genes with complementary repeats that are targeted by siRNAs in each tissue determines the way that the tissue is affected in DM1. We integrated and analyzed published transcriptome data from muscle, heart, and brain biopsies of DM1 patients, and revealed shared, characteristic changes that correlated with disease phenotype. These signatures are overrepresented by genes and transcription factors bearing endogenous CTG/CAG repeats and are governed by aberrant activity of the RNAi machinery, miRNAs, and a specific gain-of-function of the CTG repeats. Computational analysis of the DM1 transcriptome enhances our understanding of the complex pathophysiology of the disease and may reveal a path for cure.
    Language English
    Publishing date 2022-08-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2022.955753
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  4. Article ; Online: Building on Existing Classifications of Behavior Change Techniques to Classify Planned Coping Strategies: Physical Activity Diary Study.

    Braun, Maya / Schroé, Helene / De Paepe, Annick L / Crombez, Geert

    JMIR formative research

    2023  Volume 7, Page(s) e50573

    Abstract: Background: When trying to be more physically active, preparing for possible barriers by considering potential coping strategies increases the likelihood of plan enactment. Digital interventions can support this process by providing personalized ... ...

    Abstract Background: When trying to be more physically active, preparing for possible barriers by considering potential coping strategies increases the likelihood of plan enactment. Digital interventions can support this process by providing personalized recommendations for coping strategies, but this requires that possible coping strategies are identified and classified. Existing classification systems of behavior change, such as the compendium of self-enactable techniques, may be reused to classify coping strategies in the context of physical activity (PA) coping planning.
    Objective: This study investigated whether coping strategies created by a student population to overcome barriers to be physically active can be mapped onto the compendium of self-enactable techniques and which adaptations or additions to the frameworks are needed.
    Methods: In total, 359 Flemish university students created action and coping plans for PA for 8 consecutive days in 2020, resulting in 5252 coping plans. A codebook was developed iteratively using the compendium of self-enactable techniques as a starting point to code coping strategies. Additional codes were added to the codebook iteratively. Interrater reliability was calculated, and descriptive statistics were provided for the coping strategies.
    Results: Interrater reliability was moderate (Cohen κ=0.72) for the coded coping strategies. Existing self-enactable techniques covered 64.6% (3393/5252) of the coded coping strategies, and added coping strategies covered 28.52% (n=1498). The remaining coping strategies could not be coded as entries were too vague or contained no coping strategy. The added classes covered multiple ways of adapting the original action plan, managing one's time, ensuring the availability of required material, and doing the activity with someone else. When exploring the data further, we found that almost half (n=2371, 45.1%) of the coping strategies coded focused on contextual factors.
    Conclusions: The study's objective was to categorize PA coping strategies. The compendium of self-enactable techniques addressed almost two-thirds (3393/5252, 64.6%) of these strategies, serving as valuable starting points for classification. In total, 9 additional strategies were integrated into the self-enactable techniques, which are largely absent in other existing classification systems. These new techniques can be seen as further refinements of "problem-solving" or "coping planning." Due to data constraints stemming from the COVID-19 pandemic and the study's focus on a healthy Flemish student population, it is anticipated that more coping strategies would apply under normal conditions, in the general population, and among clinical groups. Future research should expand to diverse populations and establish connections between coping strategies and PA barriers, with ontologies recommended for this purpose. This study is a first step in classifying the content of coping strategies for PA. We believe this is an important and necessary step toward digital health interventions that incorporate personalized suggestions for PA coping plans.
    Language English
    Publishing date 2023-12-18
    Publishing country Canada
    Document type Journal Article
    ISSN 2561-326X
    ISSN (online) 2561-326X
    DOI 10.2196/50573
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Building on Existing Classifications of Behavior Change Techniques to Classify Planned Coping Strategies

    Maya Braun / Helene Schroé / Annick L De Paepe / Geert Crombez

    JMIR Formative Research, Vol 7, p e

    Physical Activity Diary Study

    2023  Volume 50573

    Abstract: BackgroundWhen trying to be more physically active, preparing for possible barriers by considering potential coping strategies increases the likelihood of plan enactment. Digital interventions can support this process by providing personalized ... ...

    Abstract BackgroundWhen trying to be more physically active, preparing for possible barriers by considering potential coping strategies increases the likelihood of plan enactment. Digital interventions can support this process by providing personalized recommendations for coping strategies, but this requires that possible coping strategies are identified and classified. Existing classification systems of behavior change, such as the compendium of self-enactable techniques, may be reused to classify coping strategies in the context of physical activity (PA) coping planning. ObjectiveThis study investigated whether coping strategies created by a student population to overcome barriers to be physically active can be mapped onto the compendium of self-enactable techniques and which adaptations or additions to the frameworks are needed. MethodsIn total, 359 Flemish university students created action and coping plans for PA for 8 consecutive days in 2020, resulting in 5252 coping plans. A codebook was developed iteratively using the compendium of self-enactable techniques as a starting point to code coping strategies. Additional codes were added to the codebook iteratively. Interrater reliability was calculated, and descriptive statistics were provided for the coping strategies. ResultsInterrater reliability was moderate (Cohen κ=0.72) for the coded coping strategies. Existing self-enactable techniques covered 64.6% (3393/5252) of the coded coping strategies, and added coping strategies covered 28.52% (n=1498). The remaining coping strategies could not be coded as entries were too vague or contained no coping strategy. The added classes covered multiple ways of adapting the original action plan, managing one’s time, ensuring the availability of required material, and doing the activity with someone else. When exploring the data further, we found that almost half (n=2371, 45.1%) of the coping strategies coded focused on contextual factors. ConclusionsThe study’s objective was to categorize PA coping strategies. The compendium ...
    Keywords Medicine ; R
    Subject code 360
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher JMIR Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Transcriptome changes in DM1 patients’ tissues are governed by the RNA interference pathway

    Maya Braun / Shachar Shoshani / Yuval Tabach

    Frontiers in Molecular Biosciences, Vol

    2022  Volume 9

    Abstract: Myotonic dystrophy type 1 (DM1) is a multisystemic disease caused by pathogenic expansions of CTG repeats. The expanded repeats are transcribed to long RNA and induce cellular toxicity. Recent studies suggest that the CUG repeats are processed by the RNA ...

    Abstract Myotonic dystrophy type 1 (DM1) is a multisystemic disease caused by pathogenic expansions of CTG repeats. The expanded repeats are transcribed to long RNA and induce cellular toxicity. Recent studies suggest that the CUG repeats are processed by the RNA interference (RNAi) pathway to generate small interfering repeated RNA (siRNA). However, the effects of the CTG repeat-derived siRNAs remain unclear. We hypothesize that the RNAi machinery in DM1 patients generates distinct gene expression patterns that determine the disease phenotype in the individual patient. The abundance of genes with complementary repeats that are targeted by siRNAs in each tissue determines the way that the tissue is affected in DM1. We integrated and analyzed published transcriptome data from muscle, heart, and brain biopsies of DM1 patients, and revealed shared, characteristic changes that correlated with disease phenotype. These signatures are overrepresented by genes and transcription factors bearing endogenous CTG/CAG repeats and are governed by aberrant activity of the RNAi machinery, miRNAs, and a specific gain-of-function of the CTG repeats. Computational analysis of the DM1 transcriptome enhances our understanding of the complex pathophysiology of the disease and may reveal a path for cure.
    Keywords small RNAs ; RNA interference ; myotonic dystrophy type 1 ; expansion repeat disorders ; trinucleotide repeats ; gene signature ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2022-08-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Identifying app components that promote physical activity: a group concept mapping study.

    Braun, Maya / Carlier, Stéphanie / De Backere, Femke / Van De Velde, Marie / De Turck, Filip / Crombez, Geert / De Paepe, Annick L

    PeerJ

    2024  Volume 12, Page(s) e17100

    Abstract: Background: Digital interventions are a promising avenue to promote physical activity in healthy adults. Current practices recommend to include end-users early on in the development process. This study focuses on the wishes and needs of users regarding ... ...

    Abstract Background: Digital interventions are a promising avenue to promote physical activity in healthy adults. Current practices recommend to include end-users early on in the development process. This study focuses on the wishes and needs of users regarding an a mobile health (mHealth) application that promotes physical activity in healthy adults, and on the differences between participants who do or do not meet the World Health Organization's recommendation of an equivalent of 150 minutes of moderate intensity physical activity.
    Methods: We used a mixed-method design called Group Concept Mapping. In a first phase, we collected statements completing the prompt "In an app that helps me move more, I would like to see/ do/ learn the following…" during four brainstorming sessions with physically inactive individuals (
    Results: Six clusters of statements were identified, namely 'Ease-of-use and Self-monitoring', 'Technical Aspects and Advertisement', 'Personalised Information and Support', 'Motivational Aspects', 'Goal setting, goal review and rewards', and 'Social Features'. The cluster 'Ease-of-use and Self-monitoring' was rated highest in the overall group and the active subgroup, whereas the cluster 'Technical Aspects and Advertisement' was scored as most relevant in the inactive subgroup. For all groups, the cluster 'Social Features' was scored the lowest. Explorative analysis revealed minor between-group differences.
    Discussion: The present study identified priorities of users for an mHealth application that promotes physical activity. First, the application should be user-friendly and accessible. Second, the application should provide personalized support and information. Third, users should be able to monitor their behaviour and compare their current activity to their past performance. Fourth, users should be provided autonomy within the app, such as over which and how many notifications they would like to receive, and whether or not they want to engage with social features. These priorities can serve as guiding principles for developing mHealth applications to promote physical activity in the general population.
    MeSH term(s) Adult ; Humans ; Mobile Applications ; Exercise ; Telemedicine ; Learning ; Sedentary Behavior
    Language English
    Publishing date 2024-03-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2703241-3
    ISSN 2167-8359 ; 2167-8359
    ISSN (online) 2167-8359
    ISSN 2167-8359
    DOI 10.7717/peerj.17100
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  8. Article ; Online: The relationship of affective and bodily states with goals and plans to increase physical activity: An 8-day study in students.

    Braun, Maya / Schroé, Helene / Van Dyck, Delfien / Crombez, Geert / De Paepe, Annick L

    Applied psychology. Health and well-being

    2023  Volume 16, Issue 1, Page(s) 273–295

    Abstract: Planning is an important tool to translate intentions into physical activity (PA) behavior. Affective and bodily states are known to influence how much PA individuals perform, but their impact on to formulation of PA plans is not yet known. The aim of ... ...

    Abstract Planning is an important tool to translate intentions into physical activity (PA) behavior. Affective and bodily states are known to influence how much PA individuals perform, but their impact on to formulation of PA plans is not yet known. The aim of the current study is to explore the effect of within- and between-subject variations in affective and bodily states on the content of PA goals and plans. Over eight consecutive days, 362 students created action and coping plans to achieve their daily PA goals. They also reported their affective and bodily states. Generalized linear mixed effect models were used to analyze the associations between these states and the content of the goals and plans. The results showed that both between- and within-subject variations in affective and bodily states were associated with goals formulated in terms of minutes, the intensity and context of planned activities, and anticipated barriers, though more effects were found for within-subject differences. Affective and bodily states impact daily PA goals and plans, highlighting the dynamic nature of planning. Our findings can be a first step toward personalized suggestions for goals, action plans, and coping strategies that are based on individual affective and bodily states.
    MeSH term(s) Humans ; Goals ; Exercise ; Intention ; Coping Skills ; Students
    Language English
    Publishing date 2023-09-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2483053-7
    ISSN 1758-0854 ; 1758-0846
    ISSN (online) 1758-0854
    ISSN 1758-0846
    DOI 10.1111/aphw.12485
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  9. Article ; Online: Pathogenic Variants of Scavenger Receptor

    Canavati, Christina / Siam, Ahmad / Labes, Sapir / Trabelsi, Nirit / Regev, Eshcar / Parnasa, Elchanan / Barhoum, Barhoum / Magadle, Nur / Perzon, Ofer / Braun, Maya / Mor-Shaked, Hagar / Schueler-Furman, Ora / Tabach, Yuval / Mevorach, Dror

    Circulation

    2024  Volume 149, Issue 3, Page(s) 270–273

    MeSH term(s) Humans ; BNT162 Vaccine/adverse effects ; COVID-19/prevention & control ; Efferocytosis ; Myocarditis/chemically induced ; Vaccination/adverse effects
    Chemical Substances BNT162 Vaccine
    Language English
    Publishing date 2024-01-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.123.064884
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    In stock of ZB MED Cologne/Königswinter

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  10. Article ; Online: Hypermobility spectrum disorders and active migraine in Israeli adolescents: A nationwide study.

    Zloof, Yair / Simchoni, Maya / Derazne, Estela / Tsur, Avishai M / Tzur, Dorit / Braun, Maya / Amarilyo, Gil / Shlaifer, Amir / Honig, Asaf / Braun-Moscovici, Yolanda

    Headache

    2023  Volume 63, Issue 7, Page(s) 934–941

    Abstract: Objective: To assess the association between hypermobility spectrum disorders/hypermobile type Ehlers Danlos Syndrome (HSD/hEDS) and migraine in a national sample of adolescents in Israel.: Background: The association between HSD/hEDS and migraine is ...

    Abstract Objective: To assess the association between hypermobility spectrum disorders/hypermobile type Ehlers Danlos Syndrome (HSD/hEDS) and migraine in a national sample of adolescents in Israel.
    Background: The association between HSD/hEDS and migraine is unclear, even more so in pediatric populations.
    Methods: This population-based, cross-sectional study included 1,627,345 Israeli adolescents (945,519/1,626,407 [58%] males; mean age 17 ± 0.5 years) who were medically assessed before mandatory military service during 1998-2020. Diagnoses of migraine with at least one attack per month (active migraine) and HSD/hEDS were confirmed by certified specialists. The prevalences of active migraine in adolescents with and without HSD/hEDS were computed and the association between HSD/hEDS and active migraine was examined.
    Results: Active migraine was significantly more prevalent in adolescents with HSD/hEDS (307/4686 [6.5%]) compared to those without HSD/hEDS (51,931/1,621,721 [3.2%]) (OR = 2.16, 95% CI 1.90-2.45). The association between HSD/hEDS and active migraine persisted in a multivariable analysis (OR = 2.08, 95% CI 1.85-2.34) and in several sensitivity analyses.
    Conclusions: We found a significant association between HSD/hEDS and active migraine in both male and female adolescents. Clinical awareness of the association can promote early diagnosis and treatment of migraine. Further research is required to identify appropriate pharmacologic and nonpharmacologic migraine treatment strategies for individuals with HSD/hEDS.
    MeSH term(s) Child ; Humans ; Male ; Female ; Adolescent ; Israel/epidemiology ; Cross-Sectional Studies ; Joint Instability/complications ; Joint Instability/diagnosis ; Ehlers-Danlos Syndrome/complications ; Ehlers-Danlos Syndrome/diagnosis ; Ehlers-Danlos Syndrome/therapy
    Language English
    Publishing date 2023-06-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 410130-3
    ISSN 1526-4610 ; 0017-8748
    ISSN (online) 1526-4610
    ISSN 0017-8748
    DOI 10.1111/head.14526
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