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  1. Article ; Online: A Deep Ensemble Dynamic Learning Network for Corona Virus Disease 2019 Diagnosis.

    Zhang, Zhijun / Chen, Bozhao / Luo, Yamei

    IEEE transactions on neural networks and learning systems

    2024  Volume 35, Issue 3, Page(s) 3912–3926

    Abstract: Corona virus disease 2019 is an extremely fatal pandemic around the world. Intelligently recognizing X-ray chest radiography images for automatically identifying corona virus disease 2019 from other types of pneumonia and normal cases provides clinicians ...

    Abstract Corona virus disease 2019 is an extremely fatal pandemic around the world. Intelligently recognizing X-ray chest radiography images for automatically identifying corona virus disease 2019 from other types of pneumonia and normal cases provides clinicians with tremendous conveniences in diagnosis process. In this article, a deep ensemble dynamic learning network is proposed. After a chain of image preprocessing steps and the division of image dataset, convolution blocks and the final average pooling layer are pretrained as a feature extractor. For classifying the extracted feature samples, two-stage bagging dynamic learning network is trained based on neural dynamic learning and bagging algorithms, which diagnoses the presence and types of pneumonia successively. Experimental results manifest that using the proposed deep ensemble dynamic learning network obtains 98.7179% diagnosis accuracy, which indicates more excellent diagnosis effect than existing state-of-the-art models on the open image dataset. Such accurate diagnosis effects provide convincing evidences for further detections and treatments.
    MeSH term(s) Humans ; COVID-19/diagnostic imaging ; Neural Networks, Computer ; Algorithms ; Learning ; COVID-19 Testing
    Language English
    Publishing date 2024-02-29
    Publishing country United States
    Document type Journal Article
    ISSN 2162-2388
    ISSN (online) 2162-2388
    DOI 10.1109/TNNLS.2022.3201198
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Identification of immune-related genes and integrated analysis of immune-cell infiltration in melanoma.

    He, Zhenghao / Chen, Manli / Luo, Zhijun

    Aging

    2024  Volume 16, Issue 1, Page(s) 911–927

    Abstract: Objective: This study was conducted to screen out immune-related genes in connection with the prognosis of melanoma, construct a prognosis model and explore the relevant mechanisms.: Methods and materials: 1973 genes associated with immune system ... ...

    Abstract Objective: This study was conducted to screen out immune-related genes in connection with the prognosis of melanoma, construct a prognosis model and explore the relevant mechanisms.
    Methods and materials: 1973 genes associated with immune system were derived from the Immport database, and RNA-seq data of melanoma and information of patients were searched from the Xena database. Cox univariate analysis, Lasso analysis and Cox multivariate analysis were used to screen out six genes to construct the model. Then the risk scores were estimated for patients based on our constructed prognosis model. Estimate was used to affirm that the model was about immune infiltration, and CIBERSORT was used to screen out immune cells associated with prognosis. TIDE was applied to predict the efficacy of immunotherapy. Finally, GSE65904 and GSE19234 were used to confirm the effectiveness of the model.
    Results: ADCYAP1R1, GPI, NTS might cause poor prognosis while IFITM1, KIR2DL4, LIF were more likely conductive to prognosis of melanoma patients and a model of prognosis was constructed on the basis of these six genes. The effectiveness of the model has been proven by the ROC curve, and the miRNAs targeting the screened genes were found out, suggesting that the immune system might impact on the prognosis of melanoma by T cell CD8
    Conclusions: In this study, the screened six genes were associated with the prognosis of melanoma, which was conductive to clinical prognostic prediction and individualized treatment strategy.
    MeSH term(s) Humans ; Melanoma/genetics ; MicroRNAs ; Databases, Factual ; Immunotherapy ; Killer Cells, Natural ; Prognosis ; Tumor Microenvironment/genetics
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Journal Article
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.205427
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A Jump-Gain Integral Recurrent Neural Network for Solving Noise-Disturbed Time-Variant Nonlinear Inequality Problems.

    Zhang, Zhijun / Song, Yating / Zheng, Lunan / Luo, Yamei

    IEEE transactions on neural networks and learning systems

    2024  Volume 35, Issue 4, Page(s) 5793–5806

    Abstract: Nonlinear inequalities are widely used in science and engineering areas, attracting the attention of many researchers. In this article, a novel jump-gain integral recurrent (JGIR) neural network is proposed to solve noise-disturbed time-variant nonlinear ...

    Abstract Nonlinear inequalities are widely used in science and engineering areas, attracting the attention of many researchers. In this article, a novel jump-gain integral recurrent (JGIR) neural network is proposed to solve noise-disturbed time-variant nonlinear inequality problems. To do so, an integral error function is first designed. Then, a neural dynamic method is adopted and the corresponding dynamic differential equation is obtained. Third, a jump gain is exploited and applied to the dynamic differential equation. Fourth, the derivatives of errors are substituted into the jump-gain dynamic differential equation, and the corresponding JGIR neural network is set up. Global convergence and robustness theorems are proposed and proved theoretically. Computer simulations verify that the proposed JGIR neural network can solve noise-disturbed time-variant nonlinear inequality problems effectively. Compared with some advanced methods, such as modified zeroing neural network (ZNN), noise-tolerant ZNN, and varying-parameter convergent-differential neural network, the proposed JGIR method has smaller computational errors, faster convergence speed, and no overshoot when disturbance exists. In addition, physical experiments on manipulator control have verified the effectiveness and superiority of the proposed JGIR neural network.
    Language English
    Publishing date 2024-04-04
    Publishing country United States
    Document type Journal Article
    ISSN 2162-2388
    ISSN (online) 2162-2388
    DOI 10.1109/TNNLS.2023.3241207
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The complete Chloroplast genome of Stachys geobombycis and comparative analysis with related Stachys species.

    Wang, Ru / Lan, Zheng / Luo, Yongjian / Deng, Zhijun

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 8523

    Abstract: Herb genomics, at the forefront of traditional Chinese medicine research, combines genomics with traditional practices, facilitating the scientific validation of ancient remedies. This integration enhances public understanding of traditional Chinese ... ...

    Abstract Herb genomics, at the forefront of traditional Chinese medicine research, combines genomics with traditional practices, facilitating the scientific validation of ancient remedies. This integration enhances public understanding of traditional Chinese medicine's efficacy and broadens its scope in modern healthcare. Stachys species encompass annual or perennial herbs or small shrubs, exhibiting simple petiolate or sessile leaves. Despite their wide-ranging applications across various fields, molecular data have been lacking, hindering the precise identification and taxonomic elucidation of Stachys species. To address this gap, we assembled the complete chloroplast (CP) genome of Stachys geobombycis and conducted reannotation and comparative analysis of seven additional species within the Stachys genus. The findings demonstrate that the CP genomes of these species exhibit quadripartite structures, with lengths ranging from 14,523 to 150,599 bp. Overall, the genome structure remains relatively conserved, hosting 131 annotated genes, including 87 protein coding genes, 36 tRNA genes, and 8 rRNA genes. Additionally, 78 to 98 SSRs and long repeat sequences were detected , and notably, 6 highly variable regions were identified as potential molecular markers in the CP genome through sequence alignment. Phylogenetic analysis based on Bayesian inference and maximum likelihood methods strongly supported the phylogenetic position of the genus Stachys as a member of Stachydeae tribe. Overall, this comprehensive bioinformatics study of Stachys CP genomes lays the groundwork for phylogenetic classification, plant identification, genetic engineering, evolutionary studies, and breeding research concerning medicinal plants within the Stachys genus.
    MeSH term(s) Stachys ; Bayes Theorem ; Genome, Chloroplast ; Phylogeny ; Plant Breeding
    Language English
    Publishing date 2024-04-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-59132-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Pediatric pulmonary infection caused by oral obligate anaerobes: Case Series.

    Zhijun, Lai / Wenhai, Yang / Peibin, Zeng / Qingming, Luo

    Frontiers in pediatrics

    2023  Volume 11, Page(s) 1226706

    Abstract: Background: Pneumonia is quite common in people with chronic bedridden, severe malnutrition and underlying diseases of cerebral palsy. Although poor oral hygiene and inadequate airway protection are risk factors, case reports of childhood pneumonia ... ...

    Abstract Background: Pneumonia is quite common in people with chronic bedridden, severe malnutrition and underlying diseases of cerebral palsy. Although poor oral hygiene and inadequate airway protection are risk factors, case reports of childhood pneumonia caused by oral obligate anaerobes are rare.
    Introduction: We reported 4 cases of oral anaerobic pneumonia and empyema diagnosed by the pediatric intensive care unit (PICU) of our hospital.
    Discussion: No bacteria were detected in sputum bacterial culture, pleural water bacterial culture and blood culture of the four children. Considering that multiple sputum cultures were negative, the pleural effusion and bronchoalveolar lavage fluid were subjected to next-generation sequencing (NGS) to identify the pathogen causing pneumonia. The results found oral obligate anaerobes represented by
    Conclusion: Oral obligate anaerobes are one of the pathogens to consider for pneumonia in the elderly, but they may be easily overlooked in pediatric groups. Therefore, when receiving children with high-risk factors, we should be alert to the possibility of oral obligate anaerobic bacteria infection. Educating family members to pay attention to children's oral hygiene plays an important role in preventing oral obligatory anaerobic bacteria pneumonia. NGS can be used as a rapid diagnostic method when sputum culture cannot distinguish between pathogens.
    Language English
    Publishing date 2023-09-01
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2023.1226706
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The complete chloroplast genome and phylogenetic analysis of

    Wang, Ru / Deng, Zhijun / Luo, Yongjian

    Mitochondrial DNA. Part B, Resources

    2022  Volume 7, Issue 11, Page(s) 1964–1967

    Abstract: A species ... ...

    Abstract A species of
    Language English
    Publishing date 2022-11-15
    Publishing country England
    Document type Journal Article
    ISSN 2380-2359
    ISSN (online) 2380-2359
    DOI 10.1080/23802359.2022.2141081
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: CsXDH1

    Tang, Qianhui / Liu, Keyi / Yue, Chuan / Luo, Liyong / Zeng, Liang / Wu, Zhijun

    Horticulture research

    2023  Volume 10, Issue 6, Page(s) uhad090

    Abstract: Tea plant ( ...

    Abstract Tea plant (
    Language English
    Publishing date 2023-05-04
    Publishing country England
    Document type Journal Article
    ISSN 2662-6810
    ISSN 2662-6810
    DOI 10.1093/hr/uhad090
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: RETRACTED

    Zhijun Luo / Yuan Yuan / Song Qi / Jin Xu

    Forests, Vol 14, Iss 12, p

    Luo et al. Evaluating the Carrying Capacity and Spatial Pattern Matching of Urban and Rural Construction Land in a Representative City of Middle China. Forests 2022, 13 , 1514

    2023  Volume 2380

    Abstract: The journal retracts the article ‘Evaluating the Carrying Capacity and Spatial Pattern Matching of Urban and Rural Construction Land in a Representative City of Middle China’ [.] ...

    Abstract The journal retracts the article ‘Evaluating the Carrying Capacity and Spatial Pattern Matching of Urban and Rural Construction Land in a Representative City of Middle China’ [.]
    Keywords n/a ; Plant ecology ; QK900-989
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: RETRACTED

    Zhijun Luo / Jie Zhao / Song Qi / Xiaojing Feng

    Forests, Vol 14, Iss 12, p

    Luo et al. Evaluation of Soil Pollution by Potential Toxic Elements in Cultivated Land in the Poyang Lake Region Based on an Improved Matter–Element Extension Model. Forests 2022, 13 , 1445

    2023  Volume 2381

    Abstract: The journal retracts the article entitled ‘Evaluation of Soil Pollution by Potential Toxic Elements in Cultivated Land in the Poyang Lake Region Based on an Improved Matter–Element Extension Model’ [.] ...

    Abstract The journal retracts the article entitled ‘Evaluation of Soil Pollution by Potential Toxic Elements in Cultivated Land in the Poyang Lake Region Based on an Improved Matter–Element Extension Model’ [.]
    Keywords n/a ; Plant ecology ; QK900-989
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Multi-omics and tumor immune microenvironment characterization of a prognostic model based on aging-related genes in melanoma.

    He, Zhenghao / Chen, Manli / Li, Qianwen / Luo, Zhijun / Li, Xidie

    American journal of cancer research

    2024  Volume 14, Issue 3, Page(s) 1052–1070

    Abstract: Melanoma is a common and fatal cutaneous malignancy with strong invasiveness and high mortality rate. Clinically, elderly melanoma patients tend to exhibit stronger invasion ability and poorer prognosis. Given the heterogeneity of tumors, we analyzed the ...

    Abstract Melanoma is a common and fatal cutaneous malignancy with strong invasiveness and high mortality rate. Clinically, elderly melanoma patients tend to exhibit stronger invasion ability and poorer prognosis. Given the heterogeneity of tumors, we analyzed the prognosis and risk assessment of melanoma through aging-related genes rather than age stratification. FOXM1 and CCL4 were identified to be closely associated with melanoma prognosis. Single-cell transcriptome analysis showed that FOXM1 was significantly up-regulated in tumor cells, while CCL4 was markedly elevated in immune cells. A melanoma prognostic model was constructed based on the two independent prognostic factors. This model showed a high accuracy in predicting the mortality of melanoma patients over several years. The patients in low-risk group appeared to have more immune cell infiltration and better immune therapy efficacy. Cellular experiments showed that CCL4 could promote apoptosis of melanoma cells through immune cells, and apoptosis could regulate the expression of FOXM1. In addition, the results of the spatial transcriptome and immunohistochemistry suggested that CCL4 was highly expressed in macrophages and the expression of FOXM1 in melanoma cell was negatively correlated with immune cell infiltration, especially macrophages. Here, we established a novel prognostic model for melanoma, which showed promising predictive performance and may serve as a biomarker for the efficacy of immune checkpoint inhibition therapy in melanoma patients. In addition, we explored the function of two genes in the model in melanoma.
    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2589522-9
    ISSN 2156-6976
    ISSN 2156-6976
    DOI 10.62347/UZGP9704
    Database MEDical Literature Analysis and Retrieval System OnLINE

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