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  1. Book ; Online: Precision Medicine

    Turgeon, Jacques / Michaud, Veronique

    Applied Concepts of Pharmacogenomics in Patients with Various Diseases and Polypharmacy

    2022  

    Keywords Medicine ; Clinical & internal medicine ; fibromyalgia (FM) ; myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) ; microRNA ; miRNome ; pharmacogenomics ; pharmacoepigenomics ; SM2miR ; Pharmaco-miR ; repoDB ; ME/CFS Common Data Elements (CDEs) ; dihydropyrimidine dehydrogenase ; DPYD ; 5-fluorouracil ; fluoropyrimidine ; therapeutic drug monitoring ; orthotopic liver transplant ; busulfan ; glutathione S-transferase ; genetic polymorphism ; limited sampling strategy ; pharmacokinetics ; clinical pharmacogenetics ; pharmacogenetic testing ; adverse drug reactions ; genotype ; phenotype ; pharmacogene ; barriers to pharmacogenetics implementation ; Sub-Saharan Africa ; chronic low back pain (cLBP) ; genetics ; personalized treatment ; polymorphism ; CYP450 ; tacrolimus ; CYP3A5 ; liver transplant ; pharmacogenomic ; minority ; data collection ; drug ; biomarker ; pharmacogenetics ; pharmacogenetic test ; personalized medicine ; gene expression ; infliximab ; adalimumab ; ulcerative colitis ; Crohn disease ; inflammatory bowel disease ; n/a
    Language 0|e
    Size 1 electronic resource (170 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021613215
    ISBN 9783036510279 ; 3036510273
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Isolated Closed Rupture of the Middle Finger Flexor Digitorum Superficialis Tendon in a Climber.

    Chemali, Karl / Boudier-Revéret, Mathieu / Freire, Véronique / Michaud, Johan

    American journal of physical medicine & rehabilitation

    2023  Volume 102, Issue 8, Page(s) e112–e114

    MeSH term(s) Humans ; Tendons/surgery ; Fingers ; Rupture ; Finger Injuries/surgery
    Language English
    Publishing date 2023-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 219390-5
    ISSN 1537-7385 ; 0002-9491 ; 0894-9115
    ISSN (online) 1537-7385
    ISSN 0002-9491 ; 0894-9115
    DOI 10.1097/PHM.0000000000002171
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ue I Zs.100: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Precision Medicine: Applied Concepts of Pharmacogenomics in Patients with Various Diseases and Polypharmacy.

    Michaud, Veronique / Turgeon, Jacques

    Pharmaceutics

    2021  Volume 13, Issue 2

    Abstract: Over the last century, the process of choosing medications to treat certain diseases has evolved significantly [ ... ]. ...

    Abstract Over the last century, the process of choosing medications to treat certain diseases has evolved significantly [...].
    Language English
    Publishing date 2021-02-02
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics13020197
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Revisiting conclusions on the empiric segmentation of high-risk patients.

    Michaud, Veronique / Dow, Pamela / Turgeon, Jacques

    The American journal of managed care

    2022  Volume 28, Issue 6, Page(s) 251–252

    Abstract: The authors provide feedback on generalizations made regarding interventions for high-risk populations in previous research. ...

    Abstract The authors provide feedback on generalizations made regarding interventions for high-risk populations in previous research.
    Language English
    Publishing date 2022-06-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2035781-3
    ISSN 1936-2692 ; 1088-0224 ; 1096-1860
    ISSN (online) 1936-2692
    ISSN 1088-0224 ; 1096-1860
    DOI 10.37765/ajmc.2022.89153
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5353: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 86: Show issues

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  5. Article ; Online: Multidrug Interactions: Why Do They Occur and How to Handle?

    Dow, Pamela / Michaud, Veronique / Turgeon, Jacques

    Clinical therapeutics

    2023  Volume 45, Issue 2, Page(s) 99–105

    Abstract: A nonoptimized medication therapy (NOMT) event is an iatrogenic hazard or incident associated with medications and is a leading cause of death, serious injury, and illness. NOMT events are often related to multidrug interactions in patients with ... ...

    Abstract A nonoptimized medication therapy (NOMT) event is an iatrogenic hazard or incident associated with medications and is a leading cause of death, serious injury, and illness. NOMT events are often related to multidrug interactions in patients with polypharmacy. In these patients, NOMT events can be avoided by using advanced clinical decision support systems and clinical interventions such as separating the time of administration of certain drugs during the day. At the individual level, medication reconciliation is a first logical step for reducing adverse side effects. Then, intersubject variability in drug response should be considered to optimize patient drug regimens. Furthermore, patient pharmacogenomic status information can help ensure appropriateness of drug therapy. However, in patients with polypharmacy, such information is most valuable when combined with phenoconversion probability. At a population level, the virtual addition of drugs to various drug regimens and the use of a medication risk score can help predict the risk of NOMT events. This review outlines some of the mechanisms behind multidrug interactions and their association with drug safety and NOMTs, polypharmacy and its impact on patient outcomes, the value of pharmacogenomics, and an assessment of simulation studies and the virtual addition of drugs to a drug regimen using real-world data.
    MeSH term(s) Humans ; Drug-Related Side Effects and Adverse Reactions ; Polypharmacy ; Risk Factors ; Pharmacogenetics ; Decision Support Systems, Clinical ; Drug Interactions
    Language English
    Publishing date 2023-01-20
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 603113-4
    ISSN 1879-114X ; 0149-2918
    ISSN (online) 1879-114X
    ISSN 0149-2918
    DOI 10.1016/j.clinthera.2022.12.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1435: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 404: Show issues

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  6. Article ; Online: Effect of wettability and textile architecture on fluid displacement and pore formation during infiltration of carbon fibrous preforms

    Teixidó, Helena / Caglar, Baris / Michaud, Véronique

    Composites Part A. 2023 Aug. 07, p.107733-

    2023  , Page(s) 107733–

    Abstract: We seek to address how air entrapment mechanisms during infiltration are influenced by the wetting characteristics of the fluid and the pore network formed by the reinforcement. To this end, we evaluated the behavior of two model fluids with different ... ...

    Abstract We seek to address how air entrapment mechanisms during infiltration are influenced by the wetting characteristics of the fluid and the pore network formed by the reinforcement. To this end, we evaluated the behavior of two model fluids with different surface tensions, infiltrating three carbon fiber reinforcements, by means of X-ray radiography. We also assessed initial (dry) and final (wetted) states for each experiment by performing X-ray CT scans. We found that the fluid characteristics strongly affect the flow front patterns and pore filling events for a given fabric architecture. Two main promoters of snap-off events are involved in capillary dominated flows: a very wetting system leading to corner flows and the fabric bundles oriented perpendicular to the flow acting as obstacles, specifically in fabric architectures prone to variations in nesting. Finally, we evaluated the applicability of a pore network model to further link preform architecture and void formation.
    Keywords X-radiation ; air ; carbon ; carbon fibers ; computed tomography ; fabrics ; models ; radiography ; wettability ; A. Carbon Fibers ; B. Porosity ; B. Wettability ; E. Resin Flow
    Language English
    Dates of publication 2023-0807
    Publishing place Elsevier Ltd
    Document type Article ; Online
    Note Pre-press version
    ZDB-ID 2012223-8
    ISSN 1359-835X
    ISSN 1359-835X
    DOI 10.1016/j.compositesa.2023.107733
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Measurement and modelling of dynamic fluid saturation in carbon reinforcements

    Teixidó, Helena / Broggi, Guillaume / Caglar, Baris / Michaud, Véronique

    Composites Part A. 2023 June, v. 169 p.107520-

    2023  

    Abstract: We propose a methodology to monitor the progressive saturation of a non-translucent unidirectional carbon fabric stack through its thickness by means of X-ray radiography and extract the dynamic saturation curves using image analysis. Four constant flow ... ...

    Abstract We propose a methodology to monitor the progressive saturation of a non-translucent unidirectional carbon fabric stack through its thickness by means of X-ray radiography and extract the dynamic saturation curves using image analysis. Four constant flow rate injections with increasing flow speed were carried out. These were simulated by a numerical two-phase flow model for both capillary and viscous leading flow conditions. The hydraulic functions describing pressure and relative permeability versus saturation were determined by fitting the saturation curves using a heuristic optimization routine. As the fluid velocity increases and the flow regime at the flow front shifts from capillary to hydrodynamically driven, the resulting capillary pressure curves for a given saturation level are shifted to higher values, from negative to positive. These as well as the capillary pressure calculated from the pressure drop within the unsaturated region of the fabric correlate well with a corresponding change in the averaged dynamic contact angle.
    Keywords X-radiation ; carbon ; contact angle ; fabrics ; image analysis ; models ; permeability ; radiography ; A. Carbon fibers ; B. Wettability ; C. Process Modeling ; E. Resin Flow
    Language English
    Dates of publication 2023-06
    Publishing place Elsevier Ltd
    Document type Article ; Online
    Note Use and reproduction
    ZDB-ID 2012223-8
    ISSN 1359-835X
    ISSN 1359-835X
    DOI 10.1016/j.compositesa.2023.107520
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Recycling of Bottle Grade PET: Influence of HDPE Contamination on the Microstructure and Mechanical Performance of 3D Printed Parts.

    Vaucher, Joanne / Demongeot, Adrien / Michaud, Véronique / Leterrier, Yves

    Polymers

    2022  Volume 14, Issue 24

    Abstract: As part of a project that aims to provide people with disabilities with simple assistive devices in Colombia, the possibility of creating a PET filament that can be printed by Fused Deposition Modelling (FDM) from beverage bottle waste was investigated, ... ...

    Abstract As part of a project that aims to provide people with disabilities with simple assistive devices in Colombia, the possibility of creating a PET filament that can be printed by Fused Deposition Modelling (FDM) from beverage bottle waste was investigated, with the aim to remain as simple as possible in terms of plastic collection, sorting, processing, and printing. Recycled PET filaments were thus produced by extrusion from collected PET bottles, with the potential addition of HDPE, which comes from caps and rings. The microstructure, mechanical performance, and printing quality of parts produced with these filaments were investigated in comparison to commercial PET virgin and recycled filaments. HDPE presence as an immiscible blend did not affect the ease of extrusion or the quality of the printing, which were all satisfactory. In some conditions, the addition of 5 wt% of HDPE to recycled PET had a toughening effect on otherwise brittle samples. This behavior was attributed to the presence of elongated HDPE inclusions resulting from shear forces induced by the layer-by-layer printing, provided that the interface temperature remained high between layer depositions. This confirms that the mechanical performance of recycled PET is very sensitive to the processing conditions, especially in the case of 3D printing. Nonetheless, this low-cost process that did not require sophisticated compatibilization schemes allowed for the printing of parts with mechanical properties comparable to those obtained with high purity, commercially recycled filaments, opening interesting perspectives for a low-cost PET recycling process.
    Language English
    Publishing date 2022-12-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym14245507
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Rôle de la pharmacogénétique dans le métabolisme et le transport des antirétroviraux.

    Michaud, Véronique / Turgeon, Jacques / Flockhart, David / Wainberg, Mark A

    Virologie (Montrouge, France)

    2022  Volume 15, Issue 3, Page(s) 157–174

    Abstract: Wide intra- and inter-subject variability in antiretroviral drug response is observed. Pharmacotherapy of HIV-infected patients is challenging considering the great numbers of co-morbidities increasing the risk of drug-drug interactions. Drug-metabolism ... ...

    Title translation Importance of pharmacogenetics in antiretroviral metabolism and drug-transporters.
    Abstract Wide intra- and inter-subject variability in antiretroviral drug response is observed. Pharmacotherapy of HIV-infected patients is challenging considering the great numbers of co-morbidities increasing the risk of drug-drug interactions. Drug-metabolism enzymes and drug-transporters regulate drug access to the systemic circulation, target cells and sanctuary sites; these factors determine pharmacokinetics and could explain variability in efficacy and adverse drug reactions associated with antiretroviral drugs. Notions related to the major enzymes (CYP450s and UGTs) involved in antiretroviral metabolism and drugtransporters are reviewed with an attention paid on genetic polymorphisms. Genetic polymorphisms affecting the activity or the expression of membrane proteins in the transport of drugs would be highlighted with examples such as neurotoxicity with efavirenz, nephrotoxicity with tenofovir, hepatotoxicity with nevirapine and hyperlibirubinemia associated with indinavir and atazanavir. The objective is to provide a better understanding on mechanisms involved in drugdisposition of antiretroviral helping out health care providers in the management of pharmacotherapy of HIV-infected patients.
    Language French
    Publishing date 2022-09-19
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 2118387-9
    ISSN 1950-6961 ; 1267-8694
    ISSN (online) 1950-6961
    ISSN 1267-8694
    DOI 10.1684/vir.2011.17135
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Contribution of CYP2D6 Functional Activity to Oxycodone Efficacy in Pain Management: Genetic Polymorphisms, Phenoconversion, and Tissue-Selective Metabolism.

    Deodhar, Malavika / Turgeon, Jacques / Michaud, Veronique

    Pharmaceutics

    2021  Volume 13, Issue 9

    Abstract: Oxycodone is a widely used opioid for the management of chronic pain. Analgesic effects observed following the administration of oxycodone are mediated mostly by agonistic effects on the μ-opioid receptor. Wide inter-subject variability observed in ... ...

    Abstract Oxycodone is a widely used opioid for the management of chronic pain. Analgesic effects observed following the administration of oxycodone are mediated mostly by agonistic effects on the μ-opioid receptor. Wide inter-subject variability observed in oxycodone efficacy could be explained by polymorphisms in the gene coding for the μ-opioid receptor (
    Language English
    Publishing date 2021-09-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics13091466
    Database MEDical Literature Analysis and Retrieval System OnLINE

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