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  1. Article ; Online: Receptor-Loaded Virion Endangers GPCR Signaling

    Qiangmin Zhang / Peter A. Friedman

    International Journal of Molecular Sciences, Vol 22, Iss 10963, p

    Mechanistic Exploration of SARS-CoV-2 Infections and Pharmacological Implications

    2021  Volume 10963

    Abstract: SARS-CoV-2 exploits the respiratory tract epithelium including lungs as the primary entry point and reaches other organs through hematogenous expansion, consequently causing multiorgan injury. Viral E protein interacts with cell junction-associated ... ...

    Abstract SARS-CoV-2 exploits the respiratory tract epithelium including lungs as the primary entry point and reaches other organs through hematogenous expansion, consequently causing multiorgan injury. Viral E protein interacts with cell junction-associated proteins PALS1 or ZO-1 to gain massive penetration by disrupting the inter-epithelial barrier. Conversely, receptor-mediated viral invasion ensures limited but targeted infections in multiple organs. The ACE2 receptor represents the major virion loading site by virtue of its wide tissue distribution as demonstrated in highly susceptible lung, intestine, and kidney. In brain, NRP1 mediates viral endocytosis in a similar manner to ACE2. Prominently, PDZ interaction involves the entire viral loading process either outside or inside the host cells, whereas E, ACE2, and NRP1 provide the PDZ binding motif required for interacting with PDZ domain-containing proteins PALS1, ZO-1, and NHERF1, respectively. Hijacking NHERF1 and β-arrestin by virion loading may impair specific sensory GPCR signalosome assembling and cause disordered cellular responses such as loss of smell and taste. PDZ interaction enhances SARS-CoV-2 invasion by supporting viral receptor membrane residence, implying that the disruption of these interactions could diminish SARS-CoV-2 infections and be another therapeutic strategy against COVID-19 along with antibody therapy. GPCR-targeted drugs are likely to alleviate pathogenic symptoms-associated with SARS-CoV-2 infection.
    Keywords SARS-CoV-2 ; PDZ interaction ; viral cell entry ; GPCR signaling ; drug development ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 572
    Language English
    Publishing date 2021-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Receptor-Loaded Virion Endangers GPCR Signaling: Mechanistic Exploration of SARS-CoV-2 Infections and Pharmacological Implications.

    Zhang, Qiangmin / Friedman, Peter A

    International journal of molecular sciences

    2021  Volume 22, Issue 20

    Abstract: SARS-CoV-2 exploits the respiratory tract epithelium including lungs as the primary entry point and reaches other organs through hematogenous expansion, consequently causing multiorgan injury. Viral E protein interacts with cell junction-associated ... ...

    Abstract SARS-CoV-2 exploits the respiratory tract epithelium including lungs as the primary entry point and reaches other organs through hematogenous expansion, consequently causing multiorgan injury. Viral E protein interacts with cell junction-associated proteins PALS1 or ZO-1 to gain massive penetration by disrupting the inter-epithelial barrier. Conversely, receptor-mediated viral invasion ensures limited but targeted infections in multiple organs. The ACE2 receptor represents the major virion loading site by virtue of its wide tissue distribution as demonstrated in highly susceptible lung, intestine, and kidney. In brain, NRP1 mediates viral endocytosis in a similar manner to ACE2. Prominently, PDZ interaction involves the entire viral loading process either outside or inside the host cells, whereas E, ACE2, and NRP1 provide the PDZ binding motif required for interacting with PDZ domain-containing proteins PALS1, ZO-1, and NHERF1, respectively. Hijacking NHERF1 and β-arrestin by virion loading may impair specific sensory GPCR signalosome assembling and cause disordered cellular responses such as loss of smell and taste. PDZ interaction enhances SARS-CoV-2 invasion by supporting viral receptor membrane residence, implying that the disruption of these interactions could diminish SARS-CoV-2 infections and be another therapeutic strategy against COVID-19 along with antibody therapy. GPCR-targeted drugs are likely to alleviate pathogenic symptoms-associated with SARS-CoV-2 infection.
    MeSH term(s) Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; COVID-19/drug therapy ; COVID-19/metabolism ; COVID-19/pathology ; COVID-19/virology ; Humans ; PDZ Domains ; Receptors, G-Protein-Coupled/chemistry ; Receptors, G-Protein-Coupled/metabolism ; SARS-CoV-2/isolation & purification ; SARS-CoV-2/physiology ; Signal Transduction ; Virus Internalization/drug effects
    Chemical Substances Antiviral Agents ; Receptors, G-Protein-Coupled
    Language English
    Publishing date 2021-10-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms222010963
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Observation on Microenvironment Changes of Dynamic Catalysts in Acidic CO

    Liu, Heming / Yan, Tian / Tan, Shendong / Sun, Linxuan / Zhang, Zhiyuan / Hu, Shuqi / Li, Shao-Hai / Kang, Xin / Lei, Yu / Jiang, Lu / Hou, Tingzheng / Liu, Le / Yu, Qiangmin / Liu, Bilu

    Journal of the American Chemical Society

    2024  Volume 146, Issue 8, Page(s) 5333–5342

    Abstract: Electrochemical ... ...

    Abstract Electrochemical CO
    Language English
    Publishing date 2024-02-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.3c12321
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 4' 55/32: Show issues
    Z 7.3: Show issues

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  4. Article ; Online: Two-Dimensional Metal Coordination Polymer Derived Indium Nanosheet for Efficient Carbon Dioxide Reduction to Formate.

    Li, Shao-Hai / Hu, Shuqi / Liu, Heming / Liu, Jiarong / Kang, Xin / Ge, Shiyu / Zhang, Zhiyuan / Yu, Qiangmin / Liu, Bilu

    ACS nano

    2023  Volume 17, Issue 10, Page(s) 9338–9346

    Abstract: Main group indium materials have been known as promising electrocatalysts for two-electron-involved carbon dioxide reduction to produce formate, which is a key energy vector in many industrial reactions. However, the synthesis of two-dimensional (2D) ... ...

    Abstract Main group indium materials have been known as promising electrocatalysts for two-electron-involved carbon dioxide reduction to produce formate, which is a key energy vector in many industrial reactions. However, the synthesis of two-dimensional (2D) monometallic nonlayered indium remains a great challenge. Here, we present a facile electrochemical reduction strategy to transform 2D indium coordination polymer into elemental indium nanosheets. In a customized flow cell, the reconstructed metallic indium exhibits a high Faradaic efficiency (FE) of 96.3% for formate with a maximum partial current density exceeding 360 mA cm
    Language English
    Publishing date 2023-05-04
    Publishing country United States
    Document type Journal Article
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.3c01059
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Ampere-Level Current Density CO

    Hu, Shuqi / Chen, Yumo / Zhang, Zhiyuan / Li, Shaohai / Liu, Heming / Kang, Xin / Liu, Jiarong / Ge, Shiyu / Wang, Jingwei / Lv, Wei / Zeng, Zhiyuan / Zou, Xiaolong / Yu, Qiangmin / Liu, Bilu

    Small (Weinheim an der Bergstrasse, Germany)

    2023  Volume 20, Issue 14, Page(s) e2308226

    Abstract: The carbon dioxide reduction reaction ( ... ...

    Abstract The carbon dioxide reduction reaction (CO
    Language English
    Publishing date 2023-11-16
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2168935-0
    ISSN 1613-6829 ; 1613-6810
    ISSN (online) 1613-6829
    ISSN 1613-6810
    DOI 10.1002/smll.202308226
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  6. Article ; Online: Identification of disulfidptosis related subtypes, characterization of tumor microenvironment infiltration, and development of DRG prognostic prediction model in RCC, in which

    Xu, Kai / Zhang, Ye / Yan, Zhiwei / Wang, Yuchan / Li, Yanze / Qiu, Qiangmin / Du, Yang / Chen, Zhiyuan / Liu, Xiuheng

    Frontiers in immunology

    2023  Volume 14, Page(s) 1205250

    Abstract: Disulfidptosis is a newly discovered mode of cell death induced by disulfide stress. However, the prognostic value of disulfidptosis-related genes (DRGs) in renal cell carcinoma (RCC) remains to be further elucidated. In this study, consistent cluster ... ...

    Abstract Disulfidptosis is a newly discovered mode of cell death induced by disulfide stress. However, the prognostic value of disulfidptosis-related genes (DRGs) in renal cell carcinoma (RCC) remains to be further elucidated. In this study, consistent cluster analysis was used to classify 571 RCC samples into three DRG-related subtypes based on changes in DRGs expression. Through univariate regression analysis and LASSO-Cox regression analysis of differentially expressed genes (DEGs) among three subtypes, we constructed and validated a DRG risk score to predict the prognosis of patients with RCC, while also identifying three gene subtypes. Analysis of DRG risk score, clinical characteristics, tumor microenvironment (TME), somatic cell mutations, and immunotherapy sensitivity revealed significant correlations between them. A series of studies have shown that
    MeSH term(s) Humans ; Prognosis ; Carcinoma, Renal Cell/genetics ; Tumor Microenvironment/genetics ; Cell Death ; Kidney Neoplasms/genetics ; MutS Homolog 3 Protein
    Chemical Substances MSH3 protein, human ; MutS Homolog 3 Protein
    Language English
    Publishing date 2023-06-23
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1205250
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A corrosion-resistant RuMoNi catalyst for efficient and long-lasting seawater oxidation and anion exchange membrane electrolyzer.

    Kang, Xin / Yang, Fengning / Zhang, Zhiyuan / Liu, Heming / Ge, Shiyu / Hu, Shuqi / Li, Shaohai / Luo, Yuting / Yu, Qiangmin / Liu, Zhibo / Wang, Qiang / Ren, Wencai / Sun, Chenghua / Cheng, Hui-Ming / Liu, Bilu

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 3607

    Abstract: Direct seawater electrolysis is promising for sustainable hydrogen gas ( ... ...

    Abstract Direct seawater electrolysis is promising for sustainable hydrogen gas (H
    MeSH term(s) Chlorides ; Corrosion ; Anions ; Membranes ; Gasoline ; Halogens ; Seawater
    Chemical Substances Chlorides ; Anions ; Gasoline ; Halogens
    Language English
    Publishing date 2023-06-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-39386-5
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  8. Article ; Online: ACE2 interaction with cytoplasmic PDZ protein enhances SARS-CoV-2 invasion.

    Zhang, Qiangmin / Gefter, Julia / Sneddon, W Bruce / Mamonova, Tatyana / Friedman, Peter A

    iScience

    2021  Volume 24, Issue 7, Page(s) 102770

    Abstract: SARS-CoV-2 is responsible for the global COVID-19 pandemic. Angiotensin converting enzyme 2 (ACE2) is the membrane-delimited receptor for SARS-CoV-2. Lung, intestine, and kidney, major sites of viral infection, express ACE2 that harbors an intracellular, ...

    Abstract SARS-CoV-2 is responsible for the global COVID-19 pandemic. Angiotensin converting enzyme 2 (ACE2) is the membrane-delimited receptor for SARS-CoV-2. Lung, intestine, and kidney, major sites of viral infection, express ACE2 that harbors an intracellular, carboxy-terminal PDZ-recognition motif. These organs prominently express the PDZ protein Na
    Language English
    Publishing date 2021-06-24
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2021.102770
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  9. Article ; Online: MITD1 Deficiency Suppresses Clear Cell Renal Cell Carcinoma Growth and Migration by Inducing Ferroptosis through the TAZ/SLC7A11 Pathway.

    Zhang, Ye / Li, Yanze / Qiu, Qiangmin / Chen, Zhiyuan / Du, Yang / Liu, Xiuheng

    Oxidative medicine and cellular longevity

    2022  Volume 2022, Page(s) 7560569

    Abstract: Clear cell renal cell carcinoma (ccRCC), the major histopathological subtype of renal cancer, is sensitive to ferroptosis. MIT-domain containing protein 1 (MITD1) has been reported to play an important role in hepatocellular carcinoma, while it remains ... ...

    Abstract Clear cell renal cell carcinoma (ccRCC), the major histopathological subtype of renal cancer, is sensitive to ferroptosis. MIT-domain containing protein 1 (MITD1) has been reported to play an important role in hepatocellular carcinoma, while it remains unclear whether MITD1 is involved in ccRCC. Based on available data in The Cancer Genome Atlas, we found the expression of MITD1 increased through bioinformatics analysis and high MITD1 expression suggests a poor prognosis. And we validated that MITD1 expressed significantly in ccRCC through Western blot analysis. Then, we further compared the proliferation and migration capacity of ccRCC before and after MITD1 knockdown and further explored the effect of MITD1 knockdown on ferroptosis. The results indicated that MITD1 knockdown inhibited ccRCC cell proliferation and migration and induced ferroptosis in ccRCC. Furthermore, we found and analyzed the key molecule TAZ which was involved in ferroptosis caused by MITD1 knockdown. Subsequent overexpression experiments demonstrated that MITD1 knockdown induced ferroptosis and suppressed tumor growth and migration through the TAZ/SLC7A11 pathway. In summary, our study revealed the role of MITD1 in the ferroptosis of ccRCC and provided a novel target for ccRCC treatment.
    MeSH term(s) Amino Acid Transport System y+/genetics ; Amino Acid Transport System y+/metabolism ; Carcinoma, Renal Cell/pathology ; Cell Line, Tumor ; Cell Proliferation/genetics ; Ferroptosis ; Gene Expression Regulation, Neoplastic ; Humans ; Kidney Neoplasms/pathology ; Membrane Proteins/metabolism ; Microtubule-Associated Proteins/metabolism ; Transcriptional Coactivator with PDZ-Binding Motif Proteins
    Chemical Substances Amino Acid Transport System y+ ; MITD1 protein, human ; Membrane Proteins ; Microtubule-Associated Proteins ; SLC7A11 protein, human ; Transcriptional Coactivator with PDZ-Binding Motif Proteins ; WWTR1 protein, human
    Language English
    Publishing date 2022-08-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2455981-7
    ISSN 1942-0994 ; 1942-0994
    ISSN (online) 1942-0994
    ISSN 1942-0994
    DOI 10.1155/2022/7560569
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Identification of a basement membrane-related genes signature with immune correlation in bladder urothelial carcinoma and verification in vitro.

    Li, Yanze / Xu, Kai / Zhang, Ye / Mao, Hu / Qiu, Qiangmin / Yan, Zhiwei / Liu, Xiuheng / Du, Yang / Chen, Zhiyuan

    BMC cancer

    2023  Volume 23, Issue 1, Page(s) 1021

    Abstract: Background: Bladder urothelial carcinoma (BLCA) is the most common genitourinary cancer and the prognosis of patients is often poor. However, studies of basement membrane-related genes (BM-related genes) in BLCA are less reported. Therefore, we ... ...

    Abstract Background: Bladder urothelial carcinoma (BLCA) is the most common genitourinary cancer and the prognosis of patients is often poor. However, studies of basement membrane-related genes (BM-related genes) in BLCA are less reported. Therefore, we established a BM-related genes signature to explore their functional and prognostic value in BLCA.
    Methods: In this study, a BM-related genes signature was constructed by LASSO-Cox regression analysis, and then a series of bioinformatics methods was used to assess the accuracy and validity of the signature. We constructed a nomogram for clinical application and also screened for possible therapeutic drugs. To investigate the functions and pathways affected by BM-related genes in BLCA, we performed functional enrichment analyses. In addition, we analyzed the immune cell infiltration landscape and immune checkpoint-related genes in the high and low-risk groups. Finally, we confirmed the prognostic value of BM-related genes in BLCA in vitro.
    Results: Combining multiple bioinformatics approaches, we identified a seven-gene signature. The accuracy and validity of this signature in predicting BLCA patients were confirmed by the test cohort. In addition, the risk score was strongly correlated with prognosis, immune checkpoint genes, drug sensitivity, and immune cell infiltration landscape. The risk score is an independent prognostic factor for BLCA patients. Further experiments revealed that all seven signature genes were differentially expressed between BLCA cell lines and normal bladder cells. Finally, overexpression of LAMA2 inhibited the migration and invasion ability of BLCA cell lines.
    Conclusions: In summary, the BM-related genes signature was able to predict the prognosis of BLCA patients accurately, indicating that the BM-related genes possess great clinical value in the diagnosis and treatment of BLCA. Moreover, LAMA2 could be a potential therapeutic target, which provides new insights into the application of the BM-related genes in BLCA patients.
    MeSH term(s) Humans ; Carcinoma, Transitional Cell/genetics ; Urinary Bladder Neoplasms/genetics ; Urinary Bladder ; Epithelial Cells ; Basement Membrane ; Prognosis
    Language English
    Publishing date 2023-10-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041352-X
    ISSN 1471-2407 ; 1471-2407
    ISSN (online) 1471-2407
    ISSN 1471-2407
    DOI 10.1186/s12885-023-11340-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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