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  1. Article ; Online: Imsidolimab: an emerging biological therapy for generalized pustular psoriasis.

    Gleeson, David / Mahil, Satveer K

    The British journal of dermatology

    2023  Volume 189, Issue 2, Page(s) 153

    MeSH term(s) Humans ; Psoriasis/drug therapy ; Antibodies, Monoclonal ; Chronic Disease ; Acute Disease ; Biological Therapy
    Chemical Substances Antibodies, Monoclonal
    Language English
    Publishing date 2023-04-20
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1093/bjd/ljad128
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  2. Article ; Online: Spesolimab in the treatment of generalized pustular psoriasis: a critically appraised research paper.

    Ali, Fatima / Smith, Catherine H / Mahil, Satveer K

    The British journal of dermatology

    2023  Volume 188, Issue 3, Page(s) 328–329

    MeSH term(s) Humans ; Psoriasis ; Antibodies, Monoclonal, Humanized ; Chronic Disease ; Acute Disease
    Chemical Substances spesolimab (5IB2J79MCX) ; Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2023-02-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1093/bjd/ljac049
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  3. Article ; Online: In chronic plaque psoriasis, roflumilast cream safely increased likelihood of clear or almost clear state at 6 weeks.

    Mahil, Satveer K / Smith, Catherine H

    Annals of internal medicine

    2020  Volume 173, Issue 10, Page(s) JC55

    Abstract: Source citation: Lebwohl MG, Papp KA, Stein Gold L, et al. ...

    Abstract Source citation: Lebwohl MG, Papp KA, Stein Gold L, et al.
    MeSH term(s) Aminopyridines/adverse effects ; Benzamides/adverse effects ; Cyclopropanes ; Humans ; Psoriasis/drug therapy ; Treatment Outcome
    Chemical Substances Aminopyridines ; Benzamides ; Cyclopropanes ; Roflumilast (0P6C6ZOP5U)
    Keywords covid19
    Language English
    Publishing date 2020-11-16
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/ACPJ202011170-055
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  4. Article ; Online: Psoriasis biologics: a new era of choice.

    Mahil, Satveer K / Smith, Catherine H

    Lancet (London, England)

    2019  Volume 394, Issue 10201, Page(s) 807–808

    MeSH term(s) Antibodies, Monoclonal ; Biological Products ; Humans ; Psoriasis
    Chemical Substances Antibodies, Monoclonal ; Biological Products ; guselkumab (089658A12D) ; secukinumab (DLG4EML025)
    Language English
    Publishing date 2019-08-08
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(19)31772-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: PSORIASIS: FROM GENE TO CLINIC CONGRESS REPORTInternational conference showcases cutting-edge psoriasis research.

    Mahil, Satveer K

    The Journal of clinical and aesthetic dermatology

    2015  Volume 8, Issue 7 Suppl 3, Page(s) 17–22

    Language English
    Publishing date 2015-04-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2571623-2
    ISSN 1941-2789
    ISSN 1941-2789
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Psoriasis: a brief overview.

    Raharja, Antony / Mahil, Satveer K / Barker, Jonathan N

    Clinical medicine (London, England)

    2021  Volume 21, Issue 3, Page(s) 170–173

    Abstract: Psoriasis is a clinically heterogeneous lifelong skin disease that presents in multiple forms such as plaque, flexural, guttate, pustular or erythrodermic. An estimated 60 million people have psoriasis worldwide, with 1.52% of the general population ... ...

    Abstract Psoriasis is a clinically heterogeneous lifelong skin disease that presents in multiple forms such as plaque, flexural, guttate, pustular or erythrodermic. An estimated 60 million people have psoriasis worldwide, with 1.52% of the general population affected in the UK. An immune-mediated inflammatory disease, psoriasis has a major genetic component. Its association with psoriatic arthritis and increased rates of cardiometabolic, hepatic and psychological comorbidity requires a holistic and multidisciplinary care approach. Psoriasis treatments include topical agents (vitamin D analogues and corticosteroids), phototherapy (narrowband ultraviolet B radiation (NB-UVB) and psoralen and ultraviolet A radiation (PUVA)), standard systemic (methotrexate, ciclosporin and acitretin), biologic (tumour necrosis factor (TNF), interleukin (IL)-17 and IL-23 inhibitors) or small molecule inhibitor (dimethyl fumarate and apremilast) therapies. Advances in the understanding of its pathophysiology have led to development of highly effective and targeted treatments.
    MeSH term(s) Acitretin ; Humans ; Immunosuppressive Agents ; Methotrexate ; Phototherapy ; Psoriasis/epidemiology ; Psoriasis/therapy
    Chemical Substances Immunosuppressive Agents ; Acitretin (LCH760E9T7) ; Methotrexate (YL5FZ2Y5U1)
    Language English
    Publishing date 2021-05-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2048646-7
    ISSN 1473-4893 ; 1470-2118
    ISSN (online) 1473-4893
    ISSN 1470-2118
    DOI 10.7861/clinmed.2021-0257
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: The Impact of Immune-Modifying Treatments for Skin Diseases on the Immune Response to COVID-19 Vaccines: a Narrative Review.

    Liew, Su-Yi / Tree, Timothy / Smith, Catherine H / Mahil, Satveer K

    Current dermatology reports

    2022  , Page(s) 1–26

    Abstract: Purpose of review: SARS-CoV-2 has had a devastating global effect, with vaccinations being paramount in the public health strategy against COVID-19. Vaccinations have uncoupled infection from adverse COVID-19 outcomes worldwide. While immune-modifying ... ...

    Abstract Purpose of review: SARS-CoV-2 has had a devastating global effect, with vaccinations being paramount in the public health strategy against COVID-19. Vaccinations have uncoupled infection from adverse COVID-19 outcomes worldwide. While immune-modifying therapies are effective for the management of skin diseases such as psoriasis and atopic dermatitis, these medications also impair protective immune responses. There has been longstanding uncertainty and concern over the impact of immune-modifying therapies on the effectiveness of vaccines; for example, it is well recognised that methotrexate impairs humoral responses to both influenza and pneumococcal vaccines. This narrative review aims to discuss the evidence to date on the impact of immune-modifying therapies on the immune response to COVID-19 vaccines, with a focus on the first two vaccine doses.
    Recent findings: Individuals receiving immune-modifying therapy are more likely to have attenuated humoral responses to a single dose of COVID-19 vaccine compared to healthy controls; however, this may be improved by a complete course of vaccination. B cell targeted biologics such as rituximab markedly impair the humoral response to both the first and second COVID-19 vaccination. There remains a paucity of data on cellular immune responses, with the few available studies indicating lower responses to two vaccine doses in individuals receiving immune-modifying therapies compared to healthy controls, which may impact the durability of immune responses.
    Summary: Inadequate humoral immune responses to a single dose of vaccine in the context of immune-modifying therapy are improved by a complete course of vaccination. Individuals receiving immune-modifying treatments should be encouraged to take up a complete vaccine course to mitigate their risk against COVID-19. Research in large patient populations on the longevity/kinetics of the complex humoral and cellular response to subsequent vaccine doses, including against newer variants of concern, is warranted, in addition to data on immune correlates of vaccine clinical effectiveness.
    Language English
    Publishing date 2022-10-25
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2162-4933
    ISSN 2162-4933
    DOI 10.1007/s13671-022-00376-3
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  8. Article ; Online: Are Janus kinase inhibitors an effective treatment for palmoplantar pustulosis? A critically appraised topic.

    Gleeson, David / Barker, Jonathan N W N / Capon, Francesca / Pink, Andrew E / Woolf, Richard T / Smith, Catherine H / Mahil, Satveer K

    The British journal of dermatology

    2023  Volume 188, Issue 4, Page(s) 471–473

    MeSH term(s) Humans ; Janus Kinase Inhibitors/therapeutic use ; Psoriasis/drug therapy ; Exanthema ; Chronic Disease ; Treatment Outcome
    Chemical Substances Janus Kinase Inhibitors
    Language English
    Publishing date 2023-01-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1093/bjd/ljac130
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  9. Article: In chronic plaque psoriasis, roflumilast cream safely increased likelihood of clear or almost clear state at 6 weeks

    Mahil, Satveer K / Smith, Catherine H

    Ann Intern Med

    Abstract: SOURCE CITATION: Lebwohl MG, Papp KA, Stein Gold L, et al. Trial of roflumilast cream for chronic plaque psoriasis. N Engl J Med. 2020;383:229-39. 32668113. ...

    Abstract SOURCE CITATION: Lebwohl MG, Papp KA, Stein Gold L, et al. Trial of roflumilast cream for chronic plaque psoriasis. N Engl J Med. 2020;383:229-39. 32668113.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #33197348
    Database COVID19

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  10. Article ; Online: Single-cell analysis of psoriasis resolution demonstrates an inflammatory fibroblast state targeted by IL-23 blockade.

    Francis, Luc / McCluskey, Daniel / Ganier, Clarisse / Jiang, Treasa / Du-Harpur, Xinyi / Gabriel, Jeyrroy / Dhami, Pawan / Kamra, Yogesh / Visvanathan, Sudha / Barker, Jonathan N / Smith, Catherine H / Capon, Francesca / Mahil, Satveer K

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 913

    Abstract: Biologic therapies targeting the IL-23/IL-17 axis have transformed the treatment of psoriasis. However, the early mechanisms of action of these drugs remain poorly understood. Here, we perform longitudinal single-cell RNA-sequencing in affected ... ...

    Abstract Biologic therapies targeting the IL-23/IL-17 axis have transformed the treatment of psoriasis. However, the early mechanisms of action of these drugs remain poorly understood. Here, we perform longitudinal single-cell RNA-sequencing in affected individuals receiving IL-23 inhibitor therapy. By profiling skin at baseline, day 3 and day 14 of treatment, we demonstrate that IL-23 blockade causes marked gene expression shifts, with fibroblast and myeloid populations displaying the most extensive changes at day 3. We also identify a transient WNT5A+/IL24+ fibroblast state, which is only detectable in lesional skin. In-silico and in-vitro studies indicate that signals stemming from these WNT5A+/IL24+ fibroblasts upregulate multiple inflammatory genes in keratinocytes. Importantly, the abundance of WNT5A+/IL24+ fibroblasts is significantly reduced after treatment. This observation is validated in-silico, by deconvolution of multiple transcriptomic datasets, and experimentally, by RNA in-situ hybridization. These findings demonstrate that the evolution of inflammatory fibroblast states is a key feature of resolving psoriasis skin.
    MeSH term(s) Humans ; Psoriasis/drug therapy ; Psoriasis/genetics ; Psoriasis/metabolism ; Skin/metabolism ; Keratinocytes/metabolism ; Interleukin-23/genetics ; Interleukin-23/metabolism ; RNA/metabolism ; Fibroblasts/metabolism ; Single-Cell Analysis
    Chemical Substances Interleukin-23 ; RNA (63231-63-0)
    Language English
    Publishing date 2024-01-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-44994-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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