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  1. Article ; Online: Introduction to the special issue: Cellular and molecular diversity in rheumatic autoimmune diseases.

    Rivellese, Felice / Pitzalis, Costantino

    Seminars in immunology

    2022  Volume 58, Page(s) 101667

    Language English
    Publishing date 2022-10-28
    Publishing country England
    Document type Editorial
    ZDB-ID 1018141-6
    ISSN 1096-3618 ; 1044-5323
    ISSN (online) 1096-3618
    ISSN 1044-5323
    DOI 10.1016/j.smim.2022.101667
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2843: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Article ; Online: Cellular and molecular diversity in Rheumatoid Arthritis.

    Rivellese, Felice / Pitzalis, Costantino

    Seminars in immunology

    2022  Volume 58, Page(s) 101519

    Abstract: Rheumatoid Arthritis (RA) is a chronic systemic autoimmune disease. RA mainly affects synovial joints, with inflammation of the synovial membrane (synovitis), characterised by neo-angiogenesis, hyperplasia of lining layer, and immune cell infiltration ... ...

    Abstract Rheumatoid Arthritis (RA) is a chronic systemic autoimmune disease. RA mainly affects synovial joints, with inflammation of the synovial membrane (synovitis), characterised by neo-angiogenesis, hyperplasia of lining layer, and immune cell infiltration that drive local inflammation and, if untreated, can lead to joint destruction and disability. In parallel to the well-known clinical heterogeneity, the underlying synovitis can also be significantly heterogeneous, both at cellular and molecular level, which can at least in part explain why despite the availability of highly effective treatment options, a large proportion of patients are resistant to some individual treatments. The assimilation of recent high-throughput data from analysis at the single-cell level with rigorous and high-quality clinical outcomes obtained from large randomised clinical trials support the definition of disease and treatment response endotypes. Looking ahead, the integration of histological and molecular signatures from the diseased tissue into clinical algorithms may help decision making in the management of patients with Rheumatoid Arthritis in clinical practice.
    Language English
    Publishing date 2022-01-13
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1018141-6
    ISSN 1096-3618 ; 1044-5323
    ISSN (online) 1096-3618
    ISSN 1044-5323
    DOI 10.1016/j.smim.2021.101519
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2843: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Synovial biopsies for molecular definition of rheumatoid arthritis and treatment response phenotyping: where can we improve?

    Iaquinta, Francesco Salvatore / Rivellese, Felice / Pitzalis, Costantino

    Expert review of molecular diagnostics

    2023  Volume 23, Issue 12, Page(s) 1071–1076

    Abstract: Introduction: The extensive knowledge gained in the cellular and molecular mechanisms underlying Rheumatoid Arthritis (RA) pathogenesis has led to therapeutic advances. However, up to 10-20% of patients fail to respond to multiple therapeutic agents ... ...

    Abstract Introduction: The extensive knowledge gained in the cellular and molecular mechanisms underlying Rheumatoid Arthritis (RA) pathogenesis has led to therapeutic advances. However, up to 10-20% of patients fail to respond to multiple therapeutic agents being classified as multi-drugresistant. A key challenge moving forward will be the implementation of synovial biopsies in clinical practice to facilitate the shift from the current trial-and-error strategy toward new forms of clinical trials. Biomarker-driven trials have the potential to improve drug selection and patient stratification, reduce economic costs and unnecessary drug-related toxicity.
    Areas covered: This special report explores the clinical and research applications of synovial biopsy, the advancement in the molecular pathobiology of RA to better understand disease pathogenesis and treatment response, and the way forward for the paradigm shift needed.
    Expert opinion: In the current era of highly targeted biologic drugs which have dramatically transformed the outlook of RA patients, the use of synovial biopsy represents a valuable practical tool to dissect disease pathogenesis and, consequently, treatment response. In the near future, it is hoped that technological advances will allow for speeding up synovial molecular analysis and that the design of new biomarker-driven trials will enable the allocation of patients to more effective treatment.
    MeSH term(s) Humans ; Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/diagnosis ; Arthritis, Rheumatoid/drug therapy ; Biopsy ; Biomarkers/analysis ; Treatment Outcome
    Chemical Substances Antirheumatic Agents ; Biomarkers
    Language English
    Publishing date 2023-12-15
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2112530-2
    ISSN 1744-8352 ; 1473-7159
    ISSN (online) 1744-8352
    ISSN 1473-7159
    DOI 10.1080/14737159.2023.2284774
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6073: Show issues Location:
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  4. Article: Editorial: Smoldering Inflammation in Cardio-Immune-Metabolic Disorders.

    Varricchi, Gilda / Paolocci, Nazareno / Rivellese, Felice / Rengo, Giuseppe

    Frontiers in physiology

    2021  Volume 12, Page(s) 651946

    Language English
    Publishing date 2021-03-19
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2021.651946
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  5. Article ; Online: ACE2 at the centre of COVID-19 from paucisymptomatic infections to severe pneumonia.

    Rivellese, Felice / Prediletto, Edoardo

    Autoimmunity reviews

    2020  Volume 19, Issue 6, Page(s) 102536

    MeSH term(s) Air Pollution/statistics & numerical data ; Alveolar Epithelial Cells/metabolism ; Alveolar Epithelial Cells/pathology ; Alveolar Epithelial Cells/virology ; Angiotensin-Converting Enzyme 2 ; Betacoronavirus/metabolism ; Betacoronavirus/pathogenicity ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/immunology ; Coronavirus Infections/pathology ; Coronavirus Infections/virology ; Down-Regulation/drug effects ; Humans ; Lung Injury/pathology ; Lung Injury/virology ; Lymphohistiocytosis, Hemophagocytic/pathology ; Lymphohistiocytosis, Hemophagocytic/virology ; Macrophages/immunology ; Models, Biological ; Pandemics ; Peptidyl-Dipeptidase A/deficiency ; Peptidyl-Dipeptidase A/metabolism ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/immunology ; Pneumonia, Viral/pathology ; Pneumonia, Viral/virology ; Receptors, Virus/deficiency ; Receptors, Virus/metabolism ; Respiratory Distress Syndrome/epidemiology ; Respiratory Distress Syndrome/immunology ; Respiratory Distress Syndrome/pathology ; Respiratory Distress Syndrome/virology ; SARS-CoV-2 ; Stem Cells/pathology ; Stem Cells/virology ; Viral Load ; Virus Replication
    Chemical Substances Receptors, Virus ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Keywords covid19
    Language English
    Publishing date 2020-04-03
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 2144145-5
    ISSN 1873-0183 ; 1568-9972
    ISSN (online) 1873-0183
    ISSN 1568-9972
    DOI 10.1016/j.autrev.2020.102536
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5913: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  7. Article ; Online: ACE2 at the centre of COVID-19 from paucisymptomatic infections to severe pneumonia

    Rivellese, Felice / Prediletto, Edoardo

    Autoimmunity Reviews

    2020  Volume 19, Issue 6, Page(s) 102536

    Keywords Immunology ; Immunology and Allergy ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2144145-5
    ISSN 1568-9972
    ISSN 1568-9972
    DOI 10.1016/j.autrev.2020.102536
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Tertiary Lymphoid Organs in Rheumatoid Arthritis.

    Rivellese, Felice / Pontarini, Elena / Pitzalis, Costantino

    Current topics in microbiology and immunology

    2020  Volume 426, Page(s) 119–141

    Abstract: Rheumatoid Arthritis (RA) is a chronic systemic autoimmune disease. RA mainly affects the joints, with inflammation of the synovial membrane, characterized by hyperplasia, neo-angiogenesis, and immune cell infiltration that drives local inflammation and, ...

    Abstract Rheumatoid Arthritis (RA) is a chronic systemic autoimmune disease. RA mainly affects the joints, with inflammation of the synovial membrane, characterized by hyperplasia, neo-angiogenesis, and immune cell infiltration that drives local inflammation and, if untreated, can lead to joint destruction and disability. In parallel to the well-known clinical heterogeneity, the underlying synovitis can also be significantly heterogeneous. In particular, in about 40% of patients with RA, synovitis is characterized by a dense lymphocytic infiltrate that can acquire the features of fully functional tertiary lymphoid organs (TLO). These structures amplify autoimmunity and inflammation locally associated with worse prognosis and potential implications for treatment response. Here, we will review the current knowledge on TLO in RA, with a focus on their pathogenetic and clinical relevance.
    MeSH term(s) Arthritis, Rheumatoid/immunology ; Arthritis, Rheumatoid/pathology ; Autoimmunity ; Humans ; Lymphoid Tissue/immunology ; Lymphoid Tissue/pathology ; Neovascularization, Pathologic ; Synovial Membrane/immunology ; Synovial Membrane/pathology ; Synovitis/pathology
    Language English
    Publishing date 2020-01-25
    Publishing country Germany
    Document type Journal Article ; Review
    ISSN 0070-217X
    ISSN 0070-217X
    DOI 10.1007/82_2020_216
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    In stock of ZB MED Bonn / Germany

    Einzelsignatur: Show issues

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  9. Article ; Online: Comparative analysis of late-stage rheumatoid arthritis and osteoarthritis reveals shared histopathological features.

    Boutet, Marie-Astrid / Nerviani, Alessandra / Fossati-Jimack, Liliane / Hands-Greenwood, Rebecca / Ahmed, Manzoor / Rivellese, Felice / Pitzalis, Costantino

    Osteoarthritis and cartilage

    2023  Volume 32, Issue 2, Page(s) 166–176

    Abstract: Objectives: Osteoarthritis (OA) is a debilitating and heterogeneous condition, characterized by various levels of articular cartilage degradation, osteophytes formation, and synovial inflammation. Multiple evidences suggest that synovitis may appear ... ...

    Abstract Objectives: Osteoarthritis (OA) is a debilitating and heterogeneous condition, characterized by various levels of articular cartilage degradation, osteophytes formation, and synovial inflammation. Multiple evidences suggest that synovitis may appear early in the disease development and correlates with disease severity and pain, therefore representing a relevant therapeutic target. In a typical synovitis-driven joint disease, namely rheumatoid arthritis (RA), several pathotypes have been described by our group and associated with clinical phenotypes, disease progression, and response to therapy. However, whether these pathotypes can be also observed in the OA synovium is currently unknown.
    Methods: Here, using histological approaches combined with semi-quantitative scoring and quantitative digital image analyses, we comparatively characterize the immune cell infiltration in a large cohort of OA and RA synovial tissue samples collected at the time of total joint replacement.
    Results: We demonstrate that OA synovium can be categorized also into three pathotypes and characterized by disease- and stage-specific features. Moreover, we revealed that pathotypes specifically reflect distinct levels of peripheral inflammation.
    Conclusions: In this study, we provide a novel and relevant pathological classification of OA synovial inflammation. Further studies investigating synovial molecular pathology in OA may contribute to the development of disease-modifying therapies.
    MeSH term(s) Humans ; Osteoarthritis/metabolism ; Arthritis, Rheumatoid/metabolism ; Synovial Membrane/metabolism ; Synovitis/pathology ; Inflammation/metabolism
    Language English
    Publishing date 2023-11-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 1167809-4
    ISSN 1522-9653 ; 1063-4584
    ISSN (online) 1522-9653
    ISSN 1063-4584
    DOI 10.1016/j.joca.2023.10.009
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    Zs.A 3828: Show issues Location:
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  10. Article: Persistence of Mast Cell-Positive Synovitis in Early Rheumatoid Arthritis Following Treatment With Conventional Synthetic Disease Modifying Anti-Rheumatic Drugs.

    Rivellese, Felice / Rossi, Francesca W / Giorli, Giovanni / Napolitano, Filomena / de Paulis, Amato / Pitzalis, Costantino

    Frontiers in pharmacology

    2020  Volume 11, Page(s) 1051

    Abstract: Mast cells (MCs) are immune cells infiltrating the synovial membrane and implicated in the pathogenesis of Rheumatoid Arthritis (RA). Their infiltration in the synovia of early RA patients has been shown to be associated with systemic inflammation, ... ...

    Abstract Mast cells (MCs) are immune cells infiltrating the synovial membrane and implicated in the pathogenesis of Rheumatoid Arthritis (RA). Their infiltration in the synovia of early RA patients has been shown to be associated with systemic inflammation, disease activity and autoantibody positivity. Here, we analyzed their presence in matched synovial samples obtained by ultrasound-guided synovial biopsies pre- and post-treatment with conventional synthetic Disease Modifying Anti-Rheumatic Drugs (csDMARDs) (n=20). Upon IHC staining, patients were classified as MC
    Language English
    Publishing date 2020-07-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2020.01051
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