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Article: Salicornia ramosissima

Barreto, André / Couto, Ana / Jerónimo, Daniel / Laranjeira, Adriana / Silva, Bruna / Nunes, Catarina / Veríssimo, Ana C S / Pinto, Diana C G A / Dias, Jorge / Pacheco, Mário / Costas, Benjamin / Rocha, Rui J M

Animals : an open access journal from MDPI

2024 Volume 14, Issue 4

Abstract: The green tips ... ...

Abstract	The green tips of
Language	English
Publishing date	2024-02-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani14040614
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Article ; Online: Glial-restricted precursors stimulate endogenous cytogenesis and effectively recover emotional deficits in a model of cytogenesis ablation.

Martins-Macedo, Joana / Araújo, Bruna / Anjo, Sandra I / Silveira-Rosa, Tiago / Patrício, Patrícia / Alves, Nuno Dinis / Silva, Joana M / Teixeira, Fábio G / Manadas, Bruno / Rodrigues, Ana J / Lepore, Angelo C / Salgado, António J / Gomes, Eduardo D / Pinto, Luísa

Molecular psychiatry

2024

Abstract: Adult cytogenesis, the continuous generation of newly-born neurons (neurogenesis) and glial cells (gliogenesis) throughout life, is highly impaired in several neuropsychiatric disorders, such as Major Depressive Disorder (MDD), impacting negatively on ... ...

Abstract	Adult cytogenesis, the continuous generation of newly-born neurons (neurogenesis) and glial cells (gliogenesis) throughout life, is highly impaired in several neuropsychiatric disorders, such as Major Depressive Disorder (MDD), impacting negatively on cognitive and emotional domains. Despite playing a critical role in brain homeostasis, the importance of gliogenesis has been overlooked, both in healthy and diseased states. To examine the role of newly formed glia, we transplanted Glial Restricted Precursors (GRPs) into the adult hippocampal dentate gyrus (DG), or injected their secreted factors (secretome), into a previously validated transgenic GFAP-tk rat line, in which cytogenesis is transiently compromised. We explored the long-term effects of both treatments on physiological and behavioral outcomes. Grafted GRPs reversed anxiety-like deficits and demonstrated an antidepressant-like effect, while the secretome promoted recovery of only anxiety-like behavior. Furthermore, GRPs elicited a recovery of neurogenic and gliogenic levels in the ventral DG, highlighting the unique involvement of these cells in the regulation of brain cytogenesis. Both GRPs and their secretome induced significant alterations in the DG proteome, directly influencing proteins and pathways related to cytogenesis, regulation of neural plasticity and neuronal development. With this work, we demonstrate a valuable and specific contribution of glial progenitors to normalizing gliogenic levels, rescuing neurogenesis and, importantly, promoting recovery of emotional deficits characteristic of disorders such as MDD.
Language	English
Publishing date	2024-03-07
Publishing country	England
Document type	Journal Article
ZDB-ID	1330655-8
ISSN	1476-5578 ; 1359-4184
ISSN (online)	1476-5578
ISSN	1359-4184
DOI	10.1038/s41380-024-02490-z
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Article ; Online: Recruitment methods and yield rates in a clinical trial of physical exercise for older adults with hypertension-HAEL Study: a study within a trial.

Botton, Cíntia E / Santos, Lucas P / Moraes, Bruna G / Monteiro, Raíssa B / Gomes, Maria Laura B / Wilhelm, Eurico N / Pinto, Stephanie S / Umpierre, Daniel

BMC medical research methodology

2022 Volume 22, Issue 1, Page(s) 42

Abstract: Background: Although the prevalence of hypertension is high in older adults, clinical trial recruitment is a challenge. Our main aim was to describe the HAEL Study recruitment methods and yield rates. The secondary objectives were to explore the reasons ...

Abstract	Background: Although the prevalence of hypertension is high in older adults, clinical trial recruitment is a challenge. Our main aim was to describe the HAEL Study recruitment methods and yield rates. The secondary objectives were to explore the reasons for exclusion and to describe the characteristics of the enrolled participants. Methods: This is a descriptive study within a trial. The HAEL Study was a Brazilian randomized two-center, parallel trial with an estimated sample of 184 participants. The recruitment strategy was based on four methods: electronic health records, word of mouth, print and electronic flyer, and press media. The yield rate was the ratio of the number of participants who underwent randomization to the total number of volunteers screened, calculated for overall, per recruitment method, by study center and by age group and sex. Additionally, we described the reasons for exclusion in the screening phase, as well as the demographic characteristics of those enrolled. The data are presented in absolute/relative frequencies and mean ± standard deviation. Results: A total of 717 individuals were screened, and 168 were randomized over 32 months. The yield rate was higher for word of mouth (30.1%) in the overall sample. However, press media contributed the most (39.9%) to the absolute number of participants randomized in the trial. The coordinating center and participating center differed in methods with the highest yield ratios and absolute numbers of randomized participants. The main reason for exclusion in the screening phase was due to the physically active status in those intending to participate in the study (61.5%). Out of 220 participants included, 52 were excluded mainly because they did not meet the eligibility criteria (26.9%). Most of the screened volunteers were women (60.2%) age 60-69 years (59.5%), and most of the randomized participants were Caucasian/white (78.0%). Conclusions: Multiple recruitment methods constituted effective strategies. We observed that approximately one of every four individuals screened was allocated to an intervention group. Even so, there were limitations in obtaining a representative sample of older Brazilian adults with hypertension. Data show an underrepresentation of race and age groups. Trial registration: This SWAT was not registered.
MeSH term(s)	Aged ; Brazil ; COVID-19 ; Exercise ; Female ; Humans ; Hypertension/therapy ; Middle Aged ; SARS-CoV-2
Language	English
Publishing date	2022-02-10
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2041362-2
ISSN	1471-2288 ; 1471-2288
ISSN (online)	1471-2288
ISSN	1471-2288
DOI	10.1186/s12874-022-01535-7
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Article ; Online: Neurological syndromes and potential triggers associated with antibodies to neuronal surface antigens.

Klein da Costa, Bruna / de Oliveira Pinto, Paula / Staub, Lia / Hansel, Gisele / Vanik Pinto, Guilherme / Porcello Schilling, Lucas / Rodrigues Dos Passos, Giordani / Alves Martins, William / Becker, Jefferson / Machado Castilhos, Raphael / Palmini, André / Sato, Douglas Kazutoshi

Multiple sclerosis and related disorders

2023 Volume 80, Page(s) 105022

Abstract: Background: Autoantibodies against surface neuronal antigens have been associated with specific neurological presentations including autoimmune encephalitis (AE), with variable association with neoplasia and infections.: Methods: We described the ... ...

Abstract	Background: Autoantibodies against surface neuronal antigens have been associated with specific neurological presentations including autoimmune encephalitis (AE), with variable association with neoplasia and infections. Methods: We described the phenotype and environmental associations of patients with neurological syndromes associated with antibodies against neuronal surface antigens who were referred to a tertiary center in the South of Brazil. All patients were tested for neuronal autoantibodies using cell-based assays. Clinical, radiological, and laboratory findings were retrospectively reviewed. Results: We identified 16 patients, 15 had subacute, and one had a progressive disease course. Among patients with subacute onset, 11 (73 %) were N-Methyl-d-Aspartate receptor (NMDAr-IgG)+, 3 (20 %) were Leucine-rich Glioma-Inactivated-1 (LGI1-IgG)+, and 1 (6 %) was positive for Glycine receptor-IgG. The patient with a progressive disease course had antibodies against IgLON5. Most patients had disease onset in spring and summer suggesting environmental factors for the development of AE. Also, we observed a different pattern of brain lesions when NMDAr-IgG encephalitis followed herpes encephalitis and a previously unreported association with Rosai-Dorfman-Destombe disease. All patients with encephalopathy met criteria for possible AE and all proven NMDAr-IgG+ met criteria for NMDAr-IgG encephalitis. However, only one LGI1-IgG+ patient fulfilled clinical criteria for limbic encephalitis. All but one received high-dose intravenous methylprednisolone, 11 also had intravenous human immunoglobulin, and 4 plasma exchange. Furthermore, all patients received second-line immunotherapy. Importantly, most patients improved with immunotherapy, even when initiated later in the disease course. Conclusion: We identified seasonal variability associated with neuronal surface antibodies suggesting environmental triggers. Also, we described the coexistence of NMDAr-IgG encephalitis with histiocytosis. In our series, most patients received second-line immunotherapy. We observed neurologic improvement after treatment even in cases of delayed diagnosis. Increasing the recognition and availability of tests and treatments for these conditions is of paramount importance in low- and middle-income countries.
MeSH term(s)	Humans ; Retrospective Studies ; Antigens, Surface ; Autoantibodies ; Syndrome ; Encephalitis, Herpes Simplex ; Immunoglobulin G ; Anti-N-Methyl-D-Aspartate Receptor Encephalitis ; Cell Adhesion Molecules, Neuronal
Chemical Substances	Antigens, Surface ; Autoantibodies ; Immunoglobulin G ; IgLON5 protein, human ; Cell Adhesion Molecules, Neuronal
Language	English
Publishing date	2023-09-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2645330-7
ISSN	2211-0356 ; 2211-0348
ISSN (online)	2211-0356
ISSN	2211-0348
DOI	10.1016/j.msard.2023.105022
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Article: Laboratory-Scale Investigation of the Pressurization of T-Junctions in Hydraulic Systems

Pinto, Leandro C. / Tassi, Rutineia / Vasconcelos, Jose G. / Allasia, Daniel G. / Bocchi, João P. P. / Minetto, Bruna / Pachaly, Robson L.

Water. 2021 Oct. 21, v. 13, no. 21

2021

Abstract: The increasing frequency of intense rain events will worsen the operational conditions of stormwater systems, including the frequency in which these systems experience pressurization. Unfortunately, there has been limited research on the issue, ... ...

Abstract	The increasing frequency of intense rain events will worsen the operational conditions of stormwater systems, including the frequency in which these systems experience pressurization. Unfortunately, there has been limited research on the issue, particularly the pressurization of junctions in stormwater systems that are subject to rapid filling. Past research provided valuable insights on flows in junctions operating either on pressurized or open-channel flow conditions, but did not focus on the transition between these two flow regimes. This work summarizes the results of an experimental investigation that focused on describing the pressurization processes in a junction undergoing rapid filling. The experimental program considered a total of 67 unique combinations, with variables including different slopes of the upstream and lateral pipes, as well as different inflow rates in each one of these conduits. Fast blockage of the flow led to the pressurization process, that was characterized through video-recording and pressure monitoring at selected points along in the apparatus. This innovative research identified for the first time five unique pressurization modes based on the video recordings of the pressurization. The pressurization modes were dependent on the experimental setup, including lateral and main branch flows as well as their slopes. An independent clustering-based analysis of the experimental data was used and confirmed this classification. These results are the first ones of its kind and clearly indicates potential limitations of numerical models in representing flows in the junctions when air pocket entrapment occurs due to rapid filling conditions. Future research should address the limitations of the present experimental work in terms of scale effects, including a wider range of tested flow conditions and slopes, besides different junction geometries with storage.
Keywords	air ; rain ; stormwater ; video recording
Language	English
Dates of publication	2021-1021
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2521238-2
ISSN	2073-4441
ISSN	2073-4441
DOI	10.3390/w13212970
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Article ; Online: Synthesis and characterization of photosensitive gelatin-based hydrogels for photodynamic therapy in HeLa-CCL2 cell line.

Ambrósio, Jéssica A R / Pinto, Bruna C S / Marmo, Vitor Luca Moura / Santos, Kennedy Wallace Dos / Junior, Milton Beltrame / Pinto, Juliana G / Ferreira-Strixino, Juliana / Raniero, Leandro José / Simioni, Andreza R

Photodiagnosis and photodynamic therapy

2022 Volume 38, Page(s) 102818

Abstract: Background: Hydrogel systems are increasingly gaining visibility involving biomedicine, tissue engineering, environmental treatments, and drug delivery systems. These systems have a three-dimensional network composition and high-water absorption ... ...

Abstract	Background: Hydrogel systems are increasingly gaining visibility involving biomedicine, tissue engineering, environmental treatments, and drug delivery systems. These systems have a three-dimensional network composition and high-water absorption capacity, are biocompatible, allowing them to become an option as photosensitizer carriers (PS) for applications in Photodynamic Therapy (PDT) protocols. Methods: A nanohydrogel system (NAHI), encapsulated with chloroaluminium phthalocyanine (ClAlPc) was synthesized for drug delivery.. NAHI was synthesized using gelatin as based polymer by the chemical cross-linking technique. The drug was encapsulated by immersing the hydrogel in a 1.0 mg.mL Results: The images from the SEM analysis showed the presence of three-dimensional networks in the formulation. The swelling test demonstrated that the nanohydrogel freeze-drying process increases its water holding capacity. All spectroscopic results showed excellent photophysical parameters of the drug studied when served in the NAHI system. The incorporation efficiency was 70%. The results of trypan blue exclusion test have shown significant reduction (p < 0.05) in the cell viability for all groups treated with PDT, in all concentrations tested. In HeLa cells, PDT mediated by 0,5 mg.mL Conclusions: Given the peculiar performance of the selected system, the resulting nanohydrogel is a versatile platform and display potential applications as controlled delivery systems of photosensitizer for photodynamic therapy application.
MeSH term(s)	Gelatin ; HeLa Cells ; Humans ; Hydrogels ; Indoles ; Photochemotherapy/methods ; Photosensitizing Agents/chemistry ; Photosensitizing Agents/pharmacology
Chemical Substances	Hydrogels ; Indoles ; Photosensitizing Agents ; Gelatin (9000-70-8)
Language	English
Publishing date	2022-03-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2149918-4
ISSN	1873-1597 ; 1572-1000
ISSN (online)	1873-1597
ISSN	1572-1000
DOI	10.1016/j.pdpdt.2022.102818
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Article ; Online: No Associations Between Physical Activity and Immunogenicity in SARS-CoV-2 Seropositive Patients With Autoimmune Rheumatic Diseases Prior to and After Vaccination.

Smaira, Fabiana Infante / Mazzolani, Bruna Caruso / Lemes, Ítalo Ribeiro / da Silva, Rafael Pires / Pinto, Ana J / Sieczkowska, Sofia M / Aikawa, Nadia E / Pasoto, Sandra G / Medeiros-Ribeiro, Ana C / Saad, Carla G S / Yuk, Emily F N / Silva, Clovis A / Swinton, Paul / Kupa, Leonard de Vinci Kanda / Hallal, Pedro C / Roschel, Hamilton / Gualano, Bruno / Bonfa, Eloisa

Journal of physical activity & health

2023 Volume 20, Issue 10, Page(s) 980–983

Abstract: ... 2 S1/S2 immunoglobulin G (IgG), geometric mean titers of anti-S1/S2 IgG, frequency of positive ...

Abstract	Aim: To investigate the association between physical activity and immunogenicity among SARS-CoV-2 seropositive patients with autoimmune rheumatic diseases prior to and following a 2-dose schedule of CoronaVac (Sinovac inactivated vaccine). Methods: This was a prospective cohort study within an open-label, single-arm, phase 4 vaccination trial conducted in Sao Paulo, Brazil. In this substudy, only SARS-CoV-2 seropositive patients were included. Immunogenicity was assessed by seroconversion rates of total anti-SARS-CoV-2 S1/S2 immunoglobulin G (IgG), geometric mean titers of anti-S1/S2 IgG, frequency of positive neutralizing antibodies, and neutralizing activity before and after vaccination. Physical activity was assessed through a questionnaire. Model-based analyses were performed controlling for age (<60 or ≥60 y), sex, body mass index (<25, 25-30, and >30 kg/m2), and use of prednisone, immunosuppressants, and biologics. Results: A total of 180 seropositive autoimmune rheumatic disease patients were included. There was no association between physical activity and immunogenicity before and after vaccination. Conclusions: This study suggests that the positive association between physical activity and greater antibody responses seen in immunocompromised individuals following vaccination is overridden by previous SARS-CoV-2 infection, and does not extend to natural immunity.
MeSH term(s)	Humans ; SARS-CoV-2 ; Exercise ; COVID-19/prevention & control ; Prospective Studies ; Brazil/epidemiology ; Vaccination ; Immunoglobulin G
Chemical Substances	sinovac COVID-19 vaccine ; Immunoglobulin G
Language	English
Publishing date	2023-06-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1543-5474
ISSN (online)	1543-5474
DOI	10.1123/jpah.2022-0362
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Article ; Online: Synthesis, characterization, and evaluation of chloroaluminium phthalocyanine incorporated in poly(ε-caprolactone) nanoparticles for photodynamic therapy.

Pinto, Bruna C S / Ambrósio, Jéssica A R / Marmo, Vitor Luca Moura / Pinto, Juliana G / Raniero, Leandro José / Ferreira-Strixino, Juliana / Simioni, Andreza R / Beltrame, Milton

Photodiagnosis and photodynamic therapy

2022 Volume 38, Page(s) 102850

Abstract: Background: The use of nanotechnology has been widely used in biomedical science, including orthopedic implants, tissue engineering, cancer therapy and drug elution from nanoparticle systems, such as poly-caprolactone (PCL) nanoparticles, which stand ... ...

Abstract	Background: The use of nanotechnology has been widely used in biomedical science, including orthopedic implants, tissue engineering, cancer therapy and drug elution from nanoparticle systems, such as poly-caprolactone (PCL) nanoparticles, which stand out mainly for their biocompatibility, being considered as effective carriers for photosensitizing drugs (PS) in photodynamic therapy (PDT) protocols. Methods: This manuscript describes the synthesis and characterization of PCL nanoparticles for controlled release of the drug chloro-aluminum phthalocyanine (ClAlPc) as a photosensitizer for application in PDT. The PCL-ClAlPc nanoparticles were developed by the nanoprecipitation process. The structure and morphology of the nanoparticles were studied with scanning electron microscopy (SEM) and with Fourier transform infrared (FTIR). The size of nanomaterials was studied using the Dynamic Light Scattering (DLS) method. Photophysical and photochemical characterizations were performed. Subsequently, photobiological studies were also used to characterize the system. Results: The nanoparticles had an average diameter of 384.7 ± 138.6 nm and a polydispersity index of 0.153. SEM analysis revealed that the system formed a spherical shape typical of these delivery systems. Charging efficiency was 82.1% ± 1.2%. The phthalocyanine-loaded PCL nanoparticles maintained their photophysical behavior after encapsulation. Cell viability was determined after the dark toxicity test, and it was possible to observe that there was no evidence of toxicity in the dark, for all concentrations tested. The assay also revealed that adenocarcinoma cells treated with free ClAlPc and in the nanoformulation showed 100% cell death when subjected to PDT protocols. The intracellular location of the photosensitizer indicated a high potential for accumulation in the cytoplasm and nucleus. Conclusions: From the photophysical, photochemical and photobiological analyzes obtained, it was possible to observe that the development of PCL nanoparticles encapsulated with ClAlPc, by the nanoprecipitation method was adequate and that the in vivo release study is efficient to reduce the release rate and attenuate the burst of PS loaded on PCL nanoparticles. The results reinforce that the use of this system as drug delivery systems is useful in PDT protocols.
MeSH term(s)	Caproates ; Drug Carriers/chemistry ; Indoles ; Isoindoles ; Lactones ; Nanoparticles/chemistry ; Organometallic Compounds ; Photochemotherapy/methods ; Photosensitizing Agents/chemistry ; Photosensitizing Agents/pharmacology ; Polyesters/chemistry
Chemical Substances	Caproates ; Drug Carriers ; Indoles ; Isoindoles ; Lactones ; Organometallic Compounds ; Photosensitizing Agents ; Polyesters ; chloroaluminum phthalocyanine (14154-42-8) ; polycaprolactone (24980-41-4) ; caprolactone (56RE988L1R) ; phthalocyanine (V5PUF4VLGY)
Language	English
Publishing date	2022-04-05
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2149918-4
ISSN	1873-1597 ; 1572-1000
ISSN (online)	1873-1597
ISSN	1572-1000
DOI	10.1016/j.pdpdt.2022.102850
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Article ; Online: The effect of caffeine on exercise performance is not influenced by ADORA2A genotypes, alone or pooled with CYP1A2 genotypes, in adolescent athletes

Dos Santos, Maryssa P. Pinto / Spineli, Higor / Dos Santos, Bruna P. / Lima-Silva, Adriano E. / Gitaí, Daniel L. G. / Bishop, David J. / de Araujo, Gustavo Gomes

Eur J Nutr. 2023 Mar., v. 62, no. 2 p.1041-1050

2023

Abstract: PURPOSE: This study investigated the influence of the different genotypes of ADORA2A (1976 C > T, rs 5751876), alone or pooled with CYP1A2 (163 C > A rs 762551) genotypes, on the ergogenic effects of caffeine (CAF) on various aspects of physical ... ...

Abstract	PURPOSE: This study investigated the influence of the different genotypes of ADORA2A (1976 C > T, rs 5751876), alone or pooled with CYP1A2 (163 C > A rs 762551) genotypes, on the ergogenic effects of caffeine (CAF) on various aspects of physical performance in male adolescent athletes. METHODS: Ninety male adolescent athletes (age = 15.5 ± 2 years) were classified according to their genotypes for 1976 C > T ADORA2A (TT homozygous or CADORA₂A allele carriers) and 163 C > A CYP1A2 (AA homozygous or CCYP₁A₂ allele carriers). Participants were further divided in four groups (1-TTADORA₂A + AACYP₁A₂; 2-TTADORA₂A + AC/CCCYP₁A₂; 3-AACYP₁A₂ + CT/CCADORA₂A;4-AC/CCCYP₁A₂ + CT/CCADORA₂A). Using a randomized, crossover, counterbalanced, and double-blind design, participants ingested CAF (6 mg kg⁻¹) or a placebo (PLA, 300 mg of cellulose) one hour before performing a sequence of physical tests: handgrip strength, agility test, countermovement jump (CMJ), Spike Jump (SJ), sit-ups, push-ups, and the Yo-Yo intermittent recovery test level 1 (Yo-Yo IR1). RESULTS: CAF enhanced handgrip strength (CAF: 35.0 ± 9.2 kg force; PLA: 33.5 ± 8.9 kg force; p = 0.050), CMJ height (CAF: 49.6 ± 12.3 cm; PLA: 48.3 ± 13.6 cm; p = 0.013), SJ height (CAF: 54.7 ± 13.3 cm; PLA: 53.1 ± 14.8 cm; p = 0.013), number of sit-ups (CAF: 37 ± 8; PLA: 35 ± 8; p = 0.001), and distance covered on the Yoyo IR1 test (CAF: 991.6 ± 371.0 m; PLA: 896.0 ± 311.0 m; p = 0.001), This CAF-induced improvement on exercise performance was, however, independent of genotypes groups (all p > 0.05). CAF had no effect on agility (CAF: 15.8 ± 1.2 s; PLA: 15.9 ± 1.3 s; p = 0.070) and push-up (CAF: 26.6 ± 12.0; PLA: 25.0 ± 11.0; p = 0.280) tests. CONCLUSION: The acute caffeine intake of 6.0 mg.kg⁻¹ improves several aspects of physical performance, which seems to be independent of ADORA2A genotypes, alone or in combination with CYP1A2 genotypes.
Keywords	adolescents ; alleles ; athletic performance ; caffeine ; cellulose ; hand strength ; homozygosity ; males ; physical activity ; placebos
Language	English
Dates of publication	2023-03
Size	p. 1041-1050.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	1466536-0
ISSN	1436-6215 ; 1436-6207
ISSN (online)	1436-6215
ISSN	1436-6207
DOI	10.1007/s00394-022-03045-0
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Article ; Online: Caffeine improves various aspects of athletic performance in adolescents independent of their 163 C > A CYP1A2 genotypes.

Spineli, Higor / Pinto, Maryssa P / Dos Santos, Bruna P / Lima-Silva, Adriano E / Bertuzzi, Romulo / Gitaí, Daniel L G / de Araujo, Gustavo G

Scandinavian journal of medicine & science in sports

2020 Volume 30, Issue 10, Page(s) 1869–1877

Abstract: Purpose: The purpose of this study was to investigate whether variations in 163 C > A CYP1A2 genotypes (rs 762 551) (AA, AC, and CC) modify the ergogenic effects of caffeine (CAF) on strength, power, muscular endurance, agility, and endurance in ... ...

Abstract	Purpose: The purpose of this study was to investigate whether variations in 163 C > A CYP1A2 genotypes (rs 762 551) (AA, AC, and CC) modify the ergogenic effects of caffeine (CAF) on strength, power, muscular endurance, agility, and endurance in adolescent athletes. Methods: One hundred adolescents (age = 15 ± 2 years) were recruited. Participants ingested CAF (6 mg.kg Results: Compared to PLA, CAF enhanced (P < .05) sit-up (CAF = 37 ± 9; PLA = 35 ± 8 repetitions) and push-up repetitions (CAF = 26 ± 11; PLA = 24 ± 11 repetitions), and increased distance covered in Yo-Yo IR1 test (CAF = 1010.4 ± 378.9; PLA = 903.2 ± 325.7 m). There was no influence of CAF on handgrip strength (CAF = 35.1 ± 8.9; PLA = 33.7 ± 8.7 kgf), countermovement jump height (CAF = 49.3 ± 12.6; PLA = 47.9 ± 13.8 cm), spike jump height (CAF = 54.2 ± 13.6; PLA = 52.9 ± 14.5 cm), and time in agility test (CAF = 15.8 ± 1.1; PLA = 15.9 ± 1.3 s, P > .05). When present, the ergogenic effect of CAF was not dependent of genotype. Conclusion: CAF improves muscular endurance and aerobic performance in adolescent athletes, regardless of their 163 C > A CYP1A2 genotype.
MeSH term(s)	Adolescent ; Athletic Performance/physiology ; Caffeine/pharmacology ; Central Nervous System Stimulants/pharmacology ; Cross-Over Studies ; Cytochrome P-450 CYP1A2/blood ; Cytochrome P-450 CYP1A2/genetics ; Double-Blind Method ; Exercise/physiology ; Genotype ; Hand Strength/physiology ; Humans ; Muscle, Skeletal/drug effects ; Muscle, Skeletal/physiology ; Placebos/pharmacology ; Polymorphism, Genetic
Chemical Substances	Central Nervous System Stimulants ; Placebos ; Caffeine (3G6A5W338E) ; CYP1A2 protein, human (EC 1.14.14.1) ; Cytochrome P-450 CYP1A2 (EC 1.14.14.1)
Language	English
Publishing date	2020-07-13
Publishing country	Denmark
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	1077418-x
ISSN	1600-0838 ; 0905-7188
ISSN (online)	1600-0838
ISSN	0905-7188
DOI	10.1111/sms.13749
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