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  1. Article ; Online: Photodestruction Action Spectroscopy of Silver Cluster Anions, Ag

    Kawamura, Shun / Yamaguchi, Masato / Kono, Satoshi / Arakawa, Masashi / Yasuike, Tomokazu / Horio, Takuya / Terasaki, Akira

    The journal of physical chemistry. A

    2023  Volume 127, Issue 29, Page(s) 6063–6070

    Abstract: Electron detachment thresholds of metal cluster anions, ... ...

    Abstract Electron detachment thresholds of metal cluster anions, M
    Language English
    Publishing date 2023-07-12
    Publishing country United States
    Document type Journal Article
    ISSN 1520-5215
    ISSN (online) 1520-5215
    DOI 10.1021/acs.jpca.3c02900
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  2. Article ; Online: Angiotensin-Converting Enzyme 2 (ACE2) in the Pathogenesis of ARDS in COVID-19.

    Kuba, Keiji / Yamaguchi, Tomokazu / Penninger, Josef M

    Frontiers in immunology

    2021  Volume 12, Page(s) 732690

    Abstract: Seventeen years after the epidemic of SARS coronavirus, a novel coronavirus SARS-CoV-2-emerged resulting in an unprecedented pandemic. Angiotensin-converting enzyme 2 (ACE2) is an essential receptor for cell entry of SARS-CoV-2 as well as the SARS ... ...

    Abstract Seventeen years after the epidemic of SARS coronavirus, a novel coronavirus SARS-CoV-2-emerged resulting in an unprecedented pandemic. Angiotensin-converting enzyme 2 (ACE2) is an essential receptor for cell entry of SARS-CoV-2 as well as the SARS coronavirus. Despite many similarities to SARS coronavirus, SARS-CoV-2 exhibits a higher affinity to ACE2 and shows higher infectivity and transmissibility, resulting in explosive increase of infected people and COVID-19 patients. Emergence of the variants harboring mutations in the receptor-binding domain of the Spike protein has drawn critical attention to the interaction between ACE2 and Spike and the efficacies of vaccines and neutralizing antibodies. ACE2 is a carboxypeptidase which degrades angiotensin II, B1-bradykinin, or apelin, and thereby is a critical regulator of cardiovascular physiology and pathology. In addition, the enzymatic activity of ACE2 is protective against acute respiratory distress syndrome (ARDS) caused by viral and non-viral pneumonias, aspiration, or sepsis. Upon infection, both SARS-CoV-2 and SARS coronaviruses downregulates ACE2 expression, likely associated with the pathogenesis of ARDS. Thus, ACE2 is not only the SARS-CoV-2 receptor but might also play an important role in multiple aspects of COVID-19 pathogenesis and possibly post-COVID-19 syndromes. Soluble forms of recombinant ACE2 are currently utilized as a pan-variant decoy to neutralize SARS-CoV-2 and a supplementation of ACE2 carboxypeptidase activity. Here, we review the role of ACE2 in the pathology of ARDS in COVID-19 and the potential application of recombinant ACE2 protein for treating COVID-19.
    MeSH term(s) Angiotensin-Converting Enzyme 2/metabolism ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; COVID-19/pathology ; Cardiovascular System/metabolism ; Down-Regulation ; Humans ; Lung Injury/pathology ; Lung Injury/virology ; Protein Domains/genetics ; Receptors, Virus/metabolism ; Renin-Angiotensin System/physiology ; Respiratory Distress Syndrome/pathology ; SARS-CoV-2/genetics ; SARS-CoV-2/metabolism ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/metabolism ; Virus Internalization
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral ; Receptors, Virus ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Language English
    Publishing date 2021-12-22
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.732690
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  3. Article: Suspected malnutrition-induced reversible feline skin fragility syndrome in a cat with congenital axial deformities.

    Yu, Yoshihiko / Miyamoto, Tadashi / Kimura, Yui / Itamoto, Kazuhito / Michishita, Masaki / Hatakeyama, Hitoshi / Nagashima, Tomokazu / Asada, Rikako / Yamaguchi, Tomomi / Hasegawa, Daisuke / Nomura, Yoshihiro / Lyons, Leslie A / Kosho, Tomoki

    The Canadian veterinary journal = La revue veterinaire canadienne

    2024  Volume 65, Issue 3, Page(s) 227–233

    Abstract: A stray cat, an intact female Japanese domestic shorthair cat of unknown age (suspected to be a young adult), was rescued. The cat was lethargic and thin and had marked skin fragility, delayed wound healing without skin hyperextensibility, and hind limb ... ...

    Abstract A stray cat, an intact female Japanese domestic shorthair cat of unknown age (suspected to be a young adult), was rescued. The cat was lethargic and thin and had marked skin fragility, delayed wound healing without skin hyperextensibility, and hind limb proprioceptive ataxia and paresis. Survey radiography, computed tomography, and magnetic resonance imaging revealed congenital vertebral anomalies, including thoracolumbar transitional vertebrae, scoliosis resulting from a thoracic lateral wedge-shaped vertebra, and a kinked tail, and a dilated spinal cord central canal. Through nutritional support, the cat's general condition normalized, followed by a gradual and complete improvement of skin features. Whole-genome sequencing was completed; however, no pathogenic genetic variant was identified that could have caused this phenotype, including congenital scoliosis. A skin biopsy obtained 7 y after the rescue revealed no remarkable findings on histopathology or transmission electron microscopy. Based on clinical course and microscopic findings, malnutrition-induced reversible feline skin fragility syndrome (FSFS) was suspected, and nutritional support was considered to have improved the skin condition. Key clinical message: This is the second reported case of presumed malnutrition-induced reversible FSFS and was accompanied by long-term follow-up.
    MeSH term(s) Female ; Cats ; Animals ; Scoliosis/veterinary ; Malnutrition/veterinary ; Ataxia/veterinary ; Biopsy/veterinary ; Cat Diseases/diagnosis ; Cat Diseases/etiology
    Language English
    Publishing date 2024-02-28
    Publishing country Canada
    Document type Case Reports
    ZDB-ID 41603-4
    ISSN 0008-5286
    ISSN 0008-5286
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    Zs.B 572: Show issues Location:
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  4. Article ; Online: Squamous cell carcinoma-derived G-CSF promotes tumor growth and metastasis in mice through neutrophil recruitment and tumor cell proliferation, associated with poor prognosis of the patients.

    Kemuriyama, Kohei / An, Jianbo / Motoyama, Satoru / Nagaki, Yushi / Yamaguchi, Tomokazu / Sato, Yusuke / Wakita, Akiyuki / Minamiya, Yoshihiro / Kuba, Keiji

    Genes to cells : devoted to molecular & cellular mechanisms

    2023  Volume 28, Issue 8, Page(s) 573–584

    Abstract: Tumor-derived G-CSF is a well-known factor to aggravate disease progression in various types of cancers. In this study, we investigated a role of G-CSF in squamous cell carcinoma (SCC). High expression of G-CSF in the tumor tissues of esophageal SCC ( ... ...

    Abstract Tumor-derived G-CSF is a well-known factor to aggravate disease progression in various types of cancers. In this study, we investigated a role of G-CSF in squamous cell carcinoma (SCC). High expression of G-CSF in the tumor tissues of esophageal SCC (ESCC) patients correlated with poor prognosis. Murine SCC NR-S1M cells produce considerable amount of G-CSF, which expression is correlated with its metastatic potentials. Deletion of G-CSF in NR-S1M cells mitigated tumor growth and metastasis to lymph node and lung of subcutaneous NR-S1M tumors in the mice. Mechanistically, G-CSF enhanced cell proliferation in autocrine manner in vitro, whereas in NR-S1M tumor-bearing mice, accumulation of plasma G-CSF was associated with expansion of peripheral neutrophils, which led to a decreased proportion of CD8
    MeSH term(s) Animals ; Mice ; CD8-Positive T-Lymphocytes/metabolism ; CD8-Positive T-Lymphocytes/pathology ; Granulocyte Colony-Stimulating Factor/metabolism ; Neutrophil Infiltration ; Esophageal Neoplasms/genetics ; Carcinoma, Squamous Cell/genetics ; Cell Proliferation ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic
    Chemical Substances Granulocyte Colony-Stimulating Factor (143011-72-7)
    Language English
    Publishing date 2023-05-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 1330000-3
    ISSN 1365-2443 ; 1356-9597
    ISSN (online) 1365-2443
    ISSN 1356-9597
    DOI 10.1111/gtc.13051
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    Zs.A 4539: Show issues Location:
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  5. Article ; Online: Relationship between brain volume reduction during the acute phase of sepsis and activities of daily living in elderly patients: A prospective cohort study.

    Hosokawa, Toru / Kinoshita, Kosaku / Ihara, Shingo / Nakagawa, Katsuhiro / Iguchi, Umefumi / Hirabayashi, Marina / Mutoh, Tomokazu / Sawada, Nami / Kuwana, Tsukasa / Yamaguchi, Junko

    PloS one

    2023  Volume 18, Issue 5, Page(s) e0284886

    Abstract: Brain damage in acute sepsis may be associated with poor long-term outcomes that impair reintegration into society. We aimed to clarify whether brain volume reduction occurs during the acute phase of sepsis in patients with acute brain damage. In this ... ...

    Abstract Brain damage in acute sepsis may be associated with poor long-term outcomes that impair reintegration into society. We aimed to clarify whether brain volume reduction occurs during the acute phase of sepsis in patients with acute brain damage. In this prospective, noninterventional observational study, brain volume reduction was evaluated by comparing head computed tomography findings at admission with those obtained during hospitalization. We examined the association between brain volume reduction and performance of the activities of daily living in 85 consecutive patients (mean age, 77 ± 12.7 years) with sepsis or septic shock. The bicaudate ratio increased in 38/58 (65.5%) patients, Evans index increased in 35/58 (60.3%) patients, and brain volume by volumetry decreased in 46/58 (79.3%) patients from the first to the second measurement, with significant increases in the bicaudate ratio (P < 0.0001) and Evans index (P = 0.0005) and a significant decrease in the brain volume by volumetry (P < 0.0001). The change rate for brain volume by volumetry was significantly correlated with the Katz index (ρ = -0.3790, P = 0.0094). In the acute phase of sepsis in this sample of older patients, 60-79% of patients showed decreased brain volumes. This was associated with a decreased capacity for performing activities of daily living.
    MeSH term(s) Humans ; Aged ; Middle Aged ; Aged, 80 and over ; Prospective Studies ; Activities of Daily Living ; Sepsis/complications ; Shock, Septic/complications ; Brain/diagnostic imaging
    Language English
    Publishing date 2023-05-16
    Publishing country United States
    Document type Observational Study ; Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0284886
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  6. Article ; Online: Successful management of segmental zoster paresis on the upper arm with temporally burst spinal cord stimulation.

    Yamaguchi, Keisuke / Kawabe-Ishibashi, Chika / Iida, Shie / Saito, Takayuki / Takakura, Tomokazu

    Journal of anesthesia

    2022  Volume 36, Issue 2, Page(s) 323–326

    Abstract: Segmental zoster paresis (SZP) of the limbs is characterized by a focal, asymmetric neurogenic weakness that may occur in an extremity affected by herpes zoster (HZ). In this case report, we describe the case of a patient with SZP who presented with ... ...

    Abstract Segmental zoster paresis (SZP) of the limbs is characterized by a focal, asymmetric neurogenic weakness that may occur in an extremity affected by herpes zoster (HZ). In this case report, we describe the case of a patient with SZP who presented with these problems and responded well to temporary spinal cord stimulation (SCS) and systematic rehabilitation. A 62-year-old female patient was referred for right upper limb pain, weakness, and insomnia due to pain. After completing the 14-day trial stimulation, the pain numerical rating scale of the patient in the right upper extremity decreased from 8/10 to 2/10. The Athens insomnia scale score decreased from 15/24 to 10/24. Furthermore, the grip strength of the right hands increased from 6.7 to 16.8 kg at discharge. We induced temporal SCS and rehabilitation of the right upper limb SZP and successfully reduced the pain. An in-depth understanding of the neurological complications secondary to HZ should be emphasized, with temporal SCS and rehabilitation expected to play a crucial role in the motor recovery of patients with SZP.
    MeSH term(s) Arm ; Female ; Herpes Zoster/complications ; Herpes Zoster/therapy ; Humans ; Middle Aged ; Paresis/complications ; Paresis/therapy ; Spinal Cord Stimulation ; Upper Extremity
    Language English
    Publishing date 2022-03-10
    Publishing country Japan
    Document type Case Reports ; Journal Article
    ZDB-ID 1107821-2
    ISSN 1438-8359 ; 0913-8668
    ISSN (online) 1438-8359
    ISSN 0913-8668
    DOI 10.1007/s00540-022-03056-5
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    Zs.A 3408: Show issues Location:
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  7. Article ; Online: Evaluation of improvement in quality of life after acupuncture in a patient with cervical dystonia: a case report.

    Horibe, Go / Yamaguchi, Satoru / Kikuchi, Tomokazu / Kubo, Asako / Kouchi, Ai / Isobe, Hideyuki / Araki, Nobuo

    Acupuncture in medicine : journal of the British Medical Acupuncture Society

    2020  Volume 39, Issue 4, Page(s) 391–393

    Language English
    Publishing date 2020-12-16
    Publishing country England
    Document type Letter
    ZDB-ID 1360533-1
    ISSN 1759-9873 ; 0964-5284
    ISSN (online) 1759-9873
    ISSN 0964-5284
    DOI 10.1177/0964528420958721
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    Zs.A 4628: Show issues Location:
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  8. Article ; Online: Author Correction: Lgals9 deficiency ameliorates obesity by modulating redox state of PRDX2.

    Nunoue, Tomokazu / Yamaguchi, Satoshi / Teshigawara, Sanae / Katayama, Akihiro / Nakatsuka, Atsuko / Eguchi, Jun / Niki, Toshiro / Wada, Jun

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 18611

    Language English
    Publishing date 2021-09-14
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-98293-1
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  9. Article: PMX-DHP Therapy for Dyspnea and Deoxygenation in Severe COVID-19 Pneumonia: A Case Series.

    Kuwana, Tsukasa / Kinoshita, Kosaku / Hirabayashi, Marina / Ihara, Shingo / Sawada, Nami / Mutoh, Tomokazu / Yamaguchi, Junko

    Infection and drug resistance

    2021  Volume 14, Page(s) 1305–1310

    Abstract: Hypercytokinemia induced by coronavirus disease-19 (COVID-19) is associated with severe pulmonary involvement, which may lead to respiratory failure. These conditions play an important role in the worsening of clinical symptoms in patients with severe ... ...

    Abstract Hypercytokinemia induced by coronavirus disease-19 (COVID-19) is associated with severe pulmonary involvement, which may lead to respiratory failure. These conditions play an important role in the worsening of clinical symptoms in patients with severe COVID-19. There is no established treatment for hypercytokinemia. We report on two patients whose clinical symptoms improved after direct hemoperfusion using polymyxin B-immobilized fiber column (PMX-DHP), following the administration of the anti-inflammatory agent tocilizumab. Case A was a 70-year-old man diagnosed with COVID-19 pneumonia. Despite treatment with ciclesonide and favipiravir, supplemental oxygen was administered due to the worsening of dyspnea with tachypnea. Although tocilizumab was started on day 6, the patient deteriorated into deoxygenation, presenting with the PaO
    Language English
    Publishing date 2021-04-06
    Publishing country New Zealand
    Document type Case Reports
    ZDB-ID 2494856-1
    ISSN 1178-6973
    ISSN 1178-6973
    DOI 10.2147/IDR.S299023
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  10. Article: Moraxella lacunata

    Sawada, Nami / Morohashi, Tamaki / Mutoh, Tomokazu / Kuwana, Tsukasa / Yamaguchi, Junko / Kinoshita, Kosaku / Morioka, Ichiro / Hao, Hiroyuki

    Open medicine (Warsaw, Poland)

    2020  Volume 15, Issue 1, Page(s) 962–967

    Abstract: Moraxella ... ...

    Abstract Moraxella lacunata
    Language English
    Publishing date 2020-10-01
    Publishing country Poland
    Document type Case Reports
    ZDB-ID 2829380-0
    ISSN 2391-5463
    ISSN 2391-5463
    DOI 10.1515/med-2020-0234
    Database MEDical Literature Analysis and Retrieval System OnLINE

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