Article: The Traditional Chinese Medicine Hua Tuo Zai Zao Wan Alleviates Atherosclerosis by Deactivation of Inflammatory Macrophages.
Evidence-based complementary and alternative medicine : eCAM
2022 Volume 2022, Page(s) 2200662
Abstract: ... Zai Zao Wan (HTZZW) has been used for the treatment of atherosclerosis (AS), although with an unclear ...
| Abstract | Introduction: Positive effects have been observed when the traditional Chinese medicine Hua Tuo Zai Zao Wan (HTZZW) has been used for the treatment of atherosclerosis (AS), although with an unclear mechanism. Methods: ApoE-/- C57/BALB mice were used to determine the efficacy of HTZZW by blood lipid biochemical analysis and histopathology H&E staining. qPCR and western blot were used to determine the expression of METTL3/14 and NF- Results: High-fat diet-fed ApoE-/- mice that consumed HTZZW exhibited significantly smaller plaque areas and significantly decreased unstable collagen areas in the aortic arch as well as significantly lower blood levels of total cholesterol, triglycerides, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol compared with the control group. Consumption of HTZZW significantly decreased the proportion of M Conclusion: HTZZW significantly alleviated the progression of AS by regulating the expression of the m6A methyltransferases METTL14 and METTL3 in macrophages, eliminating m6A modifications of NF- |
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| Language | English |
| Publishing date | 2022-03-28 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 2171158-6 |
| ISSN | 1741-4288 ; 1741-427X |
| ISSN (online) | 1741-4288 |
| ISSN | 1741-427X |
| DOI | 10.1155/2022/2200662 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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