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Article ; Online: Pilot Randomized Control Trial of an App-Based CBT Program for Reducing Anxiety in Individuals with ASD without Intellectual Disability.

Yang, Yoon Jung / Chung, Kyong-Mee

Journal of autism and developmental disorders

2022 Volume 53, Issue 4, Page(s) 1331–1346

Abstract: This study developed and tested the effectiveness of an app-based cognitive behavioral therapy (CBT) program in alleviating anxiety among adolescents and adults with autism without co-occurring intellectual disability. Thirty participants from 15 to 35 ... ...

Abstract	This study developed and tested the effectiveness of an app-based cognitive behavioral therapy (CBT) program in alleviating anxiety among adolescents and adults with autism without co-occurring intellectual disability. Thirty participants from 15 to 35 years old were randomly assigned to either the intervention or waitlist control group, and self- and caregiver proxy report questionnaires were administered, accompanied by direct behavior observation before and after the intervention period. There was a significant decrease in anxiety level, an increase in positive affect, and a decline in stereotypic behaviors, hyperactivity, noncompliance, and inappropriate speech in proxy reports for the intervention group, compared to the control group. A significant rise in passive response in the direct observation was also seen in the intervention group.
MeSH term(s)	Adult ; Adolescent ; Humans ; Young Adult ; Intellectual Disability/therapy ; Mobile Applications ; Pilot Projects ; Treatment Outcome ; Autism Spectrum Disorder/therapy ; Autism Spectrum Disorder/psychology ; Anxiety/therapy ; Cognitive Behavioral Therapy
Language	English
Publishing date	2022-06-10
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	391999-7
ISSN	1573-3432 ; 0162-3257
ISSN (online)	1573-3432
ISSN	0162-3257
DOI	10.1007/s10803-022-05617-9
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Article ; Online: Global Spread of a Local Fire: Transmission of Endoplasmic Reticulum Stress via Connexin 43.

Yang, Yoon Mee / Seki, Ekihiro

Cell metabolism

2021 Volume 33, Issue 2, Page(s) 229–230

Abstract: Endoplasmic reticulum (ER) stress is essential in the development of obesity, insulin resistance, and hepatosteatosis. In the latest issue of Cell Metabolism, Tirosh et al. (2020) demonstrate that intracellular ER stress can be transmitted to neighboring ...

Abstract	Endoplasmic reticulum (ER) stress is essential in the development of obesity, insulin resistance, and hepatosteatosis. In the latest issue of Cell Metabolism, Tirosh et al. (2020) demonstrate that intracellular ER stress can be transmitted to neighboring hepatocytes via connexin 43, thus propagating ER stress and promoting hepatosteatosis and insulin resistance.
MeSH term(s)	Connexin 43 ; Endoplasmic Reticulum Stress ; Humans ; Insulin Resistance ; Liver ; Obesity
Chemical Substances	Connexin 43
Language	English
Publishing date	2021-01-29
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	2176834-1
ISSN	1932-7420 ; 1550-4131
ISSN (online)	1932-7420
ISSN	1550-4131
DOI	10.1016/j.cmet.2021.01.009
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Article ; Online: Crosstalk between Oxidative Stress and Inflammatory Liver Injury in the Pathogenesis of Alcoholic Liver Disease

Yoon Mee Yang / Ye Eun Cho / Seonghwan Hwang

International Journal of Molecular Sciences, Vol 23, Iss 774, p

2022 Volume 774

Abstract: Alcoholic liver disease (ALD) is characterized by the injury, inflammation, and scarring in the liver owing to excessive alcohol consumption. Currently, ALD is a leading cause for liver transplantation. Therefore, extensive studies (in vitro, in ... ...

Abstract	Alcoholic liver disease (ALD) is characterized by the injury, inflammation, and scarring in the liver owing to excessive alcohol consumption. Currently, ALD is a leading cause for liver transplantation. Therefore, extensive studies (in vitro, in experimental ALD models and in humans) are needed to elucidate pathological features and pathogenic mechanisms underlying ALD. Notably, oxidative changes in the liver have been recognized as a signature trait of ALD. Progression of ALD is linked to the generation of highly reactive free radicals by reactions involving ethanol and its metabolites. Furthermore, hepatic oxidative stress promotes tissue injury and, in turn, stimulates inflammatory responses in the liver, forming a pathological loop that promotes the progression of ALD. Accordingly, accumulating further knowledge on the relationship between oxidative stress and inflammation may help establish a viable therapeutic approach for treating ALD.
Keywords	alcoholic liver disease ; oxidative stress ; inflammatory liver injury ; fatty liver ; alcoholic steatohepatitis ; cirrhosis ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	610
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article: Exosomal microRNAs as diagnostic and therapeutic biomarkers in non-malignant liver diseases.

Hwang, Seonghwan / Yang, Yoon Mee

Archives of pharmacal research

2021 Volume 44, Issue 6, Page(s) 574–587

Abstract: The liver is a vital organ responsible for various physiological functions, such as metabolism, immune response, digestion, and detoxification. Crosstalk between hepatocytes, hepatic macrophages, and hepatic stellate cells is critical for liver pathology. ...

Abstract	The liver is a vital organ responsible for various physiological functions, such as metabolism, immune response, digestion, and detoxification. Crosstalk between hepatocytes, hepatic macrophages, and hepatic stellate cells is critical for liver pathology. Exosomes are small extracellular vesicles (50-150 nm) that play an important role in cell-cell or organ-organ communication as they transfer their cargo, such as protein, DNA, and RNA to recipient cells or distant organs. In various liver diseases, the number of liver cell-derived exosomes is increased and the exosomal microRNA (miRNA) profile is altered. Early studies investigated the value of circulating exosomal miRNAs as biomarkers. Several exosomal miRNAs showed excellent diagnostic values, suggesting their potential as diagnostic biomarkers in liver diseases. Exosomal miRNAs have emerged as critical regulators of liver pathology because they control the expression of multiple genes in recipient cells. In this review, we discuss the biology of exosomes and summarize the recent findings of exosome-mediated intercellular and organ-to-organ communication during liver pathology. As there are many review articles dealing with exosomal miRNAs in liver cancer, we focused on non-malignant liver diseases. The therapeutic potential of exosomal miRNAs in liver pathology is also highlighted.
MeSH term(s)	Adipocytes/metabolism ; Animals ; Biomarkers/metabolism ; Cell Communication/physiology ; Exosomes/genetics ; Exosomes/metabolism ; Hepatic Stellate Cells/metabolism ; Humans ; Liver Diseases/diagnosis ; Liver Diseases/genetics ; Liver Diseases/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Prognosis
Chemical Substances	Biomarkers ; MicroRNAs
Language	English
Publishing date	2021-06-24
Publishing country	Korea (South)
Document type	Journal Article ; Review
ZDB-ID	447623-2
ISSN	1976-3786 ; 0253-6269
ISSN (online)	1976-3786
ISSN	0253-6269
DOI	10.1007/s12272-021-01338-2
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Article ; Online: Crosstalk between Oxidative Stress and Inflammatory Liver Injury in the Pathogenesis of Alcoholic Liver Disease.

Yang, Yoon Mee / Cho, Ye Eun / Hwang, Seonghwan

International journal of molecular sciences

2022 Volume 23, Issue 2

Abstract	Alcoholic liver disease (ALD) is characterized by the injury, inflammation, and scarring in the liver owing to excessive alcohol consumption. Currently, ALD is a leading cause for liver transplantation. Therefore, extensive studies (in vitro, in experimental ALD models and in humans) are needed to elucidate pathological features and pathogenic mechanisms underlying ALD. Notably, oxidative changes in the liver have been recognized as a signature trait of ALD. Progression of ALD is linked to the generation of highly reactive free radicals by reactions involving ethanol and its metabolites. Furthermore, hepatic oxidative stress promotes tissue injury and, in turn, stimulates inflammatory responses in the liver, forming a pathological loop that promotes the progression of ALD. Accordingly, accumulating further knowledge on the relationship between oxidative stress and inflammation may help establish a viable therapeutic approach for treating ALD.
MeSH term(s)	Animals ; Biomarkers ; Disease Susceptibility/immunology ; Ethanol/adverse effects ; Ethanol/metabolism ; Fatty Liver/complications ; Fatty Liver/etiology ; Fatty Liver/metabolism ; Fatty Liver, Alcoholic/etiology ; Fatty Liver, Alcoholic/metabolism ; Fatty Liver, Alcoholic/pathology ; Gene Expression Regulation ; Hepatitis/complications ; Hepatitis/etiology ; Hepatitis/metabolism ; Hepatocytes/drug effects ; Hepatocytes/metabolism ; Humans ; Immunity, Innate ; Metabolic Networks and Pathways ; MicroRNAs/genetics ; Oxidation-Reduction ; Oxidative Stress ; Signal Transduction
Chemical Substances	Biomarkers ; MicroRNAs ; Ethanol (3K9958V90M)
Language	English
Publishing date	2022-01-11
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23020774
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Panaxydol extracted from Panax ginseng inhibits NLRP3 inflammasome activation to ameliorate NASH-induced liver injury.

Kim, Mi-Yeon / Jeong, Birang / Lee, Geun-Shik / Jeon, Hongjun / Yang, Yoon Mee / Yang, Heejung / Han, Yong-Hyun

International immunopharmacology

2024 Volume 128, Page(s) 111565

Abstract: Activation of NOD-like receptor protein 3 (NLRP3) inflammasome exacerbates liver inflammation and fibrosis in nonalcoholic steatohepatitis (NASH), suggesting that development of inflammasome inhibitor can become leading candidate to ameliorate NASH. ... ...

Abstract	Activation of NOD-like receptor protein 3 (NLRP3) inflammasome exacerbates liver inflammation and fibrosis in nonalcoholic steatohepatitis (NASH), suggesting that development of inflammasome inhibitor can become leading candidate to ameliorate NASH. Panax ginseng (P. ginseng) contains numerous bioactive natural components to reduce inflammation. This study aims to identify inhibitory components of P. ginseng for NLRP3 inflammasome activation. We separated polar and non-polar fractions of P. ginseng and tested modulation of NLRP3 inflammasome, and then identified pure component for inflammasome inhibitor which ameliorates diet-induced NASH. Non-polar P. ginseng fractions obtained from ethyl acetate solvent attenuated IL-1β secretion and expression of active caspase-1. We revealed that panaxydol (PND) is pure component to inhibit NLRP3 inflammasome activation. PND blocked inflammasome cytokines release, pyroptotic cell death, caspase-1 activation and specking of inflammasome complex. Inhibitory effect of PND was specific to NLRP3-dependent pathway via potential interaction with ATP binding motif of NLRP3. Moreover, in vivo studies showed that PND plays beneficial roles to reduce tissue inflammations through disruption of NLRP3 inflammasome and to ameliorate the development of NASH. These results provide new insight of natural products, panaxydol, for NLRP3 inflammasome inhibitor and could offer potential therapeutic candidate for reliving NASH.
MeSH term(s)	Humans ; Animals ; Mice ; Non-alcoholic Fatty Liver Disease/drug therapy ; Inflammasomes/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; NLR Proteins ; Panax/metabolism ; Chemical and Drug Induced Liver Injury, Chronic ; Inflammation ; Caspases ; Mice, Inbred C57BL ; Fatty Alcohols ; Diynes
Chemical Substances	Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; panaxydol (72800-72-7) ; NLR Proteins ; Caspases (EC 3.4.22.-) ; Fatty Alcohols ; Diynes
Language	English
Publishing date	2024-01-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2024.111565
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Article: Exosomal microRNAs as diagnostic and therapeutic biomarkers in non-malignant liver diseases

Hwang, Seonghwan / Yang, Yoon Mee

Archives of pharmacal research. 2021 June, v. 44, no. 6

2021

Abstract	The liver is a vital organ responsible for various physiological functions, such as metabolism, immune response, digestion, and detoxification. Crosstalk between hepatocytes, hepatic macrophages, and hepatic stellate cells is critical for liver pathology. Exosomes are small extracellular vesicles (50–150 nm) that play an important role in cell–cell or organ–organ communication as they transfer their cargo, such as protein, DNA, and RNA to recipient cells or distant organs. In various liver diseases, the number of liver cell-derived exosomes is increased and the exosomal microRNA (miRNA) profile is altered. Early studies investigated the value of circulating exosomal miRNAs as biomarkers. Several exosomal miRNAs showed excellent diagnostic values, suggesting their potential as diagnostic biomarkers in liver diseases. Exosomal miRNAs have emerged as critical regulators of liver pathology because they control the expression of multiple genes in recipient cells. In this review, we discuss the biology of exosomes and summarize the recent findings of exosome-mediated intercellular and organ-to-organ communication during liver pathology. As there are many review articles dealing with exosomal miRNAs in liver cancer, we focused on non-malignant liver diseases. The therapeutic potential of exosomal miRNAs in liver pathology is also highlighted.
Keywords	DNA ; biomarkers ; digestion ; exosomes ; hepatocytes ; immune response ; liver ; liver neoplasms ; macrophages ; metabolism ; microRNA ; research ; therapeutics
Language	English
Dates of publication	2021-06
Size	p. 574-587.
Publishing place	Pharmaceutical Society of Korea
Document type	Article
Note	Review
ZDB-ID	447623-2
ISSN	1976-3786 ; 0253-6269
ISSN (online)	1976-3786
ISSN	0253-6269
DOI	10.1007/s12272-021-01338-2
Database	NAL-Catalogue (AGRICOLA)

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Article: Hepatokines and Non-Alcoholic Fatty Liver Disease: Linking Liver Pathophysiology to Metabolism.

Kim, Tae Hyun / Hong, Dong-Gyun / Yang, Yoon Mee

Biomedicines

2021 Volume 9, Issue 12

Abstract: The liver plays a key role in maintaining energy homeostasis by sensing and responding to changes in nutrient status under various metabolic conditions. Recently highlighted as a major endocrine organ, the contribution of the liver to systemic glucose ... ...

Abstract	The liver plays a key role in maintaining energy homeostasis by sensing and responding to changes in nutrient status under various metabolic conditions. Recently highlighted as a major endocrine organ, the contribution of the liver to systemic glucose and lipid metabolism is primarily attributed to signaling crosstalk between multiple organs via hepatic hormones, cytokines, and hepatokines. Hepatokines are hormone-like proteins secreted by hepatocytes, and a number of these have been associated with extra-hepatic metabolic regulation. Mounting evidence has revealed that the secretory profiles of hepatokines are significantly altered in non-alcoholic fatty liver disease (NAFLD), the most common hepatic manifestation, which frequently precedes other metabolic disorders, including insulin resistance and type 2 diabetes. Therefore, deciphering the mechanism of hepatokine-mediated inter-organ communication is essential for understanding the complex metabolic network between tissues, as well as for the identification of novel diagnostic and/or therapeutic targets in metabolic disease. In this review, we describe the hepatokine-driven inter-organ crosstalk in the context of liver pathophysiology, with a particular focus on NAFLD progression. Moreover, we summarize key hepatokines and their molecular mechanisms of metabolic control in non-hepatic tissues, discussing their potential as novel biomarkers and therapeutic targets in the treatment of metabolic diseases.
Language	English
Publishing date	2021-12-14
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines9121903
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Article ; Online: Hepatokines and Non-Alcoholic Fatty Liver Disease

Tae Hyun Kim / Dong-Gyun Hong / Yoon Mee Yang

Biomedicines, Vol 9, Iss 1903, p

Linking Liver Pathophysiology to Metabolism

2021 Volume 1903

Abstract	The liver plays a key role in maintaining energy homeostasis by sensing and responding to changes in nutrient status under various metabolic conditions. Recently highlighted as a major endocrine organ, the contribution of the liver to systemic glucose and lipid metabolism is primarily attributed to signaling crosstalk between multiple organs via hepatic hormones, cytokines, and hepatokines. Hepatokines are hormone-like proteins secreted by hepatocytes, and a number of these have been associated with extra-hepatic metabolic regulation. Mounting evidence has revealed that the secretory profiles of hepatokines are significantly altered in non-alcoholic fatty liver disease (NAFLD), the most common hepatic manifestation, which frequently precedes other metabolic disorders, including insulin resistance and type 2 diabetes. Therefore, deciphering the mechanism of hepatokine-mediated inter-organ communication is essential for understanding the complex metabolic network between tissues, as well as for the identification of novel diagnostic and/or therapeutic targets in metabolic disease. In this review, we describe the hepatokine-driven inter-organ crosstalk in the context of liver pathophysiology, with a particular focus on NAFLD progression. Moreover, we summarize key hepatokines and their molecular mechanisms of metabolic control in non-hepatic tissues, discussing their potential as novel biomarkers and therapeutic targets in the treatment of metabolic diseases.
Keywords	ANGPTL ; energy metabolism ; Fetuin ; FGF21 ; inter-organ communication ; Biology (General) ; QH301-705.5
Subject code	570
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Associations between Body Mass Index, Waist Circumference, and Myocardial Infarction in Older Adults Aged over 75 Years: A Population-Based Cohort Study.

Han, So Yoon / Kim, Nan Hee / Kim, Do Hoon / Kim, Yang Hyun / Park, Yong Kyu / Kim, Seon Mee

Medicina (Kaunas, Lithuania)

2022 Volume 58, Issue 12

Abstract: Background and ... ...

Abstract	Background and Objectives
Language	English
Publishing date	2022-11-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina58121768
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