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  1. Article: Rumination and altered reactivity to sensory input as vulnerability factors for developing post-traumatic stress symptoms among adults with autistic traits.

    Dell'Osso, Liliana / Amatori, Giulia / Giovannoni, Federico / Massimetti, Enrico / Cremone, Ivan Mirko / Carpita, Barbara

    CNS spectrums

    2024  Volume 29, Issue 2, Page(s) 119–125

    Abstract: Objective: Recent literature has suggested that individuals with autism spectrum disorder (ASD) or autistic traits (ATs) would be more likely to encounter traumatic events in their lifetime and to develop post-traumatic stress disorder (PTSD). However, ... ...

    Abstract Objective: Recent literature has suggested that individuals with autism spectrum disorder (ASD) or autistic traits (ATs) would be more likely to encounter traumatic events in their lifetime and to develop post-traumatic stress disorder (PTSD). However, the nature of this relationship has not yet been fully elucidated. The aims of this study were to evaluate the relationship between AT and PTSD and to investigate which specific autistic dimension was more associated with trauma and stress-related symptoms.
    Methods: A total of 68 subjects with ASD and 64 healthy controls (HCs) were assessed with the Adult Autism Subthreshold Spectrum (AdAS Spectrum) and the Trauma and Loss Spectrum (TALS) questionnaires. Statistical analyses included Mann-Whitney
    Results: Patients with significant AT reported a 30% rate of PTSD and higher TALS total and domain scores than HCs, among whom no PTSD was found instead. Significant positive correlations were reported between AdAS Spectrum and TALS-SR scores in the whole sample. AdAS Spectrum total scores were statistically predictive of the presence of PTSD. High scores at AdAS Spectrum
    Conclusion: Compared to HCs, subjects with significant AT are more likely to present symptoms of PTSD. In particular, AT related to ruminative thinking, narrow interests, and sensorial reactivity would seem to predict the presence of post-traumatic stress symptomatology.
    MeSH term(s) Adult ; Humans ; Autistic Disorder ; Autism Spectrum Disorder/diagnosis ; Stress Disorders, Post-Traumatic/epidemiology ; Surveys and Questionnaires
    Language English
    Publishing date 2024-01-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2008418-3
    ISSN 2165-6509 ; 1092-8529
    ISSN (online) 2165-6509
    ISSN 1092-8529
    DOI 10.1017/S1092852924000014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: SARS-CoV-2-induced lung pathology: AHR as a candidate therapeutic target.

    Giovannoni, Federico / Quintana, Francisco J

    Cell research

    2020  Volume 31, Issue 1, Page(s) 1–2

    MeSH term(s) Animals ; Antiviral Agents/therapeutic use ; Basic Helix-Loop-Helix Transcription Factors/antagonists & inhibitors ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; COVID-19/metabolism ; COVID-19/pathology ; Drug Delivery Systems ; Humans ; Lung/metabolism ; Lung/pathology ; Lung/virology ; Receptors, Aryl Hydrocarbon/antagonists & inhibitors ; Receptors, Aryl Hydrocarbon/metabolism ; SARS-CoV-2/metabolism ; COVID-19 Drug Treatment
    Chemical Substances AHR protein, human ; Antiviral Agents ; Basic Helix-Loop-Helix Transcription Factors ; Receptors, Aryl Hydrocarbon
    Language English
    Publishing date 2020-11-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 1319303-x
    ISSN 1748-7838 ; 1001-0602
    ISSN (online) 1748-7838
    ISSN 1001-0602
    DOI 10.1038/s41422-020-00447-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The Role of Astrocytes in CNS Inflammation.

    Giovannoni, Federico / Quintana, Francisco J

    Trends in immunology

    2020  Volume 41, Issue 9, Page(s) 805–819

    Abstract: Astrocytes are the most abundant cell type in the central nervous system (CNS), performing complex functions in health and disease. It is now clear that multiple astrocyte subsets or activation states (plastic phenotypes driven by intrinsic and extrinsic ...

    Abstract Astrocytes are the most abundant cell type in the central nervous system (CNS), performing complex functions in health and disease. It is now clear that multiple astrocyte subsets or activation states (plastic phenotypes driven by intrinsic and extrinsic cues) can be identified, associated to specific genomic programs and functions. The characterization of these subsets and the mechanisms that control them may provide unique insights into the pathogenesis of neurologic diseases, and identify potential targets for therapeutic intervention. In this article, we provide an overview of the role of astrocytes in CNS inflammation, highlighting recent discoveries on astrocyte subsets and the mechanisms that control them.
    MeSH term(s) Astrocytes/cytology ; Astrocytes/immunology ; Central Nervous System/cytology ; Central Nervous System/immunology ; Humans ; Inflammation/immunology ; Nervous System Diseases/immunology
    Language English
    Publishing date 2020-08-13
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2036831-8
    ISSN 1471-4981 ; 1471-4906
    ISSN (online) 1471-4981
    ISSN 1471-4906
    DOI 10.1016/j.it.2020.07.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Rethinking Clozapine: Lights and Shadows of a Revolutionary Drug.

    Dell'Osso, Liliana / Bonelli, Chiara / Nardi, Benedetta / Giovannoni, Federico / Pronestì, Cristiana / Cremone, Ivan Mirko / Amatori, Giulia / Pini, Stefano / Carpita, Barbara

    Brain sciences

    2024  Volume 14, Issue 1

    Abstract: The current literature globally highlights the efficacy of Clozapine in several psychiatric disorders all over the world, with an FDA indication for reducing the risk of repeated suicidal behavior in patients with schizophrenia or schizoaffective ... ...

    Abstract The current literature globally highlights the efficacy of Clozapine in several psychiatric disorders all over the world, with an FDA indication for reducing the risk of repeated suicidal behavior in patients with schizophrenia or schizoaffective disorder. A growing field of research is also stressing a possible broader beneficial effect of Clozapine in promoting neuroprotection and neurotrophism. However, this drug is linked to several life-threatening side effects, such as agranulocytosis, myocarditis and seizures, that limit its use in daily clinical practice. For this work, a search was performed on PubMed using the terms "Clozapine indications", "Clozapine adverse effects", "Clozapine regenerative effects", and "Clozapine neuroplasticity" with the aim of reviewing the scientific literature on Clozapine's treatment indications, adverse effects and potential regenerative role. The results confirmed the efficacy of clozapine in clinical practice, although limited by its adverse effects. It appears crucial to raise awareness among clinicians about the potential benefits of using Clozapine, as well educating medical personnel about its risks and the early identification of possible adverse effects and their management.
    Language English
    Publishing date 2024-01-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci14010103
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Post-traumatic Stress and Depressive Symptoms in Women With Ovarian Cancer 3-6 Months After Diagnosis.

    Carmassi, Claudia / Pedrinelli, Virginia / Fantasia, Sara / Andreoli, Debora / Giovannoni, Federico / Massimetti, Enrico / Cosio, Stefania / Dell'osso, Liliana / Gadducci, Angiolo

    Anticancer research

    2024  Volume 44, Issue 2, Page(s) 829–838

    Abstract: Background/aim: The potentially traumatic role of severe life-threatening medical conditions is still debated in psychiatry and not yet recognized, particularly among post-traumatic stress disorders. However, increasing evidence suggests the ... ...

    Abstract Background/aim: The potentially traumatic role of severe life-threatening medical conditions is still debated in psychiatry and not yet recognized, particularly among post-traumatic stress disorders. However, increasing evidence suggests the psychopathological impact of severe medical conditions related to their poor prognosis, high lethality, treatments heaviness and invasiveness. Ovarian cancer (OC) is one of the malignancies with the highest mortality and the aim of this study was to investigate post-traumatic stress and depressive symptoms in women 3 to 6 months after diagnosis.
    Patients and methods: A sample of 83 women diagnosed with OC at different stages (from AI to IV) was recruited and assessed by means of the: Structural Clinical Interview for Mental Disorders according to DSM-5 (SCID-5), Trauma and Loss Spectrum Self-Report (TALS-SR), Impact Event Scale-Revised (IES-R), Hamilton Rating Scale for Depression (HAM-D), Mood Spectrum-Self Report (MOOD-SR), Work and Social Adjustment Scale (WSAS).
    Results: Full data on the psychiatric assessments were available for 45 patients: 13 (28.9%) patients reported a diagnosis of PTSD. Patients with PTSD reported statistically significant higher depressive symptoms and more severe impact on work and social functioning compared to those without PTSD.
    Conclusion: Our results highlight the need to carefully assess the potentially traumatic burden of a diagnosis of OC and its association with depressive symptoms for their impact on patients' global functioning, in order to provide appropriate preventive and therapeutic interventions.
    MeSH term(s) Humans ; Female ; Stress Disorders, Post-Traumatic/diagnosis ; Stress Disorders, Post-Traumatic/etiology ; Stress Disorders, Post-Traumatic/psychology ; Depression/diagnosis ; Depression/etiology ; Ovarian Neoplasms/complications ; Ovarian Neoplasms/diagnosis
    Language English
    Publishing date 2024-02-02
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 604549-2
    ISSN 1791-7530 ; 0250-7005
    ISSN (online) 1791-7530
    ISSN 0250-7005
    DOI 10.21873/anticanres.16875
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: May Female Autism Spectrum Be Masked by Eating Disorders, Borderline Personality Disorder, or Complex PTSD Symptoms? A Case Series.

    Carpita, Barbara / Nardi, Benedetta / Pronestì, Cristiana / Parri, Francesca / Giovannoni, Federico / Cremone, Ivan Mirko / Pini, Stefano / Dell'Osso, Liliana

    Brain sciences

    2023  Volume 14, Issue 1

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-12-30
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci14010037
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Modulation of the Aryl Hydrocarbon Receptor Signaling Pathway Impacts on Junín Virus Replication.

    Pelaez, Miguel Angel / Torti, María Florencia / Alvarez De Lauro, Aaron Ezequiel / Marquez, Agostina Belén / Giovannoni, Federico / Damonte, Elsa Beatriz / García, Cybele Carina

    Viruses

    2023  Volume 15, Issue 2

    Abstract: Junín virus (JUNV), a member of the ... ...

    Abstract Junín virus (JUNV), a member of the family
    MeSH term(s) Animals ; Humans ; Arenaviridae ; Argentina ; Junin virus ; Mammals ; Receptors, Aryl Hydrocarbon/genetics ; Signal Transduction ; Virus Replication
    Chemical Substances Receptors, Aryl Hydrocarbon
    Language English
    Publishing date 2023-01-28
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15020369
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Promyelocytic leukemia protein is a restriction factor for Junín virus independently of Z matrix protein

    Giovannoni, Federico / Vazquez, Cecilia A. / Thomas, Pablo / Gómez, Ricardo M. / García, Cybele C.

    Biochemical and biophysical research communications. 2022 Mar. 15,

    2022  

    Abstract: The New World (NW) mammarenavirus Junín (JUNV) is the etiological agent of Argentine hemorrhagic fever, a human endemic disease of Argentina. Promyelocytic leukemia protein (PML) has been reported as a restriction factor for several viruses although the ... ...

    Abstract The New World (NW) mammarenavirus Junín (JUNV) is the etiological agent of Argentine hemorrhagic fever, a human endemic disease of Argentina. Promyelocytic leukemia protein (PML) has been reported as a restriction factor for several viruses although the mechanism/s behind PML-mediated antiviral effect may be diverse and are a matter of debate. Previous studies have reported a nuclear to cytoplasm translocation of PML during the murine Old World mammarenavirus lymphocytic choriomeningitis virus (LCMV) infection. This translocation was found to be mediated by the viral Z protein. Here, we show that PML restricts JUNV infection in human A549 cells. However, in contrast to LCVM, JUNV infection enhances PML expression and PML is not translocated to the cytoplasm neither it colocalizes with JUNV Z protein. Our study demonstrates that a NW mammarenavirus as JUNV interacts differently with the antiviral protein PML than LCMV.
    Keywords Argentine hemorrhagic fever ; Lymphocytic choriomeningitis mammarenavirus ; antiviral properties ; antiviral proteins ; cytoplasm ; endemic diseases ; etiological agents ; humans ; leukemia ; mice ; research ; viruses ; Argentina
    Language English
    Dates of publication 2022-0315
    Publishing place Elsevier Inc.
    Document type Article
    Note Pre-press version
    ZDB-ID 205723-2
    ISSN 0006-291X ; 0006-291X
    ISSN (online) 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2022.03.074
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: The Aryl Hydrocarbon Receptor as a Modulator of Anti-viral Immunity.

    Torti, Maria Florencia / Giovannoni, Federico / Quintana, Francisco Javier / García, Cybele Carina

    Frontiers in immunology

    2021  Volume 12, Page(s) 624293

    Abstract: The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor, which interacts with a wide range of organic molecules of endogenous and exogenous origin, including environmental pollutants, tryptophan metabolites, and microbial ... ...

    Abstract The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor, which interacts with a wide range of organic molecules of endogenous and exogenous origin, including environmental pollutants, tryptophan metabolites, and microbial metabolites. The activation of AHR by these agonists drives its translocation into the nucleus where it controls the expression of a large number of target genes that include the AHR repressor (AHRR), detoxifying monooxygenases (CYP1A1 and CYP1B1), and cytokines. Recent advances reveal that AHR signaling modulates aspects of the intrinsic, innate and adaptive immune response to diverse microorganisms. This review will focus on the increasing evidence supporting a role for AHR as a modulator of the host response to viral infection.
    MeSH term(s) Active Transport, Cell Nucleus ; Adaptive Immunity ; Animals ; Gene Expression Regulation ; Host-Pathogen Interactions ; Humans ; Immunity, Innate ; Ligands ; Receptors, Aryl Hydrocarbon/metabolism ; Signal Transduction ; Virus Diseases/genetics ; Virus Diseases/immunology ; Virus Diseases/metabolism ; Virus Diseases/virology ; Viruses/genetics ; Viruses/immunology ; Viruses/pathogenicity
    Chemical Substances Ligands ; Receptors, Aryl Hydrocarbon
    Language English
    Publishing date 2021-03-05
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.624293
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Promyelocytic leukemia protein is a restriction factor for Junín virus independently of Z matrix protein.

    Giovannoni, Federico / Vazquez, Cecilia A / Thomas, Pablo / Gómez, Ricardo M / García, Cybele C

    Biochemical and biophysical research communications

    2022  Volume 606, Page(s) 168–173

    Abstract: The New World (NW) mammarenavirus Junín (JUNV) is the etiological agent of Argentine hemorrhagic fever, a human endemic disease of Argentina. Promyelocytic leukemia protein (PML) has been reported as a restriction factor for several viruses although the ... ...

    Abstract The New World (NW) mammarenavirus Junín (JUNV) is the etiological agent of Argentine hemorrhagic fever, a human endemic disease of Argentina. Promyelocytic leukemia protein (PML) has been reported as a restriction factor for several viruses although the mechanism/s behind PML-mediated antiviral effect may be diverse and are a matter of debate. Previous studies have reported a nuclear to cytoplasm translocation of PML during the murine Old World mammarenavirus lymphocytic choriomeningitis virus (LCMV) infection. This translocation was found to be mediated by the viral Z protein. Here, we show that PML restricts JUNV infection in human A549 cells. However, in contrast to LCVM, JUNV infection enhances PML expression and PML is not translocated to the cytoplasm neither it colocalizes with JUNV Z protein. Our study demonstrates that a NW mammarenavirus as JUNV interacts differently with the antiviral protein PML than LCMV.
    MeSH term(s) A549 Cells ; Hemorrhagic Fever, American/metabolism ; Humans ; Junin virus ; Promyelocytic Leukemia Protein/genetics ; Viral Proteins ; Virus Replication
    Chemical Substances Promyelocytic Leukemia Protein ; Viral Proteins
    Language English
    Publishing date 2022-03-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2022.03.074
    Database MEDical Literature Analysis and Retrieval System OnLINE

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