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  1. Article ; Online: Small regulatory RNAs: from bench to bedside - a keystone symposia meeting report.

    Lee, Soo Mi / Winters, Michael T / Martinez, Ivan / Slack, Frank J

    RNA biology

    2023  Volume 20, Issue 1, Page(s) 136–139

    Abstract: The Keystone Symposium ' ...

    Abstract The Keystone Symposium '
    MeSH term(s) Humans ; RNA, Untranslated/genetics ; Congresses as Topic
    Chemical Substances RNA, Untranslated
    Language English
    Publishing date 2023-04-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2159587-2
    ISSN 1555-8584 ; 1555-8584
    ISSN (online) 1555-8584
    ISSN 1555-8584
    DOI 10.1080/15476286.2023.2196046
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  2. Article ; Online: Catheter reconstruction and dosimetric verification of MRI-only treatment planning (MRTP) for interstitial HDR brachytherapy using PETRA sequence.

    Lee, Casey Y / Kaza, Evangelia / Harris, Thomas C / O'Farrell, Desmond A / King, Martin T / Dyer, Michael A / Cormack, Robert A / Buzurovic, Ivan

    Physics in medicine and biology

    2023  Volume 68, Issue 3

    Abstract: ... ...

    Abstract Objective
    MeSH term(s) Female ; Humans ; Brachytherapy/methods ; Catheters ; Magnetic Resonance Imaging/methods ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted/methods ; Genital Neoplasms, Female/radiotherapy
    Chemical Substances metariboadenosine triphosphorous
    Language English
    Publishing date 2023-01-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 208857-5
    ISSN 1361-6560 ; 0031-9155
    ISSN (online) 1361-6560
    ISSN 0031-9155
    DOI 10.1088/1361-6560/acaf48
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  3. Article ; Online: Masqueraders of angioedema after a dental procedure.

    Lee, Ivan T / Arioka, Masaki / Kleinman, Sara H / Gernez, Yael

    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

    2020  Volume 124, Issue 6, Page(s) 536–541

    MeSH term(s) Angioedema/diagnosis ; Angioedema/etiology ; Child, Preschool ; Diagnosis, Differential ; Female ; Humans ; Postoperative Complications ; Pulpotomy/adverse effects ; Pulpotomy/methods ; Risk Factors ; Symptom Assessment
    Language English
    Publishing date 2020-03-20
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1228189-x
    ISSN 1534-4436 ; 0003-4738 ; 1081-1206
    ISSN (online) 1534-4436
    ISSN 0003-4738 ; 1081-1206
    DOI 10.1016/j.anai.2020.03.008
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  4. Article: Digital Modeling on Large Kernel Metamaterial Neural Network.

    Liu, Quan / Zheng, Hanyu / Swartz, Brandon T / Lee, Ho Hin / Asad, Zuhayr / Kravchenko, Ivan / Valentine, Jason G / Huo, Yuankai

    The Journal of imaging science and technology

    2023  Volume 67, Issue 6

    Abstract: Deep neural networks (DNNs) utilized recently are physically deployed with computational units (e.g., CPUs and GPUs). Such a design might lead to a heavy computational burden, significant latency, and intensive power consumption, which are critical ... ...

    Abstract Deep neural networks (DNNs) utilized recently are physically deployed with computational units (e.g., CPUs and GPUs). Such a design might lead to a heavy computational burden, significant latency, and intensive power consumption, which are critical limitations in applications such as the Internet of Things (IoT), edge computing, and the usage of drones. Recent advances in optical computational units (e.g., metamaterial) have shed light on energy-free and light-speed neural networks. However, the digital design of the metamaterial neural network (MNN) is fundamentally limited by its physical limitations, such as precision, noise, and bandwidth during fabrication. Moreover, the unique advantages of MNN's (e.g., light-speed computation) are not fully explored via standard 3×3 convolution kernels. In this paper, we propose a novel large kernel metamaterial neural network (LMNN) that maximizes the digital capacity of the state-of-the-art (SOTA) MNN with model re-parametrization and network compression, while also considering the optical limitation explicitly. The new digital learning scheme can maximize the learning capacity of MNN while modeling the physical restrictions of meta-optic. With the proposed LMNN, the computation cost of the convolutional front-end can be offloaded into fabricated optical hardware. The experimental results on two publicly available datasets demonstrate that the optimized hybrid design improved classification accuracy while reducing computational latency. The development of the proposed LMNN is a promising step towards the ultimate goal of energy-free and light-speed AI.
    Language English
    Publishing date 2023-11-29
    Publishing country United States
    Document type Journal Article
    ISSN 1062-3701
    ISSN 1062-3701
    DOI 10.2352/j.imagingsci.technol.2023.67.6.060404
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  5. Article ; Online: First pointwise encoding time reduction with radial acquisition (PETRA) implementation for catheter detection in interstitial high-dose-rate (HDR) brachytherapy.

    Kaza, Evangelia / Lee, Casey Y / King, Martin T / Dyer, Michael A / Cormack, Robert A / Buzurovic, Ivan

    Brachytherapy

    2022  Volume 21, Issue 4, Page(s) 501–510

    Abstract: Purpose: A pointwise encoding time reduction with radial acquisition (PETRA) sequence was optimized to detect empty catheters in interstitial (HDR) brachytherapy with clinically acceptable spatial accuracy for the first time. Image quality and catheter ... ...

    Abstract Purpose: A pointwise encoding time reduction with radial acquisition (PETRA) sequence was optimized to detect empty catheters in interstitial (HDR) brachytherapy with clinically acceptable spatial accuracy for the first time. Image quality and catheter detectability were assessed in phantoms, and the feasibility of PETRA's clinical implementation was assessed on a gynecological cancer patient.
    Methods and results: Empty catheters embedded in a gelatin phantom displayed positive signal on PETRA and more accurate cross-sections than on clinically employed T2-weighted sequences, differing by 0.4 mm on average from their nominal 2 mm diameter. PETRA presented minimal susceptibility differences and a symmetric metal artifact, contrary to the clinical sequences. The PETRA-CT catheter tip position differences assessed by a treatment planning system (TPS) were < 1 mm. PETRA also detected an interstitial template with empty catheters penetrating a poultry phantom and fused very well with CT. Interstitial catheter positional difference between PETRA and CT images was < 1 mm on average, increasing with distance from isocenter. All interstitial catheters and the employed interstitial template were detected on PETRA images of an endometrial adenocarcinoma patient. Empty needles were traceable using a TPS, with higher spatial resolution and more favorable contrast than on T2-weighted images used for contouring. A treatment plan could be produced by combining information from PETRA for catheter detection and from T2-weighted images for tumor and organs delineation.
    Conclusions: PETRA detected successfully and accurately interstitial catheters in phantoms. Its first clinical implementation shows a potential for MR-only treatment planning in interstitial HDR brachytherapy.
    MeSH term(s) Brachytherapy/methods ; Catheters ; Humans ; Needles ; Phantoms, Imaging ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted/methods
    Language English
    Publishing date 2022-03-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2098608-7
    ISSN 1873-1449 ; 1538-4721
    ISSN (online) 1873-1449
    ISSN 1538-4721
    DOI 10.1016/j.brachy.2022.01.003
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    Zs.A 6116: Show issues Location:
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  6. Article ; Online: Feasibility of advancing the development of compact energy systems.

    Gunukula, Sampath / Lee, Ivan C / Tran, Dat T

    RSC advances

    2019  Volume 9, Issue 49, Page(s) 28618–28626

    Abstract: It is necessary to advance the development of compact energy systems for making energy from biomass like wood or switchgrass, as an alternative to the construction of highly capital-intensive large scale biorefineries. Compact energy systems consist of ... ...

    Abstract It is necessary to advance the development of compact energy systems for making energy from biomass like wood or switchgrass, as an alternative to the construction of highly capital-intensive large scale biorefineries. Compact energy systems consist of four individual components: a biomass preparation unit, a biomass converter, a fuel processor, and a powered engine. The individual unit processes within each component and the possible types of compact energy systems with different biomass converter technologies like fermentation, pyrolysis, and gasification are presented. The size, weight, and energy efficiency of upgrading biomass to energy using a compact energy system with various gasification technologies has been estimated. A compact energy system with a hydrogen fuel cell as a powered-engine component, processing 10 kg of dry biomass per day, generates a net energy (kW h) of -7.5, -30, 18.7, 13.1, and 11.7 with the super-critical, microwave assisted, catalytic, steam, and conventional gasification technologies as biomass converter technologies, respectively. The low yields of super-critical gasification and low efficacy of converting electric energy to heat
    Language English
    Publishing date 2019-09-11
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/c9ra06039a
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  7. Article ; Online: Prognostic value of severe acute respiratory syndrome coronavirus-2 viral load and antibodies in patients hospitalized with COVID-19.

    Bauer, Rebecca N / Teterina, Anastasia / Shivram, Haridha / McBride, Jacqueline / Rosenberger, Carrie M / Cai, Fang / Bao, Min / Tsai, Larry / Gordon, Oliver / Lee, Ivan T / Wallin, Jeffrey J / Porter, Danielle / Juneja, Kavita / Camus, Gregory / Rosas, Ivan O / Wildum, Steffen

    Clinical and translational science

    2023  Volume 16, Issue 6, Page(s) 1049–1062

    Abstract: Observational studies have identified the potential prognostic value for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) viral load and anti-SARS-CoV-2 antibodies in coronavirus disease 2019 (COVID-19). However, viral load in nasopharyngeal ( ...

    Abstract Observational studies have identified the potential prognostic value for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) viral load and anti-SARS-CoV-2 antibodies in coronavirus disease 2019 (COVID-19). However, viral load in nasopharyngeal (NP) swabs produced inconsistent results in prognostic analyses, and the prognostic value of viral load or antibodies has not been confirmed in large clinical trials. COVACTA and REMDACTA were double-blind, randomized, controlled trials with a combined enrollment of 1078 patients hospitalized with COVID-19 treated with tocilizumab or placebo in COVACTA or tocilizumab plus remdesivir or placebo plus remdesivir in REMDACTA. We assessed the potential prognostic value of NP and serum SARS-CoV-2 viral load and serum anti-SARS-CoV-2 antibodies at baseline as biomarkers for clinical outcomes in patients enrolled in these trials. In adjusted Cox proportional hazard models, serum viral load was a more reliable predictor of clinical outcomes than NP viral load; high serum viral load was associated with higher risk for death and mechanical ventilation/death and lower likelihood of hospital discharge (high vs. negative viral load hazard ratios [95% confidence interval {CI}] were 2.87 [1.57-5.25], 3.86 [2.23-6.68], and 0.23 [0.14-0.36], respectively, in COVACTA and 8.11 [2.95-22.26], 10.29 [4.5-23.55], and 0.21 [0.15-0.29], respectively, in REMDACTA) and high serum viral load correlated with levels of inflammatory cytokines and lung damage biomarkers. High anti-SARS-CoV-2 spike protein antibody (ACOV2S) levels were associated with higher likelihood of hospital discharge (high vs. below the limit of quantification hazard ratios [95% CI] were 2.55 [1.59-4.08] for COVACTA and 1.54 [1.13-2.09] for REMDACTA). These results support the role of baseline SARS-CoV-2 serum viral load and ACOV2S antibody titers in predicting clinical outcomes for patients hospitalized with COVID-19.
    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2 ; Prognosis ; Viral Load ; Lung ; Antibodies, Viral
    Chemical Substances Antibodies, Viral
    Language English
    Publishing date 2023-03-29
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2433157-0
    ISSN 1752-8062 ; 1752-8054
    ISSN (online) 1752-8062
    ISSN 1752-8054
    DOI 10.1111/cts.13511
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  8. Article ; Online: Prognostic value of severe acute respiratory syndrome coronavirus‐2 viral load and antibodies in patients hospitalized with COVID‐19

    Rebecca N. Bauer / Anastasia Teterina / Haridha Shivram / Jacqueline McBride / Carrie M. Rosenberger / Fang Cai / Min Bao / Larry Tsai / Oliver Gordon / Ivan T. Lee / Jeffrey J. Wallin / Danielle Porter / Kavita Juneja / Gregory Camus / Ivan O. Rosas / Steffen Wildum

    Clinical and Translational Science, Vol 16, Iss 6, Pp 1049-

    2023  Volume 1062

    Abstract: Abstract Observational studies have identified the potential prognostic value for severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) viral load and anti‐SARS‐CoV‐2 antibodies in coronavirus disease 2019 (COVID‐19). However, viral load in ... ...

    Abstract Abstract Observational studies have identified the potential prognostic value for severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) viral load and anti‐SARS‐CoV‐2 antibodies in coronavirus disease 2019 (COVID‐19). However, viral load in nasopharyngeal (NP) swabs produced inconsistent results in prognostic analyses, and the prognostic value of viral load or antibodies has not been confirmed in large clinical trials. COVACTA and REMDACTA were double‐blind, randomized, controlled trials with a combined enrollment of 1078 patients hospitalized with COVID‐19 treated with tocilizumab or placebo in COVACTA or tocilizumab plus remdesivir or placebo plus remdesivir in REMDACTA. We assessed the potential prognostic value of NP and serum SARS‐CoV‐2 viral load and serum anti‐SARS‐CoV‐2 antibodies at baseline as biomarkers for clinical outcomes in patients enrolled in these trials. In adjusted Cox proportional hazard models, serum viral load was a more reliable predictor of clinical outcomes than NP viral load; high serum viral load was associated with higher risk for death and mechanical ventilation/death and lower likelihood of hospital discharge (high vs. negative viral load hazard ratios [95% confidence interval {CI}] were 2.87 [1.57–5.25], 3.86 [2.23–6.68], and 0.23 [0.14–0.36], respectively, in COVACTA and 8.11 [2.95–22.26], 10.29 [4.5–23.55], and 0.21 [0.15–0.29], respectively, in REMDACTA) and high serum viral load correlated with levels of inflammatory cytokines and lung damage biomarkers. High anti‐SARS‐CoV‐2 spike protein antibody (ACOV2S) levels were associated with higher likelihood of hospital discharge (high vs. below the limit of quantification hazard ratios [95% CI] were 2.55 [1.59–4.08] for COVACTA and 1.54 [1.13–2.09] for REMDACTA). These results support the role of baseline SARS‐CoV‐2 serum viral load and ACOV2S antibody titers in predicting clinical outcomes for patients hospitalized with COVID‐19.
    Keywords Therapeutics. Pharmacology ; RM1-950 ; Public aspects of medicine ; RA1-1270
    Subject code 610
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Suture medialization of middle turbinate during endoscopic sinus surgery does not impair olfaction.

    Shih, Liang-Chun / Hsu, Chun-Chieh / Bing-Han, Hsieh / Lee, Ivan T / Tsou, Yung-An / Tsai, Ming-Hsui / Tai, Chih-Jaan

    International forum of allergy & rhinology

    2021  Volume 12, Issue 3, Page(s) 318–320

    MeSH term(s) Chronic Disease ; Endoscopy ; Humans ; Olfaction Disorders ; Paranasal Sinuses/surgery ; Rhinitis/surgery ; Smell ; Sutures ; Turbinates/surgery
    Language English
    Publishing date 2021-12-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2625826-2
    ISSN 2042-6984 ; 2042-6976
    ISSN (online) 2042-6984
    ISSN 2042-6976
    DOI 10.1002/alr.22908
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    Zs.A 6927: Show issues Location:
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  10. Article ; Online: Clinical outcomes and dosimetric predictors of toxicity for re-irradiation of vaginal recurrence of endometrial cancer.

    Lee, Larissa J / Alban, Gabriela M / Cheng, Teresa / Buzurovic, Ivan / Pretz, Jennifer / Singer, Lisa / King, Martin T

    Brachytherapy

    2022  Volume 21, Issue 3, Page(s) 263–272

    Abstract: Objective: To report clinical outcomes and dosimetric predictors of late toxicity for patients with vaginal recurrence of endometrial cancer treated with brachytherapy in the re-irradiation setting.: Methods: On retrospective review, 32 patients with ...

    Abstract Objective: To report clinical outcomes and dosimetric predictors of late toxicity for patients with vaginal recurrence of endometrial cancer treated with brachytherapy in the re-irradiation setting.
    Methods: On retrospective review, 32 patients with vaginal recurrence of endometrial cancer received salvage brachytherapy with or without pelvic radiotherapy (RT) from 06/2003-12/2017. Prior RT modalities were vaginal brachytherapy (19, 59%), pelvic RT (7, 22%) or both (6, 19%). Image-guided brachytherapy was performed with CT- (25, 78%) or MR-guidance (7, 22%). Vaginal control, recurrence-free survival (RFS) and overall survival (OS) were estimated by Kaplan-Meier method. Late toxicity was graded by Common Toxicity Criteria for Adverse Events.
    Results: Median time from prior RT to re-irradiation was 22 months (range, 4-140). Salvage RT modalities were pelvic RT and brachytherapy (25, 78%) or brachytherapy alone (7, 22%). With median follow-up of 47 months, 3/5-year vaginal control, RFS and OS rates were 64/56%, 47/41% and 68/42%, respectively. Six patients (19%) had no evidence of disease at 85-155 months. Late grade 2/3 GI, GU and vaginal toxicity rates were 13%/16%, 19%/13%, and 9%/16%. Cumulative D2cc rectum (sum of prior and salvage RT courses) was predictive of grade 2+ and grade 3 GI toxicity. Cumulative D2cc rectum for an estimated 10% risk of late grade 2+ and 3 GI toxicity was 86 Gy and 92 Gy, respectively.
    Conclusions: Salvage image-guided brachytherapy in the re-irradiation setting results in modest local control and increased late toxicity for localized recurrent endometrial cancer. With long-term disease control, cumulative D2cc rectum may be used to reduce late GI complication risk.
    MeSH term(s) Brachytherapy/methods ; Endometrial Neoplasms/radiotherapy ; Female ; Humans ; Neoplasm Recurrence, Local/etiology ; Neoplasm Recurrence, Local/radiotherapy ; Re-Irradiation/adverse effects ; Retrospective Studies ; Salvage Therapy/methods
    Language English
    Publishing date 2022-01-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2098608-7
    ISSN 1873-1449 ; 1538-4721
    ISSN (online) 1873-1449
    ISSN 1538-4721
    DOI 10.1016/j.brachy.2021.12.010
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