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  1. Article ; Online: Grey Matter 150th anniversary of Charcot's description of amyotrophic lateral sclerosis.

    Corcia, Philippe / Meininger, Vincent

    Brain : a journal of neurology

    2019  Volume 142, Issue 10, Page(s) 3306–3313

    MeSH term(s) Amyotrophic Lateral Sclerosis/history ; Anniversaries and Special Events ; Gray Matter ; History, 19th Century ; Humans
    Language English
    Publishing date 2019-09-16
    Publishing country England
    Document type Biography ; Historical Article ; Journal Article ; Portrait
    ZDB-ID 80072-7
    ISSN 1460-2156 ; 0006-8950
    ISSN (online) 1460-2156
    ISSN 0006-8950
    DOI 10.1093/brain/awz280
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  2. Article: ALS, what new 144 years after Charcot?

    Meininger, Vincent

    Archives italiennes de biologie

    2011  Volume 149, Issue 1, Page(s) 29–37

    Abstract: The most important challenge of ALS remains finding biomarkers. Clinical features remain of key importance in the diagnosis and for follow up. Neurophysiology remains difficult to use in clinical trials. Neuroimaging have some utility for upper motor ... ...

    Abstract The most important challenge of ALS remains finding biomarkers. Clinical features remain of key importance in the diagnosis and for follow up. Neurophysiology remains difficult to use in clinical trials. Neuroimaging have some utility for upper motor neuron integrity and function. Among proteins and chemical markers, one of the most promising marker is the level of Nogo in muscle biopsy. In CSF, many candidate proteins have been suggested but their sensitivity and specificity remains disappointing. Recently, -omics technologies have been applied to try to discover biomarkers in ALS, including genomic, proteomic and metabolomic methodologies.
    MeSH term(s) Amyotrophic Lateral Sclerosis/diagnosis ; Amyotrophic Lateral Sclerosis/history ; Amyotrophic Lateral Sclerosis/metabolism ; Biomarkers ; Diagnostic Imaging ; History, 19th Century ; History, 20th Century ; History, 21st Century ; Humans ; Neurophysiology
    Chemical Substances Biomarkers
    Language English
    Publishing date 2011-03
    Publishing country Italy
    Document type Biography ; Historical Article ; Journal Article ; Review
    ZDB-ID 532-0
    ISSN 0003-9829
    ISSN 0003-9829
    DOI 10.4449/aib.v149i1.1265
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4571: Show issues Location:
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  3. Article ; Online: Use of a modular ontology and a semantic annotation tool to describe the care pathway of patients with amyotrophic lateral sclerosis in a coordination network.

    Cardoso, Sonia / Meneton, Pierre / Aimé, Xavier / Meininger, Vincent / Grabli, David / Guezennec, Gilles / Charlet, Jean

    PloS one

    2021  Volume 16, Issue 1, Page(s) e0244604

    Abstract: The objective of this study was to describe the care pathway of patients with amyotrophic lateral sclerosis (ALS) based on real-life textual data from a regional coordination network, the Ile-de-France ALS network. This coordination network provides care ...

    Abstract The objective of this study was to describe the care pathway of patients with amyotrophic lateral sclerosis (ALS) based on real-life textual data from a regional coordination network, the Ile-de-France ALS network. This coordination network provides care for 92% of patients diagnosed with ALS living in Ile-de-France. We developed a modular ontology (OntoPaRON) for the automatic processing of these unstructured textual data. OntoPaRON has different modules: the core, medical, socio-environmental, coordination, and consolidation modules. Our approach was unique in its creation of fully defined concepts at different levels of the modular ontology to address specific topics relating to healthcare trajectories. We also created a semantic annotation tool specific to the French language and the specificities of our corpus, the Ontology-Based Semantic Annotation Module (OnBaSAM), using the OntoPaRON ontology as a reference. We used these tools to annotate the records of 928 patients automatically. The semantic (qualitative) annotations of the concepts were transformed into quantitative data. By using these pipelines we were able to transform unstructured textual data into structured quantitative data. Based on data processing, semantic annotations, sociodemographic data for the patient and clinical variables, we found that the need and demand for human and technical assistance depend on the initial form of the disease, the motor state, and the patient age. The presence of exhaustion in care management, is related to the patient's motor and cognitive state.
    MeSH term(s) Amyotrophic Lateral Sclerosis/therapy ; Delivery of Health Care ; France ; Humans ; Language ; Natural Language Processing
    Language English
    Publishing date 2021-01-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0244604
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Comparison between PFN1 and SOD1 mutations in amyotrophic lateral sclerosis.

    Corcia, Philippe / Lejeune, Pascal / Vourc'h, Patrick / Beltran, Stephane / Piegay, Anne-Sophie / Blasco, Helene / Meininger, Vincent

    European journal of neurology

    2022  Volume 30, Issue 2, Page(s) 552–554

    Abstract: Background: The objective of this study was to characterize the prototypical phenotype of patients with amyotrophic lateral sclerosis (ALS) associated with PFN1 mutations in profilin 1 (PFN1) and to determine clinical indications to test for mutations ... ...

    Abstract Background: The objective of this study was to characterize the prototypical phenotype of patients with amyotrophic lateral sclerosis (ALS) associated with PFN1 mutations in profilin 1 (PFN1) and to determine clinical indications to test for mutations in this gene.
    Material and methods: The phenotype of three relatives carrying the M114V PFN1 mutation are detailed here and are compared with those of patients with ALS linked to PFN1 previously reported in the literature.
    Results: In this pedigree and in the literature, the main clinical findings which best describe familial ALS linked to PFN1 might be the following characteristics: pedigrees over five cases, age of onset around 50 years, site of onset systematically lower limbs and the absence of cognitive impairment.
    Conclusion: First, the infrequent incidence of patients with ALS linked to PFN1 mutation supports the pursuit of a precise characterization of the phenotype linked to PFN1 mutations. Then, the numerous similarities between the phenotype amongst patients linked to SOD1 and PFN1 mutations and between histological features amongst both mice models prompts a review of the current ALS classifications, taking into consideration both phenotype and genotype.
    MeSH term(s) Animals ; Humans ; Mice ; Amyotrophic Lateral Sclerosis/genetics ; Amyotrophic Lateral Sclerosis/pathology ; Mutation/genetics ; Profilins/genetics ; Superoxide Dismutase-1/genetics
    Chemical Substances PFN1 protein, human ; Profilins ; SOD1 protein, human ; Superoxide Dismutase-1 (EC 1.15.1.1)
    Language English
    Publishing date 2022-10-18
    Publishing country England
    Document type Comparative Study ; Journal Article ; Review
    ZDB-ID 1280785-0
    ISSN 1468-1331 ; 1351-5101 ; 1471-0552
    ISSN (online) 1468-1331
    ISSN 1351-5101 ; 1471-0552
    DOI 10.1111/ene.15583
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4738: Show issues Location:
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    Zs.MO 592: Show issues

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  5. Article ; Online: Use of a modular ontology and a semantic annotation tool to describe the care pathway of patients with amyotrophic lateral sclerosis in a coordination network.

    Sonia Cardoso / Pierre Meneton / Xavier Aimé / Vincent Meininger / David Grabli / Gilles Guezennec / Jean Charlet

    PLoS ONE, Vol 16, Iss 1, p e

    2021  Volume 0244604

    Abstract: The objective of this study was to describe the care pathway of patients with amyotrophic lateral sclerosis (ALS) based on real-life textual data from a regional coordination network, the Ile-de-France ALS network. This coordination network provides care ...

    Abstract The objective of this study was to describe the care pathway of patients with amyotrophic lateral sclerosis (ALS) based on real-life textual data from a regional coordination network, the Ile-de-France ALS network. This coordination network provides care for 92% of patients diagnosed with ALS living in Ile-de-France. We developed a modular ontology (OntoPaRON) for the automatic processing of these unstructured textual data. OntoPaRON has different modules: the core, medical, socio-environmental, coordination, and consolidation modules. Our approach was unique in its creation of fully defined concepts at different levels of the modular ontology to address specific topics relating to healthcare trajectories. We also created a semantic annotation tool specific to the French language and the specificities of our corpus, the Ontology-Based Semantic Annotation Module (OnBaSAM), using the OntoPaRON ontology as a reference. We used these tools to annotate the records of 928 patients automatically. The semantic (qualitative) annotations of the concepts were transformed into quantitative data. By using these pipelines we were able to transform unstructured textual data into structured quantitative data. Based on data processing, semantic annotations, sociodemographic data for the patient and clinical variables, we found that the need and demand for human and technical assistance depend on the initial form of the disease, the motor state, and the patient age. The presence of exhaustion in care management, is related to the patient's motor and cognitive state.
    Keywords Medicine ; R ; Science ; Q
    Subject code 006
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Treatment of emotional lability in ALS.

    Meininger, Vincent

    The Lancet. Neurology

    2005  Volume 4, Issue 2, Page(s) 70

    MeSH term(s) Affective Symptoms/drug therapy ; Affective Symptoms/etiology ; Amyotrophic Lateral Sclerosis/complications ; Animals ; Dextromethorphan/therapeutic use ; Enzyme Inhibitors/therapeutic use ; Excitatory Amino Acid Antagonists/therapeutic use ; Humans ; Quinidine/therapeutic use ; Randomized Controlled Trials as Topic
    Chemical Substances Enzyme Inhibitors ; Excitatory Amino Acid Antagonists ; Dextromethorphan (7355X3ROTS) ; Quinidine (ITX08688JL)
    Language English
    Publishing date 2005-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2081241-3
    ISSN 1474-4422
    ISSN 1474-4422
    DOI 10.1016/S1474-4422(05)00970-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5955: Show issues Location:
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  7. Article: Clinical trials in ALS: what did we learn from recent trials in humans?

    Meininger, Vincent

    Neuro-degenerative diseases

    2005  Volume 2, Issue 3-4, Page(s) 208–214

    Abstract: Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease. No treatment is currently able to stop the disease process. In the absence of new active compounds there is an urgent need to develop new strategies based on the ... ...

    Abstract Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease. No treatment is currently able to stop the disease process. In the absence of new active compounds there is an urgent need to develop new strategies based on the neuroprotective activity of available drugs. ALS is a heterogeneous disease. To build up these therapeutic trials, we need to have a better understanding of the prognostic factors in this disease. During the Phase IV Rilutek Trial in France, we developed in a large population of patients a prognostic score based on clinical parameters available at the bedside. The most significant variables are vital capacity, spasticity, fasciculations, swallowing, cough and creatininemia. This score proved to be very useful in daily use in the clinic and for planning disease management in ALS as in the design of therapeutic trials. In ALS clinical trials, efficacy can be evaluated using survival or functional parameters. In phase II trials, function remains the most commonly used. In phase III trials, the gold standard endpoint remains the survival rate at month 18. We analyzed the most recent ALS trials published in the literature. This review suggests that in these trials there is a discrepancy between drug effects on survival versus function. These results suggest that a reappraisal of strategies to identify therapeutic targets for ALS is required.
    MeSH term(s) Amyotrophic Lateral Sclerosis/drug therapy ; Amyotrophic Lateral Sclerosis/mortality ; Animals ; Clinical Trials as Topic ; Excitatory Amino Acid Antagonists/therapeutic use ; Female ; Humans ; Male ; Mice ; Middle Aged ; Prognosis ; Riluzole/therapeutic use
    Chemical Substances Excitatory Amino Acid Antagonists ; Riluzole (7LJ087RS6F)
    Language English
    Publishing date 2005
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2143569-8
    ISSN 1660-2862 ; 1660-2854
    ISSN (online) 1660-2862
    ISSN 1660-2854
    DOI 10.1159/000089627
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    Zs.A 5918: Show issues Location:
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    Zs.MO 567: Show issues

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  8. Article: European ALS Consortium.

    Meininger, Vincent

    Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases

    2004  Volume 5 Suppl 1, Page(s) 133–134

    MeSH term(s) Amyotrophic Lateral Sclerosis ; Clinical Trials as Topic ; Cooperative Behavior ; Europe ; Humans ; Societies, Medical/organization & administration
    Language English
    Publishing date 2004-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2023460-0
    ISSN 1471-180X ; 1466-0822
    ISSN (online) 1471-180X
    ISSN 1466-0822
    DOI 10.1080/17434470410019843
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  9. Article ; Online: Using Equivalent Classes of an Ontology to Understand Care Pathway in Amyotrophic Lateral Sclerosis.

    Cardoso, Sonia / Aimé, Xavier / Meininger, Vincent / Grabli, David / Meneton, Pierre / Charlet, Jean

    Studies in health technology and informatics

    2019  Volume 262, Page(s) 93–96

    Abstract: To understand the home-based difficulties encountered in the health care pathways of patients with Amyotrophic Lateral Sclerosis (ALS), we must annotate a large amount of textual data, from a database created by the ALS Île de France coordination network. ...

    Abstract To understand the home-based difficulties encountered in the health care pathways of patients with Amyotrophic Lateral Sclerosis (ALS), we must annotate a large amount of textual data, from a database created by the ALS Île de France coordination network. For this purpose, we have developed a modular ontology, consisting of four modules, and a semantic annotation tool integrating the created ontology. The specificity of our approach is the creation of equivalent classes at different levels of the ontology. These equivalent classes represent variables of interest allowing a statistical approach and a clinical analysis of comprehension of care pathways ruptures causing.
    MeSH term(s) Amyotrophic Lateral Sclerosis ; Comprehension ; Critical Pathways ; Delivery of Health Care ; France ; Humans ; Semantics
    Language English
    Publishing date 2019-06-28
    Publishing country Netherlands
    Document type Journal Article
    ISSN 1879-8365
    ISSN (online) 1879-8365
    DOI 10.3233/SHTI190025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Survival endpoint: summary.

    Meininger, Vincent

    Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases

    2002  Volume 3 Suppl 1, Page(s) S41–4

    MeSH term(s) Amyotrophic Lateral Sclerosis/drug therapy ; Amyotrophic Lateral Sclerosis/mortality ; Amyotrophic Lateral Sclerosis/physiopathology ; Disease Progression ; Endpoint Determination/methods ; Motor Neurons/pathology ; Reproducibility of Results ; Survival ; Tracheostomy ; Vital Capacity/physiology
    Language English
    Publishing date 2002
    Publishing country England
    Document type Journal Article
    ZDB-ID 2023460-0
    ISSN 1471-180X ; 1466-0822
    ISSN (online) 1471-180X
    ISSN 1466-0822
    DOI 10.1080/146608202320374255
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