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  1. Article ; Online: Further Exploration of MARS.

    Warrillow, Stephen / Fisher, Caleb

    Critical care medicine

    2022  Volume 50, Issue 2, Page(s) 346–348

    Language English
    Publishing date 2022-01-31
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000005202
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1261: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article ; Online: Terlipressin: Leading the Water to the Thirsty.

    Nanchal, Rahul S / Warrillow, Stephen

    Critical care medicine

    2022  Volume 50, Issue 10, Page(s) 1533–1535

    MeSH term(s) Humans ; Liver Cirrhosis/drug therapy ; Terlipressin/therapeutic use ; Vasoconstrictor Agents/therapeutic use
    Chemical Substances Vasoconstrictor Agents ; Terlipressin (7Z5X49W53P)
    Language English
    Publishing date 2022-09-12
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000005635
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1261: Show issues Location:
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  3. Article: Measuring analgesia in ICU: no pain, no gain?

    Casamento, Andrew / Jones, Daryl / Warrillow, Stephen

    Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine

    2023  Volume 24, Issue 3, Page(s) 200–201

    Language English
    Publishing date 2023-10-18
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 2401976-8
    ISSN 1441-2772
    ISSN 1441-2772
    DOI 10.51893/2022.3.E
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6672: Show issues Location:
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  4. Article: What you need to know about: acute liver failure.

    Matthewman, Madeline Coxwell / Warrillow, Stephen

    British journal of hospital medicine (London, England : 2005)

    2022  Volume 83, Issue 9, Page(s) 1–11

    Abstract: Acute liver failure is a rare but important clinical syndrome, with a high mortality rate. Prompt recognition, appropriate management and early referral to a liver transplant centre can lead to good outcomes in these critically unwell patients. This ... ...

    Abstract Acute liver failure is a rare but important clinical syndrome, with a high mortality rate. Prompt recognition, appropriate management and early referral to a liver transplant centre can lead to good outcomes in these critically unwell patients. This article gives an overview of the key clinical challenges and optimal management of patients with acute liver failure. Acute liver failure is defined and a comprehensive list of aetiologies and suggested investigations is provided. The clinical challenges of sepsis, renal impairment, coagulopathy, hypoglycaemia, haemodynamic instability and cerebral oedema are discussed. Quadruple H therapy, a combination of therapies aimed to reduce cerebral oedema in acute liver failure, is described. A systemic guide to managing patients with acute liver failure is provided, as are indications for referral to a liver transplant centre.
    MeSH term(s) Brain Edema/etiology ; Brain Edema/therapy ; Humans ; Hypoglycemia/complications ; Liver Failure, Acute/complications ; Liver Failure, Acute/diagnosis ; Liver Transplantation/adverse effects
    Language English
    Publishing date 2022-09-28
    Publishing country England
    Document type Journal Article
    ISSN 1750-8460
    ISSN 1750-8460
    DOI 10.12968/hmed.2022.0051
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Life on MARS?

    Warrillow, Stephen

    Critical care medicine

    2017  Volume 45, Issue 10, Page(s) 1776–1777

    MeSH term(s) Acute-On-Chronic Liver Failure ; Humans ; Life ; Retrospective Studies ; Water
    Chemical Substances Water (059QF0KO0R)
    Language English
    Publishing date 2017-09-14
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000002604
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1261: Show issues Location:
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  6. Article ; Online: Ammonia and nutritional therapy in the critically ill: when to worry, when to test and how to treat?

    Redant, Sebastien / Warrillow, Stephen / Honoré, Patrick M

    Current opinion in clinical nutrition and metabolic care

    2023  Volume 26, Issue 2, Page(s) 160–166

    Abstract: Purpose of review: Hyperammonaemia is almost always develops in patients with severe liver failure and this remains the commonest cause of elevated ammonia concentrations in the ICU. Nonhepatic hyperammonaemia in ICU presents diagnostic and management ... ...

    Abstract Purpose of review: Hyperammonaemia is almost always develops in patients with severe liver failure and this remains the commonest cause of elevated ammonia concentrations in the ICU. Nonhepatic hyperammonaemia in ICU presents diagnostic and management challenges for treating clinicians. Nutritional and metabolic factors play an important role in the cause and management of these complex disorders.
    Recent findings: Nonhepatic hyperammonaemia causes such as drugs, infection and inborn errors of metabolism may be unfamiliar to clinicians and risk being overlooked. Although cirrhotic patients may tolerate marked elevations in ammonia, other causes of acute severe hyperammonaemia may result in fatal cerebral oedema. Any coma of unclear cause should prompt urgent measurement of ammonia and severe elevations warrant immediate protective measures as well as treatments such as renal replacement therapy to avoid life-threatening neurological injury.
    Summary: The current review explores important clinical considerations, the approach to testing and key treatment principles that may prevent progressive neurological damage and improve outcomes for patients with hyperammonaemia, especially from nonhepatic causes.
    MeSH term(s) Humans ; Hyperammonemia/etiology ; Hyperammonemia/therapy ; Ammonia/metabolism ; Critical Illness/therapy ; Nutritional Support ; Nutrition Therapy
    Chemical Substances Ammonia (7664-41-7)
    Language English
    Publishing date 2023-01-20
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 1460178-3
    ISSN 1473-6519 ; 1363-1950
    ISSN (online) 1473-6519
    ISSN 1363-1950
    DOI 10.1097/MCO.0000000000000899
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5586: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Ceremonial purification: which rite is right in liver failure?

    Fisher, Caleb / Warrillow, Stephen / Bellomo, Rinaldo

    Intensive care medicine

    2022  Volume 49, Issue 3, Page(s) 366

    MeSH term(s) Humans ; Liver Failure/therapy
    Language English
    Publishing date 2022-11-09
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-022-06923-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1089: Show issues Location:
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  8. Article ; Online: The evolving role of intensive care in health care and society.

    Warrillow, Stephen / Raper, Raymond

    The Medical journal of Australia

    2019  Volume 211, Issue 7, Page(s) 294–297.e1

    MeSH term(s) Australia ; Critical Care/trends ; Health Personnel/trends ; Humans ; Intensive Care Units/trends ; New Zealand
    Language English
    Publishing date 2019-09-22
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 186082-3
    ISSN 1326-5377 ; 0025-729X
    ISSN (online) 1326-5377
    ISSN 0025-729X
    DOI 10.5694/mja2.50340
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.398: Show issues Location:
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  9. Article ; Online: The Impact of Early Positive Studies on the Evolution of Extracorporeal Albumin Dialysis Literature: A Bibliometric Analysis.

    Chaba, Anis / Warrillow, Stephen / Fisher, Caleb / Maeda, Akinori / Spano, Sofia / Bellomo, Rinaldo

    Blood purification

    2023  Volume 53, Issue 4, Page(s) 279–287

    Abstract: Introduction: Liver failure is a life-threatening condition characterized by the accumulation of metabolic toxins. Extracorporeal albumin dialysis (ECAD) has been promoted as a possible therapy.: Methods: We employed bibliometric analysis to ... ...

    Abstract Introduction: Liver failure is a life-threatening condition characterized by the accumulation of metabolic toxins. Extracorporeal albumin dialysis (ECAD) has been promoted as a possible therapy.
    Methods: We employed bibliometric analysis to scrutinize the conceptual, intellectual, and social structure of the ECAD literature including its co-citation network and thematic analysis to explore its evolution and organization.
    Results: We identified 784 documents with a mean of 30.25 citations per document in a corpus of 15,191 references. The average citation rate peaked in 1998 at 280.75 citations/year before a second 2013 peak of 54.81 citations/year and then progressively decreased to its nadir in 2022 (1.48 yearly citations). We identified four primary co-citation clusters, with the most impactful publications being small "positive" manuscripts by Mitzner et al. (2000) and Heemann et al. (2002) (Cluster 1). This first cluster had several relational citations with clusters 2 and 3, but almost no citation link with cluster 4 represented by Bañares et al. (2013), Saliba et al. (2013), and Larsen et al. (2016), with their three negative randomized controlled trials. Finally, the thematic map revealed a shift in focus over time, with inflammation and ammonia as recent emergent themes.
    Conclusions: This bibliometric analysis provided a transparent and reproducible longitudinal assessment of ECAD literature and demonstrated how positive studies with low levels of evidence can dominate a research field and overshadow negative findings from higher quality studies. These insights hold significant implications for future research and clinical practice within this domain.
    MeSH term(s) Humans ; Renal Dialysis ; Bibliometrics ; Albumins ; Liver Failure
    Chemical Substances Albumins
    Language English
    Publishing date 2023-10-31
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 605548-5
    ISSN 1421-9735 ; 0253-5068
    ISSN (online) 1421-9735
    ISSN 0253-5068
    DOI 10.1159/000534915
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1872: Show issues Location:
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  10. Article: Midodrine use in critically ill patients: a narrative review.

    Costa-Pinto, Rahul / Jones, Daryl A / Udy, Andrew A / Warrillow, Stephen J / Bellomo, Rinaldo

    Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine

    2023  Volume 24, Issue 4, Page(s) 298–308

    Abstract: Midodrine is a peripherally acting, oral α-agonist that is increasingly used in intensive care units despite conflicting evidence for its effectiveness. It has pharmacological effects on blood vessels as well as pupillary, cardiac, renal, ... ...

    Abstract Midodrine is a peripherally acting, oral α-agonist that is increasingly used in intensive care units despite conflicting evidence for its effectiveness. It has pharmacological effects on blood vessels as well as pupillary, cardiac, renal, gastrointestinal, genitourinary, lymphatic and skin tissue. It has approval for use as a treatment for orthostatic hypotension, but a surge in interest over the past decade has prompted its use for a growing number of off-label indications. In critically ill patients, midodrine has been used as either an adjunctive oral therapy to wean vasoplegic patients off low dose intravenous vasopressor infusions, or as an oral vasopressor agent to prevent or minimise the need for intravenous infusion. Clinical trials have mostly focused on midodrine as an intravenous vasopressor weaning agent. Early retrospective studies supported its use for this indication, but more recent randomised controlled trials have largely refuted this practice. Key questions remain on its role in managing critically ill patients before intensive care admission, during intensive care stay, and following discharge. This narrative review presents a comprehensive overview of midodrine use for the critical care physician and highlights why lingering questions around ideal patient selection, dosing, timing of initiation, and efficacy of midodrine for critically ill patients remain unanswered.
    Language English
    Publishing date 2023-10-16
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2401976-8
    ISSN 1441-2772
    ISSN 1441-2772
    DOI 10.51893/2022.4.R
    Database MEDical Literature Analysis and Retrieval System OnLINE

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