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  1. Article ; Online: Evidence-based prescribing of medications for ADHD: where are we in 2023?

    Cortese, Samuele

    Expert opinion on pharmacotherapy

    2023  Volume 24, Issue 4, Page(s) 425–434

    Abstract: Introduction: A large number of randomized controlled trials (RCTs) and observational studies on the pharmacotherapy of ADHD are available.: Areas covered: Based on a search in PubMed and PsycInfo (up to 15 September 2022), this review addresses to ... ...

    Abstract Introduction: A large number of randomized controlled trials (RCTs) and observational studies on the pharmacotherapy of ADHD are available.
    Areas covered: Based on a search in PubMed and PsycInfo (up to 15 September 2022), this review addresses to which extent this body of research is currently able to inform routine prescribing practice, in terms of the choice of medication, titration strategy, augmentation treatments, and use of alternative, non-approved treatments.
    Expert opinion: A growing body of evidence is informing prescribers on some, but certainly not all, aspects related to the pharmacological treatment of ADHD in the daily clinical practice, with important weaknesses/gaps that need to be addressed. First, evidence synthesis of RCTs is not able to inform decision-making at the individual patient level. Second, the maximum safe and effective doses, possibly beyond those currently recommended, are not well understood. Third, evidence from RCTs on augmenting strategies is still limited. Fourth, no novel agents with the same or higher effect size of stimulants, in terms of efficacy, but with better tolerability and lower abuse potential, have been found. Implementation of precision psychiatry approaches and stratification of patients in future RCTs will be key to, respectively, individualize the treatment strategies and test etiopathophysiology-based agents.
    MeSH term(s) Humans ; Attention Deficit Disorder with Hyperactivity/drug therapy ; Central Nervous System Stimulants/adverse effects
    Chemical Substances Central Nervous System Stimulants
    Language English
    Publishing date 2023-01-21
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 2001535-5
    ISSN 1744-7666 ; 1465-6566
    ISSN (online) 1744-7666
    ISSN 1465-6566
    DOI 10.1080/14656566.2023.2169604
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Treatment of ADHD in preschool children.

    Cortese, Samuele

    The Lancet. Child & adolescent health

    2022  Volume 6, Issue 12, Page(s) 830–831

    MeSH term(s) Child, Preschool ; Humans ; Attention Deficit Disorder with Hyperactivity/therapy
    Language English
    Publishing date 2022-10-26
    Publishing country England
    Document type Journal Article
    ISSN 2352-4650
    ISSN (online) 2352-4650
    DOI 10.1016/S2352-4642(22)00312-1
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  3. Article ; Online: Towards pathophysiology-based interventions for children with ADHD and increased screen time utilisation.

    Cortese, Samuele

    EBioMedicine

    2022  Volume 80, Page(s) 104075

    MeSH term(s) Attention Deficit Disorder with Hyperactivity/diagnosis ; Attention Deficit Disorder with Hyperactivity/therapy ; Child ; Humans ; Screen Time
    Language English
    Publishing date 2022-05-21
    Publishing country Netherlands
    Document type Journal Article ; Comment
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2022.104075
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  4. Article ; Online: Towards pathophysiology-based interventions for children with ADHD and increased screen time utilisation

    Samuele Cortese

    EBioMedicine, Vol 80, Iss , Pp 104075- (2022)

    2022  

    Keywords Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Methylphenidate for prison inmates with ADHD: yes or no?

    Cortese, Samuele

    The British journal of psychiatry : the journal of mental science

    2022  Volume 222, Issue 1, Page(s) 4–6

    Abstract: In a double-blind randomised controlled trial by Asherson et al., involving prisoners with attention-deficit hyperactivity disorder (ADHD), the rates of response to osmotic-release oral system methylphenidate (OROS-methylphenidate) and placebo were very ... ...

    Abstract In a double-blind randomised controlled trial by Asherson et al., involving prisoners with attention-deficit hyperactivity disorder (ADHD), the rates of response to osmotic-release oral system methylphenidate (OROS-methylphenidate) and placebo were very similar (~50%). I critically discuss this trial against other international literature, highlighting the key issues in the field in terms of clinical practice and research.
    MeSH term(s) Humans ; Methylphenidate/therapeutic use ; Attention Deficit Disorder with Hyperactivity/drug therapy ; Central Nervous System Stimulants/therapeutic use ; Prisons ; Administration, Oral ; Prisoners ; Double-Blind Method ; Treatment Outcome ; Delayed-Action Preparations/therapeutic use
    Chemical Substances Methylphenidate (207ZZ9QZ49) ; Central Nervous System Stimulants ; Delayed-Action Preparations
    Language English
    Publishing date 2022-10-20
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article ; Comment
    ZDB-ID 218103-4
    ISSN 1472-1465 ; 0007-1250
    ISSN (online) 1472-1465
    ISSN 0007-1250
    DOI 10.1192/bjp.2022.139
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Setting the Foundations of Developmental Precision Psychiatry for ADHD.

    Cortese, Samuele

    The American journal of psychiatry

    2021  Volume 178, Issue 8, Page(s) 677–679

    MeSH term(s) Attention Deficit Disorder with Hyperactivity/diagnosis ; Humans ; Psychiatry
    Language English
    Publishing date 2021-08-12
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 280045-7
    ISSN 1535-7228 ; 0002-953X
    ISSN (online) 1535-7228
    ISSN 0002-953X
    DOI 10.1176/appi.ajp.2021.21050549
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  7. Article ; Online: Sleep and ADHD: Adding pieces to the puzzle.

    Cortese, Samuele / Hill, Catherine M

    Sleep medicine

    2023  Volume 103, Page(s) 144–145

    MeSH term(s) Humans ; Attention Deficit Disorder with Hyperactivity ; Sleep ; Sleep Wake Disorders/epidemiology
    Language English
    Publishing date 2023-02-06
    Publishing country Netherlands
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2012041-2
    ISSN 1878-5506 ; 1389-9457
    ISSN (online) 1878-5506
    ISSN 1389-9457
    DOI 10.1016/j.sleep.2023.02.002
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  8. Article ; Online: Pharmacologic Treatment of Attention Deficit-Hyperactivity Disorder.

    Cortese, Samuele

    The New England journal of medicine

    2020  Volume 383, Issue 11, Page(s) 1050–1056

    MeSH term(s) Adolescent ; Adult ; Amphetamines/adverse effects ; Amphetamines/therapeutic use ; Atomoxetine Hydrochloride/therapeutic use ; Attention Deficit Disorder with Hyperactivity/drug therapy ; Child ; Child, Preschool ; Growth/drug effects ; Guanfacine/adverse effects ; Guanfacine/therapeutic use ; Heart Rate/drug effects ; Humans ; Hypertension/chemically induced ; Methylphenidate/therapeutic use ; Patient Dropouts ; Polymers/adverse effects ; Polymers/therapeutic use ; Practice Guidelines as Topic ; Treatment Outcome
    Chemical Substances Amphetamines ; Polymers ; Methylphenidate (207ZZ9QZ49) ; Guanfacine (30OMY4G3MK) ; Atomoxetine Hydrochloride (57WVB6I2W0) ; conidine (87323-81-7)
    Language English
    Publishing date 2020-09-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMra1917069
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  9. Article ; Online: Long-Term Cardiovascular Effects of Medications for Attention-Deficit/Hyperactivity Disorder-Balancing Benefits and Risks of Treatment.

    Cortese, Samuele / Fava, Cristiano

    JAMA psychiatry

    2023  Volume 81, Issue 2, Page(s) 123–124

    MeSH term(s) Humans ; Attention Deficit Disorder with Hyperactivity/drug therapy ; Central Nervous System Stimulants/therapeutic use ; Blood Pressure ; Risk Assessment
    Chemical Substances Central Nervous System Stimulants
    Language English
    Publishing date 2023-11-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701203-7
    ISSN 2168-6238 ; 2168-622X
    ISSN (online) 2168-6238
    ISSN 2168-622X
    DOI 10.1001/jamapsychiatry.2023.4126
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  10. Article: Regional analysis of UK primary care prescribing and adult service referrals for young people with attention-deficit hyperactivity disorder: from little to very little.

    Cortese, Samuele

    BJPsych open

    2020  Volume 6, Issue 3, Page(s) e43

    Abstract: Drawing on data from the Clinical Practice Research Datalink, Price et al reported UK regional variations in primary care prescribing and referral rates to adult mental health services for young people with attention-deficit hyperactivity disorder (ADHD) ...

    Abstract Drawing on data from the Clinical Practice Research Datalink, Price et al reported UK regional variations in primary care prescribing and referral rates to adult mental health services for young people with attention-deficit hyperactivity disorder (ADHD) in transition from child and adolescent mental health services. Overall, considering that around 65% of young adults with childhood ADHD present with impairing ADHD symptoms and up to 90% of individuals with ADHD may benefit from ADHD medications, the study by Price et al shows that the rate of appropriate treatment for youngsters in the transition period varies from low to very low across the UK. As such, there is a continuous need for education and training for patients, their families, mental health professionals and commissioners, to eradicate the misconception that, in the majority of the cases, ADHD remits during adolescence and to support the devolvement of appropriate services for the evidence-based management of adult ADHD across the UK.
    Language English
    Publishing date 2020-04-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2829557-2
    ISSN 2056-4724
    ISSN 2056-4724
    DOI 10.1192/bjo.2020.28
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