Article ; Online: Efficacy and safety of PARP inhibitors for maintenance treatment of ovarian cancer, regardless of BRCA or HRD status: a comprehensive updated meta-analysis.
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology
2023 Volume 43, Issue 1, Page(s) 2171282
Abstract: Without taking into account existing biomarkers like genetic mutations (BRCA mutation, Homologous recombination deficiency) with advanced ovarian cancer (OC), the overall survival (OS), progress-free survival (PFS) of the aggregate all groups that have ... ...
Abstract | Without taking into account existing biomarkers like genetic mutations (BRCA mutation, Homologous recombination deficiency) with advanced ovarian cancer (OC), the overall survival (OS), progress-free survival (PFS) of the aggregate all groups that have been classified were hazard ratio (HR): 0.72, 95% confidence intervals (CI): 0.66-0.79 and HR: 0.48, 95%CI: 0.44-0.52, respectively. Meanwhile, the OS and PFS of the whole population (regardless of existing genetic mutation markers) were HR: 0.74, 95%CI: 0.64-0.87 and HR: 0.52, 95%CI: 0.42-0.65, separately. Furthermore, the OS and PFS of positive gene mutation markers were HR: 0.71, 95%CI: 0.61-0.83 (HRD and BRACm) and HR: 0.47, 95%CI: 0.42-0.52 (HRD and BRACm), individually. The poly ADP-ribose polymers (PARP) inhibitors have desired efficiency and security in the maintenance treatment of advanced OC patients with BRCAm or BRCAwt, HRD or HRP and unknown gene status. |
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MeSH term(s) | Humans ; Female ; Poly(ADP-ribose) Polymerase Inhibitors/therapeutic use ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/genetics ; Carcinoma, Ovarian Epithelial/drug therapy ; Carcinoma, Ovarian Epithelial/genetics ; Mutation |
Chemical Substances | Poly(ADP-ribose) Polymerase Inhibitors |
Language | English |
Publishing date | 2023-02-02 |
Publishing country | England |
Document type | Meta-Analysis ; Journal Article |
ZDB-ID | 604639-3 |
ISSN | 1364-6893 ; 0144-3615 |
ISSN (online) | 1364-6893 |
ISSN | 0144-3615 |
DOI | 10.1080/01443615.2023.2171282 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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