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  1. Article: Not all that is miliary is tuberculosis: Metastatic medullary thyroid carcinoma mimicking miliary tuberculosis.

    Askari, Elham / Pourabdollah Toutkaboni, Mihan / Haseli, Sara / Rezaei, Mitrasadat / Tabarsi, Payam / Marjani, Majid / Moniri, Afshin / Khalili, Neda

    Clinical case reports

    2021  Volume 9, Issue 5, Page(s) e04231

    Abstract: Medullary carcinoma of the thyroid should be considered in the differential diagnosis of miliary pattern of micronodules on chest imaging, irrespective of clinical features. ...

    Abstract Medullary carcinoma of the thyroid should be considered in the differential diagnosis of miliary pattern of micronodules on chest imaging, irrespective of clinical features.
    Language English
    Publishing date 2021-05-15
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.4231
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: ACE2: Its potential role and regulation in severe acute respiratory syndrome and COVID-19.

    Rezaei, Mitrasadat / Ziai, Seyed Ali / Fakhri, Sajad / Pouriran, Ramin

    Journal of cellular physiology

    2020  Volume 236, Issue 4, Page(s) 2430–2442

    Abstract: COVID-19, a new disease caused by the 2019-novel coronavirus (SARS-CoV-2), has swept the world and challenged its culture, economy, and health infrastructure. Forced emergence to find an effective vaccine to immunize people has led scientists to design ... ...

    Abstract COVID-19, a new disease caused by the 2019-novel coronavirus (SARS-CoV-2), has swept the world and challenged its culture, economy, and health infrastructure. Forced emergence to find an effective vaccine to immunize people has led scientists to design and examine vaccine candidates all over the world. Until a vaccine is developed, however, effective treatment is needed to combat this virus, which is resistant to all conventional antiviral drugs. Accordingly, more about the structure, entry mechanism, and pathogenesis of COVID-19 is required. Angiotensin-converting enzyme 2 (ACE2) is the gateway to SARS-CoV and SARS-CoV-2, so our knowledge of SARS-CoV-2 can help us to complete its mechanism of interaction with ACE2 and virus endocytosis, which can be interrupted by neutralizing small molecules or proteins. ACE2 also plays a crucial role in lung injury.
    MeSH term(s) Angiotensin-Converting Enzyme 2/metabolism ; COVID-19/metabolism ; COVID-19/physiopathology ; Humans ; SARS-CoV-2/pathogenicity ; Severe Acute Respiratory Syndrome/metabolism ; Severe Acute Respiratory Syndrome/physiopathology ; Virus Internalization
    Chemical Substances ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Keywords covid19
    Language English
    Publishing date 2020-09-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 3116-1
    ISSN 1097-4652 ; 0021-9541
    ISSN (online) 1097-4652
    ISSN 0021-9541
    DOI 10.1002/jcp.30041
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: ACE2

    Rezaei, Mitrasadat / Ziai, Seyed Ali / Fakhri, Sajad / Pouriran, Ramin

    Journal of Cellular Physiology ; ISSN 0021-9541 1097-4652

    Its potential role and regulation in severe acute respiratory syndrome and COVID‐19

    2020  

    Keywords Clinical Biochemistry ; Cell Biology ; Physiology ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    DOI 10.1002/jcp.30041
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Not all that is miliary is tuberculosis

    Elham Askari / Mihan Pourabdollah Toutkaboni / Sara Haseli / Mitrasadat Rezaei / Payam Tabarsi / Majid Marjani / Afshin Moniri / Neda Khalili

    Clinical Case Reports, Vol 9, Iss 5, Pp n/a-n/a (2021)

    Metastatic medullary thyroid carcinoma mimicking miliary tuberculosis

    2021  

    Abstract: Abstract Medullary carcinoma of the thyroid should be considered in the differential diagnosis of miliary pattern of micronodules on chest imaging, irrespective of clinical features. ...

    Abstract Abstract Medullary carcinoma of the thyroid should be considered in the differential diagnosis of miliary pattern of micronodules on chest imaging, irrespective of clinical features.
    Keywords case report ; computed tomography ; immunohistochemistry ; medullary thyroid carcinoma ; miliary tuberculosis ; Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2021-05-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Relapse of Lymphangioleiomyomatosis Five Years after Bilateral-Lung Transplantation.

    Heshmatnia, Jalal / Mirenayat, Maryam Sadat / Rezaei, Mitrasadat / Bongomin, Felix / Bakhshayeshkaram, Mehrdad / Tabarsi, Payam / Sheikhy, Kambiz / Mortezaee, Vida

    Archives of Iranian medicine

    2021  Volume 24, Issue 9, Page(s) 701–703

    Abstract: Pulmonary lymphangioleiomyomatosis (LAM) is an uncommon disease principally affecting women during childbearing years and eventually leading to progressive respiratory failure. Lung transplantation is a viable option for patients with end-stage disease. ... ...

    Abstract Pulmonary lymphangioleiomyomatosis (LAM) is an uncommon disease principally affecting women during childbearing years and eventually leading to progressive respiratory failure. Lung transplantation is a viable option for patients with end-stage disease. LAM-related complications remain common, but recurrence of LAM following allograft transplantation is rare. We present a 25-year-old woman who presented with progressive dyspnea five years after bilateral lung transplantation for end-stage LAM. Histological examination of transbronchial lung biopsy sample confirmed recurrent LAM. We changed cyclosporine to sirolimus and she is currently being considered for re-transplantation.
    MeSH term(s) Adult ; Chronic Disease ; Female ; Humans ; Lung Neoplasms/etiology ; Lung Neoplasms/surgery ; Lung Transplantation/adverse effects ; Lymphangioleiomyomatosis/surgery ; Neoplasm Recurrence, Local
    Language English
    Publishing date 2021-09-01
    Publishing country Iran
    Document type Case Reports ; Journal Article
    ZDB-ID 2204979-4
    ISSN 1735-3947 ; 1029-2977
    ISSN (online) 1735-3947
    ISSN 1029-2977
    DOI 10.34172/aim.2021.101
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6228: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: ACE2: Its potential role and regulation in severe acute respiratory syndrome and COVID-19

    Rezaei, Mitrasadat / Ziai, Seyed Ali / Fakhri, Sajad / Pouriran, Ramin

    J. cell. physiol

    Abstract: COVID-19, a new disease caused by the 2019-novel coronavirus (SARS-CoV-2), has swept the world and challenged its culture, economy, and health infrastructure. Forced emergence to find an effective vaccine to immunize people has led scientists to design ... ...

    Abstract COVID-19, a new disease caused by the 2019-novel coronavirus (SARS-CoV-2), has swept the world and challenged its culture, economy, and health infrastructure. Forced emergence to find an effective vaccine to immunize people has led scientists to design and examine vaccine candidates all over the world. Until a vaccine is developed, however, effective treatment is needed to combat this virus, which is resistant to all conventional antiviral drugs. Accordingly, more about the structure, entry mechanism, and pathogenesis of COVID-19 is required. Angiotensin-converting enzyme 2 (ACE2) is the gateway to SARS-CoV and SARS-CoV-2, so our knowledge of SARS-CoV-2 can help us to complete its mechanism of interaction with ACE2 and virus endocytosis, which can be interrupted by neutralizing small molecules or proteins. ACE2 also plays a crucial role in lung injury.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #754821
    Database COVID19

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  7. Article: Radiological and Laboratory Findings of Patients with COVID-19 Infection at the Time of Admission.

    Mirsadraee, Saeed / Pourabrollah Toutkaboni, Mihan / Bakhshayeshkaram, Mehrdad / Rezaei, Mitrasadat / Askari, Elham / Haseli, Sara / Sadraee, Nazanin

    Iranian journal of pathology

    2020  Volume 16, Issue 2, Page(s) 137–143

    Abstract: Background & objective: Diagnosis of coronavirus disease 2019 (COVID-19) can be challenging, especially when the real-time quantitative reverse transcription polymerase chain reaction (RT-PCR) is not available or it is negative. In this study, we ... ...

    Abstract Background & objective: Diagnosis of coronavirus disease 2019 (COVID-19) can be challenging, especially when the real-time quantitative reverse transcription polymerase chain reaction (RT-PCR) is not available or it is negative. In this study, we evaluated imaging and laboratory findings in a group of patients with a multidisciplinary diagnosis of COVID-19 pneumonia.
    Methods: A total of 163 patients with a clinical diagnosis of COVID-19 pneumonia admitted to a specialised respiratory centre in Tehran, Iran were enrolled in this study. The distribution and characteristics of presenting radiological and laboratory findings were evaluated and the relationship to the outcome was investigated.
    Results: RT-PCR was positive in 92 patients. The diagnosis of COVID-19 in RT-PCR negative patients was made on clinical and radiological features (n=71) and 24 (14.7%) patients died of disease. The common computed tomography (CT) scan findings included ground-glass (94%) and consolidating opacification (12%), mainly in the lower lobes (90%). Peripheral and central lung changes were observed in 90% and 52% of patients, respectively. Lymphopenia, positive CRP, and raised LDH were present in 32%, 65%, and 96% of cases, respectively. A raised LDH of >500U/L was the best predictor of death in these patients (R
    Conclusion: Diagnosis of COVID-19 can be challenging, and a multidisciplinary approach is often needed. Whilst RT-PCR is still the standard diagnostic test, a negative test should be interpreted with caution. Blood tests and imaging can be useful in the diagnosis, monitoring, and risk assessment in patients with COVID-19.
    Language English
    Publishing date 2020-10-21
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2478278-6
    ISSN 1735-5303 ; 2345-3656
    ISSN 1735-5303 ; 2345-3656
    DOI 10.30699/IJP.2020.128909.2415
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  8. Article ; Online: In Silico Identification of Potentially Effective Herbal Inhibitors of SARS-Cov-2 Main Protease by Virtual Screening Method

    Dowlati Beirami, Amirreza / Hatamabadi, Dara / Iranpanah, Sayna / Rezaei, Mitrasadat / Ziai, Seyed Ali

    School of Medicine Students' Journal; Vol. 2 No.; 2-6 ; 2676-7597

    Potential Anti-COVID-19 Molecules

    2020  Volume 3, Issue : Summer

    Abstract: Background: The COVID-19 pandemic is a global health emergency caused by SARS-CoV-2. Unfortunately, no effective drugs have been found to date. There is also a major need for new therapies to treat this disease. The main protease is an attractive drug ... ...

    Abstract Background: The COVID-19 pandemic is a global health emergency caused by SARS-CoV-2. Unfortunately, no effective drugs have been found to date. There is also a major need for new therapies to treat this disease. The main protease is an attractive drug target among coronaviruses due to its important role in the processing of viral RNA-translated polyproteins. Objective of This study was conducted to screen databases of herbal compounds for potential main protease inhibitors.Material and Methods: Natural products from 3 database banks were first tested and filtered by ADME / toxicity, then their molecular energy was minimized, and finally, they were docked into the SARS-CoV-2 main protease and compared with indinavir.Results: The binding energies of 6570 molecules from different herbal compounds comprising databases were tested and five of the molecules with the highest binding energies for SARS-CoV-2 main protease docking were selected and key interactions were studied.Conclusion: In conclusion, five herbal compounds including Sodwanone B, Cyclomulberrin, and a glycosylated derivative of kaempferol had lower docking energy compared to indinavir and were suggested for further research.
    Keywords covid19
    Subject code 540
    Language English
    Publishing date 2020-09-07
    Publisher School of Medicine Students' Journal
    Publishing country ir
    Document type Article ; Online
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  9. Article: Demographics, laboratory parameters and outcomes of 1061 patients with COVID-19: A report from Tehran, Iran

    Toutkaboni, Mihan Pourabdollah / Askari, Elham / Khalili, Nastaran / Tabarsi, Payam / Jamaati, Hamidreza / Velayati, Ali Akbar / Dorudinia, Atosa / Rezaei, Mitrasadat / Nadji, Seyed Alireza / Mohamadnia, Abdolreza / Khalili, Neda

    New Microbes New Infect

    Abstract: We aimed to determine the characteristics of coronavirus disease-2019 among the Iranian population. In this study, we collected and analyzed the demographics, laboratory findings and outcomes of patients with COVID-19 who were admitted to Masih ... ...

    Abstract We aimed to determine the characteristics of coronavirus disease-2019 among the Iranian population. In this study, we collected and analyzed the demographics, laboratory findings and outcomes of patients with COVID-19 who were admitted to Masih Daneshvari Hospital in Tehran, Iran between February 20, 2020 and April 2, 2020. Of 1061 patients, the median age was 55 years (interquartile range [IQR], 44-66 years) and 692 (65.2%) were male. Among these, 129 (12.2%) patients died at some point during hospitalization in the ward or intensive care unit (ICU). From the remaining 932 survivors, 46 (5.0%) patients were admitted to the ICU and 886 (95.0%) patients were hospitalized in the ward. Patients who died were significantly older than those hospitalized in the ward (p<0.001). The median absolute number of lymphocytes was 1.2 × 103 per microliter (IQR, 0.9-1.6 × 103 per microliter) and 708 (66.7%) patients had lymphopenia (absolute lymphocyte count <1500 per microliter). Among the laboratory tests, D-dimer, serum ferritin and albumin had the strongest correlation with mortality (r = 0.455, r = 0.412, r = -0.406, respectively; p-values <0.001). Conclusively, laboratory findings could provide useful information in regard to the management of patients with COVID-19.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #813800
    Database COVID19

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