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  1. Article ; Online: PAX2 and CAKUT Phenotypes: Report on Two New Variants and a Review of Mutations from the Leiden Open Variation Database.

    Negrisolo, Susanna / Benetti, Elisa

    International journal of molecular sciences

    2023  Volume 24, Issue 4

    Abstract: ... ...

    Abstract PAX2
    MeSH term(s) Humans ; Kidney/abnormalities ; Kidney Diseases/genetics ; Mutation ; PAX2 Transcription Factor/genetics ; Phenotype ; Urinary Tract ; Vesico-Ureteral Reflux/genetics
    Chemical Substances PAX2 protein, human ; PAX2 Transcription Factor
    Language English
    Publishing date 2023-02-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24044165
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  2. Article ; Online: [Congenital Nephrotic Syndrome: Role of Podxl Gene].

    Zeni, Angela / Pecoraro, Luca / Benetti, Elisa / Brugnara, Milena

    Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia

    2023  Volume 40, Issue 6

    Abstract: In the last decades, our understanding of the genetic disorders of inherited podocytopathies has advanced immensely; this has been possible thanks to the development of next-generation sequencing technologies that offer the possibility to evaluate ... ...

    Abstract In the last decades, our understanding of the genetic disorders of inherited podocytopathies has advanced immensely; this has been possible thanks to the development of next-generation sequencing technologies that offer the possibility to evaluate targeted genes at a lower cost than in the past. Identifying new genetic mutations has helped to recognize the key role of the podocyte in the health of the glomerular filter and to understand the mechanisms that regulate the cell biology and pathology of the podocyte. Here we describe a patient with congenital nephrotic syndrome due to a mutation in PODXL. This gene encodes podocalyxin, a podocyte-specific surface sialomucin known to maintain the characteristic architecture of the foot processes and the patency of the filtration slits.
    MeSH term(s) Humans ; Kidney Diseases/metabolism ; Kidney Glomerulus/pathology ; Nephrotic Syndrome/genetics ; Podocytes/metabolism
    Language Italian
    Publishing date 2023-12-22
    Publishing country Italy
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 1237110-5
    ISSN 1724-5990 ; 0393-5590
    ISSN (online) 1724-5990
    ISSN 0393-5590
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4313: Show issues Location:
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  3. Article ; Online: The use of burosumab to treat autosomal-recessive hypophosphatemic rickets type 2: rationale and a first clinical experience.

    Parolin, Mattia / Partigiani, Nicola Bertazza / Benetti, Elisa / Longo, Germana / Vidal, Enrico

    Journal of nephrology

    2024  

    Language English
    Publishing date 2024-02-03
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 1093991-x
    ISSN 1724-6059 ; 1120-3625 ; 1121-8428
    ISSN (online) 1724-6059
    ISSN 1120-3625 ; 1121-8428
    DOI 10.1007/s40620-023-01884-6
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    Zs.A 3369: Show issues Location:
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  4. Article ; Online: Micronized Palmitoylethanolamide, Hempseed Oil, and Maritime Pine Bark Dry Extract (Pelvipea

    Tafuri, Alessandro / Panunzio, Andrea / De Mitri, Rita / Benetti, Federico / Gaio, Elisa / Pagliarulo, Vincenzo

    Cells

    2023  Volume 12, Issue 4

    Abstract: Urothelial inflammation plays a key role in the pathogenesis of chronic pelvic pain due to its origin in the bladder. The aim of this study was to evaluate the efficacy of a patent-pending formulation ( ... ...

    Abstract Urothelial inflammation plays a key role in the pathogenesis of chronic pelvic pain due to its origin in the bladder. The aim of this study was to evaluate the efficacy of a patent-pending formulation (Pelvipea
    MeSH term(s) Urothelium ; Plant Bark ; Interleukin-6 ; Interleukin-8 ; Pelvic Pain ; Inflammation ; Pinus
    Chemical Substances hempseed oil (69VJ1LPN1S) ; palmidrol (6R8T1UDM3V) ; Interleukin-6 ; Interleukin-8
    Language English
    Publishing date 2023-02-14
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12040616
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  5. Article ; Online: Evaluation of Short Chain Fatty Acids (SCFAs) intestinal absorption, following digestion and fermentation of a novel medical device containing partially-hydrolyzed Guar gum plus simethicone

    Federico Benetti / Marta Micheletto / Erik Tedesco / Elisa Gaio / Giorgio Ciprandi

    Journal of Biological Research (2023)

    2023  

    Abstract: Irritable Bowel Syndrome (IBS) is a common disease characterized by alternate symptoms (diarrhea and constipation) and intestinal gas overproduction. A new medical device (Fibergone®), containing Partially Hydrolyzed Guar Gum (PHGG) and Simethicone (SM) ... ...

    Abstract Irritable Bowel Syndrome (IBS) is a common disease characterized by alternate symptoms (diarrhea and constipation) and intestinal gas overproduction. A new medical device (Fibergone®), containing Partially Hydrolyzed Guar Gum (PHGG) and Simethicone (SM) has been proposed for managing patients with bowel disorders. PHGG acts also as a prebiotic so increasing the Short-Chain Fatty Acid (SCFA) production, useful for intestinal physiology. This in vitro study investigated the effects exerted by PHGG+SM on SCFA production and their intestinal absorption following in vitro digestive process and fermentation model. An in vitro model evaluated the digestive process and fermentation using simulated digestive fluids and a human intestinal epithelium in vitro model derived from based on intestinal adenocarcinoma Caco-2 cells (ATCC, HTB-37TM) and organized as a functional monolayer on Transwell® inserts. PHGG+SM was added in experiments and compared with a control (non-treated). SCFA production and absorption were assessed. Viability and barrier integrity of the of the intestinal epithelium model were also evaluated. PHGG+SM significantly (p<0.05) increased SCFAs content after fermentation, indicating that this medical device is effectively fermented at the large intestine level. However, in relation to SCFAs bioavailability, their absorption did not increase compared to the non-treated condition in the light of the physiological contribution of SCFAs resulting from the microflora. PHGG+SM did not affect intestinal epithelium apparent permeability (Papp) and viability. This in vitro study documented that partially hydrolyzed guar gum combined with simethicone significantly affects short-chain fatty acids production and consequently could be fruitfully employed in managing patients with intestinal disorders.
    Keywords irritable bowel syndrome ; short-chain fatty acids ; partially hydrolyzed Guar gum ; simethicone ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher PAGEPress Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Corrigendum to "Reversal of the deleterious effects of chronic dietary HFCS-55 intake by PPAR-δ agonism correlates with impaired NLRP3 inflammasome activation'' [Biochem. Pharmacol. 85(2) (2013) 257-264].

    Collino, Massimo / Benetti, Elisa / Rogazzo, Mara / Mastrocola, Raffaella / Yaqoob, Muhammed M / Aragno, Manuela / Theimermann, Christroph / Fantozzi, Roberto

    Biochemical pharmacology

    2024  Volume 222, Page(s) 116060

    Language English
    Publishing date 2024-03-02
    Publishing country England
    Document type Published Erratum
    ZDB-ID 208787-x
    ISSN 1873-2968 ; 0006-2952
    ISSN (online) 1873-2968
    ISSN 0006-2952
    DOI 10.1016/j.bcp.2024.116060
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    Zs.A 19: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  7. Article ; Online: Impact of the first 24 h of continuous kidney replacement therapy on hemodynamics, ventilation, and analgo-sedation in critically ill children.

    Imberti, Simona / Comoretto, Rosanna / Ceschia, Giovanni / Longo, Germana / Benetti, Elisa / Amigoni, Angela / Daverio, Marco

    Pediatric nephrology (Berlin, Germany)

    2023  Volume 39, Issue 3, Page(s) 879–887

    Abstract: Background: In a group of children admitted to the paediatric intensive care unit (PICU) receiving continuous kidney replacement therapy (CKRT), we aim to evaluate the data about their hemodynamic, ventilation and analgo-sedation profile in the first 24  ...

    Abstract Background: In a group of children admitted to the paediatric intensive care unit (PICU) receiving continuous kidney replacement therapy (CKRT), we aim to evaluate the data about their hemodynamic, ventilation and analgo-sedation profile in the first 24 h of treatment and possible associations with mortality.
    Methods: Retrospective cohort study of children admitted to the PICU of the University Hospital of Padova undergoing CKRT between January 2011 and March 2021. Data was collected at baseline (T
    Results: Sixty-nine patients received CKRT, of whom 38 (55%) died during the PICU stay. Overall, the vasoactive inotropic score and the adrenaline dose increased at T
    Conclusions: CKRT showed a significant impact on hemodynamics and ventilation in the first 24 h of treatment. We observed a significant rise in the inotropic/vasoactive support required after 1 h of treatment in the overall population, and an improvement in the ventilation parameters at 24 h only in survivors.
    MeSH term(s) Child ; Humans ; Critical Illness/therapy ; Retrospective Studies ; Lung ; Hemodynamics ; Renal Replacement Therapy
    Language English
    Publishing date 2023-09-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-023-06155-x
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    Zs.A 2196: Show issues Location:
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  8. Article ; Online: Pediatric kidney transplantation: is it safe to perform during night-time or day-off?

    Ghidini, Filippo / Andreetta, Marina / De Corti, Federica / Benetti, Elisa / Vidal, Enrico / Gamba, Piergiorgio / Fascetti Leon, Francesco

    Pediatric surgery international

    2024  Volume 40, Issue 1, Page(s) 82

    Abstract: Purpose: To investigate the impact of after-hours surgery on the outcomes of pediatric kidney transplantation (KT).: Methods: Medical records of pediatric KTs performed at a single institution between 2013 and 2021 were retrospectively reviewed. The ... ...

    Abstract Purpose: To investigate the impact of after-hours surgery on the outcomes of pediatric kidney transplantation (KT).
    Methods: Medical records of pediatric KTs performed at a single institution between 2013 and 2021 were retrospectively reviewed. The population was split into three groups according to the incision time and calendar: ordinary day (8.00 AM - 6.30 PM), day-off, and night-time (6.30 PM - 8.00 AM). The following endpoints were compared: ischemia times, length of surgery, complications, delayed graft function (DGF), primary graft non-function (PGNF), and eGFR at three-month follow-up.
    Results: Ninety-six non-living donor KTs were performed, median age 11 (IQR 4.3-14) years and median body weight 26 (IQR 13-50) kg. Forty-one (43%) were performed during night-time and 28 (29%) during day-off. Ischemia times were similar (p = 0.769, p = 0.536). Day-off KTs presented an extended length of surgery (p = 0.011). Thirty-two complications were reported in 31 KTs. No difference in the overall rate of complications, DGF, PNGF, and three-month eGFR was found (p = 0.669, p = 0.383, p = 0.949, p = 0.093). Post-operative bleedings were more common in days-off (p = 0.003).
    Conclusion: The number of pediatric KTs performed during after-hours was considerable. Even though similar outcomes were reported, more caution should be focused on the KTs performed in days-off to avoid severe complications.
    MeSH term(s) Humans ; Child ; Kidney Transplantation ; Retrospective Studies ; Graft Survival ; Cadaver ; Ischemia ; Risk Factors ; Kidney
    Language English
    Publishing date 2024-03-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 632773-4
    ISSN 1437-9813 ; 0179-0358
    ISSN (online) 1437-9813
    ISSN 0179-0358
    DOI 10.1007/s00383-024-05666-4
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2138: Show issues Location:
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  9. Article ; Online: Pterodon emarginatus

    Froldi, Guglielmina / Benetti, Francesco / Mondin, Andrea / Roverso, Marco / Pangrazzi, Elisa / Djeujo, Francine Medjiofack / Pastore, Paolo

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 22

    Abstract: The study of medicinal plants and their active compounds is relevant to maintaining knowledge of traditional medicine and to the development of new drugs of natural origin with lower environmental impact. From the seeds of the Brazilian ... ...

    Abstract The study of medicinal plants and their active compounds is relevant to maintaining knowledge of traditional medicine and to the development of new drugs of natural origin with lower environmental impact. From the seeds of the Brazilian plant
    MeSH term(s) Humans ; Farnesol/pharmacology ; Polycyclic Sesquiterpenes ; Oils, Volatile/chemistry ; Fabaceae/chemistry ; Plant Extracts/chemistry ; Antioxidants/analysis ; Seeds/chemistry
    Chemical Substances caryophyllene (BHW853AU9H) ; Farnesol (4602-84-0) ; Polycyclic Sesquiterpenes ; Oils, Volatile ; Plant Extracts ; Antioxidants
    Language English
    Publishing date 2023-11-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28227494
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    Zs.MO 81: Show issues

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  10. Article ; Online: Correction: New frontiers to cure Alport syndrome: COL4A3 and COL4A5 gene editing in podocyte-lineage cells.

    Daga, Sergio / Donati, Francesco / Capitani, Katia / Croci, Susanna / Tita, Rossella / Giliberti, Annarita / Valentino, Floriana / Benetti, Elisa / Fallerini, Chiara / Niccheri, Francesca / Baldassarri, Margherita / Mencarelli, Maria Antonietta / Frullanti, Elisa / Furini, Simone / Conticello, Silvestro Giovanni / Renieri, Alessandra / Pinto, Anna Maria

    European journal of human genetics : EJHG

    2023  Volume 32, Issue 1, Page(s) 131

    Language English
    Publishing date 2023-01-18
    Publishing country England
    Document type Published Erratum
    ZDB-ID 1141470-4
    ISSN 1476-5438 ; 1018-4813
    ISSN (online) 1476-5438
    ISSN 1018-4813
    DOI 10.1038/s41431-023-01287-y
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    Zs.A 3589: Show issues Location:
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