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Article ; Online: Shear stress makes its mark on the endothelial genome.

Serbanovic-Canic, Jovana / Souilhol, Celine / Evans, Paul C

2019 Volume 115, Issue 10, Page(s) 1449–1451

MeSH term(s)	Endothelial Cells ; Endothelium, Vascular ; Stress, Mechanical
Language	English
Publishing date	2019-03-29
Publishing country	England
Document type	Editorial ; Comment
ZDB-ID	80340-6
ISSN	1755-3245 ; 0008-6363
ISSN (online)	1755-3245
ISSN	0008-6363
DOI	10.1093/cvr/cvz088
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Article ; Online: Persistence of β-Cell Responsiveness for Over Two Years in Autoantibody-Positive Children With Marked Metabolic Impairment at Screening.

Sims, Emily K / Cuthbertson, David / Felton, Jamie L / Ismail, Heba M / Nathan, Brandon M / Jacobsen, Laura M / Paprocki, Emily / Pugliese, Alberto / Palmer, Jerry / Atkinson, Mark / Evans-Molina, Carmella / Skyler, Jay S / Redondo, Maria J / Herold, Kevan C / Sosenko, Jay M

Diabetes care

2022 Volume 45, Issue 12, Page(s) 2982–2990

Abstract: ... peptide changes (on a two-dimensional grid) also differed significantly (P < 0.001). Despite marked ...

Abstract	Objective: We studied longitudinal differences between progressors and nonprogressors to type 1 diabetes with similar and substantial baseline risk. Research design and methods: Changes in 2-h oral glucose tolerance test indices were used to examine variability in diabetes progression in the Diabetes Prevention Trial-Type 1 (DPT-1) study (n = 246) and Type 1 Diabetes TrialNet Pathway to Prevention study (TNPTP) (n = 503) among autoantibody (Ab)+ children (aged <18.0 years) with similar baseline metabolic impairment (DPT-1 Risk Score [DPTRS] of 6.5-7.5), as well as in TNPTP Ab- children (n = 94). Results: Longitudinal analyses revealed annualized area under the curve (AUC) of C-peptide increases in nonprogressors versus decreases in progressors (P ≤ 0.026 for DPT-1 and TNPTP). Vector indices for AUC glucose and AUC C-peptide changes (on a two-dimensional grid) also differed significantly (P < 0.001). Despite marked baseline metabolic impairment of nonprogressors, changes in AUC C-peptide, AUC glucose, AUC C-peptide-to-AUC glucose ratio (AUC ratio), and Index60 did not differ from Ab- relatives during follow-up. Divergence between nonprogressors and progressors occurred by 6 months from baseline in both cohorts (AUC glucose, P ≤ 0.007; AUC ratio, P ≤ 0.034; Index60, P < 0.001; vector indices of change, P < 0.001). Differences in 6-month change were positively associated with greater diabetes risk (respectively, P < 0.001, P ≤ 0.019, P < 0.001, and P < 0.001) in DPT-1 and TNPTP, except AUC ratio, which was inversely associated with risk (P < 0.001). Conclusions: Novel findings show that even with similarly abnormal baseline risk, progressors had appreciably more metabolic impairment than nonprogressors within 6 months and that the measures showing impairment were predictive of type 1 diabetes. Longitudinal metabolic patterns did not differ between nonprogressors and Ab- relatives, suggesting persistent β-cell responsiveness in nonprogressors.
MeSH term(s)	Child ; Humans ; C-Peptide/metabolism ; Diabetes Mellitus, Type 1/diagnosis ; Blood Glucose/metabolism ; Glucose Tolerance Test ; Autoantibodies ; Glucose ; Disease Progression
Chemical Substances	C-Peptide ; Blood Glucose ; Autoantibodies ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2022-01-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	441231-x
ISSN	1935-5548 ; 0149-5992
ISSN (online)	1935-5548
ISSN	0149-5992
DOI	10.2337/dc22-1362
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Zs.A 1434: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 365: Show issues

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Article ; Online: Underdiagnosis of Hereditary Breast and Ovarian Cancer in Medicare Patients: Genetic Testing Criteria Miss the Mark.

Yang, Shan / Axilbund, Jennifer E / O'Leary, Erin / Michalski, Scott T / Evans, Robbie / Lincoln, Stephen E / Esplin, Edward D / Nussbaum, Robert L

Annals of surgical oncology

2018 Volume 25, Issue 10, Page(s) 2925–2931

Abstract: Background: An estimated 5-10% of breast and ovarian cancers are due to hereditary causes such as hereditary breast and ovarian cancer (HBOC) syndrome. Medicare, the third-party payer that covers 44 million patients in the United States, has implemented ...

Abstract	Background: An estimated 5-10% of breast and ovarian cancers are due to hereditary causes such as hereditary breast and ovarian cancer (HBOC) syndrome. Medicare, the third-party payer that covers 44 million patients in the United States, has implemented a set of clinical criteria to determine coverage for the testing of the BRCA1 and BRCA2 genes. These criteria, developed to identify carriers of BRCA1/2 variants, have not been evaluated in the panel testing era. This study investigated a series of Medicare patients undergoing genetic testing for HBOC to determine the efficacy of genetic testing criteria in identifying patients with hereditary risk. Methods: This study retrospectively examined de-identified data from a consecutive series of Medicare patients undergoing genetic testing based on personal and family history of breast and gynecologic cancer. Ordering clinicians indicated whether patients did or did not meet established criteria for BRCA1/2 genetic testing. The genetic test results were compared between the group that met the criteria and the group that did not. Patients in families with known pathogenic (P) or likely pathogenic (LP) variants were excluded from the primary analysis. Results: Among 4196 unique Medicare patients, the rate of P/LP variants for the patients who met the criteria for genetic testing was 10.5%, and for those who did not, the rate was 9% (p = 0.26). Conclusions: The results of this study indicate that a substantial number of Medicare patients with clinically actionable genetic variants are being missed by current testing criteria and suggest the need for significant expansion and simplification of the testing criteria for HBOC.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Diagnostic Errors ; Female ; Genes, BRCA1 ; Genes, BRCA2 ; Genetic Predisposition to Disease ; Genetic Testing/methods ; Genetic Testing/standards ; Hereditary Breast and Ovarian Cancer Syndrome/diagnosis ; Hereditary Breast and Ovarian Cancer Syndrome/genetics ; Humans ; Male ; Medicare ; Middle Aged ; Patient Selection ; Retrospective Studies ; Treatment Outcome ; United States ; Young Adult
Language	English
Publishing date	2018-07-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	1200469-8
ISSN	1534-4681 ; 1068-9265
ISSN (online)	1534-4681
ISSN	1068-9265
DOI	10.1245/s10434-018-6621-4
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Article ; Online: Theta and high-frequency activity mark spontaneous recall of episodic memories.

Burke, John F / Sharan, Ashwini D / Sperling, Michael R / Ramayya, Ashwin G / Evans, James J / Healey, M Karl / Beck, Erin N / Davis, Kathryn A / Lucas, Timothy H / Kahana, Michael J

The Journal of neuroscience : the official journal of the Society for Neuroscience

2014 Volume 34, Issue 34, Page(s) 11355–11365

Abstract: Humans possess the remarkable ability to search their memory, allowing specific past episodes to be re-experienced spontaneously. Here, we administered a free recall test to 114 neurosurgical patients and used intracranial theta and high-frequency ... ...

Abstract	Humans possess the remarkable ability to search their memory, allowing specific past episodes to be re-experienced spontaneously. Here, we administered a free recall test to 114 neurosurgical patients and used intracranial theta and high-frequency activity (HFA) to identify the spatiotemporal pattern of neural activity underlying spontaneous episodic retrieval. We found that retrieval evolved in three electrophysiological stages composed of: (1) early theta oscillations in the right temporal cortex, (2) increased HFA in the left hemisphere including the medial temporal lobe (MTL), left inferior frontal gyrus, as well as the ventrolateral temporal cortex, and (3) motor/language activation during vocalization of the retrieved item. Of these responses, increased HFA in the left MTL predicted recall performance. These results suggest that spontaneous recall of verbal episodic memories involves a spatiotemporal pattern of spectral changes across the brain; however, high-frequency activity in the left MTL represents a final common pathway of episodic retrieval.
MeSH term(s)	Brain Mapping ; Cerebral Cortex/physiopathology ; Electroencephalography ; Epilepsy/pathology ; Epilepsy/surgery ; Female ; Functional Laterality ; Gamma Rhythm/physiology ; Humans ; Language ; Longitudinal Studies ; Male ; Memory, Episodic ; Mental Recall/physiology ; Neuropsychological Tests ; Photic Stimulation ; Spectrum Analysis ; Theta Rhythm/physiology ; Time Factors ; Verbal Learning
Language	English
Publishing date	2014-08-20
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural
ZDB-ID	604637-x
ISSN	1529-2401 ; 0270-6474
ISSN (online)	1529-2401
ISSN	0270-6474
DOI	10.1523/JNEUROSCI.2654-13.2014
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Article ; Online: Contrast enhancement of bite mark images using the grayscale mixer in ACR in Photoshop®.

Evans, Sam / Noorbhai, Suzanne / Lawson, Zoe / Stacey-Jones, Seren / Carabott, Romina

Journal of forensic sciences

2013 Volume 58, Issue 3, Page(s) 804–810

Abstract: Enhanced images may improve bite mark edge definition, assisting forensic analysis. Current ... intervals, all corresponding colors affected. Stage 2 used a bite mark image, and found only red, orange ... defined for nine out of 10 bite marks. The study has shown potential benefits for this new technique ...

Abstract	Enhanced images may improve bite mark edge definition, assisting forensic analysis. Current contrast enhancement involves color extraction, viewing layered images by channel. A novel technique, producing a single enhanced image using the grayscale mix panel within Adobe Camera Raw®, has been developed and assessed here, allowing adjustments of multiple color channels simultaneously. Stage 1 measured RGB values in 72 versions of a color chart image; eight sliders in Photoshop® were adjusted at 25% intervals, all corresponding colors affected. Stage 2 used a bite mark image, and found only red, orange, and yellow sliders had discernable effects. Stage 3 assessed modality preference between color, grayscale, and enhanced images; on average, the 22 survey participants chose the enhanced image as better defined for nine out of 10 bite marks. The study has shown potential benefits for this new technique. However, further research is needed before use in the analysis of bite marks.
MeSH term(s)	Bites, Human/pathology ; Forensic Dentistry/methods ; Humans ; Image Enhancement/methods ; Image Processing, Computer-Assisted/instrumentation ; Image Processing, Computer-Assisted/methods ; Software ; Surveys and Questionnaires
Language	English
Publishing date	2013-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	219216-0
ISSN	1556-4029 ; 0022-1198
ISSN (online)	1556-4029
ISSN	0022-1198
DOI	10.1111/1556-4029.12085
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Article: Wanted dead or alive: a state-space mark–recapture–recovery model incorporating multiple recovery types and state uncertainty

Hostetter, Nathan J / Gardner, Beth / Evans, Allen F / Cramer, Bradley M / Payton, Quinn / Collis, Ken / Roby, Daniel D

Canadian journal of fisheries and aquatic sciences. 2018, v. 75, no. 7

2018

Abstract: We developed a state-space mark–recapture–recovery model that incorporates multiple recovery types ... framework to integrate multiple sources of tag recovery data into mark–recapture studies. ...

Abstract	We developed a state-space mark–recapture–recovery model that incorporates multiple recovery types and state uncertainty to estimate survival of an anadromous fish species. We apply the model to a dataset of outmigrating juvenile steelhead trout (Oncorhynchus mykiss (Walbaum, 1792)) tagged with passive integrated transponders, recaptured during outmigration, and recovered on bird colonies in the Columbia River basin (2008–2014). Recoveries on bird colonies are often ignored in survival studies because the river reach of mortality is often unknown, which we model as a form of state uncertainty. Median outmigration survival from release to the lower river (river kilometre 729 to 75) ranged from 0.27 to 0.35, depending on year. Recovery probabilities were frequently ≥0.20 in the first river reach following tagging, indicating that one out of five fish that died in that reach was recovered on a bird colony. Integrating dead recovery data provided increased parameter precision, estimation of where birds consumed fish, and survival estimates across larger spatial scales. More generally, these modeling approaches provide a flexible framework to integrate multiple sources of tag recovery data into mark–recapture studies.
Keywords	Oncorhynchus mykiss ; anadromous fish ; birds ; data collection ; juveniles ; mark-recapture studies ; models ; mortality ; rivers ; transponders ; uncertainty ; watersheds ; Columbia River
Language	English
Size	p. 1117-1127.
Publishing place	NRC Research Press
Document type	Article
ZDB-ID	1473089-3
ISSN	1205-7533 ; 0706-652X
ISSN (online)	1205-7533
ISSN	0706-652X
DOI	10.1139/cjfas-2016-0246
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Landmarks in the evolution of prostate biopsy.

Connor, Martin J / Gorin, Michael A / Eldred-Evans, David / Bass, Edward J / Desai, Ankit / Dudderidge, Tim / Winkler, Mathias / Ahmed, Hashim U

Nature reviews. Urology

2023 Volume 20, Issue 4, Page(s) 241–258

Abstract: Approaches and techniques used for diagnostic prostate biopsy have undergone considerable evolution over the past few decades: from the original finger-guided techniques to the latest MRI-directed strategies, from aspiration cytology to tissue core ... ...

Abstract	Approaches and techniques used for diagnostic prostate biopsy have undergone considerable evolution over the past few decades: from the original finger-guided techniques to the latest MRI-directed strategies, from aspiration cytology to tissue core sampling, and from transrectal to transperineal approaches. In particular, increased adoption of transperineal biopsy approaches have led to reduced infectious complications and improved antibiotic stewardship. Furthermore, as image fusion has become integral, these novel techniques could be incorporated into prostate biopsy methods in the future, enabling 3D-ultrasonography fusion reconstruction, molecular targeting based on PET imaging and autonomous robotic-assisted biopsy.
MeSH term(s)	Male ; Humans ; Prostate/diagnostic imaging ; Prostate/pathology ; Prostatic Neoplasms/diagnosis ; Image-Guided Biopsy ; Biopsy ; Ultrasonography ; Magnetic Resonance Imaging/methods ; Ultrasonography, Interventional/methods
Language	English
Publishing date	2023-01-18
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2493737-X
ISSN	1759-4820 ; 1759-4812
ISSN (online)	1759-4820
ISSN	1759-4812
DOI	10.1038/s41585-022-00684-0
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Article ; Online: Marking Time: Colorful New Insights into Master Clock Circuits.

Joye, Deborah A M / Evans, Jennifer A

Neuron

2020 Volume 108, Issue 1, Page(s) 2–5

Abstract: A neural clock controls what we do each day, and understanding its circuitry is important for health. In this issue of Neuron, Shan et al. visualize molecular rhythms in subtypes of master clock neurons to test principles of cell identity and network ... ...

Abstract	A neural clock controls what we do each day, and understanding its circuitry is important for health. In this issue of Neuron, Shan et al. visualize molecular rhythms in subtypes of master clock neurons to test principles of cell identity and network wiring.
MeSH term(s)	Circadian Rhythm ; Neurons ; Suprachiasmatic Nucleus
Language	English
Publishing date	2020-10-15
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	808167-0
ISSN	1097-4199 ; 0896-6273
ISSN (online)	1097-4199
ISSN	0896-6273
DOI	10.1016/j.neuron.2020.09.007
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Zs.A 2496: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 92: Show issues

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Article ; Online: Pruritic and erythematous rash resembling marks caused by a lashing.

Lannan, Ford M / Evans, Thomas R / Edhegard Ii, Kim D

Cutis

2020 Volume 104, Issue 6, Page(s) 335–336

MeSH term(s)	Adult ; Dermatitis/etiology ; Dermatitis/pathology ; Humans ; Male ; Shiitake Mushrooms
Language	English
Publishing date	2020-01-15
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	391840-3
ISSN	2326-6929 ; 0011-4162 ; 0151-9522
ISSN (online)	2326-6929
ISSN	0011-4162 ; 0151-9522
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Article: Short of the mark. A Modern Healthcare analysis of Form 990s shows some very profitable hospitals offering little subsidized care.

Carlson, Joe / Evans, Melanie

Modern healthcare

2011 Volume 41, Issue 12, Page(s) 6, 14, 16, 1

Abstract: A Modern Healthcare analysis finds a widely uneven distribution in the levels of charity care given to the poor by various hospitals. Many of the charitable healthcare providers even acknowledge billing patients who, in retrospect, probably should have ... ...

Abstract	A Modern Healthcare analysis finds a widely uneven distribution in the levels of charity care given to the poor by various hospitals. Many of the charitable healthcare providers even acknowledge billing patients who, in retrospect, probably should have qualified for free care. "Hospitals, if they're not-for-profits, should act like a charity," says Sen. Chuck Grassley, left. "I expect nonprofit hospitals to fulfill their not-for-profit status by providing whatever charity care is needed".
MeSH term(s)	Economics, Hospital/legislation & jurisprudence ; Hospitals, Voluntary/economics ; Taxes/legislation & jurisprudence ; Uncompensated Care/economics ; United States
Language	English
Publishing date	2011-03-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	187602-8
ISSN	0160-7480
ISSN	0160-7480
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