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Article ; Online: Neural étendue expander for ultra-wide-angle high-fidelity holographic display.

Tseng, Ethan / Kuo, Grace / Baek, Seung-Hwan / Matsuda, Nathan / Maimone, Andrew / Schiffers, Florian / Chakravarthula, Praneeth / Fu, Qiang / Heidrich, Wolfgang / Lanman, Douglas / Heide, Felix

Nature communications

2024 Volume 15, Issue 1, Page(s) 2907

Abstract: Holographic displays can generate light fields by dynamically modulating the wavefront of a coherent beam of light using a spatial light modulator, promising rich virtual and augmented reality applications. However, the limited spatial resolution of ... ...

Abstract	Holographic displays can generate light fields by dynamically modulating the wavefront of a coherent beam of light using a spatial light modulator, promising rich virtual and augmented reality applications. However, the limited spatial resolution of existing dynamic spatial light modulators imposes a tight bound on the diffraction angle. As a result, modern holographic displays possess low étendue, which is the product of the display area and the maximum solid angle of diffracted light. The low étendue forces a sacrifice of either the field-of-view (FOV) or the display size. In this work, we lift this limitation by presenting neural étendue expanders. This new breed of optical elements, which is learned from a natural image dataset, enables higher diffraction angles for ultra-wide FOV while maintaining both a compact form factor and the fidelity of displayed contents to human viewers. With neural étendue expanders, we experimentally achieve 64 × étendue expansion of natural images in full color, expanding the FOV by an order of magnitude horizontally and vertically, with high-fidelity reconstruction quality (measured in PSNR) over 29 dB on retinal-resolution images.
Language	English
Publishing date	2024-04-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-46915-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online ; Thesis: Untersuchungen von Phospho-AMPK a, VEGF-A und VEGF-R2 im Myokard sowie Analysen von morphologischen Veränderungen im Modell der chronischen Herzinsuffizienz induziert durch sequentielle, repetitive koronare Mikroembolisation an der Spezies Schaf

Heidrich, Florian

2010

Abstract: Die Basis und zugleich Mittelpunkt dieser Dissertation bildete das Modell der chronischen Herzinsuffizienz (vergleichbar NYHA III), induziert durch sequentielle, repetitive koronare Mikroembolisation an der Spezies Schaf. Im Rahmen dieser Dissertation ... ...

Author's details	vorgelegt von Florian Heidrich
Abstract	Die Basis und zugleich Mittelpunkt dieser Dissertation bildete das Modell der chronischen Herzinsuffizienz (vergleichbar NYHA III), induziert durch sequentielle, repetitive koronare Mikroembolisation an der Spezies Schaf. Im Rahmen dieser Dissertation gelang erstmalig eine morphologische Systemvalidierung (HE- und PSR-Färbungen von Myokard-, Leber- und Nierengewebe) zur Prüfung eines Vorwärts- sowie Rückwärtsversagens, welches bereits durch hämodynamische Analysen verifiziert wurde. Des Weiteren wurde mit Hilfe der RT-PCR und des Western Blotting Phospho-AMPK a, VEGF-A und VEGF-R2 analysiert. Ziel war die Definition von Kompensationsmechanismen, die für eine Adaptation an die induzierte Druck- und Volumenbelastung verantwortlich sein könnten. AMPK agiert als zentrales Schlüsselenzym im kardialen Energiestoffwechsel und besitzt verschiedene kardioprotektive Eigenschaften. Mit VEGF-A und VEGF-R2 wurden obligate Parameter der Neoangiogenese (suffiziente Kollateralisierung) untersucht. Repetitive, sequentielle Mikroembolisation induziert eine ischämische Kardiomyopathie und führen konsekutiv zu pathologischen Veränderungen der Leber und Niere. Quantitative sowie qualitative Analysen zeigten einen signifikanten Anstieg der Phosphorylierung von AMPK. Die ermittelten Werte von VEGF-A und VEGF-R2 lagen stets im Bereich der Kontrollgruppe. Somit könnte lediglich Phospho-AMPK a als möglicher Kompensationsmechanismus postuliert werden. Die retrospektive Betrachtung aller Ergebnisse ergab eine führende rechtsventrikuläre Schädigung. Infolgedessen konnte eindrucksvoll herausgearbeitet werden, dass sich das etablierte Versuchstiermodell primär für Studien einer Globalinsuffizienz und nicht hingegen, wie angenommen, für Studien einer isolierten Linksherzinsuffizienz eignet.
Language	German
Size	Online-Ressource (PDF-Datei: 111 S., 10.000 KB), Ill., graph. Darst
Document type	Book ; Online ; Thesis
Thesis / German Habilitation thesis	Univ., Diss.--Göttingen, 2011
Database	Former special subject collection: coastal and deep sea fishing

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Article ; Online: Prediction of melanin content of Fonsecaea pedrosoi using Fourier transform infrared spectroscopy (FTIR) and chemometrics.

Koehler, Alessandra / de Moraes, Paulo Cezar / Heidrich, Daiane / Scroferneker, Maria Lúcia / Ferrão, Marco Flôres / Corbellini, Valeriano Antonio

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

2024 Volume 310, Page(s) 123945

Abstract: Fungal melanin contributes to the survival and virulence of pathogenic fungi, such as Fonsecaea pedrosoi, which is responsible for causing chromoblastomycosis. The objective of this study was to employ Fourier transform infrared spectroscopy (FTIR) to ... ...

Abstract	Fungal melanin contributes to the survival and virulence of pathogenic fungi, such as Fonsecaea pedrosoi, which is responsible for causing chromoblastomycosis. The objective of this study was to employ Fourier transform infrared spectroscopy (FTIR) to predict the melanin content of F. pedrosoi. The melanin content, in percentage, was previously determined using gravimetry for twenty-six clinical isolates. Quintuplicate spectra of each isolate were obtained using attenuated total reflection (ATR) within the range of 4000 to 650 cm
MeSH term(s)	Spectroscopy, Fourier Transform Infrared/methods ; Melanins ; Chemometrics ; Least-Squares Analysis ; Fonsecaea
Chemical Substances	Melanins
Language	English
Publishing date	2024-01-26
Publishing country	England
Document type	Journal Article
ZDB-ID	210413-1
ISSN	1873-3557 ; 0370-8322 ; 0584-8539 ; 1386-1425
ISSN (online)	1873-3557
ISSN	0370-8322 ; 0584-8539 ; 1386-1425
DOI	10.1016/j.saa.2024.123945
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Article ; Online: First report on sepsis caused by Porphyromonas pogonae.

Schröttner, Percy / Heidrich, Katharina / Rudolph, Wolfram W / Stölzel, Friedrich / Jacobs, Enno / Gunzer, Florian

Anaerobe

2017 Volume 44, Page(s) 96–98

Abstract: We report on a 62 year old patient who developed sepsis due to an infection caused by Porphyromonas pogonae, a recently described species of the bacterial genus Porphyromonas. This is the first case of an invasive infection with this pathogen. ...

Abstract	We report on a 62 year old patient who developed sepsis due to an infection caused by Porphyromonas pogonae, a recently described species of the bacterial genus Porphyromonas. This is the first case of an invasive infection with this pathogen.
MeSH term(s)	Bacteriological Techniques ; Bacteroidaceae Infections/diagnosis ; Bacteroidaceae Infections/microbiology ; Bacteroidaceae Infections/pathology ; Humans ; Male ; Middle Aged ; Porphyromonas/chemistry ; Porphyromonas/classification ; Porphyromonas/isolation & purification ; Sepsis/diagnosis ; Sepsis/microbiology ; Sepsis/pathology ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Language	English
Publishing date	2017-04
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1237621-8
ISSN	1095-8274 ; 1075-9964
ISSN (online)	1095-8274
ISSN	1075-9964
DOI	10.1016/j.anaerobe.2017.02.016
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Article: First report on sepsis caused by Porphyromonas pogonae

Schröttner, Percy / Enno Jacobs / Florian Gunzer / Friedrich Stölzel / Katharina Heidrich / Wolfram W. Rudolph

Anaerobe. 2017 Apr., v. 44

2017

Abstract	We report on a 62 year old patient who developed sepsis due to an infection caused by Porphyromonas pogonae, a recently described species of the bacterial genus Porphyromonas. This is the first case of an invasive infection with this pathogen.
Keywords	pathogens ; patients ; Porphyromonas ; sepsis (infection)
Language	English
Dates of publication	2017-04
Size	p. 96-98.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	1237621-8
ISSN	1075-9964
ISSN	1075-9964
DOI	10.1016/j.anaerobe.2017.02.016
Database	NAL-Catalogue (AGRICOLA)

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Conference proceedings: Partizipation im Forschungspraxennetz RESPoNsE: Praxisbeiräte – ein Werkstattbericht

Wolf, Florian / Akdenizli, Kemal / Bleidorn, Jutta / Fleischhauer, Christian / Fritsch, Sarah / Heidrich, Florian / Heintze, Christoph / Henße, Jana / Holz, Stefanie / Isbrecht, Ina / Kaden, Frank / Kümpel, Lisa / Kuschick, Doreen / Lieb, Christian / Medrow, Natascha / Mühlberg, Juliane / Neidhardt-Akdenizli, Andrea / Reicherdt, Isabelle / Riese, Kerstin /

Rost, Liljana / Steenweg, Lydia / Stengler, Katja / Toutaoui, Kahina / Zitterbart, Ulf / Döpfmer, Susanne

2021 , Page(s) V–06–01

Event/congress	55. Kongress für Allgemeinmedizin und Familienmedizin; Lübeck; Deutsche Gesellschaft für Allgemeinmedizin und Familienmedizin; 2021
Keywords	Medizin, Gesundheit
Publishing date	2021-09-17
Publisher	German Medical Science GMS Publishing House; Düsseldorf
Document type	Conference proceedings
DOI	10.3205/21degam029
Database	German Medical Science

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Article ; Online: Clostridium Difficile infections in patients with AML or MDS undergoing allogeneic hematopoietic stem cell transplantation identify high risk for adverse outcome.

Amberge, Simon / Kramer, Michael / Schröttner, Percy / Heidrich, Katharina / Schmelz, Renate / Middeke, Jan M / Gunzer, Florian / Hampe, Jochen / Schetelig, Johannes / Bornhäuser, Martin / Stölzel, Friedrich

Bone marrow transplantation

2019 Volume 55, Issue 2, Page(s) 367–375

Abstract: Clostridium difficile (CD) infection is the main cause of nosocomial enterocolitis in western countries and in patients undergoing allogeneic hematopoietic stem cell transplantation (alloHCT). Recipients of alloHCT are at high risk for CD infection but ... ...

Abstract	Clostridium difficile (CD) infection is the main cause of nosocomial enterocolitis in western countries and in patients undergoing allogeneic hematopoietic stem cell transplantation (alloHCT). Recipients of alloHCT are at high risk for CD infection but large studies in this population are rare and conflicting results have been reported. We analyzed 727 patients with AML or MDS undergoing alloHCT in our center from 2004 to 2015. Ninety-six patients (13%) had CD infection and 103 patients (14%) were identified as asymptomatic carriers by screening at admission and once a week during aplasia. Patients with CD infection had a shorter median overall survival of 8 months (95% CI, 6-36 months) compared with 25 months (95% CI, 17-35 months) for patients without CD infection, (HR 1.4, p = 0.04). CD positive patients were less likely to develop acute graft-versus-host disease (aGvHD; HR 0.6, p = 0.004) compared with CD-negative patients, but did not show differences in gastrointestinal aGvHD (HR 0.9, p = 0.5). Symptomatic patients developed gastrointestinal aGvHD (HR 2.5, p = 0.02) more often compared with asymptomatic CD positive patients. This analysis demonstrates a high prevalence for CD infection in patients undergoing alloHCT. A significant lower overall survival for patients with CD infection could be demonstrated.
MeSH term(s)	Clostridium Infections/etiology ; Graft vs Host Disease/etiology ; Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; Leukemia, Myeloid, Acute/therapy ; Retrospective Studies ; Transplantation, Homologous
Language	English
Publishing date	2019-09-18
Publishing country	England
Document type	Journal Article
ZDB-ID	632854-4
ISSN	1476-5365 ; 0268-3369 ; 0951-3078
ISSN (online)	1476-5365
ISSN	0268-3369 ; 0951-3078
DOI	10.1038/s41409-019-0678-y
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Book ; Online: Neural \'{E}tendue Expander for Ultra-Wide-Angle High-Fidelity Holographic Display

Tseng, Ethan / Baek, Seung-Hwan / Kuo, Grace / Matsuda, Nathan / Maimone, Andrew / Schiffers, Florian / Chakravarthula, Praneeth / Fu, Qiang / Heidrich, Wolfgang / Lanman, Douglas / Heide, Felix

2021

Abstract	Holographic displays can generate light fields by dynamically modulating the wavefront of a coherent beam of light using a spatial light modulator, promising rich virtual and augmented reality applications. However, the limited spatial resolution of existing dynamic spatial light modulators imposes a tight bound on the diffraction angle. As a result, modern holographic displays possess low \'{e}tendue, which is the product of the display area and the maximum solid angle of diffracted light. The low \'{e}tendue forces a sacrifice of either the field-of-view (FOV) or the display size. In this work, we lift this limitation by presenting neural \'{e}tendue expanders. This new breed of optical elements, which is learned from a natural image dataset, enables higher diffraction angles for ultra-wide FOV while maintaining both a compact form factor and the fidelity of displayed contents to human viewers. With neural \'{e}tendue expanders, we experimentally achieve 64$\times$ \'{e}tendue expansion of natural images in full color, expanding the FOV by an order of magnitude horizontally and vertically, with high-fidelity reconstruction quality (measured in PSNR) over 29 dB on retinal-resolution images.
Keywords	Electrical Engineering and Systems Science - Image and Video Processing ; Computer Science - Computer Vision and Pattern Recognition ; Physics - Optics
Subject code	535
Publishing date	2021-09-16
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Rapid classification of chromoblastomycosis agents genera by infrared spectroscopy and chemometrics supervised by sequencing of rDNA regions.

Heidrich, Daiane / Koehler, Alessandra / Ramírez-Castrillón, Mauricio / Pagani, Danielle Machado / Ferrão, Marco Flores / Scroferneker, Maria Lúcia / Corbellini, Valeriano Antonio

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

2021 Volume 254, Page(s) 119647

Abstract: Chromoblastomycosis (CBM) is a skin and subcutaneous infection caused by species of seven fungal genera. Identification of CBM species is performed by DNA sequencing of one or more genes, which becomes a time-consuming work. Fourier Transform Infrared ... ...

Abstract	Chromoblastomycosis (CBM) is a skin and subcutaneous infection caused by species of seven fungal genera. Identification of CBM species is performed by DNA sequencing of one or more genes, which becomes a time-consuming work. Fourier Transform Infrared Spectroscopy (FTIR) has been used for the identification of other microorganisms, however, only one CBM genus was evaluated by FTIR analysis to date. Therefore, the study is aimed to differentiate the CBM agents for identification at genera level using FTIR supervised by Internal Transcribed Spacer (ITS) rDNA region. Seventy-seven isolates of the main five CBM genera were prepared for Attenuated Total Reflection FTIR (ATR-FTIR) with a new methodology using slices of dry fungus in glass fixing-modeling proposed in this study. The algorithm Hierarchical Cluster Analysis (HCA) was used to analyze the differences and similarities between species through the spectra. Orthogonal Partial Least Square Discriminant Analysis (OPLS-DA) allowed to correctly classify all samples of five CBM genera. The ATR-FTIR/OPLS-DA models highlighted important contributions of regions attributed to NH and OH stretching, amide I of proteins, polysaccharides bands and fingerprint region for the complete differentiation of the genera investigated. Thus, FTIR can be a fast and inexpensive alternative for identification of CBM agents.
MeSH term(s)	Chromoblastomycosis/diagnosis ; DNA, Ribosomal ; Discriminant Analysis ; Humans ; Least-Squares Analysis ; Spectroscopy, Fourier Transform Infrared
Chemical Substances	DNA, Ribosomal
Language	English
Publishing date	2021-03-10
Publishing country	England
Document type	Journal Article
ZDB-ID	210413-1
ISSN	1873-3557 ; 0370-8322 ; 0584-8539 ; 1386-1425
ISSN (online)	1873-3557
ISSN	0370-8322 ; 0584-8539 ; 1386-1425
DOI	10.1016/j.saa.2021.119647
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Article ; Online: Five-year follow-up of 96 weeks peginterferon plus tenofovir disoproxil fumarate in hepatitis D.

Anastasiou, Olympia E / Caruntu, Florin A / Curescu, Manuela G / Yalcin, Kendal / Akarca, Ulus S / Gürel, Selim / Zeuzem, Stefan / Erhardt, Andreas / Lüth, Stefan / Papatheodoridis, George V / Keskin, Onur / Port, Kerstin / Radu, Monica / Celen, Mustafa K / Idilman, Ramazan / Heidrich, Benjamin / Mederacke, Ingmar / von der Leyen, Heiko / Kahlhöfer, Julia /

von Karpowitz, Maria / Hardtke, Svenja / Cornberg, Markus / Yurdaydin, Cihan / Wedemeyer, Heiner

Liver international : official journal of the International Association for the Study of the Liver

2023 Volume 44, Issue 1, Page(s) 139–147

Abstract: Background & aims: Until recently, pegylated interferon-alfa-2a (PEG-IFNa) therapy was the only treatment option for patients infected with hepatitis D virus (HDV). Treatment with PEG-IFNa with or without tenofovir disoproxil fumarate (TDF) for 96 weeks ...

Abstract	Background & aims: Until recently, pegylated interferon-alfa-2a (PEG-IFNa) therapy was the only treatment option for patients infected with hepatitis D virus (HDV). Treatment with PEG-IFNa with or without tenofovir disoproxil fumarate (TDF) for 96 weeks resulted in HDV RNA suppression in 44% of patients at the end of therapy but did not prevent short-term relapses within 24 weeks. The virological and clinical long-term effects after prolonged PEG-IFNa-based treatment of hepatitis D are unknown. Methods: In the HIDIT-II study patients (including 40% with liver cirrhosis) received 180 μg PEG-IFNa weekly plus 300 mg TDF once daily (n = 59) or 180 μg PEG-IFNa weekly plus placebo (n = 61) for 96 weeks. Patients were followed until week 356 (5 years after end of therapy). Results: Until the end of follow-up, 16 (13%) patients developed liver-related complications (PEG-IFNa + TDF, n = 5 vs PEG-IFNa + placebo, n = 11; p = .179). Achieving HDV suppression at week 96 was associated with decreased long-term risk for the development of hepatocellular carcinoma (p = .04) and hepatic decompensation (p = .009). Including complications irrespective of PEG-IFNa retreatment status, the number of patients developing serious complications was similar with (3/18) and without retreatment with PEG-IFNa (16/102, p > .999) but was associated with a higher chance of HDV-RNA suppression (p = .024, odds ratio 3.9 [1.3-12]). Conclusions: Liver-related clinical events were infrequent and occurred less frequently in patients with virological responses to PEG-IFNa treatment. PEG-IFNa treatment should be recommended to HDV-infected patients until alternative therapies become available. Retreatment with PEG-IFNa should be considered for patients with inadequate response to the first course of treatment. Clinical trial registration: NCT00932971.
MeSH term(s)	Humans ; Tenofovir/adverse effects ; Antiviral Agents/adverse effects ; Follow-Up Studies ; Treatment Outcome ; Drug Therapy, Combination ; Neoplasm Recurrence, Local ; Hepatitis D/drug therapy ; Polyethylene Glycols/adverse effects ; Hepatitis Delta Virus/genetics ; RNA, Viral
Chemical Substances	Tenofovir (99YXE507IL) ; Antiviral Agents ; Polyethylene Glycols (3WJQ0SDW1A) ; RNA, Viral
Language	English
Publishing date	2023-10-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2102783-3
ISSN	1478-3231 ; 1478-3223
ISSN (online)	1478-3231
ISSN	1478-3223
DOI	10.1111/liv.15745
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