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  1. Article: Left atrial strain importance in atrial fibrillation screening process.

    Inciardi, Riccardo M / Lupi, Laura / Benussi, Stefano

    Annals of cardiothoracic surgery

    2023  Volume 13, Issue 2, Page(s) 173–175

    Language English
    Publishing date 2023-11-16
    Publishing country China
    Document type Editorial
    ZDB-ID 2713627-9
    ISSN 2304-1021 ; 2225-319X
    ISSN (online) 2304-1021
    ISSN 2225-319X
    DOI 10.21037/acs-2023-afm-0061
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  2. Article ; Online: Glassy dynamics of water in TIP4P/Ice aqueous solutions of trehalose in comparison with the bulk phase.

    Lupi, Laura / Gallo, Paola

    The Journal of chemical physics

    2022  Volume 159, Issue 15

    Abstract: We perform molecular dynamics simulations of TIP4P/Ice water in solution with trehalose for 3.65 and 18.57 wt. % concentrations and of bulk TIP4P/Ice water at ambient pressure, to characterize the structure and dynamics of water in a sugar aqueous ... ...

    Abstract We perform molecular dynamics simulations of TIP4P/Ice water in solution with trehalose for 3.65 and 18.57 wt. % concentrations and of bulk TIP4P/Ice water at ambient pressure, to characterize the structure and dynamics of water in a sugar aqueous solution in the supercooled region. We find here that TIP4P/Ice water in solution with trehalose molecules follows the Mode Coupling Theory and undergoes a fragile to strong transition up to the highest concentration investigated, similar to the bulk. Moreover, we perform a Mode Coupling Theory test, showing that the Time Temperature Superposition principle holds for both bulk TIP4P/Ice water and for TIP4P/Ice water in the solutions and we calculate the exponents of the theory. The direct comparison of the dynamical results for bulk water and water in the solutions shows upon cooling along the isobar a fastening of water dynamics for lower temperatures, T < 240 K. We found that the counter-intuitive behavior for the low temperature solutions can be explained with the diffusion anomaly of water leading us to the conclusion that the fastening observed below T = 240 K in water dynamics is only fictitious, due to the fact that the density of water molecules in the solutions is higher than the density of the bulk at the same temperature and pressure. This result should be taken into account in experimental investigations which are often carried out at constant pressure.
    Language English
    Publishing date 2022-09-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3113-6
    ISSN 1089-7690 ; 0021-9606
    ISSN (online) 1089-7690
    ISSN 0021-9606
    DOI 10.1063/5.0168933
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  3. Article ; Online: Fulminant Myocarditis Temporally Associated with COVID-19 Vaccination.

    Ammirati, Enrico / Conti, Nicolina / Palazzini, Matteo / Rocchetti, Matteo / Spangaro, Andrea / Garascia, Andrea / Lupi, Laura / Cereda, Alberto

    Current cardiology reports

    2024  Volume 26, Issue 3, Page(s) 97–112

    Abstract: Purpose of review: Coronavirus disease-2019 (COVID-19) vaccines have been related to rare cases of acute myocarditis, occurring between 1 in 10,000 and 1 in 100,000 individuals, approximately. Incidence of COVID-19 vaccine-associated myocarditis varies ... ...

    Abstract Purpose of review: Coronavirus disease-2019 (COVID-19) vaccines have been related to rare cases of acute myocarditis, occurring between 1 in 10,000 and 1 in 100,000 individuals, approximately. Incidence of COVID-19 vaccine-associated myocarditis varies with age, sex, and type of vaccine. Although most patients with acute myocarditis temporally associated with COVID-19 vaccines have an uneventful course, a small subpopulation presents with cardiogenic shock (termed fulminant myocarditis [FM]). This review explored the prevalence, clinical presentation, management, and prognosis of COVID-19 vaccine-associated acute myocarditis, specifically focusing on FM and comparing patients with fulminant versus non-fulminant myocarditis.
    Recent findings: Cases of FM represent about 2-4% (0 to 7.5%) of COVID-19 vaccine-associated acute myocarditis cases, and mortality is around 1%, ranging between 0 and 4.4%. First, we identified 40 cases of FM up to February 2023 with sufficient granular data from case reports and case series of COVID-19 vaccine-associated acute myocarditis that occurred within 30 days from the last vaccine injection. This population was compared with 294 cases of non-fulminant acute myocarditis identified in the literature during a similar time. Patients with FM were older (48 vs. 27 years), had a larger proportion of women (58% vs. 9%), and mainly occurred after the first shot compared with non-fulminant cases (58% vs. 16%). The reported mortality was 27% (11 out of 40), in line with non-vaccine-associated fulminant myocarditis. These data were in agreement with 36 cases of FM from a large Korean registry. Herein, we reviewed the clinical features, imaging results, and histological findings of COVID-19 vaccine-associated fulminant myocarditis. In conclusion, COVID-19 vaccine-associated FM differs from non-fulminant forms, suggesting potential specific mechanisms in these rare and severe forms. Mortality in vaccine-associated FM remains high, in line with other forms of FM.
    MeSH term(s) Female ; Humans ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Myocarditis/chemically induced ; Registries ; Vaccination/adverse effects ; Male ; Adult ; Middle Aged
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2024-02-07
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2055373-0
    ISSN 1534-3170 ; 1523-3782
    ISSN (online) 1534-3170
    ISSN 1523-3782
    DOI 10.1007/s11886-024-02021-w
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    Zs.A 5524: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Article ; Online: Dynamical crossover and its connection to the Widom line in supercooled TIP4P/Ice water.

    Lupi, Laura / Vázquez Ramírez, Benjamín / Gallo, Paola

    The Journal of chemical physics

    2021  Volume 155, Issue 5, Page(s) 54502

    Abstract: We perform molecular dynamics simulations with the TIP4P/Ice water model to characterize the relationship between dynamics and thermodynamics of liquid water in the supercooled region. We calculate the relevant properties of the phase diagram, and we ... ...

    Abstract We perform molecular dynamics simulations with the TIP4P/Ice water model to characterize the relationship between dynamics and thermodynamics of liquid water in the supercooled region. We calculate the relevant properties of the phase diagram, and we find that TIP4P/Ice presents a retracing line of density maxima, similar to what was previously found for atomistic water models and models of other tetrahedral liquids. For this model, a liquid-liquid critical point between a high-density liquid and a low-density liquid was recently found. We compute the lines of the maxima of isothermal compressibility and the minima of the coefficient of thermal expansion in the one phase region, and we show that these lines point to the liquid-liquid critical point while collapsing on the Widom line. This line is the line of the maxima of correlation length that emanates from a second order critical point in the one phase region. Supercooled water was found to follow mode coupling theory and to undergo a transition from a fragile to a strong behavior right at the crossing of the Widom line. We find here that this phenomenology also happens for TIP4P/Ice. Our results appear, therefore, to be a general characteristic of supercooled water, which does not depend on the interaction potential used, and they reinforce the idea that the dynamical crossover from a region where the relaxation mechanism is dominated by cage relaxation to a region where cages are frozen and hopping dominates is correlated in water to a phase transition between a high-density liquid and a low-density liquid.
    Language English
    Publishing date 2021-07-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3113-6
    ISSN 1089-7690 ; 0021-9606
    ISSN (online) 1089-7690
    ISSN 0021-9606
    DOI 10.1063/5.0059190
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  5. Article ; Online: Implications for the Care of Patients With COVID-19 and Inflammatory Myocardial Disease-Reply.

    Inciardi, Riccardo M / Lupi, Laura / Metra, Marco

    JAMA cardiology

    2020  Volume 5, Issue 11, Page(s) 1306–1307

    MeSH term(s) Betacoronavirus ; COVID-19 ; Cardiomyopathies ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-08-21
    Publishing country United States
    Document type Letter ; Comment
    ISSN 2380-6591
    ISSN (online) 2380-6591
    DOI 10.1001/jamacardio.2020.3392
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  6. Article ; Online: Geysers, Boiling Groundwater and Tectonics: The 3D Subsurface Resistive Structure of the Haukadalur Hydrothermal Field, Iceland

    Lupi, Matteo / Collignon, Marine / Fischanger, Federico / Carrier, Aurore / Trippanera, Daniele / Pioli, Laura

    Journal of Geophysical Research: Solid Earth. 2022 Nov., v. 127, no. 11 p.e2022JB024040-

    2022  

    Abstract: Geysers are among the most fascinating geological features on Earth. Yet, little is still known about their hydrogeological structure at depth. To shed light on the spatial relationships between the vertical conduits and the aquifers feeding them, we ... ...

    Abstract Geysers are among the most fascinating geological features on Earth. Yet, little is still known about their hydrogeological structure at depth. To shed light on the spatial relationships between the vertical conduits and the aquifers feeding them, we conducted a 3D geoelectrical campaign in the Haukadalur hydrothermal field, Iceland. We deployed 24 Iris Fullwavers across the hydrothermal field and inverted resistivity and chargeability measurements. Additionally, we measured temperature variations inside Strokkur and Great Geysir geysers showing temperature fluctuations pointing out the oscillatory behavior that characterizes the geysering cycle of the geysers. By combining a semi‐quantitative temperature distribution of the thermal springs across the hydrothermal field with the inversion of the geoelectrical data, we highlight the control that extensional tectonics have on the distribution of fluids across the hydrothermal field. We also point out the occurrence of a common deep groundwater reservoir feeding the hydrothermal centers. Induced polarization data show that the geysers are fed by sub‐vertical water‐filled fracture zones. The geysers are found at the margins of highly resistive regions where we speculate boiling groundwater and vapor is found. Our proposed model suggests that local waters feeding the main groundwater reservoir downwell from the nearby region and then convect upwards, phase transitioning into vapor at about 200 m depth. From here, fluids flow toward the surface through pipes cutting a highly pressurized and hot system. This study shows to the best of our knowledge the first full 3D tomographic image of a hydrothermal field hosting geysers.
    Keywords geophysics ; groundwater ; models ; research ; tectonics ; temperature ; tomography ; vapors ; Iceland
    Language English
    Dates of publication 2022-11
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ISSN 2169-9313
    DOI 10.1029/2022JB024040
    Database NAL-Catalogue (AGRICOLA)

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  7. Article: Early and stable difficulties of everyday executive functions predict autism symptoms and emotional/behavioral problems in preschool age children with autism: a 2-year longitudinal study.

    Lupi, Elisabetta / Tucci, Federico / Casula, Laura / Novello, Roberta Lucia / Guerrera, Silvia / Vicari, Stefano / Valeri, Giovanni

    Frontiers in psychology

    2023  Volume 14, Page(s) 1092164

    Abstract: Introduction: Longitudinal studies of autistic children show that autism symptoms and emotional/behavioral problems vary and change over time. However, the factors that affect this variability remain far from certain and very little is known about what ... ...

    Abstract Introduction: Longitudinal studies of autistic children show that autism symptoms and emotional/behavioral problems vary and change over time. However, the factors that affect this variability remain far from certain and very little is known about what take place in the preschool period and the role of executive functions (EF).
    Methods: Here, we test the influence of stable difficulties in everyday executive functioning (EEF) during early childhood across 2 years on autistic symptoms and emotional and behavioral problems. Twenty-nine autistic children (24 males and 5 females) were assessed twice within the space of 2 years. At baseline (M = 29 months, SD =5.6 months), participants were assessed for EEF, cognitive development, autistic symptoms, and emotional/behavioral problems. At follow-up, we repeated the same assessment except for cognitive development.
    Results: The group with stable difficulties (across 2 years) in EEF during early childhood showed a worsening in the severity of autistic symptoms and emotional and behavioral problems compared with children without EEF difficulties (
    Discussion: Our results suggest that early and stable EEF plays the role of a modifier by interacting with the core domains of autism, in particular with the social affect domain (SA CSS), influencing social cognition and exacerbating or lessening symptom expression and emotional behavioral problems. These short-term longitudinal and preliminary findings underscore the importance of EEF as necessary target for early intervention in children with autism.
    Language English
    Publishing date 2023-07-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2023.1092164
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  8. Article: Hydration Dynamics of Model Peptides with Different Hydrophobic Character.

    Lupi, Laura / Bracco, Brenda / Sassi, Paola / Corezzi, Silvia / Morresi, Assunta / Fioretto, Daniele / Comez, Lucia / Paolantoni, Marco

    Life (Basel, Switzerland)

    2022  Volume 12, Issue 4

    Abstract: The multi-scale dynamics of aqueous solutions of the hydrophilic ... ...

    Abstract The multi-scale dynamics of aqueous solutions of the hydrophilic peptide
    Language English
    Publishing date 2022-04-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life12040572
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  9. Article ; Online: ACE2 down-regulation may contribute to the increased thrombotic risk in COVID-19.

    Lupi, Laura / Adamo, Marianna / Inciardi, Riccardo M / Metra, Marco

    European heart journal

    2020  Volume 41, Issue 33, Page(s) 3200

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Down-Regulation ; Humans ; Pandemics ; Peptidyl-Dipeptidase A/genetics ; Phenotype ; Pneumonia, Viral ; SARS-CoV-2
    Chemical Substances Peptidyl-Dipeptidase A (EC 3.4.15.1)
    Keywords covid19
    Language English
    Publishing date 2020-07-09
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehaa583
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    Zs.A 1563: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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    Zs.MO 640: Show issues

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  10. Article ; Online: Atrial fibrillation in the COVID-19 era: simple bystander or marker of increased risk?

    Inciardi, Riccardo M / Adamo, Marianna / Lupi, Laura / Metra, Marco

    European heart journal

    2020  Volume 41, Issue 32, Page(s) 3094

    MeSH term(s) Atrial Fibrillation ; Betacoronavirus ; COVID-19 ; Cardiovascular Diseases ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; Prognosis ; Risk Factors ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-15
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehaa576
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