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  1. Article ; Online: Conduct disorders and us: from heart sink to heart warming?

    Keen, Daphne V

    Archives of disease in childhood

    2007  Volume 92, Issue 10, Page(s) 838–841

    MeSH term(s) Adolescent ; Child ; Child Behavior Disorders/diagnosis ; Child Behavior Disorders/etiology ; Child, Preschool ; Conduct Disorder/diagnosis ; Conduct Disorder/psychology ; Female ; Humans ; Male ; Parent-Child Relations
    Language English
    Publishing date 2007-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 524-1
    ISSN 1468-2044 ; 0003-9888 ; 1359-2998
    ISSN (online) 1468-2044
    ISSN 0003-9888 ; 1359-2998
    DOI 10.1136/adc.2006.106369
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    In stock of ZB MED Cologne/Königswinter

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  2. Article: Childhood autism, feeding problems and failure to thrive in early infancy. Seven case studies.

    Keen, Daphne V

    European child & adolescent psychiatry

    2008  Volume 17, Issue 4, Page(s) 209–216

    Abstract: Despite longstanding clinical experience of unusual feeding difficulties in children with autism, there is no published literature describing their association with early onset FTT. This paper examines literature that may link feeding problems and ... ...

    Abstract Despite longstanding clinical experience of unusual feeding difficulties in children with autism, there is no published literature describing their association with early onset FTT. This paper examines literature that may link feeding problems and abnormal growth with developmental and psychiatric conditions and describes seven cases of children with autism, who showed growth failure caused by severe feeding problems starting in the first year of life. Inadequacies in existing classifications systems are highlighted. The presence of severe or atypical feeding problems and FTT in infancy should alert professionals to possible underlying ASD. The aetiology of feeding disorders in autism appears to involve an unusually complex interactional model with biological vulnerabilities due to dysfunction in sensory, cognitive and emotional response interacting with dysfunctional attachment and learnt behaviours to produce a severe and intractable problem. Effective treatment therefore requires a novel multifaceted approach that can address each of these areas.
    MeSH term(s) Autistic Disorder/complications ; Autistic Disorder/psychology ; Body Mass Index ; Child ; Child, Preschool ; Failure to Thrive/etiology ; Failure to Thrive/psychology ; Feeding and Eating Disorders/etiology ; Feeding and Eating Disorders/psychology ; Female ; Humans ; Infant ; Male ; Severity of Illness Index ; United Kingdom
    Language English
    Publishing date 2008-06
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 1118299-4
    ISSN 1435-165X ; 1018-8827 ; 1433-5719
    ISSN (online) 1435-165X
    ISSN 1018-8827 ; 1433-5719
    DOI 10.1007/s00787-007-0655-7
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  3. Article: World Health Organization (WHO) International Classification of Functioning, Disability and Health (ICF) Core Set Development for Interstitial Lung Disease.

    Saketkoo, Lesley Ann / Escorpizo, Reuben / Varga, Janos / Keen, Kevin John / Fligelstone, Kim / Birring, Surinder S / Alexanderson, Helene / Pettersson, Henrik / Chaudhry, Humza Ahmad / Poole, Janet L / Regardt, Malin / LeSage, Daphne / Sarver, Catherine / Lanario, Joseph / Renzoni, Elisabetta / Scholand, Mary Beth / Lammi, Matthew R / Kowal-Bielecka, Otylia / Distler, Oliver /
    Frech, Tracy / Shapiro, Lee / Varju, Cecilia / Volkmann, Elizabeth R / Bernstein, Elana J / Drent, Marjolein / Obi, Ogugua Ndili / Patterson, Karen C / Russell, Anne-Marie

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 979788

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2022-10-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.979788
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  4. Article ; Online: ADHD in children and adolescents.

    Keen, Daphne / Hadijikoumi, Irene

    BMJ clinical evidence

    2011  Volume 2011

    Abstract: Introduction: Prevalence estimates of attention deficit hyperactivity disorder (ADHD) vary according to the diagnostic criteria used and the population sampled. DSM-IV prevalence estimates among school children in the US are 3% to 5%, but other ... ...

    Abstract Introduction: Prevalence estimates of attention deficit hyperactivity disorder (ADHD) vary according to the diagnostic criteria used and the population sampled. DSM-IV prevalence estimates among school children in the US are 3% to 5%, but other estimates vary from 1.7% to 16.0%. No objective test exists to confirm the diagnosis of ADHD, which remains a clinical diagnosis. Other conditions frequently co-exist with ADHD.
    Methods and outcomes: We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of pharmacological treatments for ADHD in children and adolescents? What are the effects of psychological treatments for ADHD in children and adolescents? What are the effects of combination treatments for ADHD in children and adolescents? We searched: Medline, Embase, The Cochrane Library, and other important databases up to August 2009 (Clinical Evidence reviews are updated periodically, please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA).
    Results: We found 70 systematic reviews, RCTs, or observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions.
    Conclusions: In this systematic review we present information relating to the effectiveness and safety of the following interventions: atomoxetine, bupropion, clonidine, dexamfetamine sulphate, homeopathy, methylphenidate, modafinil, omega-3 polyunsaturated fatty acids, and psychological/behavioural treatment (either alone or in combination with a drug treatment).
    MeSH term(s) Adolescent ; Atomoxetine Hydrochloride ; Attention Deficit Disorder with Hyperactivity/drug therapy ; Attention Deficit and Disruptive Behavior Disorders/drug therapy ; Child ; Clonidine/therapeutic use ; Diagnostic and Statistical Manual of Mental Disorders ; Double-Blind Method ; Humans ; Methylphenidate/therapeutic use ; Schools
    Chemical Substances Methylphenidate (207ZZ9QZ49) ; Atomoxetine Hydrochloride (57WVB6I2W0) ; Clonidine (MN3L5RMN02)
    Language English
    Publishing date 2011-02-04
    Publishing country England
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 2393858-4
    ISSN 1752-8526 ; 1757-0816 ; 1475-9225
    ISSN (online) 1752-8526
    ISSN 1757-0816 ; 1475-9225
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Innovations in Practice: 'Off-label' clonidine: UK Paediatric and Child and Adolescent Psychiatry prescribing practice for sleep problems.

    MacLeod, Rebecca L / Keen, Daphne V

    Child and adolescent mental health

    2013  Volume 19, Issue 2, Page(s) 147–150

    Abstract: Background: Psychopharmacological prescribing of clonidine has been described in Australia and in the United States but not in Europe. This study explores UK clinician experience of clonidine 'off label' in treating paediatric sleep problems in the ... ...

    Abstract Background: Psychopharmacological prescribing of clonidine has been described in Australia and in the United States but not in Europe. This study explores UK clinician experience of clonidine 'off label' in treating paediatric sleep problems in the context of a paucity of evidence for its use.
    Methods: Survey of UK Child and Adolescent Psychiatrists (CAPs) and specialist Paediatricians.
    Results: Of 389 respondents (30% Paediatricians, 70% CAPs), 172 prescribed clonidine and 85 having used it for treating sleep. Treatment targets were sleep onset, night waking and nonspecific sleep problems, and carer respite, in patients with significant coexisting neurological and neurodevelopmental disorders. Most used clonidine as a second line medication after trying nonpharmacological approaches. The majority reported initial effectiveness, and adverse effects were mild or transient. Issues of reducing long-term effectiveness, drug tolerance and considerable differences in dosing regimes were identified.
    Conclusions: Clonidine use appears less widespread in the United Kingdom than reported elsewhere. It is seen as a potentially effective and safe intervention but this study highlights the need for good quality RCT evidence for the most effective use of clonidine in paediatric sleep disorders.
    Language English
    Publishing date 2013-07-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2073663-0
    ISSN 1475-3588 ; 1475-357X
    ISSN (online) 1475-3588
    ISSN 1475-357X
    DOI 10.1111/camh.12032
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  6. Article ; Online: ADHD in children and adolescents.

    Keen, Daphne / Hadijikoumi, Irene

    BMJ clinical evidence

    2008  Volume 2008

    Abstract: Introduction: Prevalence estimates of attention deficit hyperactivity disorder (ADHD) vary according to the diagnostic criteria used and the population sampled. DSM-IV prevalence estimates among school children in the US are 3-5%, but other estimates ... ...

    Abstract Introduction: Prevalence estimates of attention deficit hyperactivity disorder (ADHD) vary according to the diagnostic criteria used and the population sampled. DSM-IV prevalence estimates among school children in the US are 3-5%, but other estimates vary from 1.7% to 16.0%. No objective test exists to confirm the diagnosis of ADHD, which remains a clinical diagnosis. Other conditions frequently co-exist with ADHD.
    Methods and outcomes: We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of pharmacological treatments for ADHD in children and adolescents? What are the effects of psychological treatments for ADHD in children and adolescents? What are the effects of combination treatments for ADHD in children and adolescents? We searched: Medline, Embase, The Cochrane Library, and other important databases up to June 2007 (Clinical Evidence reviews are updated periodically, please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA).
    Results: We found 34 systematic reviews, RCTs, or observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions.
    Conclusions: In this systematic review we present information relating to the effectiveness and safety of the following interventions: atomoxetine, bupropion, clonidine, dexamfetamine sulphate, homeopathy, methylphenidate, modafinil, omega 3-polyunsaturated fatty acids, and psychological/behavioural treatment (either alone or in combination with a drug treatment).
    MeSH term(s) Adolescent ; Atomoxetine Hydrochloride ; Attention Deficit Disorder with Hyperactivity/diagnosis ; Attention Deficit and Disruptive Behavior Disorders/drug therapy ; Child ; Dextroamphetamine/therapeutic use ; Diagnostic and Statistical Manual of Mental Disorders ; Humans ; Methylphenidate/therapeutic use
    Chemical Substances Methylphenidate (207ZZ9QZ49) ; Atomoxetine Hydrochloride (57WVB6I2W0) ; Dextroamphetamine (TZ47U051FI)
    Language English
    Publishing date 2008-10-02
    Publishing country England
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 2393858-4
    ISSN 1752-8526 ; 1757-0816 ; 1475-9225
    ISSN (online) 1752-8526
    ISSN 1757-0816 ; 1475-9225
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Autistic spectrum disorder: a child population profile.

    Keen, Daphne / Ward, Stephanie

    Autism : the international journal of research and practice

    2004  Volume 8, Issue 1, Page(s) 39–48

    Abstract: This study analyses the prevalence of ASD, comorbidity, educational provision and ability in autistic children in a single health district, born between 1983 and 1996. The number of recorded diagnoses doubled over a 4 year period. This appeared to be due ...

    Abstract This study analyses the prevalence of ASD, comorbidity, educational provision and ability in autistic children in a single health district, born between 1983 and 1996. The number of recorded diagnoses doubled over a 4 year period. This appeared to be due to greater recognition of ASD in more able children, in children initially presenting with ADHD, and possibly in females. ADHD accounted for a substantial proportion of comorbidity. Age at diagnosis appeared to be related to school placement. Cognitive ability levels ranging from more than three standard deviations below the mean to more than one standard deviation above the mean were found in the moderate and severe learning difficulty school population as well as in the mainstream population. Exceptionally low levels of verbal ability were present in a high proportion of mainstream pupils. Measured levels of cognitive function show poor relationship with actual educational placement.
    MeSH term(s) Adolescent ; Autistic Disorder/complications ; Autistic Disorder/epidemiology ; Autistic Disorder/psychology ; Child ; Child, Preschool ; Cognition Disorders/etiology ; Comorbidity ; Educational Status ; Female ; Humans ; Incidence ; Language Disorders/etiology ; Male ; Sex Factors
    Language English
    Publishing date 2004-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 1338513-6
    ISSN 1362-3613
    ISSN 1362-3613
    DOI 10.1177/1362361304040637
    Database MEDical Literature Analysis and Retrieval System OnLINE

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