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Conference proceedings: Antikörper-Dschungel?

Krammer, Olga Barbara / Putz, Franz Josef / Günther, Florian / Fleck, Martin

2023 , Page(s) FA.28

Event/congress	Deutscher Rheumatologiekongress 2023, 51. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 37. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), 33. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR); Leipzig; ; Gesellschaft für Kinder- und Jugendrheumatologie; 2023
Keywords	Medizin, Gesundheit
Publishing date	2023-08-30
Publisher	German Medical Science GMS Publishing House; Düsseldorf
Document type	Conference proceedings
DOI	10.3205/23dgrh095
Database	German Medical Science

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Article ; Online: Aspekte der Online-Lehre und deren Zusammenhang mit positivem Erleben und Motivation bei Lehramtsstudierenden: Mixed-Method Befunde zu Beginn von COVID-19.

Krammer, Georg / Pflanzl, Barbara / Matischek-Jauk, Marlies

Zeitschrift fur bildungsforschung

2020 Volume 10, Issue 3, Page(s) 337–375

Abstract: In the summer semester 2019/20 it was degreed that universities switch to purely online learning due to COVID-19/SARS-CoV‑2. This switch offered the unique opportunity to study online learning in teacher education. The aim of the present study was to ... ...

Title translation	Aspects of online teaching and their relation to positive experience and motivation among teacher education students: mixed-method findings at the beginning of COVID-19.
Abstract	In the summer semester 2019/20 it was degreed that universities switch to purely online learning due to COVID-19/SARS-CoV‑2. This switch offered the unique opportunity to study online learning in teacher education. The aim of the present study was to give recommendations for online learning in teacher education. To this end, we identified aspects of online learning that students experienced beneficial/impeding (study 1) and analyzed their relation to the positive/negative experience of students and their goal orientation (study 2). In study 1 (
Language	German
Publishing date	2020-12-23
Publishing country	Germany
Document type	English Abstract ; Journal Article
ZDB-ID	2616315-9
ISSN	2190-6904 ; 2190-6890
ISSN (online)	2190-6904
ISSN	2190-6890
DOI	10.1007/s35834-020-00283-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Impact of lactisole on the time-intensity profile of selected sweeteners in dependence of the binding site.

Deck, Corinna M / Behrens, Maik / Wendelin, Martin / Ley, Jakob P / Krammer, Gerhard E / Lieder, Barbara

Food chemistry: X

2022 Volume 15, Page(s) 100446

Abstract: Currently, there is limited insight into the influence of the different binding sites of agonists and antagonists of the sweet taste receptor TAS1R2/TAS1R3 on temporal sensory properties of sweet tasting compounds. We investigated whether the binding ... ...

Abstract	Currently, there is limited insight into the influence of the different binding sites of agonists and antagonists of the sweet taste receptor TAS1R2/TAS1R3 on temporal sensory properties of sweet tasting compounds. We investigated whether the binding site and a competitive or allosteric inhibition of TAS1R2/TAS1R3 influence the time-dependent sensory perception and in vitro TAS1R2/TAS1R3-activation profiles. We compared time-intensity ratings of cyclamate, NHDC, acesulfame K, and aspartame with and without lactisole with the corresponding TAS1R2/TAS1R3-activation in transfected HEK293 cells. In combination with lactisole, cyclamate and NHDC demonstrated a shift of the dose-response curve corresponding to a competitive inhibition by lactisole in the sensory and the cell experiments. Allosteric inhibition by lactisole for aspartame and acesulfame K was seen in the cell experiments, but not the sensory ratings. In conclusion, the data do not support a major impact of the binding site on the time-intensity profile of the tested sweeteners.
Language	English
Publishing date	2022-09-16
Publishing country	Netherlands
Document type	Journal Article
ISSN	2590-1575
ISSN (online)	2590-1575
DOI	10.1016/j.fochx.2022.100446
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Article: Video-Recorded In Situ Simulation Before Moving to the New Combined Neonatal/Pediatric Intensive Care Facility: An Observational Study.

Krammer, Theresa / Kessler, Lisa / Aspalter, Gerhard / Kuster, Lucas / Fussenegger, Barbara / Aichner, Heidi / Simma, Burkhard

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

2022 Volume 24, Issue 1, Page(s) e1–e8

Abstract: Objectives: Moving an ICU to a new location is a challenge. The objective of this study was to use in situ simulation to identify potential problems and solutions with the new environment before commencing patient care.: Design: Planned, ... ...

Abstract	Objectives: Moving an ICU to a new location is a challenge. The objective of this study was to use in situ simulation to identify potential problems and solutions with the new environment before commencing patient care. Design: Planned, observational video-recorded simulation study using four scenarios: delivery room management of term-neonate; delivery room management of extremely low-birth-weight infant; management and transfer of an infant with respiratory syncytial virus bronchiolitis and apnea; and management and transfer of an adolescent with septic shock. Setting: Academic tertiary neonatal and combined neonatal ICU/PICU. Participants: Sixteen volunteers (eight physicians, eight nurses). Interventions: Standardized briefing introduction, with before versus after survey of thoughts about each scenario, and after 8 weeks, debriefing at least 60 minutes and additional video recording. Measurements and main results: A total of 91 potential problem areas were identified and included issues related to technical aspects ( n = 29), infrastructure ( n = 27), administration ( n = 19), and structure ( n = 16). Fifty-three (58%) of these potential issues could be resolved before the move, including: 15 of 29 technical, 15 of 27 infrastructure, nine of 19 administration, and 14 of 16 structural. The video analysis revealed an additional 13 problem areas (six technical, three infrastructure, two administration, and two structural). Participants felt more confident 8 weeks after the simulations (χ 2 = 12.125; p < 0.002). All 16 participants confirmed the usefulness of the in situ simulation, the majority wanted further introductions to the new ward ( n = 13) and noted a positive impact of the changes on the new ward ( n = 12). Conclusions: In situ simulation before moving into a new facility identifies numerousness potential problem areas. Survey shows that providers feel better prepared and are more confident. Video recording reveals additional difficulties not addressed in conventional verbal debriefing.
MeSH term(s)	Infant, Newborn ; Infant ; Humans ; Child ; Adolescent ; Intensive Care, Neonatal ; Intensive Care Units, Neonatal ; Physicians
Language	English
Publishing date	2022-10-13
Publishing country	United States
Document type	Observational Study ; Journal Article
ZDB-ID	2052349-X
ISSN	1947-3893 ; 1529-7535
ISSN (online)	1947-3893
ISSN	1529-7535
DOI	10.1097/PCC.0000000000003080
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Zs.A 5600: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 472: Show issues

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Conference proceedings: Unklare Polyarthralgien, was nun?

Krammer, Olga Barbara / Ehrenstein, Boris / Hartung, Wolfgang / Fleck, Martin

2020 , Page(s) FA.13

Event/congress	Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh); sine loco [digital]; ; Deutsche Gesellschaft für Orthopädische Rheumatologie; 2020
Keywords	Medizin, Gesundheit
Publishing date	2020-09-09
Publisher	German Medical Science GMS Publishing House; Düsseldorf
Document type	Conference proceedings
DOI	10.3205/20dgrh079
Database	German Medical Science

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Article ; Online: Reduction of cancer cell viability by synergistic combination of photodynamic treatment with the inhibition of the Id protein family.

Roschger, Cornelia / Verwanger, Thomas / Krammer, Barbara / Cabrele, Chiara

Journal of photochemistry and photobiology. B, Biology

2018 Volume 178, Page(s) 521–529

Abstract: The inhibitor of DNA binding and cell differentiation (Id) proteins are dominant negative regulators of the helix-loop-helix transcription factor family and play a key role during development as well as in vascular disorders and cancer. In fact, ... ...

Abstract	The inhibitor of DNA binding and cell differentiation (Id) proteins are dominant negative regulators of the helix-loop-helix transcription factor family and play a key role during development as well as in vascular disorders and cancer. In fact, impairing the Id-protein activity in cancer cells reduces cell growth and even chemoresistance. Recently, we have shown that a synthetic Id-protein ligand (1Y) consisting of a cyclic nonapeptide can reduce the viability of the two breast cancer cell lines MCF-7 and T47D and of the bladder cancer cells T24 to about 50% at concentrations ≥100μM. Moreover, the cyclopeptide displays both proapoptotic and antiproliferative effects on MCF-7 cells. Herein, we show that the cyclopeptide does not induce cell death at the dose of 5μΜ, but it still inhibits MCF-7 and T24 cell proliferation, which correlates with an increased protein level of the cell-cycle regulator p27
MeSH term(s)	Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Proliferation/radiation effects ; Cell Survival/drug effects ; Cell Survival/radiation effects ; Cyclin-Dependent Kinase Inhibitor p27/metabolism ; Dihematoporphyrin Ether/toxicity ; Drug Synergism ; Humans ; Inhibitor of Differentiation Protein 1/antagonists & inhibitors ; Inhibitor of Differentiation Protein 1/metabolism ; Light ; MCF-7 Cells ; Nanostructures/chemistry ; Nanostructures/toxicity ; Peptides, Cyclic/chemistry ; Peptides, Cyclic/toxicity ; Perylene/analogs & derivatives ; Perylene/toxicity ; Photosensitizing Agents/chemistry ; Photosensitizing Agents/toxicity ; Porphyrins/toxicity
Chemical Substances	ID1 protein, human ; Inhibitor of Differentiation Protein 1 ; Peptides, Cyclic ; Photosensitizing Agents ; Porphyrins ; Cyclin-Dependent Kinase Inhibitor p27 (147604-94-2) ; chlorin (2683-84-3) ; Perylene (5QD5427UN7) ; hypericin (7V2F1075HD) ; Dihematoporphyrin Ether (97067-70-4)
Language	English
Publishing date	2018-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	623022-2
ISSN	1873-2682 ; 1011-1344
ISSN (online)	1873-2682
ISSN	1011-1344
DOI	10.1016/j.jphotobiol.2017.11.038
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Zs.A 2347: Show issues

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bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Risk as a pattern over time: Delineation of time-dependent risk factors in biological, psychological, and social variables in cancer patients.

Knefel, Matthias / Zeilinger, Elisabeth L / Lubowitzki, Simone / Krammer, Katharina / Unseld, Matthias / Bartsch, Rupert / Fuereder, Thorsten / Jäger, Ulrich / Kiesewetter, Barbara / Krauth, Maria / Raderer, Markus / Staber, Philipp B / Valent, Peter / Gaiger, Alexander

Cancer

2023 Volume 129, Issue 21, Page(s) 3466–3475

Abstract: Background: Survival in cancer patients is associated with a multitude of biological, social, and psychological factors. Although it is well established that all these factors add to overall mortality, it is not well understood how the predictive power ... ...

Abstract	Background: Survival in cancer patients is associated with a multitude of biological, social, and psychological factors. Although it is well established that all these factors add to overall mortality, it is not well understood how the predictive power of these parameters changes in a comprehensive model and over time. Methods: Patients who attended the authors' outpatient clinic were invited to participate. The authors followed 5180 mixed cancer patients (51.1% female; mean age, 59.1 years [SD = 13.8]) for up to 16 years and analyzed biological (age, sex, cancer site, anemia), psychological (anxiety, depression), and social variables (marital status, education, employment status) potentially predicting overall survival in a Cox proportional hazards model. Results: The median survival time for the entire sample was 4.3 years (95% confidence interval, 4.0-4.7). The overall survival probabilities for 1 and 10 years were 76.8% and 38.0%, respectively. Following an empirical approach, the authors split the time interval into five periods: acute, subacute, short-term, medium-term, and long-term. A complex pattern of variables predicted overall survival differently in the five periods. Biological parameters were important throughout most of the time, social parameters were either time-independent predictors or tended to be more important in the longer term. Of the psychological parameters, only depression was a significant predictor and lost its predictive power in the long-term. Conclusions: The findings of this study allow the development of comprehensive patient-specific models of risk and resilience factors addressing biopsychosocial needs of cancer patients, paving the way for a personalized treatment plan that goes beyond biomedical cancer care.
Language	English
Publishing date	2023-07-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	1429-1
ISSN	1097-0142 ; 0008-543X ; 1934-662X
ISSN (online)	1097-0142
ISSN	0008-543X ; 1934-662X
DOI	10.1002/cncr.34953
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Uh III Zs.146: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article: Profiling microRNA expression during senescence and aging: mining for a diagnostic tool of senescent-cell burden.

bioRxiv : the preprint server for biology

2024

Abstract: In the last decade cellular senescence, a hallmark of aging, has come into focus for pharmacologically targeting aging processes. Senolytics are one of these interventive strategies that have advanced into clinical trials, creating an unmet need for ... ...

Abstract	In the last decade cellular senescence, a hallmark of aging, has come into focus for pharmacologically targeting aging processes. Senolytics are one of these interventive strategies that have advanced into clinical trials, creating an unmet need for minimally invasive biomarkers of senescent cell load to identify patients at need for senotherapy. We created a landscape of miRNA and mRNA expression in five human cell types induced to senescence
Language	English
Publishing date	2024-04-10
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.04.10.588794
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online: 39 Aspekte der Online-Lehre zur Förderung positiven Erlebens und/oder Motivation bei Lehramtsstudierenden

Krammer, Georg / Pflanzl, Barbara / Matischek-Jauk, Marlies

Mixed-Method Befunde zu Beginn von COVID-19 [39 aspects of online teaching to promote positive experience and/or motivation among teacher education students: mixed-method findings at the beginning of COVID-19]

2020

Abstract: Die verordnete Umstellung aufgrund von COVID-19/SARS-CoV-2 im Sommersemester 2019/20 der gesamten Hochschullehre auf Online-Lehre bot die einzigartige Möglichkeit die Online-Lehre in der Lehramtsausbildung zu beforschen. Ziel der vorliegenden Studie war ... ...

Abstract	Die verordnete Umstellung aufgrund von COVID-19/SARS-CoV-2 im Sommersemester 2019/20 der gesamten Hochschullehre auf Online-Lehre bot die einzigartige Möglichkeit die Online-Lehre in der Lehramtsausbildung zu beforschen. Ziel der vorliegenden Studie war es Empfehlungen für Online-Lehre im Lehramt abgeben zu können. Deshalb haben wir förderlich/hinderlich erlebte Aspekte der Online-Lehre identifiziert (Studie 1) und deren Zusammenhang mit dem positiven/negativen Erleben durch Studierende und deren Lern- und Leistungsmotivation analysiert (Studie 2). In Studie 1 (n=75) wurden qualitativ Aspekte der Online-Lehre erhoben, die Lehramtsstudierende als förderlich bzw. hinderlich für den subjektiven Lernerfolg erlebt haben (offene Materialien: https://osf.io/7knhj/?view_only=6fdba64dadff4d7484c6306b45c301df). Die Studie wurde vor der Datenerhebung unter https://osf.io/438p6/?view_only=bcb6291b1dd548d89fe0570070b397fe präregistriert. Wir haben 39 Aspekte mittels qualitativer Inhaltsanalyse identifiziert. In Studie 2 (n=855) wurden diese Aspekte für positive & motivierende bzw. negative & demotivierende Lehrveranstaltungen erhoben und mit der situativen Lern- und Leistungsmotivation (SELLMO) der Lehramtsstudierenden in Bezug gesetzt (offene Materialien: https://osf.io/87v5y/?view_only=bca9dc18dd8847c5bcc96a17d6383ac7). Die Studie wurde vor der Datenerhebung unter https://osf.io/rj5f9/?view_only=7fbbdc1c3955472b83d1431357dedbe0 präregistriert. Analysen mit BEST zeigten sieben Aspekte mit sehr großen Unterschieden (\|d\|>3), 18 mit großen Unterschieden (3>\|d\|>0.8), sieben mit mittleren/kleinen Unterschieden (0.8>\|d\|>0.2), und sieben ohne Unterschiede (2>\|d\|) zwischen positiven & motivierenden bzw. negativen & demotivierenden Lehrveranstaltungen. Multigruppen-Pfadanalysen identifizierten 13 Aspekte, die mit der Lern- und Leistungsmotivation in Zusammenhang standen. Unsere Ergebnisse tragen zum Verstehen von Online-Lehre im Lehramtsstudium bei. Sie zeigen auf, dass Online-Lehre je nach Ziel – positives Erleben, Lern- und Leistungsmotivation, beides – optimiert und gesteuert werden kann. [In the summer semester 2019/20 it was degreed that universities switch to purely online learning due to COVID-19/SARS-CoV-2. This switch offered the unique opportunity to study online learning in teacher education. The aim of the present study was to give recommendations for online learning in teacher education. To this end, we identified aspects of online learning that students experienced beneficial/impeding (study 1) and analyzed their relation to the positive/negative experience of students and their goal orientation (study 2). In study 1 (n=75), we asked students for aspects of online learning that they experienced as beneficially/impeding for their perceived learning gain (open materials: https://osf.io/7knhj/?view_only=6fdba64dadff4d7484c6306b45c301df). The study was pre-registered before data collection (https://osf.io/438p6/?view_only=bcb6291b1dd548d89fe0570070b397fe). We identified 39 aspects by means of qualitative content analysis. In study 2 (n=855), these aspects were rated for positive & motivating or negative & demotivating courses and related to the situational goal achievement (SELLMO) of the teacher education students (open materials: https://osf.io/87v5y/?view_only=bca9dc18dd8847c5bcc96a17d6383ac7). The study was pre-registered before data collection (https://osf.io/rj5f9/?view_only=7fbbdc1c3955472b83d1431357dedbe0). Analyses with BEST showed seven aspects with very large differences (\|d\|>3), 18 with large differences (3>\|d\|>0.8), seven with medium/small differences (0.8>\|d\|>0.2), and seven without differences (2>\|d\|) between positive & motivating or negative & demotivating courses. Multigroup path analyses identified 13 aspects that were related to goal orientation. Our results contribute to the understanding of online learning in teacher education. They highlight that online learning can be optimized and steered depending on the objective – positive experience, goal orientation, or both.]
Keywords	covid19
Publisher	Center for Open Science
Publishing country	us
Document type	Book ; Online
DOI	10.35542/osf.io/6v2yr
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Impact of lactisole on the time-intensity profile of selected sweeteners in dependence of the binding site

Deck, Corinna M. / Behrens, Maik / Wendelin, Martin / Ley, Jakob P. / Krammer, Gerhard E. / Lieder, Barbara

Food chemistry: X. 2022 Oct. 30, v. 15

2022

Abstract	Currently, there is limited insight into the influence of the different binding sites of agonists and antagonists of the sweet taste receptor TAS1R2/TAS1R3 on temporal sensory properties of sweet tasting compounds. We investigated whether the binding site and a competitive or allosteric inhibition of TAS1R2/TAS1R3 influence the time-dependent sensory perception and in vitro TAS1R2/TAS1R3-activation profiles. We compared time-intensity ratings of cyclamate, NHDC, acesulfameK, and aspartame with and without lactisole with the corresponding TAS1R2/TAS1R3-activation in transfected HEK293 cells. In combination with lactisole, cyclamate and NHDC demonstrated a shift of the dose–response curve corresponding to a competitive inhibition by lactisole in the sensory and the cell experiments. Allosteric inhibition by lactisole for aspartame and acesulfame K was seen in the cell experiments, but not the sensory ratings. In conclusion, the data do not support a major impact of the binding site on the time-intensity profile of the tested sweeteners.
Keywords	acesulfame potassium ; aspartame ; dose response ; food chemistry ; sensation ; sweetness ; taste receptors
Language	English
Dates of publication	2022-1030
Publishing place	Elsevier Ltd
Document type	Article
ISSN	2590-1575
DOI	10.1016/j.fochx.2022.100446
Database	NAL-Catalogue (AGRICOLA)

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