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Book ; Audio / Video ; Online: Y. Ping Sun oral history interview reflecting on Covid-19 pandemic

Sun, Y. Ping

Houston Asian American Archives oral history interviews, MS 573, Woodson Research Center, Fondren Library, Rice University

2020

Abstract: ... collection is created in response to COVID-19 that started in February 2020. Y. Ping Sun, a veteran community ...

Abstract	This recording and transcript form part of a collection of oral history interviews conducted by the Chao Center for Asian Studies at Rice University. This collection includes audio recordings and transcripts of interviews with Asian Americans native to or living in Houston. This special oral history collection is created in response to COVID-19 that started in February 2020. Y. Ping Sun, a veteran community member of Houston Asian American Archive, who was interviewed back in 2011, returned to speak about her role in serving the community, updates on her life, and impact upon the Asian American community. Saluted by the Asian Chamber of Commerce for serving on the Greater Houston COVID-19 Recovery Fund’s Task Force, she is deeply involved with helping the Houston community.
Keywords	covid19
Language	English
Publishing date	2020-05-27
Publisher	Rice University
Publishing country	us
Document type	Book ; Audio / Video ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Yu-Ping-Feng Formula Ameliorates Alveolar-Capillary Barrier Injury Induced by Exhausted-Exercise

Wang, Di / Li, Quan / Pan, Chun-Shui / Yan, Li / Sun, Kai / Wang, Xiao-Yi / Anwaier, Gulinigaer / Liao, Qian-Zan / Xie, Ting-Ting / Fan, Jing-Yu / Huo, Xin-Mei / Wang, Yuan / Han, Jing-Yan

Frontiers in pharmacology

2022 Volume 13, Page(s) 891802

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2022-06-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.891802
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Mechanisms and molecular targets of the Yu-Ping-Feng powder for allergic rhinitis, based on network pharmacology.

Yang, Shasha / Fu, Qinwei / Deng, Hua / Liu, Zhiqing / Zhong, Juan / Zhu, Xiaoyu / Wang, Qian / Sun, Chuanhui / Wu, Jing

Medicine

2021 Volume 100, Issue 35, Page(s) e26929

Abstract: Abstract: In traditional Chinese medicine (TCM), Yu-Ping-Feng powder (YPFP) has been used to treat ...

Abstract	Abstract: In traditional Chinese medicine (TCM), Yu-Ping-Feng powder (YPFP) has been used to treat allergic rhinitis (AR) for centuries. However, the mechanisms underlying its effects or its molecular targets in AR treatment are yet to be elucidated. Therefore, the active compounds of YPFP and their targets were collected and identified from the Traditional Chinese Medicine Systems Pharmacology database. Moreover, AR-associated targets were acquired from the GeneCards and Online Mendelian Inheritance in Man database. Proteins interactions network of YPFP presumed targets and AR-associated targets were examined and merged to reveal the candidate YPFP targets against AR.Cytoscape software and BisoGenet Database were employed to perform the Visualization and Integrated Discovery (Cluster Profiler R package, version: 3.8.1). Kyoto Encyclopedia of Genes and Genomes and genome pathway analyses. To identify the key target genes, a gene-pathway network has been constructed.We identified 44 effective active compounds and 622 YPFP targets. Also 1324 target genes related to AR were identified. Twenty pathways, including those of AGE-RAGE signaling, fluid shear stress, atherosclerosis, PI3K-Akt signaling, and tumor necrosis factor signaling was enriched significantly. MAPK1 was identified as the core gene, while others including RELA, AKT1, NFKBIA, IL6, and JUN, were also important in the gene-pathway network. Clearly, network pharmacology can be applied in revealing the molecular targets and mechanisms of action of complex herbal preparations.These findings suggested that YPFP could treat AR by regulating immunological functions, diminishing inflammation, and improving immunity through different pathways.
MeSH term(s)	Drugs, Chinese Herbal/pharmacokinetics ; Drugs, Chinese Herbal/therapeutic use ; Humans ; Pharmacology/methods ; Protein Interaction Maps/drug effects ; Rhinitis, Allergic/drug therapy
Chemical Substances	Drugs, Chinese Herbal ; yu ping feng san
Language	English
Publishing date	2021-09-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000026929
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Ua VI Zs.171: Show issues

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Article: Yu-Ping-Feng Formula Exerts Antilung Cancer Effects by Remodeling the Tumor Microenvironment through Regulating Myeloid-Derived Suppressor Cells.

Wang, Yuli / Sun, Ningyang / Luo, Yingbin / Fang, Zhihong / Fang, Yuan / Tian, Jianhui / Yu, Yongchun / Wu, Jianchun / Li, Yan

Evidence-based complementary and alternative medicine : eCAM

2021 Volume 2021, Page(s) 6624461

Abstract: Yu-Ping-Feng (YPF) formula is a classical prescription used for enhancing the body's immunity ...

Abstract	Yu-Ping-Feng (YPF) formula is a classical prescription used for enhancing the body's immunity function in traditional Chinese medicine (TCM). In clinical practice, the YPF formula has been reported to exhibit antilung cancer and immunomodulatory effect. However, the relationship between them remains unclear. The present study aimed to investigate the antilung cancer effect of the YPF formula and its immune-related mechanisms. The C57BL/6 tumor-bearing mice model was established and randomly divided into the YPF group and the control group. Tumor volume, spleen weight, and survival in both groups were measured and evaluated during 28 days of consecutive intervention. Flow cytometry was used to detect the proportion of immune cell subsets. Myeloid-derived suppressor cells (MDSCs) were induced in vitro from bone marrow cells. After intervention by the YPF formula, CCK-8 and flow cytometry analyses were performed to detect proliferation and apoptosis of MDSCs. A coculture system containing T cells and MDSCs was established to further study the role of MDSCs in the regulation of T-cell subsets proportion by the YPF formula. The expressions of MDSCs-related genes and proteins were detected by RT-PCR and Western blotting. The results showed the YPF formula inhibited tumor growth, reduced spleen weight, and prolonged the survival of mice. Besides, the proportions of MDSCs subsets and Regulatory
Language	English
Publishing date	2021-04-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2021/6624461
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Article ; Online: Yu-Ping-Feng Formula Ameliorates Alveolar-Capillary Barrier Injury Induced by Exhausted-Exercise via Regulation of Cytoskeleton

Di Wang / Quan Li / Chun-Shui Pan / Li Yan / Kai Sun / Xiao-Yi Wang / Gulinigaer Anwaier / Qian-Zan Liao / Ting-Ting Xie / Jing-Yu Fan / Xin-Mei Huo / Yuan Wang / Jing-Yan Han

Frontiers in Pharmacology, Vol

2022 Volume 13

Abstract: Background: Yu-ping-feng powder (YPF) is a compound traditional Chinese medicine extensively used ...

Abstract	Background: Yu-ping-feng powder (YPF) is a compound traditional Chinese medicine extensively used in China for respiratory diseases. However, the role of YPF in alveolar-capillary barrier dysfunction remains unknown. This study aimed to explore the effect and potential mechanism of YPF on alveolar-capillary barrier injury induced by exhausted exercise.Methods: Male Sprague–Dawley rats were used to establish an exhausted-exercise model by using a motorized rodent treadmill. YPF at doses of 2.18 g/kg was administrated by gavage before exercise training for 10 consecutive days. Food intake-weight/body weight, blood gas analysis, lung water percent content, BALF protein concentration, morphological observation, quantitative proteomics, real-time PCR, and Western blot were performed. A rat pulmonary microvascular endothelial cell line (PMVEC) subjected to hypoxia was applied for assessing the related mechanism.Results: YPF attenuated the decrease of food intake weight/body weight, improved lung swelling and hemorrhage, alleviated the increase of lung water percent content and BALF protein concentration, and inhibited the impairment of lung morphology. In addition, YPF increased the expression of claudin 3, claudin 18, occludin, VE-cadherin, and β-catenin, attenuated the epithelial and endothelial hyperpermeability in vivo and/or in vitro, and the stress fiber formation in PMVECs after hypoxia. Quantitative proteomics discovered that the effect of YPF implicated the Siah2-ubiquitin-proteasomal pathway, Gng12-PAK1-MLCK, and RhoA/ROCK, which was further confirmed by Western blot. Data are available via ProteomeXchange with identifier PXD032737.Conclusion: YPF ameliorated alveolar-capillary barrier injury induced by exhausted exercise, which is accounted for at least partly by the regulation of cytoskeleton.
Keywords	traditional Chinese medicine ; lung injury ; proteomics ; cell junctions ; stress fiber ; Therapeutics. Pharmacology ; RM1-950
Subject code	610
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Yu-Ping-Feng Formula Exerts Antilung Cancer Effects by Remodeling the Tumor Microenvironment through Regulating Myeloid-Derived Suppressor Cells

Yuli Wang / Ningyang Sun / Yingbin Luo / Zhihong Fang / Yuan Fang / Jianhui Tian / Yongchun Yu / Jianchun Wu / Yan Li

Evidence-Based Complementary and Alternative Medicine, Vol

2021 Volume 2021

Abstract: Yu-Ping-Feng (YPF) formula is a classical prescription used for enhancing the body’s immunity ...

Abstract	Yu-Ping-Feng (YPF) formula is a classical prescription used for enhancing the body’s immunity function in traditional Chinese medicine (TCM). In clinical practice, the YPF formula has been reported to exhibit antilung cancer and immunomodulatory effect. However, the relationship between them remains unclear. The present study aimed to investigate the antilung cancer effect of the YPF formula and its immune-related mechanisms. The C57BL/6 tumor-bearing mice model was established and randomly divided into the YPF group and the control group. Tumor volume, spleen weight, and survival in both groups were measured and evaluated during 28 days of consecutive intervention. Flow cytometry was used to detect the proportion of immune cell subsets. Myeloid-derived suppressor cells (MDSCs) were induced in vitro from bone marrow cells. After intervention by the YPF formula, CCK-8 and flow cytometry analyses were performed to detect proliferation and apoptosis of MDSCs. A coculture system containing T cells and MDSCs was established to further study the role of MDSCs in the regulation of T-cell subsets proportion by the YPF formula. The expressions of MDSCs-related genes and proteins were detected by RT-PCR and Western blotting. The results showed the YPF formula inhibited tumor growth, reduced spleen weight, and prolonged the survival of mice. Besides, the proportions of MDSCs subsets and Regulatory T (Treg) in the YPF group decreased, whereas those of CD4+T and CD8+T increased both in vitro and in vivo. CCK-8 and flow cytometry demonstrated that the YPF formula could inhibit proliferation and promote apoptosis of MDSCs. The coculture experiments further confirmed that MDSCs served a critical role in regulating the tumor microenvironment by the YPF formula. RT-PCR and Western blotting indicated that the levels of MDSCs’ activation and proliferation-related proteins and genes were downregulated in the YPF group. Therefore, our results demonstrated that the YPF formula could promote apoptosis and inhibit the proliferation of ...
Keywords	Other systems of medicine ; RZ201-999
Subject code	610
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: A "ping-pong ball" in the left ventricle.

Park, Jeong-Hwan / Sohn, Il-Suk / Park, Byong-Jo / Jin, Eun-Sun / Cho, Jin-Man / Kim, Chong-Jin

Journal of echocardiography

2010 Volume 8, Issue 4, Page(s) 142–143

Language	English
Publishing date	2010-12
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2209473-8
ISSN	1880-344X ; 1349-0222
ISSN (online)	1880-344X
ISSN	1349-0222
DOI	10.1007/s12574-010-0049-6
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Article ; Online: Simultaneous determination of six C21 steroids of Xiao-Ai-Ping injection in rat plasma by LC-MS/MS.

Zeng, Qinghua / Zhang, Feng / Gao, Shouhong / Sun, Liang / Jiang, Bo / Chen, Wansheng

Biomedical chromatography : BMC

2014 Volume 28, Issue 2, Page(s) 223–230

Abstract: Xiao-Ai-Ping injection (XAPI) is a traditional Chinese medicine that has been widely used to treat ...

Abstract	Xiao-Ai-Ping injection (XAPI) is a traditional Chinese medicine that has been widely used to treat cancer. Modern pharmacological studies have demonstrated that C21 steroids are the main active compounds in XAPI. In this study, a sensitive and specific liquid chromatography tandem mass spectrometry (LC-MS/MS) method was developed and validated the first time for simultanenous determination of three isomeric pregnane genins (17β-tenacigenin B, tenacigenin B and tenacigenin A) and their corresponding glycosides (tenacigenoside A, tenacissoside F and marsdenoside I) from XAPI in rat plasma. A simple liquid-liquid extraction technique was used after the addition of dexamethasone acetate as internal standard. The chromatography separation of analytes was achieved on an Agilent Zorbax Eclipse XDB-C18 column (3.5 µm, 150 × 3 mm i.d.) using methanol-water as mobile phase in a gradient elution program. Detection was performed in multiple reaction monitoring mode using electrospray ionization in the negative ion mode. The method showed satisfactory linearity over a concentration range 5.00-2000.00 ng/mL for tenacigenin B, tenacigenin A, marsdenoside I and tenacissoside F (r(2) > 0.99), 10.00-4000.00 ng/mL for 17β-tenacigenin B and tenacigenoside A (r(2) > 0.99). Intra- and inter-day precisions (valued as relative standard deviation) were <9.00% and accuracies (as relative error) in the range -6.31 to 7.23%. Finally, this validated method was successfully applied to the pharmacokinetic study of XAPI after intravenous administration to rats.
MeSH term(s)	Animals ; Chromatography, Liquid/methods ; Drug Stability ; Drugs, Chinese Herbal/chemistry ; Linear Models ; Liquid-Liquid Extraction ; Male ; Pregnanes/blood ; Pregnanes/chemistry ; Pregnanes/pharmacokinetics ; Rats ; Rats, Sprague-Dawley ; Reproducibility of Results ; Sensitivity and Specificity ; Steroids/blood ; Steroids/chemistry ; Steroids/pharmacokinetics ; Tandem Mass Spectrometry/methods
Chemical Substances	Drugs, Chinese Herbal ; Pregnanes ; Steroids ; tenacigenin B
Language	English
Publishing date	2014-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632848-9
ISSN	1099-0801 ; 0269-3879
ISSN (online)	1099-0801
ISSN	0269-3879
DOI	10.1002/bmc.3009
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 2166: Show issues

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Article: Ping-Chong-Jiang-Ni Formula Induces Apoptosis and Inhibits Proliferation of Human Ectopic Endometrial Stromal Cells in Endometriosis via the Activation of JNK Signaling Pathway.

Liang, Rui-Ning / Li, Pei-Shuang / Zou, Yang / Liu, Yu-Ling / Jiang, Zhen / Liu, Zhen / Fan, Pei / Xu, Ling / Peng, Jia-Hua / Sun, Xue-Yan

Evidence-based complementary and alternative medicine : eCAM

2017 Volume 2017, Page(s) 6489427

Abstract: ... in modern medicine achieves usually temporary cure. Ping-Chong-Jiang-Ni formula (PCJNF), a Chinese herbal medicine ...

Abstract	Endometriosis is a common gynecological condition in childbearing age women and its therapy in modern medicine achieves usually temporary cure. Ping-Chong-Jiang-Ni formula (PCJNF), a Chinese herbal medicine (CHM), was shown to be clinically effective on endometriosis. Meanwhile, c-Jun N-terminal kinase (JNK) signaling pathway was involved in the therapeutic process of CHM on endometriosis. Here, we explored the effect of PCJNF on the ectopic endometrial stromal cells (EESCs) from endometriosis and test whether JNK signaling was involved. After being treated with PCJNF-containing serum obtained from Sprague Dawley rat, cell proliferation, migration, invasion, and apoptosis were evaluated in EESCs, and the total and phosphorylated JNK, ERK, and p38 proteins were detected. Our results showed that PCJNF could suppress cell proliferation, migration, and invasion and induce apoptosis in EESCs. The suppressed proliferation and increased apoptosis were dependent on JNK activation. Additionally, PCJNF caused cell cycle arrest at G2/M phase and this effect was mediated by JNK signaling, while the decreased cell migration and invasion treated by PCJNF were independent of JNK signaling. In summary, our results provided the first evidence that PCJNF could suppress cell proliferation, migration, and invasion, while increasing apoptosis in EESCs, and the suppressed proliferation and enhanced apoptosis were mediated by JNK signaling.
Language	English
Publishing date	2017-06-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2017/6489427
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Zs.A 5995: Show issues

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Article: Xiao-Ai-Ping, a TCM Injection, Enhances the Antigrowth Effects of Cisplatin on Lewis Lung Cancer Cells through Promoting the Infiltration and Function of CD8(+) T Lymphocytes.

Li, Wanshuai / Yang, Yang / Ouyang, Zijun / Zhang, Qi / Wang, Lu / Tao, Feifei / Shu, Yongqian / Gu, Yanhong / Xu, Qiang / Sun, Yang

Evidence-based complementary and alternative medicine : eCAM

2013 Volume 2013, Page(s) 879512

Abstract: Objectives. To investigate how Xiao-Ai-Ping injection, a traditional Chinese medicine and ... Xiao-Ai-Ping, or cisplatin plus Xiao-Ai-Ping, respectively. Body weight and tumor volumes were measured ... every three days. Results. Combination of Xiao-Ai-Ping and cisplatin yielded significantly better antigrowth ...

Abstract	Objectives. To investigate how Xiao-Ai-Ping injection, a traditional Chinese medicine and an ancillary drug in tumor treatment, enhances the antitumor effects of cisplatin on Lewis lung cancer (LLC) cells. Methods. LLC-bearing mice were daily intraperitoneally injected with various doses of cisplatin, Xiao-Ai-Ping, or cisplatin plus Xiao-Ai-Ping, respectively. Body weight and tumor volumes were measured every three days. Results. Combination of Xiao-Ai-Ping and cisplatin yielded significantly better antigrowth and proapoptotic effects on LLC xenografts than sole drug treatment did. In addition, we found that Xiao-Ai-Ping triggered the infiltration of CD8(+) T cells, a group of cytotoxic T cells, to LLC xenografts. Furthermore, the mRNA levels of interferon- γ (ifn- γ ), perforin-1 (prf-1), and granzyme B (gzmb) in CD8(+) T cells were significantly increased after combination treatment of Xiao-Ai-Ping and cisplatin. In vitro studies showed that Xiao-Ai-Ping markedly upregulated the mRNA levels of ifn- γ , prf-1, and gzmb in CD8(+) T cells in a concentration-dependent manner, suggesting that Xiao-Ai-Ping augments the function of CD8(+) T cells. Conclusions. Xiao-Ai-Ping promotes the infiltration and function of CD8(+) T cells and thus enhances the antigrowth effects of cisplatin on LLC xenografts, which provides new evidence for the combination of Xiao-Ai-Ping and cisplatin in clinic in China.
Language	English
Publishing date	2013-07-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2013/879512
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