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  1. Artikel ; Online: Investment priorities for research and innovation in urban agri-food systems

    Gordon Prain / David Simon / Jess Halliday / Pay Drechsel

    Frontiers in Sustainable Food Systems, Vol

    Toward more resilient cities in the Global South

    2022  Band 6

    Abstract: Urban and peri-urban agriculture (UPA) is widely distributed throughout the Global South. Despite urban population growth and diversifying food habits, UPA delivers an important part of urban food supply, as well as other types of services to cities, ... ...

    Abstract Urban and peri-urban agriculture (UPA) is widely distributed throughout the Global South. Despite urban population growth and diversifying food habits, UPA delivers an important part of urban food supply, as well as other types of services to cities, such as employment and waste reuse. Nevertheless, the extent and importance of UPA varies between different urban areas, while challenges like limited recognition, land conversion, and water pollution and competition threaten the potential of UPA to contribute to urban resilience. Key investment priorities for research and innovation for overcoming current challenges include incentivized peri-urban zoning, urban allocation of productive lands, and increasing capacities for controlled environment agriculture (CEA). Innovative repositioning of food marketing can help to strengthen supply of healthy food from UPA production, increase decent employment, and turn food markets into nutrition hubs. Priority innovations for contributing to the circular bioeconomy of cities include scaling the safe use of wastewater for irrigation through investments in the adoption of multiple risk-barrier approaches and scaling UPA-based ecosystem services for valorising solid waste and environmental management. Innovations in urban governance are required to support these processes by bringing food systems into urban planning through food mapping and the multisectoral platforms for dialogue and policy formulation across city regions and with vertical levels of government.
    Schlagwörter urban agriculture ; food systems ; controlled environment agriculture ; informal markets ; circular bioeconomy ; resource recovery ; Nutrition. Foods and food supply ; TX341-641 ; Food processing and manufacture ; TP368-456
    Thema/Rubrik (Code) 360
    Sprache Englisch
    Erscheinungsdatum 2022-11-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Investment priorities for research and innovation in urban agri-food systems

    Prain, Gordon / Simon, David / Halliday, Jess / Drechsel, Pay

    Frontiers in Sustainable Food Systems

    toward more resilient cities in the Global South

    2022  

    Abstract: Urban and peri-urban agriculture (UPA) is widely distributed throughout the Global South. Despite urban population growth and diversifying food habits, UPA delivers an important part of urban food supply, as well as other types of services to cities, ... ...

    Abstract Urban and peri-urban agriculture (UPA) is widely distributed throughout the Global South. Despite urban population growth and diversifying food habits, UPA delivers an important part of urban food supply, as well as other types of services to cities, such as employment and waste reuse. Nevertheless, the extent and importance of UPA varies between different urban areas, while challenges like limited recognition, land conversion, and water pollution and competition threaten the potential of UPA to contribute to urban resilience. Key investment priorities for research and innovation for overcoming current challenges include incentivized peri-urban zoning, urban allocation of productive lands, and increasing capacities for controlled environment agriculture (CEA). Innovative repositioning of food marketing can help to strengthen supply of healthy food from UPA production, increase decent employment, and turn food markets into nutrition hubs. Priority innovations for contributing to the circular bioeconomy of cities include scaling the safe use of wastewater for irrigation through investments in the adoption of multiple risk-barrier approaches and scaling UPA-based ecosystem services for valorising solid waste and environmental management. Innovations in urban governance are required to support these processes by bringing food systems into urban planning through food mapping and the multisectoral platforms for dialogue and policy formulation across city regions and with vertical levels of government.
    Schlagwörter agrifood systems ; urban agriculture ; peri-urban agriculture ; investment ; research ; innovation ; resilience ; cities ; markets ; informal sector ; circular economy ; bioeconomy ; resource recovery ; waste management ; food production ; governance ; planning ; policies
    Sprache Englisch
    Erscheinungsdatum 2022-11-16T05:36:36Z
    Verlag Frontiers Media
    Erscheinungsland fr
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel: Undermining loyalty to legality? An empirical analysis of perceptions of 'lockdown' law and guidance during COVID-19.

    Finch, Naomi / Halliday, Simon / Tomlinson, Joe / Meers, Jed / Wilberforce, Mark

    The Modern law review

    2022  

    Abstract: This article substantially extends the existing constitutional and legal critiques of the use of soft law public health guidance in the UK during the COVID-19 pandemic. Drawing upon the findings of a national survey undertaken during the first wave of ... ...

    Abstract This article substantially extends the existing constitutional and legal critiques of the use of soft law public health guidance in the UK during the COVID-19 pandemic. Drawing upon the findings of a national survey undertaken during the first wave of the pandemic in June 2020, it shows how the perceived legal status of lockdown rules made a significant difference as to whether the UK public complied with them and that this effect is a product of the legitimacy that law itself enjoys within UK society. Based on this analysis, it argues that the problems with the Government's approach to guidance, that have been subjected to criticism in constitutional and legal terms, may also be open to critique on the basis that they risk undermining the public's loyalty to the law itself.
    Sprache Englisch
    Erscheinungsdatum 2022-07-05
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2016397-6
    ISSN 1468-2230 ; 0026-7961
    ISSN (online) 1468-2230
    ISSN 0026-7961
    DOI 10.1111/1468-2230.12755
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  4. Artikel ; Online: Limbic thalamus atrophy is associated with visual hallucinations in Lewy body disorders.

    Matar, Elie / Brooks, Daniel / Lewis, Simon J G / Halliday, Glenda M

    Neurobiology of aging

    2022  Band 112, Seite(n) 122–128

    Abstract: Recent models of hallucinations in Lewy body disorders implicate dysfunction in 'higher order' thalamic regions involved in perceptual integration and cognitive processing. However, the degree of pathology and degeneration in these regions has not been ... ...

    Abstract Recent models of hallucinations in Lewy body disorders implicate dysfunction in 'higher order' thalamic regions involved in perceptual integration and cognitive processing. However, the degree of pathology and degeneration in these regions has not been assessed. We sought to assess atrophy, neuronal size, and neuronal numbers in the Mediodorsal (MDn) and Anterior Principal (APn) nuclei of the thalamus across Lewy body disorders comparing between patients with and without hallucinations. Postmortem tissue was acquired from 24 patients with Lewy body disease and 10 age-matched controls and analyzed using standard stereological and quantitative neuropathological techniques. Atrophy in MDn was significantly greater in patients with well-formed visual hallucinations and did not correlate significantly with neuronal size or number. Atrophy in APn was seen across all Lewy body disorders but was not significantly associated with hallucinations. α-synuclein immunoreactivity was found to be low in both the APn and MDn across all groups. These results suggest that MDn atrophy may be a marker of hallucinations and plays a role in their pathophysiology.
    Mesh-Begriff(e) Atrophy/pathology ; Hallucinations/etiology ; Humans ; Lewy Bodies/pathology ; Lewy Body Disease/pathology ; Parkinson Disease/pathology ; Thalamus/pathology
    Sprache Englisch
    Erscheinungsdatum 2022-01-24
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604505-4
    ISSN 1558-1497 ; 0197-4580
    ISSN (online) 1558-1497
    ISSN 0197-4580
    DOI 10.1016/j.neurobiolaging.2022.01.001
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: A new technique of endoscopic decompression of suprasellar craniopharyngioma cyst.

    Halliday, Jane / Cudlip, Simon

    Acta neurochirurgica

    2019  Band 161, Heft 11, Seite(n) 2285–2288

    Abstract: Introduction: Craniopharyngiomas represent a unique management challenge. Aggressive surgical management has traditionally been associated with high rates of morbidity. Modern surgical techniques, and increasing practice of subtotal resection followed ... ...

    Abstract Introduction: Craniopharyngiomas represent a unique management challenge. Aggressive surgical management has traditionally been associated with high rates of morbidity. Modern surgical techniques, and increasing practice of subtotal resection followed by radiosurgery, have reduced morbidity and mortality rates. One cause of postoperative morbidity, and indeed mortality, is aseptic meningitis from spill-out of craniopharyngioma cyst contents. We have developed a surgical technique for the management of large craniopharygngioma cysts extending into the third ventricle, to reduce this risk.
    Methods: We describe a technique of using an epidural catheter, inserted into the working channel of a neuroendoscope, to decompress the cystic portion of a craniopharyngioma cyst before opening the cyst wall widely, preventing spill-out of large volumes of cyst content into the ventricular system.
    Results: We have had no cases of aseptic meningitis, nor any complications, from use of the described technique.
    Discussion: We believe that this is a safe and effective technique of decompression and fenestration of large suprasellar craniopharyngioma cysts that reduces rates of aseptic meningitis and the associated morbidity and mortality from this.
    Mesh-Begriff(e) Central Nervous System Cysts/surgery ; Craniopharyngioma/surgery ; Decompression, Surgical/methods ; Endoscopy/methods ; Female ; Humans ; Male ; Pituitary Neoplasms/surgery ; Third Ventricle/surgery
    Sprache Englisch
    Erscheinungsdatum 2019-08-04
    Erscheinungsland Austria
    Dokumenttyp Journal Article
    ZDB-ID 80010-7
    ISSN 0942-0940 ; 0001-6268
    ISSN (online) 0942-0940
    ISSN 0001-6268
    DOI 10.1007/s00701-019-04024-x
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Effects of STN/SNr deep brain stimulation in a case of progressive supranuclear palsy with a Parkinson disease phenotype.

    Shepherd, Claire E / Lewis, Simon J G / Tisch, Stephen / McCann, Heather / Jonker, Ben / Halliday, Glenda M

    Journal of neuropathology and experimental neurology

    2023  Band 82, Heft 9, Seite(n) 821–823

    Mesh-Begriff(e) Humans ; Parkinson Disease/complications ; Parkinson Disease/therapy ; Supranuclear Palsy, Progressive/therapy ; Deep Brain Stimulation ; Phenotype
    Sprache Englisch
    Erscheinungsdatum 2023-07-07
    Erscheinungsland England
    Dokumenttyp Case Reports ; Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 3088-0
    ISSN 1554-6578 ; 0022-3069
    ISSN (online) 1554-6578
    ISSN 0022-3069
    DOI 10.1093/jnen/nlad052
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  7. Artikel ; Online: A Primary Spinal Nongerminomatous Germ Cell Tumor With Multiple Intracranial Metastases in a Toddler.

    Ramanathan, Subramaniam / Hill, Rebecca M / Ryles, Jade / Halliday, Gail / Mitra, Dipayan / Bailey, Simon

    Journal of pediatric hematology/oncology

    2022  Band 45, Heft 3, Seite(n) e415–e418

    Abstract: Central nervous system germ cell tumors (CNS-GCTs) comprise 4% of all pediatric CNS tumors, with one third being nongerminomatous GCT (CNS-NG-GCT) type. The majority of these tumors arise in the intracranial compartment with 20% having drop metastases in ...

    Abstract Central nervous system germ cell tumors (CNS-GCTs) comprise 4% of all pediatric CNS tumors, with one third being nongerminomatous GCT (CNS-NG-GCT) type. The majority of these tumors arise in the intracranial compartment with 20% having drop metastases in the spine. We present a rare case of a 2-year-old boy with a primary intradural-extramedullary NG-GCT arising from the lumbosacral spine with a trifecta of unfavorable features, that is, young age, alpha-feto protein >1000 ng/mL, and disseminated disease within the cranium. Owing to his young age, he was treated with chemotherapy alone, avoiding radiation. His tumor marker (alpha-feto protein) declined from 8468 to 10 k-U/L over 8 weeks, and he remained in remission at the last follow-up. This atypical presentation of an intradural-extramedullary tumor with cranial dissemination in a childhood NG-GCT has yet to be described in the literature. Here we use this opportunity to highlight the treatment strategies and challenges in this unique clinical case.
    Mesh-Begriff(e) Male ; Humans ; Child, Preschool ; Child ; Neoplasms, Germ Cell and Embryonal/therapy ; Central Nervous System Neoplasms/therapy ; Biomarkers, Tumor/metabolism ; Testicular Neoplasms ; Brain Neoplasms/therapy ; Brain Neoplasms/pathology
    Chemische Substanzen Biomarkers, Tumor
    Sprache Englisch
    Erscheinungsdatum 2022-05-23
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 1231152-2
    ISSN 1536-3678 ; 1077-4114 ; 0192-8562
    ISSN (online) 1536-3678
    ISSN 1077-4114 ; 0192-8562
    DOI 10.1097/MPH.0000000000002486
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  8. Artikel ; Online: Methylphenidate improves cognitive function and health-related quality of life in survivors of childhood brain tumours.

    Verity, Sarah J / Halliday, Gail / Hill, Rebecca M / Ryles, Jade / Bailey, Simon

    Neuropsychological rehabilitation

    2022  Band 34, Heft 1, Seite(n) 133–153

    Abstract: Objectives: The growing population of survivors of childhood brain tumors present the challenge of long-term quality of survival. The domains most affected by tumor and treatment are those implicated in development of typical intellectual functions: ... ...

    Abstract Objectives: The growing population of survivors of childhood brain tumors present the challenge of long-term quality of survival. The domains most affected by tumor and treatment are those implicated in development of typical intellectual functions: attention, working memory, and processing speed, with consequent effects upon function and quality of life. In this paper we present service evaluation data on the 12-month effect upon processing speed, visual and auditory attentional domains in 29 patients receiving methylphenidate aged 5-16 years (Mean=10.6).
    Methods: Patients received immediate-release methylphenidate and were converted to modified-release as appropriate. Mean optimal dose of immediate-release methylphenidate was 0.34 mg/kg per dose (range 0.2-0.67).
    Results: Patients showed a significant positive impact of methylphenidate on attention in all tests of selective visual attention from the Test of Everyday Attention for Children 2. A significant improvement was also shown on response time. Significant change was not found on psychometric measures of sustained auditory or visual attention, or selective auditory attention. Ratings of Health-Related Quality of Life showed a positive benefit of methylphenidate at 12 months. Side effects were minimal and not statistically significant.
    Conclusions: Survivors of childhood brain tumor with attentional and processing speed deficit show clinical benefit from methylphenidate.
    Mesh-Begriff(e) Child ; Humans ; Methylphenidate/therapeutic use ; Central Nervous System Stimulants/therapeutic use ; Quality of Life ; Attention Deficit Disorder with Hyperactivity/etiology ; Attention Deficit Disorder with Hyperactivity/chemically induced ; Cross-Over Studies ; Cognition ; Brain Neoplasms/complications ; Brain Neoplasms/drug therapy ; Brain Neoplasms/chemically induced ; Survivors
    Chemische Substanzen Methylphenidate (207ZZ9QZ49) ; Central Nervous System Stimulants
    Sprache Englisch
    Erscheinungsdatum 2022-12-29
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1080508-4
    ISSN 1464-0694 ; 0960-2011
    ISSN (online) 1464-0694
    ISSN 0960-2011
    DOI 10.1080/09602011.2022.2157446
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  9. Artikel ; Online: The CTLA-4 immune checkpoint protein regulates PD-L1:PD-1 interaction via transendocytosis of its ligand CD80.

    Kennedy, Alan / Robinson, Maximillian A / Hinze, Claudia / Waters, Erin / Williams, Cayman / Halliday, Neil / Dovedi, Simon / Sansom, David M

    The EMBO journal

    2023  Band 42, Heft 5, Seite(n) e111556

    Abstract: CTLA-4 and PD-1 are key immune checkpoint receptors that are targeted in the treatment of cancer. A recently identified physical interaction between the respective ligands, CD80 and PD-L1, has been shown to block PD-L1/PD-1 binding and to prevent PD-L1 ... ...

    Abstract CTLA-4 and PD-1 are key immune checkpoint receptors that are targeted in the treatment of cancer. A recently identified physical interaction between the respective ligands, CD80 and PD-L1, has been shown to block PD-L1/PD-1 binding and to prevent PD-L1 inhibitory functions. Since CTLA-4 is known to capture and degrade its ligands via transendocytosis, we investigated the interplay between CD80 transendocytosis and CD80/PD-L1 interaction. We find that transendocytosis of CD80 results in a time-dependent recovery of PD-L1 availability that correlates with CD80 removal. Moreover, CD80 transendocytosis is highly specific in that only CD80 is internalised, while its heterodimeric PD-L1 partner remains on the plasma membrane of the antigen-presenting cell (APC). CTLA-4 interactions with CD80 do not appear to be inhibited by PD-L1, but efficient removal of CD80 requires an intact CTLA-4 cytoplasmic domain, distinguishing this process from more general trogocytosis and simple CTLA-4 binding to CD80/PD-L1 complexes. These data are consistent with CTLA-4 acting as modulator of PD-L1:PD-1 interactions via control of CD80.
    Mesh-Begriff(e) CTLA-4 Antigen ; Immune Checkpoint Proteins ; Programmed Cell Death 1 Receptor/genetics ; B7-H1 Antigen/genetics ; B7-H1 Antigen/metabolism ; Ligands ; B7-1 Antigen/genetics ; B7-1 Antigen/metabolism ; Cell Adhesion Molecules
    Chemische Substanzen CTLA-4 Antigen ; Immune Checkpoint Proteins ; Programmed Cell Death 1 Receptor ; B7-H1 Antigen ; Ligands ; B7-1 Antigen ; Cell Adhesion Molecules
    Sprache Englisch
    Erscheinungsdatum 2023-02-02
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 586044-1
    ISSN 1460-2075 ; 0261-4189
    ISSN (online) 1460-2075
    ISSN 0261-4189
    DOI 10.15252/embj.2022111556
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  10. Artikel ; Online: Evaluation of plasma levels of NFL, GFAP, UCHL1 and tau as Parkinson's disease biomarkers using multiplexed single molecule counting.

    Youssef, Priscilla / Hughes, Laura / Kim, Woojin S / Halliday, Glenda M / Lewis, Simon J G / Cooper, Antony / Dzamko, Nicolas

    Scientific reports

    2023  Band 13, Heft 1, Seite(n) 5217

    Abstract: Objective biomarkers for Parkinson's Disease (PD) could aid early and specific diagnosis, effective monitoring of disease progression, and improved design and interpretation of clinical trials. Although alpha-synuclein remains a biomarker candidate of ... ...

    Abstract Objective biomarkers for Parkinson's Disease (PD) could aid early and specific diagnosis, effective monitoring of disease progression, and improved design and interpretation of clinical trials. Although alpha-synuclein remains a biomarker candidate of interest, the multifactorial and heterogenous nature of PD highlights the need for a PD biomarker panel. Ideal biomarker candidates include markers that are detectable in easily accessible samples, (ideally blood) and that reflect the underlying pathological process of PD. In the present study, we explored the diagnostic and prognostic PD biomarker potential of the SIMOA neurology 4-plex-A biomarker panel, which included neurofilament light (NFL), glial fibrillary acid protein (GFAP), tau and ubiquitin C-terminal hydrolase L1 (UCHL-1). We initially performed a serum vs plasma comparative study to determine the most suitable blood-based matrix for the measurement of these proteins in a multiplexed assay. The levels of NFL and GFAP in plasma and serum were highly correlated (Spearman rho-0.923, p < 0.0001 and rho = 0.825, p < 0.001 respectively). In contrast, the levels of tau were significantly higher in plasma compared to serum samples (p < 0.0001) with no correlation between sample type (Spearman p > 0.05). The neurology 4-plex-A panel, along with plasma alpha-synuclein was then assessed in a cross-sectional cohort of 29 PD patients and 30 controls. Plasma NFL levels positively correlated with both GFAP and alpha-synuclein levels (rho = 0.721, p < 0.0001 and rho = 0.390, p < 0.05 respectively). As diagnostic biomarkers, the control and PD groups did not differ in their mean NFL, GFAP, tau or UCHL-1 plasma levels (t test p > 0.05). As disease state biomarkers, motor severity (MDS-UPDRS III) correlated with increased NFL (rho = 0.646, p < 0.0001), GFAP (rho = 0.450, p < 0.05) and alpha-synuclein levels (rho = 0.406, p < 0.05), while motor stage (Hoehn and Yahr) correlated with increased NFL (rho = 0.455, p < 0.05) and GFAP (rho = 0.549, p < 0.01) but not alpha-synuclein levels (p > 0.05). In conclusion, plasma was determined to be most suitable blood-based matrix for multiplexing the neurology 4-plex-A panel. Given their correlation with motor features of PD, NFL and GFAP appear to be promising disease state biomarker candidates and further longitudinal validation of these two proteins as blood-based biomarkers for PD progression is warranted.
    Mesh-Begriff(e) Humans ; Parkinson Disease/diagnosis ; Glial Fibrillary Acidic Protein ; Ubiquitin Thiolesterase ; Cross-Sectional Studies ; Biomarkers
    Chemische Substanzen Glial Fibrillary Acidic Protein ; Ubiquitin Thiolesterase (EC 3.4.19.12) ; Biomarkers ; UCHL1 protein, human
    Sprache Englisch
    Erscheinungsdatum 2023-03-30
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-32480-0
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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