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Article: Validation of the Anticolitis Efficacy of the Jian-Wei-Yu-Yang Formula.

Yan, Jing / Tang, Yan / Yu, Wei / Jiang, Lu / Liu, Chen / Li, Qi / Zhang, Zhiqiang / Shao, Changlei / Zheng, Yang / Liu, Xihao / Liu, Xincheng

Evidence-based complementary and alternative medicine : eCAM

2022 Volume 2022, Page(s) 9110704

Abstract: ... to its repetitive remission and relapse. The Jian-Wei-Yu-Yang (JW) formula has a historical application ...

Abstract	Background: Inflammatory bowel disease (IBD) is a major cause of morbidity and mortality due to its repetitive remission and relapse. The Jian-Wei-Yu-Yang (JW) formula has a historical application in the clinic to combat gastrointestinal disorders. The investigation aimed to explore the molecular and cellular mechanisms of JW. Methods: 2% dextran sodium sulfate (DSS) was diluted in drinking water and given to mice for 5 days to establish murine models of experimental colitis, and different doses of JW solution were administered for 14 days. Network pharmacology analysis and weighted gene co-expression network analysis (WGCNA) were utilized to predict the therapeutic role of JW against experimental colitis and colitis-associated colorectal cancer (CAC). 16S rRNA sequencing and untargeted metabolomics were conducted using murine feces. Western blotting, immunocytochemistry, and wound healing experiments were performed to confirm the molecular mechanisms. Results: (1) Liquid chromatography with mass spectrometry was utilized to confirm the validity of the JW formula. The high dose of JW treatment markedly attenuated DSS-induced experimental colitis progression, and the targets were enriched in inflammation, infection, and tumorigenesis. (2) The JW targets were related to the survival probability in patients with colorectal cancer, underlying a potential therapeutic value in CRC intervention. (3) Moreover, the JW therapy successfully rescued the decreased richness and diversity of microbiota, suppressed the potentially pathogenic phenotype of the gut microorganisms, and increased cytochrome P450 activity in murine colitis models. (4) Our Conclusion: The JW capsule attenuated the progression of murine colitis by a prompt resolution of inflammation and bloody stool and by re-establishing a microbiome profile that favors re-epithelization and prevents carcinogenesis.
Language	English
Publishing date	2022-08-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2022/9110704
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Article: The Cao-Xiang-Wei-Kang formula attenuates the progression of experimental colitis by restoring the homeostasis of the microbiome and suppressing inflammation.

Yu, Wei / Li, Qi / Shao, Changlei / Zhang, Yijia / Kang, Cai / Zheng, Yang / Liu, Xihao / Liu, Xincheng / Yan, Jing

Frontiers in pharmacology

2022 Volume 13, Page(s) 946065

Abstract: ... Xiang-Wei-Kang (CW) formula has been utilized to treat gastrointestinal disorders in the clinic ...

Abstract	Inflammatory bowel disease (IBD) is pathologically characterized by an immune response accommodative insufficiency and dysbiosis accompanied by persistent epithelial barrier dysfunction. The Cao-Xiang-Wei-Kang (CW) formula has been utilized to treat gastrointestinal disorders in the clinic. The present study was designed to delineate the pharmacological mechanisms of this formula from different aspects of the etiology of ulcerative colitis (UC), a major subtype of IBD. Dextran sodium sulfate (DSS) was given to mice for a week at a concentration of 2%, and the CW solution was administered for 3 weeks. 16S rRNA gene sequencing and untargeted metabolomics were conducted to examine the changes in the microbiome profile, and biochemical experiments were performed to confirm the therapeutic functions predicted by system pharmacology analysis. The CW treatment hampered DSS-induced experimental colitis progression, and the targets were enriched in inflammation, infection, and tumorigenesis, which was corroborated by suppressed caspase 3 (Casp3) and interleukin-1b (IL-1b) and increased cleaved caspase 3 expression and casp-3 activity in the colon samples from colitis mice subjected to the CW therapy. Moreover, the CW therapy rescued the decreased richness and diversity, suppressed the potentially pathogenic phenotype of the gut microorganisms, and reversed the altered linoleic acid metabolism and cytochrome P450 activity in murine colitis models. In our
Language	English
Publishing date	2022-09-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.946065
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Article ; Online: In reply of the comment "Is oral lichen planus potentially malignant: A reply to Yu-Wei Chiu et al".

Chiu, Yu-Wei / Su, Yee-Fun / Yang, Cheng-Chieh / Liu, Chung-Ji / Chen, Yi-Ju / Cheng, Han-Chieh / Wu, Cheng-Hsien / Chen, Pei-Yin / Lee, Yu-Hsien / Chen, Yen-Lin / Chen, Yi-Tzu / Peng, Chih-Yu / Lu, Ming-Yi / Yu, Chuan-Hang / Kao, Shou-Yen / Fwu, Chyng-Wen / Huang, Yu-Feng

Oral diseases

2022 Volume 29, Issue 5, Page(s) 2317–2318

MeSH term(s)	Humans ; Lichen Planus, Oral/complications ; Cell Transformation, Neoplastic ; Mouth Neoplasms
Language	English
Publishing date	2022-05-04
Publishing country	Denmark
Document type	Letter
ZDB-ID	1290529-x
ISSN	1601-0825 ; 1354-523X
ISSN (online)	1601-0825
ISSN	1354-523X
DOI	10.1111/odi.14214
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Zs.A 4427: Show issues

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Article ; Online: The Gut Microbial Co-Abundance Gene Groups (CAGs) Differentially Respond to the Flavor (Yao-Wei) of Chinese Materia Medica.

Yang, Ya-Nan / Deng, Yu-Ting / Zang, Chen-Chen / Zhang, Fang / Huang, Zi-Bao / Dong, Lin / Lu, Wei-Ying / Zhang, Xiao-Po / Wu, Chong-Ming

The American journal of Chinese medicine

2022 Volume 50, Issue 8, Page(s) 2223–2244

Abstract: The property theory is a unique principle instructing traditional Chinese doctors to prescribe proper medicines against diseases. As an essential part of it, the five-flavor theory catalogs various Chinese materia medicas (CMMs) into five flavors (sweet, ...

Abstract	The property theory is a unique principle instructing traditional Chinese doctors to prescribe proper medicines against diseases. As an essential part of it, the five-flavor theory catalogs various Chinese materia medicas (CMMs) into five flavors (sweet, bitter, sour, salty, and pungent) based on their taste and medical functions. Although CMM has been successfully applied in China for thousands of years, it is still a big challenge to interpret CMM flavor via modern biomarkers, further deepening its elusiveness. Herein, to identify the correlation between gut microbiota and CMM flavor, we selected 14 CMMs with different flavors to prepare their aqueous extracts, quantified the contained major chemical components, and then performed full-length 16S rRNA sequencing to analyze the gut microbiota of C57BL/6 mice administrated with CMM extracts. We found that flavones, alkaloids, and saponins were the richest components for sweet-, bitter-, and pungent-flavored CMMs, respectively. Medicines with merged flavors (bitter-pungent and sweet-pungent) displayed mixed profiles of components. According to gut microbial analysis, modulation of CMMs belonging to the same flavor on the taxonomic classification was inconsistent to an extent, while the functional sets of gut microbiota, co-abundance gene groups (CAGs), strongly and differentially responded to distinct flavors. Moreover, these correlations were in line with their pharmacological actions. Therefore, the gut microbial functional sets (CAGs) could act as the possible indicator to reflect CMM flavor, rather than the composition of microbial community.
MeSH term(s)	Mice ; Animals ; Materia Medica ; Medicine, Chinese Traditional ; Gastrointestinal Microbiome/genetics ; RNA, Ribosomal, 16S/genetics ; Mice, Inbred C57BL
Chemical Substances	Materia Medica ; RNA, Ribosomal, 16S
Language	English
Publishing date	2022-10-20
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	193085-0
ISSN	1793-6853 ; 0090-2942 ; 0192-415X
ISSN (online)	1793-6853
ISSN	0090-2942 ; 0192-415X
DOI	10.1142/S0192415X22500963
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Article ; Online: Comments on the ochratoxin A degradation mechanism by Lysobacter sp. CW239 - Wei Wei et al. (2020).

Qian, Yingying / Zhang, Xuanjun / Fei, Qingru / Zhou, Yu

Environmental pollution (Barking, Essex : 1987)

2021 Volume 281, Page(s) 117063

Abstract: ... regarding the previous publication in Environmental Pollution (Wei et al., 2020). Three possible degradation ...

Abstract	This is a research comment on the ochratoxin A (OTA) degradation mechanism by Lysobacter sp. CW239 regarding the previous publication in Environmental Pollution (Wei et al., 2020). Three possible degradation mechanisms were discussed in the referred publication, but without definite evidences, it was not clear which one worked actually. Here, the gene cp4 deficient mutant CW239
MeSH term(s)	Carboxypeptidases ; Lysobacter/genetics ; Ochratoxins
Chemical Substances	Ochratoxins ; ochratoxin A (1779SX6LUY) ; Carboxypeptidases (EC 3.4.-)
Language	English
Publishing date	2021-04-07
Publishing country	England
Document type	Journal Article
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2021.117063
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Zs.A 2599: Show issues

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Article: Immunomodulatory effects of modified Liu-Wei-Di-Huang-Wan Traditional Chinese medicine on allergic asthmatic mice.

Tsai, Jaw-Ji / Yen, Chung-Yang / Hsu, Chun-Hsien / Yu, Sheng-Jie / Chen, Chao-Hsien / Liao, En-Chih

Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology

2023 Volume 19, Issue 1, Page(s) 35

Abstract: ... patients. Few studies evaluate the ameliorating effects of modified Liu-Wei-Di-Huang-Wan (modified LWDHW ...

Abstract	Background: Allergic asthma occurs worldwide and is particularly prevalent in westernized countries characterized by chronic airway inflammation resulting in airway hyperresponsiveness. The house dust mites (HDM) including Dermatophagoides pteronyssinus are major sources of sensitization and triggering allergic symptoms in asthmatic patients. The Der p 2 is a major allergen and the predominant source of causative respiratory disorders which induce airway inflammation and bronchial constriction in mite-allergic patients. Few studies evaluate the ameliorating effects of modified Liu-Wei-Di-Huang-Wan (modified LWDHW) on allergic asthma. Methods: This study aimed to investigate the immunological mechanisms of modified LWDHW on the reductions of airway inflammation, signal transduction, inflammatory cytokine production, Th2 cell proliferation, and bronchial obstruction in Der p 2-induced asthmatic mice. Results: At least ten active ingredients were contained in the formula of modified LWDHW- 1217A and 1217B. Results showed that the immunoglobulin generations (Der p 2 specific- IgE and IgG1), inflammatory cytokine productions (IL-5 and IL-13) in the Sera and BALF could be down-regulated, and the Th1-cytokine productions (IL-12 and IFN-γ) be increased after immunotherapy with modified LWDHW of 1217A or 1217B. The inflammatory cell infiltrations (macrophages, eosinophils, and neutrophils) in the airway and the expressions of T Conclusion: It revealed that 1217A or 1217B could regulate the immune responses and improve pulmonary function. Data suggests that modified LWDHW of 1217A or 1217B have the potential for use as a therapeutic intervention for the treatment of mite allergen Der p 2-induced allergic asthma.
Language	English
Publishing date	2023-04-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2434973-2
ISSN	1710-1492 ; 1710-1484
ISSN (online)	1710-1492
ISSN	1710-1484
DOI	10.1186/s13223-023-00792-5
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Article: [Clinical Study of San Wei Sheng Huo Decoction in the Treatment of Refractory Chemotherapy-Induced Thrombocytopenia].

Li, Ru / Xiong, Shao-Quan / He, Li-Fang / Wu, Guo-Yu / Yuan, Yan-Wen

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition

2023 Volume 54, Issue 1, Page(s) 161–164

Abstract: ... thrombocytopenia (RCIT) with San Wei Sheng Huo Decoction (SWSHD) as the main formula.: Methods ...

Abstract	Objective: To investigate the efficacy and safety of treating refractory chemotherapy-induced thrombocytopenia (RCIT) with San Wei Sheng Huo Decoction (SWSHD) as the main formula. Methods: A retrospective study was conducted and the data of RCIT patients treated with SWSHD as the main formula were collected. Changes in peripheral blood platelet (PLT) levels at different time points of treatment were examined and the significant effective rate (SER) and effective rate (ER) were analyzed. We measured the increase in peripheral blood PLT count before and after treatment, analyzed the differences in PLT count increase for different degrees of RCIT treatment, and evaluated the safety of the treatment. Results: A total of 35 cases of RCIT were included in the study. With SWSHD as the main treatment formula, the 2-week ER and SER were 74.29% and 14.29%, respectively, the 2-month ER and SER were 84.38% and 60.50, respectively, and the 1-year ER and SER were 92.31% and 80.77%, respectively. PLT count increased at all time points after treatment compared with that before treatment ( Conclusion: SWSHD takes effect rapidly and its effect is long-lasting and stable. Furthermore, SWSHD has a more significant effect on severe RCIT.
MeSH term(s)	Humans ; Retrospective Studies ; Thrombocytopenia/chemically induced ; Thrombocytopenia/drug therapy ; Platelet Count ; Blood Platelets ; Antineoplastic Agents/adverse effects
Chemical Substances	Antineoplastic Agents
Language	Chinese
Publishing date	2023-01-16
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	2106840-9
ISSN	1672-173X
ISSN	1672-173X
DOI	10.12182/20230160506
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Article ; Online: Asicimbex Yan, Deng & Wei, a new genus with eight new species and four new combinations (Hymenoptera, Cimbicidae)

Yu-Chen Yan / Wen-Long Yan / Tie-Jun Deng / Mei-Cai Wei

Journal of Hymenoptera Research, Vol 91, Iss , Pp 265-

2022 Volume 308

Abstract: ... Deng & Wei gen. nov., A. concavicaputus Yan & Wei sp. nov., A. dengi Yan & Wei sp. nov., A. koreanus ... Yan & Wei sp. nov., A. lii Yan & Wei sp. nov., A. latistriatus Yan, Deng & Wei sp. nov ... A. maculotegularis Yan & Wei sp. nov., A. nanjingensis Yan & Wei sp. nov. and A. shengi Yan & Wei sp. nov. Four new ...

Abstract	A new genus and eight new species of Cimbicinae from the East Asia are described: Asicimbex Yan, Deng & Wei gen. nov., A. concavicaputus Yan & Wei sp. nov., A. dengi Yan & Wei sp. nov., A. koreanus Yan & Wei sp. nov., A. lii Yan & Wei sp. nov., A. latistriatus Yan, Deng & Wei sp. nov., A. maculotegularis Yan & Wei sp. nov., A. nanjingensis Yan & Wei sp. nov. and A. shengi Yan & Wei sp. nov. Four new combinations are proposed: A. eous (Semenov, 1935) comb. nov., A. elminus (Li & Wu, 2003) comb. nov., A. ulmusvorus (Yang, 1996) comb. nov. and A. malaisei (Gussakovskij, 1947) comb. nov., all from Agenocimbex. The 12 known species of Asicimbex are separated into two species groups. Asicimbex stands between Agenocimbex Rohwer 1910 and Cimbex Olivier 1791. The differences between Asicimbex and Cimbex, Asicimbex and Palaeocimbex are discussed in detail. Descriptions, remarks, illustrations, a key to the known species of Asicimbex and a key to genera of Cimbicinae are provided. A. malaisei is confirmed as a valid species and recorded from China for the first time, with the female described for the first time. The distribution of the genus is also briefly discussed.
Keywords	Zoology ; QL1-991
Subject code	590
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	Pensoft Publishers
Document type	Article ; Online
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Article ; Online: Asicimbex Yan, Deng & Wei, a new genus with eight new species and four new combinations (Hymenoptera, Cimbicidae)

Yan, Yu-Chen / Yan, Wen-Long / Deng, Tie-Jun / Wei, Mei-Cai

Journal of Hymenoptera Research. 2022 June 30, v. 91 p.265-308

2022

Abstract: ... Asicimbex Yan, Deng & Wei gen. nov., A. concavicaputus Yan & Wei sp. nov., A. dengi Yan & Wei sp. nov ... A. koreanus Yan & Wei sp. nov., A. lii Yan & Wei sp. nov., A. latistriatus Yan, Deng & Wei sp. nov ... A. maculotegularis Yan & Wei sp. nov., A. nanjingensis Yan & Wei sp. nov. and A. shengi Yan & Wei sp. nov. Four new ...

Abstract	AbstractA new genus and eight new species of Cimbicinae from the East Asia are described: Asicimbex Yan, Deng & Wei gen. nov., A. concavicaputus Yan & Wei sp. nov., A. dengi Yan & Wei sp. nov., A. koreanus Yan & Wei sp. nov., A. lii Yan & Wei sp. nov., A. latistriatus Yan, Deng & Wei sp. nov., A. maculotegularis Yan & Wei sp. nov., A. nanjingensis Yan & Wei sp. nov. and A. shengi Yan & Wei sp. nov. Four new combinations are proposed: A. eous (Semenov, 1935) comb. nov., A. elminus (Li & Wu, 2003) comb. nov., A. ulmusvorus (Yang, 1996) comb. nov. and A. malaisei (Gussakovskij, 1947) comb. nov., all from Agenocimbex. The 12 known species of Asicimbex are separated into two species groups. Asicimbex stands between Agenocimbex Rohwer 1910 and Cimbex Olivier 1791. The differences between Asicimbex and Cimbex, Asicimbex and Palaeocimbex are discussed in detail. Descriptions, remarks, illustrations, a key to the known species of Asicimbex and a key to genera of Cimbicinae are provided. A. malaisei is confirmed as a valid species and recorded from China for the first time, with the female described for the first time. The distribution of the genus is also briefly discussed.
Keywords	Cimbex ; females ; new genus ; new species ; research ; China ; Cimbicinae ; distribution pattern ; Eastern Asia ; Sawflies ; Tenthredinoidea
Language	English
Dates of publication	2022-0630
Size	p. 265-308.
Publishing place	Pensoft Publishers
Document type	Article ; Online
ZDB-ID	2477175-2
ISSN	1314-2607 ; 1070-9428
ISSN (online)	1314-2607
ISSN	1070-9428
DOI	10.3897/jhr.91.83710
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Zuotai (β-HgS)-containing 70 Wei Zhen-Zhu-Wan differs from mercury chloride and methylmercury on hepatic cytochrome P450 in mice.

Nie, Yu / Xu, Shang-Fu / Lu, Yan-Liu / Zhao, Xiu-Rong / Li, Cen / Wei, Li-Xin / Liu, Jie

F1000Research

2021 Volume 10, Page(s) 203

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Animals ; Chlorides ; Cytochrome P-450 Enzyme System ; Liver ; Mercuric Chloride ; Mercury ; Mercury Compounds ; Methylmercury Compounds ; Mice
Chemical Substances	Chlorides ; Mercury Compounds ; Methylmercury Compounds ; zuotai ; Mercuric Chloride (53GH7MZT1R) ; Cytochrome P-450 Enzyme System (9035-51-2) ; Mercury (FXS1BY2PGL)
Language	English
Publishing date	2021-03-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2699932-8
ISSN	2046-1402 ; 2046-1402
ISSN (online)	2046-1402
ISSN	2046-1402
DOI	10.12688/f1000research.40667.2
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