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  1. Book ; Thesis: Der Mathematiker Abraham de Moivre (1667 - 1754)

    Schneider, Ivo / Moivre, Abraham de

    Archive for history of exact sciences, Vol. 5, 1968, Nr. 3/4 (Geschichte der Mathematik)

    (Veröffentlichungen des Forschungsinstituts des Deutschen Museums für die Geschichte der Naturwissenschaften und der Technik : Reihe D ; 4)

    1969  Volume 5

    Author's details Ivo Schneider
    Series title Veröffentlichungen des Forschungsinstituts des Deutschen Museums für die Geschichte der Naturwissenschaften und der Technik : Reihe D ; 4
    Language German
    Size S. 178 - 317
    Edition München [u.a.] : Springer
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Naturwiss. Fak., Diss.--München, 1968
    Database Former special subject collection: coastal and deep sea fishing

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  2. Book ; Thesis: Der Mathematiker Abraham de Moivre (1667 - 1754)

    Schneider, Ivo / Moivre, Abraham de

    Archive for history of exact sciences, Vol. 5, 1968, Nr. 3/4 (Geschichte der Mathematik)

    1968  Volume 5

    Author's details Ivo Schneider
    Language German
    Size S. 178 - 317, gr. 8
    Edition München
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Naturwiss. Fak., Diss.--München, 1968
    Database Former special subject collection: coastal and deep sea fishing

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  3. Article ; Online: Hemoperfusion in Cardiac Surgery and ECMO.

    Abraham, Paul / Mendes, Vitor / Kirsch, Matthias / Schneider, Antoine

    Contributions to nephrology

    2023  Volume 200, Page(s) 180–191

    Abstract: Extracorporeal circulation (ECC) such as cardiopulmonary bypass or extracorporeal membrane oxygenation (ECMO) may induce a complex activation of the immune system. To date, strategies to mitigate this activation have failed to translate into meaningful ... ...

    Abstract Extracorporeal circulation (ECC) such as cardiopulmonary bypass or extracorporeal membrane oxygenation (ECMO) may induce a complex activation of the immune system. To date, strategies to mitigate this activation have failed to translate into meaningful improvement of clinical outcomes. Hemoperfusion is a blood purification technique, which relies on mass separation by a solid agent (hemoadsorption). It can be performed by adding a cartridge filled with adsorptive sorbent in the extracorporeal circuit. These devices have the theoretical advantage to enable the removal of excess pro- and anti-inflammatory molecules. Several studies have demonstrated the feasibility and safety of hemoperfusion during cardiac surgery. They have suggested that the procedure could decrease cytokine levels in situations where they were elevated. However, further studies are required to determine the clinical indications, timing, and duration of hemoperfusion during cardiac surgery. Although a similar rationale can apply to hemoperfusion in ECMO, available data in this situation are even more limited and results are conflicting. In this chapter, we discuss the rationale for hemoperfusion with ECC, how to practically do it, and the current level of evidence supporting this therapy.
    MeSH term(s) Humans ; Extracorporeal Membrane Oxygenation/methods ; Hemoperfusion ; Cardiac Surgical Procedures ; Cytokines
    Chemical Substances Cytokines
    Language English
    Publishing date 2023-06-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 1662-2782 ; 0302-5144
    ISSN (online) 1662-2782
    ISSN 0302-5144
    DOI 10.1159/000527338
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Hemoperfusion in Burns.

    Abraham, Paul / Monard, Céline / Lamblin, Antoine / Schneider, Antoine / Rimmelé, Thomas

    Contributions to nephrology

    2023  Volume 200, Page(s) 160–168

    Abstract: Patients with severe thermal injury require urgent specialized care in burn units. These units assure good coordination of a bundle of care including fluid resuscitation, nutritional support, respiratory care, surgical care and wound care, infection ... ...

    Abstract Patients with severe thermal injury require urgent specialized care in burn units. These units assure good coordination of a bundle of care including fluid resuscitation, nutritional support, respiratory care, surgical care and wound care, infection prevention, and rehabilitation. When severely injured, burn patients present a systemic inflammatory response syndrome, associated with a dysregulated immune homeostasis. This complex host response exposes patients to prolonged hospitalization with suppressed immune function, increased susceptibility to secondary infections, longer organ support, and increased mortality. To date, several strategies, such as hemoperfusion techniques, have been developed to mitigate immune activation. We propose herein a review of the immune response to burn injury and the rationale and potential applications of extracorporeal blood purification techniques such as hemoperfusion for burn patients' management.
    MeSH term(s) Humans ; Resuscitation/methods ; Hemoperfusion ; Fluid Therapy
    Language English
    Publishing date 2023-06-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 1662-2782 ; 0302-5144
    ISSN (online) 1662-2782
    ISSN 0302-5144
    DOI 10.1159/000527709
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Extracorporeal Blood Purification in Burns: For Whom, Why, and How?

    Abraham, Paul / Monard, Céline / Schneider, Antoine / Rimmelé, Thomas

    Blood purification

    2022  Volume 52, Issue 1, Page(s) 17–24

    Abstract: Patients with serious thermal burn injuries require immediate and specialized care in order to minimize morbidity and mortality. Optimal fluid resuscitation, nutritional support, pulmonary care, burn wound care, and infection control practices represent ... ...

    Abstract Patients with serious thermal burn injuries require immediate and specialized care in order to minimize morbidity and mortality. Optimal fluid resuscitation, nutritional support, pulmonary care, burn wound care, and infection control practices represent key aspects of patient care in burn centers. When severely burned, the patient usually presents a systemic inflammatory response syndrome, soon balanced by a counter anti-inflammatory response syndrome. These may lead to immune dysregulation/exhaustion favoring infectious complications that dramatically impair the prognosis of burn patients. This narrative review provides an overview of the main concepts, current understanding, and potential applications of extracorporeal blood purification techniques for burn patient management. Current understanding of burn patients' immune responses is reported. Hypotheses and data on the potential value of immunoregulation are reviewed. Finally, how extracorporeal blood purification may be of interest in this specific population is discussed.
    MeSH term(s) Humans ; Fluid Therapy ; Burns/immunology ; Burns/therapy ; Extracorporeal Circulation
    Language English
    Publishing date 2022-06-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 605548-5
    ISSN 1421-9735 ; 0253-5068
    ISSN (online) 1421-9735
    ISSN 0253-5068
    DOI 10.1159/000525085
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1872: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: New Targets for Extracorporeal Blood Purification Therapies in Sepsis.

    Monard, Céline / Abraham, Paul / Schneider, Antoine / Rimmelé, Thomas

    Blood purification

    2022  Volume 52, Issue 1, Page(s) 1–7

    Abstract: As highlighted by the last international consensus definition for sepsis and septic shock (sepsis-3), sepsis comes from a complex relationship between a pathogen and a dysregulated host response. To date, the treatment of sepsis is based on antimicrobial ...

    Abstract As highlighted by the last international consensus definition for sepsis and septic shock (sepsis-3), sepsis comes from a complex relationship between a pathogen and a dysregulated host response. To date, the treatment of sepsis is based on antimicrobial treatment, source control, and organ support. Extracorporeal blood purification therapies have been proposed as adjuvant therapies to modulate the dysregulated inflammatory response. These therapies aim mostly at removing inflammatory mediators (cytokines) and endotoxins from the blood. However, so far, they failed to clearly demonstrate an improvement in patient survival when evaluated in randomized trials. Recently, new devices directly targeting the primary determinants of sepsis, e.g., the pathogen itself and the host immune cells, have been developed. This short review aimed at presenting new blood purification devices that have recently been developed to target pathogens and immune cells. For each, we will present the mechanism of action of the therapy and discuss the related literature.
    MeSH term(s) Humans ; Hemofiltration ; Sepsis/therapy ; Shock, Septic/therapy ; Cytokines ; Inflammation Mediators
    Chemical Substances Cytokines ; Inflammation Mediators
    Language English
    Publishing date 2022-06-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 605548-5
    ISSN 1421-9735 ; 0253-5068
    ISSN (online) 1421-9735
    ISSN 0253-5068
    DOI 10.1159/000524973
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1872: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Glucose upregulates amphiregulin in oral dysplastic keratinocytes: A potential role in diabetes-associated oral carcinogenesis.

    Ma, Tao / Montaner, Silvia / Schneider, Abraham

    Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology

    2023  Volume 52, Issue 10, Page(s) 1004–1012

    Abstract: Background: Compelling evidence implicates diabetes-associated hyperglycemia as a promoter of tumor progression in oral potentially malignant disorders (OPMD). Yet, information on hyperglycemia-induced cell signaling networks in oral oncology remains ... ...

    Abstract Background: Compelling evidence implicates diabetes-associated hyperglycemia as a promoter of tumor progression in oral potentially malignant disorders (OPMD). Yet, information on hyperglycemia-induced cell signaling networks in oral oncology remains limited. Our group recently reported that glucose-rich conditions significantly enhance oral dysplastic keratinocyte viability and migration through epidermal growth factor receptor (EGFR) activation, a pathway strongly linked to oral carcinogenesis. Here, we investigated the basal metabolic phenotype in these cells and whether specific glucose-responsive EGFR ligands mediate these responses.
    Methods: Cell energy phenotype and lactate concentration were evaluated via commercially available assays. EGFR ligands in response to normal (5 mM) or high (20 mM) glucose were analyzed by quantitative real-time PCR, ELISA, and western blotting. Cell viability and migration assays were performed in the presence of pharmacological inhibitors or RNA interference.
    Results: When compared to normal keratinocytes, basal glycolysis in oral dysplastic keratinocytes was significantly elevated. In highly glycolytic cells, high glucose-activated EGFR increasing viability and migration. Notably, we identified amphiregulin (AREG) as the predominant glucose-induced EGFR ligand. Indeed, enhanced cell migration in response to high glucose was blunted by EGFR inhibitor cetuximab and AREG siRNA. Conversely, AREG treatment under normal glucose conditions significantly increased cell viability, migration, lactate levels, and expression of glycolytic marker pyruvate kinase M2.
    Conclusion: These novel findings point to AREG as a potential high glucose-induced EGFR activating ligand in highly glycolytic oral dysplastic keratinocytes. Future studies are warranted to gain more insight into the role of AREG in hyperglycemia-associated OPMD tumor progression.
    MeSH term(s) Humans ; Amphiregulin/genetics ; Amphiregulin/metabolism ; Glucose/pharmacology ; Glucose/metabolism ; Ligands ; ErbB Receptors/metabolism ; EGF Family of Proteins/metabolism ; Keratinocytes/metabolism ; Diabetes Mellitus ; Hyperglycemia/complications ; Hyperglycemia/metabolism ; Carcinogenesis/metabolism ; Lactates/metabolism ; Neoplasms
    Chemical Substances Amphiregulin ; Glucose (IY9XDZ35W2) ; Ligands ; ErbB Receptors (EC 2.7.10.1) ; EGF Family of Proteins ; Lactates
    Language English
    Publishing date 2023-10-10
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 1021270-x
    ISSN 1600-0714 ; 0904-2512
    ISSN (online) 1600-0714
    ISSN 0904-2512
    DOI 10.1111/jop.13493
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 825: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Article ; Online: Increased mortality among African American patients with DRESS syndrome compared to White patients.

    Schneider, Justine G / Gallardo, Matthew / Fisher, Kristopher / Kaffenberger, Benjamin H / Korman, Abraham M

    International journal of dermatology

    2023  Volume 63, Issue 3, Page(s) e80–e81

    MeSH term(s) Humans ; Black or African American ; Drug Hypersensitivity Syndrome/mortality ; White
    Language English
    Publishing date 2023-12-15
    Publishing country England
    Document type Letter
    ZDB-ID 412254-9
    ISSN 1365-4632 ; 0011-9059 ; 1461-1244
    ISSN (online) 1365-4632
    ISSN 0011-9059 ; 1461-1244
    DOI 10.1111/ijd.16988
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui VI Zs.189: Show issues Location:
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  9. Article ; Online: Partnering for Climate Resilience

    Lisa L. Greenwood / Vicki Lin / Yewande S. Abraham / Jennifer L. Schneider

    Sustainability, Vol 15, Iss 14105, p

    Exploring the Maturity of Private-Sector Efforts in the Great Lakes Region

    2023  Volume 14105

    Abstract: Communities and businesses continue to experience the effects of climate change as global temperatures rise and extreme weather events become more frequent. In the United States (US), the public sector has traditionally been responsible for mitigating ... ...

    Abstract Communities and businesses continue to experience the effects of climate change as global temperatures rise and extreme weather events become more frequent. In the United States (US), the public sector has traditionally been responsible for mitigating these risks; however, engaging the private sector is crucial, given industrial impacts on and vulnerability to climate change. Private-sector mitigation and adaptation efforts are critical in the Great Lakes Region due to aging infrastructure as well as its economic, environmental, and political importance in the US and Canada. This study explores private-sector resilience efforts in three Great Lakes cities to identify opportunities and trends that could inform climate resilience strategies in the region. Climate-related commitments and actions of nine major firms in Toronto, Chicago, and Cleveland are evaluated in relation to seven climate resilience criteria on a five-level maturity scale from January to May 2022. The results indicate a moderate level of maturity, with efforts mainly at facility and community levels of engagement. Overall, this study suggests that major firms participate in climate resilience efforts, but to a limited extent, and may have varying priorities that affect the initiatives they pursue. This study could contribute to advancing climate resilience efforts in the public and private sectors from regional to global levels.
    Keywords climate change ; climate action ; climate resilience ; Great Lakes region ; maturity matrix ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Subject code 333
    Language English
    Publishing date 2023-09-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Identification of a newly isolated lytic bacteriophage against K24 capsular type, carbapenem resistant Klebsiella pneumoniae isolates.

    Horváth, Marianna / Kovács, Tamás / Koderivalappil, Sarshad / Ábrahám, Hajnalka / Rákhely, Gábor / Schneider, György

    Scientific reports

    2020  Volume 10, Issue 1, Page(s) 5891

    Abstract: The increasing incidence of carbapenemase-producing K. pneumoniae strains (CP-Kps) in the last decade has become a serious global healthcare problem. Therapeutic options for the treatment of emerging hospital clones have drastically narrowed and ... ...

    Abstract The increasing incidence of carbapenemase-producing K. pneumoniae strains (CP-Kps) in the last decade has become a serious global healthcare problem. Therapeutic options for the treatment of emerging hospital clones have drastically narrowed and therefore novel approaches must be considered. Here we have isolated and characterized a lytic bacteriophage, named vB_KpnS_Kp13, that was effective against all Verona integron-encoded metallo-β-lactamase (VIM) producing K. pneumoniae isolates originating from hospital samples (urine, blood, sputum and faeces), belonging to the ST15 clonal lineage and expressing the K24 capsule. Morphological characterization of vB_KpnS_Kp13 showed that the newly identified phage belonged to the Siphoviridae family, and phylogenetic analysis showed that it is part of a distinct clade of the Tunavirinae subfamily. Functional analysis revealed that vB_KpnS_Kp13 had relatively short latent period times (18 minutes) compared to other K. pneumoniae bacteriophages and could degrade biofilm by more than 50% and 70% in 24 and 48 hours respectively. Complete in vivo rescue potential of the new phage was revealed in an intraperitoneal mouse model where phages were administered intraperitoneally 10 minutes after bacterial challenge. Our findings could potentially be used to develop specific anti-CP-Kps bacteriophage-based therapeutic strategies against major clonal lineages and serotypes.
    MeSH term(s) Animals ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Bacterial Proteins/metabolism ; Biofilms/drug effects ; Biofilms/growth & development ; Biological Therapy/methods ; Carbapenem-Resistant Enterobacteriaceae/drug effects ; Carbapenem-Resistant Enterobacteriaceae/isolation & purification ; Carbapenem-Resistant Enterobacteriaceae/virology ; Carbapenems/pharmacology ; Carbapenems/therapeutic use ; Disease Models, Animal ; Female ; Humans ; Klebsiella Infections/microbiology ; Klebsiella Infections/therapy ; Klebsiella pneumoniae/drug effects ; Klebsiella pneumoniae/isolation & purification ; Klebsiella pneumoniae/virology ; Mice ; Phylogeny ; Siphoviridae/genetics ; Siphoviridae/isolation & purification ; beta-Lactamases/metabolism
    Chemical Substances Anti-Bacterial Agents ; Bacterial Proteins ; Carbapenems ; beta-Lactamases (EC 3.5.2.6) ; carbapenemase (EC 3.5.2.6)
    Language English
    Publishing date 2020-04-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-62691-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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