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  1. Article: Tumeurs des tissus mous avec fusion du gène FN1 (Fibronectine 1).

    Bouvier, Corinne / Nihous, Hugo / Macagno, Nicolas

    Annales de pathologie

    2022  Volume 42, Issue 3, Page(s) 242–248

    Abstract: Translocations involving FN1 gene have been described in several tumours, which share the presence of a cartilaginous matrix with or without calcifications and a good prognosis. They encompass: soft tissue chondroma, synovial chondromatosis, calcifying ... ...

    Title translation Soft tissue tumours with FN1 (Fibronectin 1) fusion gene.
    Abstract Translocations involving FN1 gene have been described in several tumours, which share the presence of a cartilaginous matrix with or without calcifications and a good prognosis. They encompass: soft tissue chondroma, synovial chondromatosis, calcifying aponeurotic fibroma, phosphaturic mesenchymal tumour and a new spectrum of tumours: "the calcified chondroid mesenchymal neoplasms". We review all the clinical, histopathological and molecular data of these tumours and discuss the differential diagnoses.
    MeSH term(s) Chondroma/pathology ; Fibroma/pathology ; Fibroma, Ossifying ; Fibronectins/genetics ; Humans ; Mesenchymoma ; Soft Tissue Neoplasms/diagnosis ; Soft Tissue Neoplasms/genetics ; Soft Tissue Neoplasms/pathology
    Chemical Substances FN1 protein, human ; Fibronectins
    Language French
    Publishing date 2022-02-15
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 225720-8
    ISSN 0242-6498
    ISSN 0242-6498
    DOI 10.1016/j.annpat.2022.01.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Pleural effusion in a patient with Ewing sarcoma.

    Frankel, Diane / Kaspi, Elise / Bouvier, Corinne / Roll, Patrice

    Cytopathology : official journal of the British Society for Clinical Cytology

    2021  Volume 33, Issue 1, Page(s) 138–140

    MeSH term(s) Humans ; Pleural Effusion/diagnosis ; Sarcoma ; Sarcoma, Ewing/complications ; Sarcoma, Ewing/diagnosis
    Language English
    Publishing date 2021-05-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 1034190-0
    ISSN 1365-2303 ; 0956-5507 ; 1350-4037
    ISSN (online) 1365-2303
    ISSN 0956-5507 ; 1350-4037
    DOI 10.1111/cyt.12989
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Intractable low-back pain in a patient with history of multiple neoplasms.

    Haikal, Christelle / Beucler, Nathan / Fuentes, Stéphane / Bouvier, Corinne / Le Corroller, Thomas

    Skeletal radiology

    2022  Volume 52, Issue 1, Page(s) 137–139

    MeSH term(s) Humans ; Low Back Pain/diagnostic imaging ; Low Back Pain/etiology ; Chronic Pain ; Neoplasms/complications ; Neoplasms/diagnostic imaging
    Language English
    Publishing date 2022-07-06
    Publishing country Germany
    Document type Editorial
    ZDB-ID 527592-1
    ISSN 1432-2161 ; 0364-2348
    ISSN (online) 1432-2161
    ISSN 0364-2348
    DOI 10.1007/s00256-022-04115-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Intractable low-back pain in a patient with history of multiple neoplasms.

    Haikal, Christelle / Beucler, Nathan / Fuentes, Stéphane / Bouvier, Corinne / Le Corroller, Thomas

    Skeletal radiology

    2022  Volume 52, Issue 1, Page(s) 111–112

    MeSH term(s) Humans ; Low Back Pain/diagnostic imaging ; Low Back Pain/etiology ; Chronic Pain ; Neoplasms/complications ; Neoplasms/diagnostic imaging
    Language English
    Publishing date 2022-07-08
    Publishing country Germany
    Document type Editorial
    ZDB-ID 527592-1
    ISSN 1432-2161 ; 0364-2348
    ISSN (online) 1432-2161
    ISSN 0364-2348
    DOI 10.1007/s00256-022-04114-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Cas n

    Macagno, Nicolas / Bouvier, Corinne / Le Loarer, Francois

    Annales de pathologie

    2020  Volume 40, Issue 4, Page(s) 256–262

    Title translation Fine-needle biopsy of soft-tissue neoplasms: Case No.1.
    MeSH term(s) Biopsy, Large-Core Needle/methods ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Sarcoma/diagnosis ; Sarcoma/pathology ; Soft Tissue Neoplasms/pathology
    Language French
    Publishing date 2020-04-25
    Publishing country France
    Document type Case Reports ; Journal Article
    ZDB-ID 225720-8
    ISSN 0242-6498
    ISSN 0242-6498
    DOI 10.1016/j.annpat.2020.02.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Cas n

    Macagno, Nicolas / Bouvier, Corinne / Le Loarer, Francois

    Annales de pathologie

    2020  Volume 40, Issue 4, Page(s) 293–299

    Title translation Pleomorphic soft tissue tumor: Case No. 6.
    MeSH term(s) Adenoma, Pleomorphic/diagnosis ; Adenoma, Pleomorphic/physiopathology ; Aged, 80 and over ; Diagnosis, Differential ; Humans ; Immunohistochemistry ; Liposarcoma ; Male ; Soft Tissue Neoplasms/diagnosis ; Soft Tissue Neoplasms/pathology
    Language French
    Publishing date 2020-03-05
    Publishing country France
    Document type Case Reports ; Journal Article
    ZDB-ID 225720-8
    ISSN 0242-6498
    ISSN 0242-6498
    DOI 10.1016/j.annpat.2020.01.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Molecular description of meningeal solitary fibrous tumors/hemangiopericytomas compared to meningiomas: two completely separate entities.

    Apra, Caroline / Guillemot, Delphine / Frouin, Eléonore / Bouvier, Corinne / Mokhtari, Karima / Kalamarides, Michel / Pierron, Gaëlle

    Journal of neuro-oncology

    2021  Volume 154, Issue 3, Page(s) 327–334

    Abstract: Introduction: Meningeal solitary fibrous tumors (SFT), like all SFT, are defined by NAB2-STAT6 fusion and share clinicopathologic similarities with meningiomas, the most frequent meningeal tumors. Our aim is to establish the molecular identity of ... ...

    Abstract Introduction: Meningeal solitary fibrous tumors (SFT), like all SFT, are defined by NAB2-STAT6 fusion and share clinicopathologic similarities with meningiomas, the most frequent meningeal tumors. Our aim is to establish the molecular identity of meningeal SFT and seek molecular prognostic factors.
    Methods: RNA sequencing and whole exome sequencing were performed in STAT6-positive SFT and grade 2-3 meningiomas, and data concerning other soft tissues tumors was obtained from the local database. Uniform manifold approximation and projection, individual gene expression and Gene Set Enrichment Analysis were performed.
    Results: RNA clustering shows that SFT share a common molecular signature, different from any other type of tumoral tissue. Meningeal SFT aggregate with other SFT, with no clinical or histological subgroup. Comparison of genes expressions suggests significant over-expressions of ZIC2, ZIC3, ZIC5, GABBR2, TP53 in CNS-SFT. The pathogenic TP53 c.743G>T variant, previously undescribed in SFT, was found in one sample of meningeal SFT during malignant progression.
    Conclusions: Meningeal SFT are molecular counterparts of extra-meningeal SFT, completely separate from meningiomas. They might develop from the same tissues and benefit from the same treatments as SFT.
    MeSH term(s) DNA-Binding Proteins ; Hemangiopericytoma/diagnosis ; Hemangiopericytoma/genetics ; Humans ; Meningeal Neoplasms/genetics ; Meningioma/genetics ; Soft Tissue Neoplasms ; Solitary Fibrous Tumors/genetics ; Transcription Factors
    Chemical Substances DNA-Binding Proteins ; Transcription Factors ; ZIC5 protein, human
    Language English
    Publishing date 2021-08-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604875-4
    ISSN 1573-7373 ; 0167-594X
    ISSN (online) 1573-7373
    ISSN 0167-594X
    DOI 10.1007/s11060-021-03830-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Characterization of the Tumor Microenvironment in Jaw Osteosarcomas, towards Prognostic Markers and New Therapeutic Targets.

    Bertin, Hélios / Peries, Sophie / Amiaud, Jérôme / Van Acker, Nathalie / Perrot, Bastien / Bouvier, Corinne / Aubert, Sébastien / Marie, Béatrice / Larousserie, Frédérique / De Pinieux, Gonzague / Crenn, Vincent / Rédini, Françoise / Gomez-Brouchet, Anne

    Cancers

    2023  Volume 15, Issue 4

    Abstract: Background-The purpose of this study was to investigate the bone resorption, as well as the vascular and immune microenvironment, of jaw osteosarcomas (JO) and to correlate these features with patient clinical outcomes. Methods-We studied 50 JO biopsy ... ...

    Abstract Background-The purpose of this study was to investigate the bone resorption, as well as the vascular and immune microenvironment, of jaw osteosarcomas (JO) and to correlate these features with patient clinical outcomes. Methods-We studied 50 JO biopsy samples by immunohistochemical analysis of tissue microarrays (TMAs). We investigated the bone remodeling markers RANK/RANKL/OPG, the endothelial glycoprotein CD146, and biomarkers of the immune environment (CD163 and CD68 of macrophages, CD4+ and CD8+ of tumor-infiltrating lymphocytes (TILs), and an immune checkpoint PD-1/PD-L1). The biomarkers were analyzed for their influence on progression (recurrence and metastasis), overall survival (OS), and disease-free survival (DFS). Results-A strong and significant correlation has been found between CD163 staining and lower OS and DFS. The level of CD4+ and CD8+ staining was low and non-significantly associated with survival outcomes. High levels of RANK and RANKL were found in the tumor samples and correlated with lower DFS. Conclusion-Our findings suggest that CD163+ TAMs represent markers of poor prognosis in JO. Targeting TAMs could represent a valuable therapeutic strategy in JO.
    Language English
    Publishing date 2023-02-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15041004
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  9. Article: Point de vue : une leçon tirée du confinement, l’histopathologie en visioconférence.

    Delteil, Clémence / Haffner, Aurélie / Fritih, Radia / Bouvier, Corinne / Taix, Sébastien / Macagno, Nicolas

    Annales de pathologie

    2020  Volume 41, Issue 1, Page(s) 4–8

    Abstract: The use of videoconferencing had increased significantly during lockdown. During this period, videoconferencing has been used in the pathological department of pathology (Timone university hospital, Marseille, France) for academic, diagnosis and referral. ...

    Title translation Point of view: A lesson from lockdown, histopathology through videoconferencing.
    Abstract The use of videoconferencing had increased significantly during lockdown. During this period, videoconferencing has been used in the pathological department of pathology (Timone university hospital, Marseille, France) for academic, diagnosis and referral. We provide our point of view regarding the use of this tool. As discussing slides through videoconferencing is a new and specific activity, we have also summarised specific recommendations for practical remote histopathology meetings.
    MeSH term(s) France ; Humans ; Pathology, Clinical ; Telepathology ; Videoconferencing
    Keywords covid19
    Language French
    Publishing date 2020-10-07
    Publishing country France
    Document type Journal Article
    ZDB-ID 225720-8
    ISSN 0242-6498
    ISSN 0242-6498
    DOI 10.1016/j.annpat.2020.09.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Effects of sevoflurane on lung epithelial permeability in experimental models of acute respiratory distress syndrome.

    Zhai, Ruoyang / Lenga Ma Bonda, Woodys / Leclaire, Charlotte / Saint-Béat, Cécile / Theilliere, Camille / Belville, Corinne / Coupet, Randy / Blondonnet, Raiko / Bouvier, Damien / Blanchon, Loic / Sapin, Vincent / Jabaudon, Matthieu

    Journal of translational medicine

    2023  Volume 21, Issue 1, Page(s) 397

    Abstract: Background: Preclinical studies in acute respiratory distress syndrome (ARDS) have suggested that inhaled sevoflurane may have lung-protective effects and clinical trials are ongoing to assess its impact on major clinical outcomes in patients with ARDS. ...

    Abstract Background: Preclinical studies in acute respiratory distress syndrome (ARDS) have suggested that inhaled sevoflurane may have lung-protective effects and clinical trials are ongoing to assess its impact on major clinical outcomes in patients with ARDS. However, the underlying mechanisms of these potential benefits are largely unknown. This investigation focused on the effects of sevoflurane on lung permeability changes after sterile injury and the possible associated mechanisms.
    Methods: To investigate whether sevoflurane could decrease lung alveolar epithelial permeability through the Ras homolog family member A (RhoA)/phospho-Myosin Light Chain 2 (Ser19) (pMLC)/filamentous (F)-actin pathway and whether the receptor for advanced glycation end-products (RAGE) may mediate these effects. Lung permeability was assessed in RAGE
    Results: In mice after acid injury, sevoflurane was associated with better arterial oxygenation, decreased alveolar inflammation and histological damage, and non-significantly attenuated the increase in lung permeability. Preserved protein expression of zonula occludens-1 and less increase of pMLC and actin cytoskeletal rearrangement were observed in injured mice treated with sevoflurane. In vitro, sevoflurane markedly decreased electrical resistance and cytokine release of MLE-12 cells, which was associated with higher protein expression of zonula occludens-1. Improved oxygenation levels and attenuated increase in lung permeability and inflammatory response were observed in RAGE
    Conclusions: Sevoflurane decreased injury and restored epithelial barrier function in two in vivo and in vitro models of sterile lung injury, which was associated with increased expression of junction proteins and decreased actin cytoskeletal rearrangement. In vitro findings suggest that sevoflurane may decrease lung epithelial permeability through the RhoA/pMLC/F-actin pathway.
    MeSH term(s) Animals ; Mice ; Sevoflurane/pharmacology ; Sevoflurane/metabolism ; Sevoflurane/therapeutic use ; Actins/metabolism ; Receptor for Advanced Glycation End Products/metabolism ; Mice, Inbred C57BL ; Lung/pathology ; Respiratory Distress Syndrome/pathology ; Cytokines/metabolism ; Permeability ; Models, Theoretical
    Chemical Substances Sevoflurane (38LVP0K73A) ; Actins ; Receptor for Advanced Glycation End Products ; Cytokines
    Language English
    Publishing date 2023-06-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2118570-0
    ISSN 1479-5876 ; 1479-5876
    ISSN (online) 1479-5876
    ISSN 1479-5876
    DOI 10.1186/s12967-023-04253-w
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