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  1. Article ; Online: Oxygen sensing; a stunningly elegant molecular machinery highjacked in cancer.

    Claesson-Welsh, Lena

    Upsala journal of medical sciences

    2020  Volume 125, Issue 3, Page(s) 205–210

    Abstract: Oxygen is of fundamental importance for most living organisms, and the maintenance of oxygen homeostasis is a key physiological challenge for all large animals. Oxygen deprivation, hypoxia, is a critical component of many human diseases including cancer, ...

    Abstract Oxygen is of fundamental importance for most living organisms, and the maintenance of oxygen homeostasis is a key physiological challenge for all large animals. Oxygen deprivation, hypoxia, is a critical component of many human diseases including cancer, heart disease, stroke, vascular disease, and anaemia. The discovery of oxygen sensing provides fundamental knowledge of a stunningly elegant molecular machinery; it also promises development of new therapeutics for serious diseases such as cancer. As a result of their impressive contributions to our understanding of the mechanisms by which cells sense oxygen and signal in hypoxia, Gregg Semenza, Peter Ratcliffe, and William Kaelin were awarded the Nobel Prize in 2019.
    MeSH term(s) Humans ; Neoplasms/metabolism ; Nobel Prize ; Oxygen/metabolism ; Tumor Hypoxia/physiology
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2020-06-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 183949-4
    ISSN 2000-1967 ; 0300-9734
    ISSN (online) 2000-1967
    ISSN 0300-9734
    DOI 10.1080/03009734.2020.1769231
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.426: Show issues Location:
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  2. Article ; Online: How the matrix metalloproteinase MMP14 contributes to the progression of colorectal cancer.

    Claesson-Welsh, Lena

    The Journal of clinical investigation

    2020  Volume 130, Issue 3, Page(s) 1093–1095

    Abstract: Certain matrix metalloproteinase (MMP) family proteins have been associated with cell proliferation and invasion in aggressive cancers. However, attempts to target the MMPs with the hope of treating tumors have thus far failed. In this issue of the JCI, ... ...

    Abstract Certain matrix metalloproteinase (MMP) family proteins have been associated with cell proliferation and invasion in aggressive cancers. However, attempts to target the MMPs with the hope of treating tumors have thus far failed. In this issue of the JCI, Ragusa and coworkers identified an intestinal cancer subgroup of slow-growing, chemotherapy-resistant, and very aggressive matrix-rich tumors that mimic a hard-to-treat colorectal cancer subtype in humans. These tumors showed downregulated levels of the transcription factor prospero homeobox protein 1 (PROX1), which relieved repression of the matrix metalloproteinase MMP14. Upregulated MMP14 levels correlated with blood vessel dysfunction and a lack of cytotoxic T cells. Notably, blockade of proangiogenic factors in combination with stimulation of the CD40 pathway in the mouse cancer model boosted cytotoxic T cell infiltration. The study illustrates how combinatorial treatments for aggressive, T cell-deficient cancers can launch an antitumor immune response.
    MeSH term(s) Angiogenesis Inhibitors ; Animals ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/genetics ; Humans ; Immunotherapy ; Matrix Metalloproteinase 14 ; Matrix Metalloproteinases ; Mice
    Chemical Substances Angiogenesis Inhibitors ; Matrix Metalloproteinases (EC 3.4.24.-) ; MMP14 protein, human (EC 3.4.24.80) ; Matrix Metalloproteinase 14 (EC 3.4.24.80)
    Language English
    Publishing date 2020-02-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI135239
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  3. Article ; Online: What is normal? Apelin and VEGFA, drivers of tumor vessel abnormality.

    Claesson-Welsh, Lena

    EMBO molecular medicine

    2019  Volume 11, Issue 8, Page(s) e10892

    Abstract: In this issue of EMBO Molecular Medicine, Uribesalgo and coworkers show that high Apelin expression correlates with poor survival in advanced breast (MMTV-NeuT) and lung ( ... ...

    Abstract In this issue of EMBO Molecular Medicine, Uribesalgo and coworkers show that high Apelin expression correlates with poor survival in advanced breast (MMTV-NeuT) and lung (KRAS
    MeSH term(s) Animals ; Apelin ; Humans ; Intercellular Signaling Peptides and Proteins ; Lung ; Lung Neoplasms ; Mice ; Vascular Endothelial Growth Factor A
    Chemical Substances Apelin ; Intercellular Signaling Peptides and Proteins ; VEGFA protein, human ; Vascular Endothelial Growth Factor A
    Language English
    Publishing date 2019-07-18
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2467145-9
    ISSN 1757-4684 ; 1757-4676
    ISSN (online) 1757-4684
    ISSN 1757-4676
    DOI 10.15252/emmm.201910892
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6784: Show issues Location:
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  4. Article ; Online: Oxygen sensing; a stunningly elegant molecular machinery highjacked in cancer

    Lena Claesson-Welsh

    Upsala Journal of Medical Sciences, Vol 125, Iss 3, Pp 205-

    2020  Volume 210

    Abstract: Oxygen is of fundamental importance for most living organisms, and the maintenance of oxygen homeostasis is a key physiological challenge for all large animals. Oxygen deprivation, hypoxia, is a critical component of many human diseases including cancer, ...

    Abstract Oxygen is of fundamental importance for most living organisms, and the maintenance of oxygen homeostasis is a key physiological challenge for all large animals. Oxygen deprivation, hypoxia, is a critical component of many human diseases including cancer, heart disease, stroke, vascular disease, and anaemia. The discovery of oxygen sensing provides fundamental knowledge of a stunningly elegant molecular machinery; it also promises development of new therapeutics for serious diseases such as cancer. As a result of their impressive contributions to our understanding of the mechanisms by which cells sense oxygen and signal in hypoxia, Gregg Semenza, Peter Ratcliffe, and William Kaelin were awarded the Nobel Prize in 2019.
    Keywords cancer ; hypoxia ; prolyl hydroxylation ; vegf ; Medicine ; R
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher Upsala Medical Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Alk1 (Activin Receptor-Like Kinase 1) and Vascular Hyperpermeability in Diabetic Retinopathy.

    Claesson-Welsh, Lena

    Arteriosclerosis, thrombosis, and vascular biology

    2018  Volume 38, Issue 8, Page(s) 1673–1675

    MeSH term(s) Activins ; Capillary Permeability ; Diabetic Retinopathy ; Growth Differentiation Factor 2 ; Humans ; Hyperglycemia
    Chemical Substances Growth Differentiation Factor 2 ; Activins (104625-48-1)
    Language English
    Publishing date 2018-12-21
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1221433-4
    ISSN 1524-4636 ; 1079-5642
    ISSN (online) 1524-4636
    ISSN 1079-5642
    DOI 10.1161/ATVBAHA.118.311365
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1705: Show issues Location:
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  6. Article ; Online: What is normal? Apelin and VEGFA, drivers of tumor vessel abnormality

    Lena Claesson‐Welsh

    EMBO Molecular Medicine, Vol 11, Iss 8, Pp n/a-n/a (2019)

    2019  

    Abstract: In this issue of EMBO Molecular Medicine, Uribesalgo and coworkers show that high Apelin expression correlates with poor survival in advanced breast (MMTV‐NeuT) and lung (KRASG12D) murine tumor models as well as in breast and lung cancer in humans. ... ...

    Abstract In this issue of EMBO Molecular Medicine, Uribesalgo and coworkers show that high Apelin expression correlates with poor survival in advanced breast (MMTV‐NeuT) and lung (KRASG12D) murine tumor models as well as in breast and lung cancer in humans. Combining Apelin inhibition (genetically or using an inactive Apelin agonist) with anti‐angiogenic therapy using different small molecular weight kinase inhibitors (sunitinib, axitinib) led to marked delay in breast cancer growth in mice. The vasculature in Apelin‐targeted cancer showed normalized features including improved perfusion and reduced leakage. These important data provide a strong incentive to target Apelin in human cancer treatment.
    Keywords Medicine (General) ; R5-920 ; Genetics ; QH426-470
    Language English
    Publishing date 2019-08-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Book: Vascular growth factors and angiogenesis

    Claesson-Welsh, Lena

    with 3 tables

    (Current topics in microbiology and immunology ; 237)

    1999  

    Author's details ed. by Lena Claesson-Welsh
    Series title Current topics in microbiology and immunology ; 237
    Collection
    Keywords Angiogenese ; Vascular endothelial Growth Factor ; Rezeptor
    Subject VEGF ; Vascular Permeability Factor ; Endothelial Cell Growth Supplement ; Endothelzellwachstumssupplement ; Gefäßentwicklung
    Language English
    Size 189 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Berlin u.a.
    Document type Book
    HBZ-ID HT009423291
    ISBN 3-540-64731-7 ; 978-3-540-64731-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Ud II Zs 24 -237- verfügbar in Königswinter Königswinter

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  8. Article ; Online: VEGF receptor signal transduction - A brief update.

    Claesson-Welsh, Lena

    Vascular pharmacology

    2016  Volume 86, Page(s) 14–17

    Abstract: Vascular endothelial growth factor (VEGF) signal transduction through receptor tyrosine kinases VEGF receptor-1, -2 and -3 is of crucial importance for monocytes/macrophages, blood vascular endothelial and lymphatic endothelial cells both in physiology ... ...

    Abstract Vascular endothelial growth factor (VEGF) signal transduction through receptor tyrosine kinases VEGF receptor-1, -2 and -3 is of crucial importance for monocytes/macrophages, blood vascular endothelial and lymphatic endothelial cells both in physiology and in a number of pathologies notably cancer. This brief review summarizes the current status of VEGF receptor signaling with emphasis on in vivo data.
    MeSH term(s) Animals ; Endothelial Cells/metabolism ; Humans ; Macrophages/metabolism ; Monocytes/metabolism ; Neoplasms/pathology ; Receptors, Vascular Endothelial Growth Factor/metabolism ; Signal Transduction ; Vascular Endothelial Growth Factor A/metabolism
    Chemical Substances Vascular Endothelial Growth Factor A ; Receptors, Vascular Endothelial Growth Factor (EC 2.7.10.1)
    Language English
    Publishing date 2016-06-04
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2082846-9
    ISSN 1879-3649 ; 1537-1891 ; 1879-3649
    ISSN (online) 1879-3649 ; 1537-1891
    ISSN 1879-3649
    DOI 10.1016/j.vph.2016.05.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 591: Show issues Location:
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  9. Article ; Online: Quartz Crystal Microbalance Measurement of Histidine-Rich Glycoprotein and Stanniocalcin-2 Binding to Each Other and to Inflammatory Cells.

    Persson Skare, Tor / Kaito, Hiroshi / Durall, Claudia / Aastrup, Teodor / Claesson-Welsh, Lena

    Cells

    2022  Volume 11, Issue 17

    Abstract: The plasma protein histidine-rich glycoprotein (HRG) is implicated in the polarization of macrophages to an M1 antitumoral phenotype. The broadly expressed secreted protein stanniocalcin 2 (STC2), also implicated in tumor inflammation, is an HRG ... ...

    Abstract The plasma protein histidine-rich glycoprotein (HRG) is implicated in the polarization of macrophages to an M1 antitumoral phenotype. The broadly expressed secreted protein stanniocalcin 2 (STC2), also implicated in tumor inflammation, is an HRG interaction partner. With the aim to biochemically characterize the HRG and STC2 complex, binding of recombinant HRG and STC2 preparations to each other and to cells was explored using the quartz crystal microbalance (QCM) methodology. The functionality of recombinant proteins was tested in a phagocytosis assay, where HRG increased phagocytosis by monocytic U937 cells while STC2 suppressed HRG-induced phagocytosis. The binding of HRG to STC2, measured using QCM, showed an affinity between the proteins in the nanomolar range, and both HRG and STC2 bound individually and in combination to vitamin D3-treated, differentiated U937 monocytes. HRG, but not STC2, also bound to formaldehyde-fixed U937 cells irrespective of their differentiation stage in part through the interaction with heparan sulfate. These data show that HRG and STC2 bind to each other as well as to U937 monocytes with high affinity, supporting the relevance of these interactions in monocyte/macrophage polarity.
    MeSH term(s) Glycoproteins/metabolism ; Heparitin Sulfate/metabolism ; Proteins ; Quartz Crystal Microbalance Techniques
    Chemical Substances Glycoproteins ; Proteins ; histidine-rich proteins ; teleocalcin (76687-96-2) ; Heparitin Sulfate (9050-30-0)
    Language English
    Publishing date 2022-08-29
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11172684
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: CD93 maintains endothelial barrier function by limiting the phosphorylation and turnover of VE-cadherin.

    Lugano, Roberta / Vemuri, Kalyani / Barbera, Stefano / Orlandini, Maurizio / Dejana, Elisabetta / Claesson-Welsh, Lena / Dimberg, Anna

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

    2023  Volume 37, Issue 4, Page(s) e22894

    Abstract: Regulation of vascular permeability to plasma is essential for tissue and organ homeostasis and is mediated by endothelial cell-to-cell junctions that tightly regulate the trafficking of molecules between blood and tissue. The single-pass transmembrane ... ...

    Abstract Regulation of vascular permeability to plasma is essential for tissue and organ homeostasis and is mediated by endothelial cell-to-cell junctions that tightly regulate the trafficking of molecules between blood and tissue. The single-pass transmembrane glycoprotein CD93 is upregulated in endothelial cells during angiogenesis and controls cytoskeletal dynamics. However, its role in maintaining homeostasis by regulating endothelial barrier function has not been elucidated yet. Here, we demonstrate that CD93 interacts with vascular endothelial (VE)-cadherin and limits its phosphorylation and turnover. CD93 deficiency in vitro and in vivo induces phosphorylation of VE-cadherin under basal conditions, displacing it from endothelial cell-cell contacts. Consistent with this, endothelial junctions are defective in CD93
    MeSH term(s) Animals ; Mice ; Phosphorylation ; Endothelial Cells/metabolism ; Cadherins/genetics ; Cadherins/metabolism ; Antigens, CD/genetics ; Antigens, CD/metabolism ; Capillary Permeability/physiology ; Endothelium, Vascular/metabolism ; Cells, Cultured ; Adherens Junctions/metabolism
    Chemical Substances cadherin 5 ; Cadherins ; Antigens, CD
    Language English
    Publishing date 2023-03-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639186-2
    ISSN 1530-6860 ; 0892-6638
    ISSN (online) 1530-6860
    ISSN 0892-6638
    DOI 10.1096/fj.202201623RR
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    Zs.MO 296: Show issues

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