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Article ; Online: Gail Thomson, M.D. Health Protection Agency (HPA), Porton, United Kingdom.

Thomson, Gail / Glaser, Vicki

Vector borne and zoonotic diseases (Larchmont, N.Y.)

2012 Volume 12, Issue 9, Page(s) 715–717

MeSH term(s)	Animals ; Arachnid Vectors/virology ; Communicable Diseases, Emerging ; Disease Outbreaks/prevention & control ; Health Policy ; Hemorrhagic Fever Virus, Crimean-Congo/pathogenicity ; Hemorrhagic Fever, Crimean/diagnosis ; Hemorrhagic Fever, Crimean/therapy ; Hemorrhagic Fever, Crimean/transmission ; Humans ; Interdisciplinary Communication ; International Cooperation ; Tick-Borne Diseases/diagnosis ; Tick-Borne Diseases/therapy ; Tick-Borne Diseases/transmission ; Ticks/virology ; United Kingdom ; Zoonoses/diagnosis ; Zoonoses/therapy ; Zoonoses/transmission
Language	English
Publishing date	2012-09
Publishing country	United States
Document type	Interview ; Portraits
ZDB-ID	2047199-3
ISSN	1557-7759 ; 1530-3667
ISSN (online)	1557-7759
ISSN	1530-3667
DOI	10.1089/vbz.2012.9923.int
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Zs.A 6137: Show issues

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Article: Gaylord W. Anderson, M.D.

Thomson, S C

The Journal-lancet

1967 Volume 87, Issue 1, Page(s) 30–32

MeSH term(s)	Epidemiology ; History of Medicine ; Public Health ; United States
Language	English
Publishing date	1967-01
Publishing country	United States
Document type	Biography ; Historical Article ; Journal Article
ZDB-ID	410618-0
ISSN	0096-0233
ISSN	0096-0233
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Zs.B 153: Show issues

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Article: N.m.r., e.p.r. and magnetic-c.d. studies of cytochrome f. Identity of the haem axial ligands.

Rigby, S E / Moore, G R / Gray, J C / Gadsby, P M / George, S J / Thomson, A J

The Biochemical journal

1988 Volume 256, Issue 2, Page(s) 571–577

Abstract: N.m.r.-, magnetic-c.d.- and e.p.r.-spectroscopic studies of oxidized and reduced cytochrome f ... 203, 101-107]. The observation of a one-proton intensity resonance at -3.27 p.p.m. in the 1H-n.m.r ... region to low frequency of -2 p.p.m., is suggested to be a general indicator of lysine co-ordination. ...

Abstract	N.m.r.-, magnetic-c.d.- and e.p.r.-spectroscopic studies of oxidized and reduced cytochrome f from charlock, rape and woad are reported. Comparison of the spectra with corresponding spectra of other haem proteins, including horse and yeast cytochromes c, bovine cytochrome b5 and n-butylamine adduct of soya-bean leghaemoglobin support the hypothesis [Siedow, Vickery & Palmer (1980) Arch. Biochem. Biophys. 203, 101-107] that lysine is the sixth ligand of native cytochrome f. Detailed analysis of the e.p.r. spectrum of ferricytochrome f indicates that its principle g-values are 3.51, 1.70 and less than 1.3, and not 3.48, 2.07 and 1.6 as previously suggested [Siedow, Vickery & Palmer (1980) Arch. Biochem. Biophys. 203, 101-107]. The observation of a one-proton intensity resonance at -3.27 p.p.m. in the 1H-n.m.r. spectrum of ferrocytochrome f, coupled with the absence of a methionine methyl resonance from the spectral region to low frequency of -2 p.p.m., is suggested to be a general indicator of lysine co-ordination.
MeSH term(s)	Animals ; Cattle ; Circular Dichroism ; Cytochromes ; Cytochromes f ; Heme ; Horses ; Ligands ; Magnetic Resonance Spectroscopy ; Oxidation-Reduction ; Plants/enzymology ; Protein Conformation ; Yeasts
Chemical Substances	Cytochromes ; Ligands ; Heme (42VZT0U6YR) ; Cytochromes f (9035-46-5)
Language	English
Publishing date	1988-12-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2969-5
ISSN	1470-8728 ; 0264-6021 ; 0006-2936 ; 0306-3275
ISSN (online)	1470-8728
ISSN	0264-6021 ; 0006-2936 ; 0306-3275
DOI	10.1042/bj2560571
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Article ; Online: Microsurgical training pre-and post-COVID 19: Is there a re-learning curve and lessons for lockdown three.

Thomson, D R / Jones, M E

Journal of plastic, reconstructive & aesthetic surgery : JPRAS

2021 Volume 74, Issue 8, Page(s) 1931–1971

MeSH term(s)	COVID-19 ; Humans ; Learning Curve ; Mammaplasty/education ; Mammaplasty/methods ; Microsurgery/education ; Quarantine
Language	English
Publishing date	2021-04-17
Publishing country	Netherlands
Document type	Letter
ZDB-ID	2217750-4
ISSN	1878-0539 ; 1748-6815 ; 0007-1226
ISSN (online)	1878-0539
ISSN	1748-6815 ; 0007-1226
DOI	10.1016/j.bjps.2021.03.110
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Article ; Online: Exploring changes in violence across two waves of the COVID-19 pandemic in Richmond, VA.

West, Samuel J / Wood, Ariel M / Aboutanos, Michel B / Thomson, Nicholas D

Aggressive behavior

2023 Volume 49, Issue 6, Page(s) 559–567

Abstract: The first wave of the COVID-19 pandemic carried with it an increase in violence in the United States and abroad. The proportion of violence cases involving firearms also increased during this time, yet little research has examined these effects using ... ...

Abstract	The first wave of the COVID-19 pandemic carried with it an increase in violence in the United States and abroad. The proportion of violence cases involving firearms also increased during this time, yet little research has examined these effects using data from the second wave of COVID infections. Explanations for these documented increases in gun violence put forward by scholars include increased firearm purchases, alcohol consumption, unemployment, and organized crime activity. The current work examined these trends in Richmond, VA. We collected data on patients (N = 1744) presenting with violent injuries from 2018 to 2022 from the emergency department of a Level-1 Trauma Center in Richmond, VA. Data were coded on the basis of whether they presented before the pandemic, during the first wave, or during the second wave. Logistic binomial regressions revealed that the risk of gunshot wounds increased by 32% during the first wave and 44% during the second wave, relative to the pre-COVID period, but that the increase between the first and second wave was not significant. These findings held after controlling for victim age, race, sex, and injury severity. Further analyses revealed that these effects were specific to violent injury, as we found no increase in firearm use among self-injury cases. The heightened violence reported during the COVID-19 pandemic was also observed in Richmond, VA. Gun violence in particular increased over time as other forms of violence (i.e., assaults, stabbings, and self-harm) decreased.
MeSH term(s)	Humans ; United States/epidemiology ; Wounds, Gunshot/epidemiology ; Pandemics ; COVID-19/epidemiology ; Violence ; Firearms
Language	English
Publishing date	2023-06-16
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	189812-7
ISSN	1098-2337 ; 0096-140X
ISSN (online)	1098-2337
ISSN	0096-140X
DOI	10.1002/ab.22094
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Article ; Online: Piezoelectric instrumentation in secondary cleft rhinoplasty: Techniques and clinical experience.

Thomson, Richard M / Abdelrazek, Mohamed / Atherton, Duncan

Journal of plastic, reconstructive & aesthetic surgery : JPRAS

2023 Volume 82, Page(s) 276–278

Abstract: Introduction: Cleft rhinoplasty is a challenging procedure, with precision required to achieve good results. Cases often present with more complex structural and soft tissue asymmetries than non-cleft cases. Piezoelectric instrumentation uses ultrasonic ...

Abstract	Introduction: Cleft rhinoplasty is a challenging procedure, with precision required to achieve good results. Cases often present with more complex structural and soft tissue asymmetries than non-cleft cases. Piezoelectric instrumentation uses ultrasonic vibrations to cut bone. At certain frequency, it will only cut bone, sparing soft tissue and is reported to decrease postoperative pain, oedema and echymosis. It allows nasal bony work to be performed under direct vision without losing stability of the bony fragments by preserving the underlying periosteum. There is good evidence on the use of piezoelectric instrumentation in cosmetic rhinoplasty; however, none to date has focused exclusively on cleft rhinoplasty. We present a single surgeon experience using piezoelectric instrumentation in cleft rhinoplasty. Methods and patients: We reviewed the case histories of 21 consecutive patients who had Piezo-assisted cleft rhinoplasty surgery between 2017 and 2021. We present our operative techniques and results of piezoelectric cleft rhinoplasty and compare it with 19 patients undergoing cleft rhinoplasty with conventional instrumentation over the same time period, by the same surgeon. Results: Piezo-assisted rhinoplasty steps included bony osteotomies, dorsal hump removal, modification of composite cartilage/ ethmoid grafts and instrumentation of the anterior nasal spine. There were no significant complications and no revision surgeries. There was no difference in operative time compared to conventional instruments. Conclusion: Piezoelectric instrumentation is a valuable and efficient tool in cleft rhinoplasty. It offers potentially significant advantages in terms of the precision of bony work, whilst minimising trauma to the surrounding soft tissues.
MeSH term(s)	Humans ; Rhinoplasty/methods ; Nasal Bone/surgery ; Cartilage/surgery ; Osteotomy/methods ; Cleft Lip/surgery ; Nose/surgery
Language	English
Publishing date	2023-04-21
Publishing country	Netherlands
Document type	Review ; Journal Article
ZDB-ID	2217750-4
ISSN	1878-0539 ; 1748-6815 ; 0007-1226
ISSN (online)	1878-0539
ISSN	1748-6815 ; 0007-1226
DOI	10.1016/j.bjps.2023.04.069
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Article ; Online: Cancer patient and caregiver communication about economic concerns and the effect on patient and caregiver partners' perceptions of family functioning.

Thomson, Maria D / Wilson-Genderson, Maureen / Siminoff, Laura A

Journal of cancer survivorship : research and practice

2023

Abstract: Purpose: Financial strain and stressful life events can constrain open communication within families. A cancer diagnosis can bring heightened emotional stress and financial strain for most cancer patients and their families. We evaluated how level of ... ...

Abstract	Purpose: Financial strain and stressful life events can constrain open communication within families. A cancer diagnosis can bring heightened emotional stress and financial strain for most cancer patients and their families. We evaluated how level of comfort and willingness to discuss important but sensitive economic topics affected longitudinal assessments of family relationships, exploring both within-person and between partner effects over 2 years after a cancer diagnosis. Methods: A case series of hematological cancer patient-caregiver dyads (n = 171) were recruited from oncology clinics in Virginia and Pennsylvania and followed for 2 years. Multi-level models were developed to examine the associations between comfort discussing economic aspects of cancer care and family functioning. Results: Broadly, caregivers and patients who were comfortable discussing economic topics reported higher family cohesion and lower family conflict. Dyads' assessments of family functioning were influenced both by their own and their partners level of communication comfort. Overtime, caregiver but not patients perceived a significant decrease in family cohesion. Conclusions: Efforts to address financial toxicity in cancer care should include examination of how patients and families communicate as unaddressed difficulties can have detrimental effects on family functioning in the long term. Future studies should also examine whether the prominence of specific economic topics, such as employment status, varies depending on where the patient is in their cancer journey. Implications for cancer survivors: In this sample, cancer patients did not perceive the decline in family cohesion that was reported by their family caregiver. This is an important finding for future work that aims to identify the timing and nature to best intervene with caregiver supports to mitigate caregiver burden that may negatively impact long-term patient care and QoL.
Language	English
Publishing date	2023-02-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2388888-X
ISSN	1932-2267 ; 1932-2259
ISSN (online)	1932-2267
ISSN	1932-2259
DOI	10.1007/s11764-023-01341-0
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Article: Where you begin is not necessarily where you end: the mental and physical health trajectories of cancer caregivers over time.

Wilson-Genderson, Maureen / Thomson, Maria D / Siminoff, Laura A

Research square

2023

Abstract: Purpose: Cancer caregiving, a critical component in the cancer-care model, has deleterious effects on the caregiver's physical and mental health. The degree to which these negative effects are uniformly experienced by caregivers is unclear. The impact ... ...

Abstract	Purpose: Cancer caregiving, a critical component in the cancer-care model, has deleterious effects on the caregiver's physical and mental health. The degree to which these negative effects are uniformly experienced by caregivers is unclear. The impact of the secondary caregiver's absence on the primary caregivers' well-being is understudied. Methods: Terminal cancer patient-caregiver dyads (n = 223) were recruited from oncology clinics and followed for six months or until patient death. Longitudinal latent growth models were used to characterize the heterogeneity of caregiver physical health and depressive symptoms; characteristics associated with these trajectories are examined. Results: Caregivers were majority female (74%), white (55%) and patient spouses (60%). Two physical health (moderate, stable; initially good, declining) and two depressive symptom (moderate, stable; high, increasing) trajectories were identified. Declining physical health was more likely among caregivers who were healthiest at baseline, had higher levels of education, lower subjective burden, fewer depressive symptoms, cared for patients with fewer functional limitations and reported fewer caregiving tasks rendered by a secondary caregiver. Those with increasing depressive symptoms were more likely to be white, patient's wife, have higher subjective caregiver burden, lower physical health, and care for a patient with greater functional limitations. Conclusions: Decreasing physical health was evident among caregivers who were initially healthier and reported less assistance from secondary caregivers. Increasing depression was seen in white, female spouses with higher subjective burden. Sample heterogeneity revealed hidden groups unexpectedly at risk in the primary cancer caregiver role to which the oncology care team should be alert.
Language	English
Publishing date	2023-11-07
Publishing country	United States
Document type	Preprint
DOI	10.21203/rs.3.rs-3513142/v1
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Article ; Online: Pre-gerotal fat patch-A novel alternative to haemostatic agents during partial nephrectomy.

Timm, Brennan / Thomson, Alice / Bolton, Damien / Pether, Michael

BJUI compass

2023 Volume 4, Issue 6, Page(s) 709–714

Abstract: Objective: This study aimed to determine if using a pre-gerotal fat patch at open partial nephrectomy (PN) as a haemostatic bolster is a viable alternative to using synthetic haemostatic agents.: Materials and methods: Human Research Ethics Committee ...

Abstract	Objective: This study aimed to determine if using a pre-gerotal fat patch at open partial nephrectomy (PN) as a haemostatic bolster is a viable alternative to using synthetic haemostatic agents. Materials and methods: Human Research Ethics Committee approval was obtained for audit of a prospectively kept database from July 2012 to July 2021, which followed outcomes of patients who received a low-tension pre-gerotal fat patch renorrhaphy at open PN. Patient demographics, intraoperative measures, histological outcomes and post-operative complications were analysed. Using a retroperitoneal approach, the peritoneum was mobilised and a vascularised pedicle of pre-gerotal fat was rotated in the direction of the kidney. Routine definition of the hilum, clamping of the hilar vessels and dissection of mass followed. After watertight closure and haemostasis, the harvested pre-gerotal fat patch was placed over the defect and secured using low-tension renorrhaphy. Two-layer closure of the abdominal wall with placement of a drain was routine. Results: A total of 55 patients underwent open PN. Mean age was 60.4 (35-77) years. There were 38 men and 17 women, and 32 right and 23 left PNs. Mean mass size was 31.9 mm (10-95 mm) and collecting system was breached in 36.5% of cases. One patient (1.9%) suffered a Clavien-Dindo IIIb complication requiring return to theatre and transfusion due to a bleed from an intercostal artery. There were no renal bed bleeds, urine leaks or urine fistulas detected. Mean intraoperative blood loss was 355 mL (50-1500 mL) and mean post-operative creatinine increased by 10.7 μmol/L (51-172 μmol/L). Mean follow up was 40.2 (4-109) months. Conclusion: Utilisation of an anatomical pre-gerotal fat patch to provide pressure at the renorrhaphy site during open PN is an effective technique to assist with surgical haemostasis. This simple technique avoids the costs of haemostatic agents, whilst adding minimal operating time to procedures.
Language	English
Publishing date	2023-08-16
Publishing country	United States
Document type	Journal Article
ISSN	2688-4526
ISSN (online)	2688-4526
DOI	10.1002/bco2.264
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Article ; Online: Spatio-temporal patterning of extensile active stresses in microtubule-based active fluids.

Lemma, Linnea M / Varghese, Minu / Ross, Tyler D / Thomson, Matt / Baskaran, Aparna / Dogic, Zvonimir

PNAS nexus

2023 Volume 2, Issue 5, Page(s) pgad130

Abstract: Microtubule-based active fluids exhibit turbulent-like autonomous flows, which are driven by the molecular motor powered motion of filamentous constituents. Controlling active stresses in space and time is an essential prerequisite for controlling the ... ...

Abstract	Microtubule-based active fluids exhibit turbulent-like autonomous flows, which are driven by the molecular motor powered motion of filamentous constituents. Controlling active stresses in space and time is an essential prerequisite for controlling the intrinsically chaotic dynamics of extensile active fluids. We design single-headed kinesin molecular motors that exhibit optically enhanced clustering and thus enable precise and repeatable spatial and temporal control of extensile active stresses. Such motors enable rapid, reversible switching between flowing and quiescent states. In turn, spatio-temporal patterning of the active stress controls the evolution of the ubiquitous bend instability of extensile active fluids and determines its critical length dependence. Combining optically controlled clusters with conventional kinesin motors enables one-time switching from contractile to extensile active stresses. These results open a path towards real-time control of the autonomous flows generated by active fluids.
Language	English
Publishing date	2023-04-12
Publishing country	England
Document type	Journal Article
ISSN	2752-6542
ISSN (online)	2752-6542
DOI	10.1093/pnasnexus/pgad130
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