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  1. Article: Illuminating the Genetic Basis of Congenital Heart Disease in Patients with Kabuki Syndrome.

    Lee, Chung-Lin / Chuang, Chih-Kuang / Chen, Ming-Ren / Lin, Ju-Li / Chiu, Huei-Ching / Chang, Ya-Hui / Tu, Yuan-Rong / Lo, Yun-Ting / Lin, Hsiang-Yu / Lin, Shuan-Pei

    Diagnostics (Basel, Switzerland)

    2024  Volume 14, Issue 8

    Abstract: Congenital heart defects (CHDs) affect a substantial proportion of patients with Kabuki syndrome. However, the prevalence and type of CHD and the genotype-phenotype correlations in Asian populations are not fully elucidated. This study performed a ... ...

    Abstract Congenital heart defects (CHDs) affect a substantial proportion of patients with Kabuki syndrome. However, the prevalence and type of CHD and the genotype-phenotype correlations in Asian populations are not fully elucidated. This study performed a retrospective analysis of 23 Taiwanese patients with molecularly confirmed Kabuki syndrome. Twenty-two patients presented with pathogenic variants in the
    Language English
    Publishing date 2024-04-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics14080846
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Phillygenin Suppresses Glutamate Exocytosis in Rat Cerebrocortical Nerve Terminals (Synaptosomes) through the Inhibition of Ca

    Lee, Ming-Yi / Lin, Tzu-Yu / Chang, Ya-Ying / Chiu, Kuan-Ming / Wang, Su-Jane

    Biomedicines

    2024  Volume 12, Issue 3

    Abstract: Glutamate is a major excitatory neurotransmitter that mediates neuronal damage in acute and chronic brain disorders. The effect and mechanism of phillygenin, a natural compound with neuroprotective potential, on glutamate release in isolated nerve ... ...

    Abstract Glutamate is a major excitatory neurotransmitter that mediates neuronal damage in acute and chronic brain disorders. The effect and mechanism of phillygenin, a natural compound with neuroprotective potential, on glutamate release in isolated nerve terminals (synaptosomes) prepared from the rat cerebral cortex were examined. In this study, 4-aminopyridine (4-AP), a potassium channel blocker, was utilized to induce the release of glutamate, which was subsequently quantified via a fluorometric assay. Our findings revealed that phillygenin reduced 4-AP-induced glutamate release, and this inhibitory effect was reversed by removing extracellular Ca
    Language English
    Publishing date 2024-02-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines12030495
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: AgRP Neuron-Specific Ablation Represses Appetite, Energy Intake, and Somatic Growth in Larval Zebrafish.

    Lin, Chiu-Ya / Yeh, Kun-Yun / Lai, Hsin-Hung / Her, Guor Mour

    Biomedicines

    2023  Volume 11, Issue 2

    Abstract: Neuronal circuits regulating appetite are dominated by arcuate nucleus neurons, which include appetite-promoting and -suppressing neurons that release the orexigenic neuropeptide agouti-related protein (AgRP) and anorexigenic neuropeptide pro- ... ...

    Abstract Neuronal circuits regulating appetite are dominated by arcuate nucleus neurons, which include appetite-promoting and -suppressing neurons that release the orexigenic neuropeptide agouti-related protein (AgRP) and anorexigenic neuropeptide pro-opiomelanocortin, respectively, to compete for melanocortin receptors to modulate feeding behavior. In this study, we expressed novel
    Language English
    Publishing date 2023-02-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11020499
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  4. Article ; Online: Biochemical fractionation and purification of high-molecular-mass APOBEC3G complexes.

    Chiu, Ya-Lin

    Methods in molecular biology (Clifton, N.J.)

    2011  Volume 718, Page(s) 185–206

    Abstract: Human APOBEC3G (A3G) is a cytidine deaminase that broadly restricts the replication of many retroviruses, including HIV-1. In different cell types, cytoplasmic A3G is expressed in high-molecular-mass (HMM) RNA-protein complexes or low-molecular-mass (LMM) ...

    Abstract Human APOBEC3G (A3G) is a cytidine deaminase that broadly restricts the replication of many retroviruses, including HIV-1. In different cell types, cytoplasmic A3G is expressed in high-molecular-mass (HMM) RNA-protein complexes or low-molecular-mass (LMM) forms displaying different biological activities. LMM A3G has been proposed to restrict HIV-1 infection soon after virion entry in resting CD4 T cells, monocytes, and mature dendritic cells. Cellular activation and specific cytokine signaling promote the recruitment of LMM A3G into HMM complexes that are likely nucleated by the induced expression of Alu retroelement RNAs. HMM A3G sequesters these retroelement RNAs away from the nuclear LINE-derived enzymes required for Alu retrotransposition. However, assembly of A3G into HMM complexes suppresses its enzymatic activity and may render cells permissive to HIV-1 infection. During HIV-1 virion formation, newly synthesized LMM A3G is preferentially encapsidated when the HIV-1 viral protein viral infectivity factor is absent and employs sequential actions to restrict HIV-1. A3G's biological activities are tightly regulated by its ability to assemble into HMM complexes. Here, we describe in detail the procedures for biochemical fractionation and purification of HMM A3G complexes. Purified HMM A3G complexes will be useful for studying many aspects of the A3G biology, including A3G's roles in restricting retroviral replication, inhibiting retroelement mobility, and potentially regulating cellular RNA function.
    MeSH term(s) APOBEC-3G Deaminase ; Blotting, Western/methods ; Cell Separation/methods ; Cells, Cultured ; Chromatography, Affinity/methods ; Chromatography, Liquid/methods ; Cytidine Deaminase/isolation & purification ; Electrophoresis, Polyacrylamide Gel/methods ; Humans ; Transfection/methods
    Chemical Substances APOBEC-3G Deaminase (EC 3.5.4.5) ; APOBEC3G protein, human (EC 3.5.4.5) ; Cytidine Deaminase (EC 3.5.4.5)
    Language English
    Publishing date 2011
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-61779-018-8_12
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Association between clustering of unhealthy behaviors and depressive symptom among adolescents in Taiwan: A nationwide cross-sectional survey.

    Bui, Chung / Lin, Li-Yin / Lin, Chun-Ji / Chiu, Ya-Wen / Chiou, Hung-Yi

    Frontiers in public health

    2023  Volume 11, Page(s) 1049836

    Abstract: Background: Among Taiwanese adolescents, how the clustering of unhealthy behaviors, including insufficient physical activity, screen-based sedentary behavior and frequent sugar-sweetened beverage consumption affecting depressive symptom remains unclear. ...

    Abstract Background: Among Taiwanese adolescents, how the clustering of unhealthy behaviors, including insufficient physical activity, screen-based sedentary behavior and frequent sugar-sweetened beverage consumption affecting depressive symptom remains unclear. This study aims to examine the cross-sectional association between clustering of unhealthy behaviors and depressive symptom.
    Methods: We analyzed 18,509 participants from the baseline survey of the Taiwan Adolescent to Adult Longitudinal Survey in 2015. The outcome was depressive symptoms, and the main exposures were insufficient physical activity, screen-based sedentary behaviors and frequent sugar-sweetened beverage consumption. Generalized linear mixed models were performed to find key factor associated with depressive symptom.
    Results: Depressive symptoms were common among participants (31.4%), particularly in female and older adolescents. After adjustments for covariates including sex, school type, other lifestyle factors and social determinants, individuals exhibiting clustering of unhealthy behaviors were more likely (aOR = 1.53, 95% CI: 1.48-1.58) to exhibit depressive symptoms than those who have no or only one unhealthy behavior.
    Conclusions: Clustering of unhealthy behaviors is positively associated with depressive symptom among Taiwanese adolescents. The findings highlight the importance of strengthening public health interventions to improve physical activity and decrease sedentary behaviors.
    MeSH term(s) Adult ; Humans ; Adolescent ; Female ; Cross-Sectional Studies ; Depression/epidemiology ; Taiwan/epidemiology ; Exercise ; Cluster Analysis
    Language English
    Publishing date 2023-03-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2023.1049836
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: RETRACTED: Lai et al. MicroRNA-21 Plays Multiple Oncometabolic Roles in the Process of NAFLD-Related Hepatocellular Carcinoma via PI3K/AKT, TGF-β, and STAT3 Signaling.

    Lai, Chi-Yu / Yeh, Kun-Yun / Lin, Chiu-Ya / Hsieh, Yang-Wen / Lai, Hsin-Hung / Chen, Jim-Ray / Hsu, Chia-Chun / Her, Guor Mour

    Cancers

    2024  Volume 16, Issue 8

    Abstract: ... ...

    Abstract The
    Language English
    Publishing date 2024-04-22
    Publishing country Switzerland
    Document type Retraction of Publication
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16081597
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  7. Article ; Online: N-Acetylcysteine Alleviates the Progression of Chronic Kidney Disease: A Three-Year Cohort Study.

    Chiu, Ai-Hua / Wang, Chih-Jen / Lin, Ya-Ling / Wang, Chia-Liang / Chiang, Tsay-I

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 11

    Abstract: Background and ... ...

    Abstract Background and Objectives
    MeSH term(s) Humans ; Cohort Studies ; Acetylcysteine/therapeutic use ; Retrospective Studies ; Glomerular Filtration Rate ; Disease Progression ; Risk Factors ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/drug therapy ; Renal Insufficiency, Chronic/epidemiology ; Kidney Failure, Chronic/epidemiology
    Chemical Substances Acetylcysteine (WYQ7N0BPYC)
    Language English
    Publishing date 2023-11-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59111983
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6270: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: PARP-1 regulates inflammasome activity by poly-ADP-ribosylation of NLRP3 and interaction with TXNIP in primary macrophages.

    Chiu, Ling-Ya / Huang, Duen-Yi / Lin, Wan-Wan

    Cellular and molecular life sciences : CMLS

    2022  Volume 79, Issue 2, Page(s) 108

    Abstract: Poly(ADP-ribose) polymerase-1 (PARP-1) plays an essential role in DNA repair by catalyzing the polymerization of ADP-ribose unit to target proteins. Several studies have shown that PARP-1 can regulate inflammatory responses in various disease models. The ...

    Abstract Poly(ADP-ribose) polymerase-1 (PARP-1) plays an essential role in DNA repair by catalyzing the polymerization of ADP-ribose unit to target proteins. Several studies have shown that PARP-1 can regulate inflammatory responses in various disease models. The intracellular Nod-like receptor NLRP3 has emerged as the most crucial innate immune receptor because of its broad specificity in mediating immune response to pathogen invasion and danger signals associated with cellular damage. In our study, we found NLRP3 stimuli-induced caspase-1 maturation and IL-1β production were impaired by PARP-1 knockout or PARP-1 inhibition in bone marrow-derived macrophages (BMDM). The step 1 signal of NLRP3 inflammasome activation was not affected by PARP-1 deficiency. Moreover, ATP-induced cytosolic ROS production was lower in Parp-1
    MeSH term(s) Animals ; Carrier Proteins/genetics ; Carrier Proteins/metabolism ; Cell Line ; Cells, Cultured ; Gene Expression Regulation ; HEK293 Cells ; Humans ; Immunoblotting ; Inflammasomes/genetics ; Inflammasomes/metabolism ; Interleukin-1beta/genetics ; Interleukin-1beta/metabolism ; Macrophages/metabolism ; Mice, Knockout ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Poly (ADP-Ribose) Polymerase-1/genetics ; Poly (ADP-Ribose) Polymerase-1/metabolism ; Poly ADP Ribosylation ; Protein Binding ; Reactive Oxygen Species/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Thioredoxins/genetics ; Thioredoxins/metabolism ; Mice
    Chemical Substances Carrier Proteins ; Inflammasomes ; Interleukin-1beta ; NLR Family, Pyrin Domain-Containing 3 Protein ; Reactive Oxygen Species ; Txnip protein, mouse ; Thioredoxins (52500-60-4) ; Parp1 protein, mouse (EC 2.4.2.30) ; Poly (ADP-Ribose) Polymerase-1 (EC 2.4.2.30)
    Language English
    Publishing date 2022-01-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1358415-7
    ISSN 1420-9071 ; 1420-682X
    ISSN (online) 1420-9071
    ISSN 1420-682X
    DOI 10.1007/s00018-022-04138-z
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 195: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Inactivation Kinetics of Foodborne Pathogens in Carrot Juice by High-Pressure Processing.

    Hwang, Chiu-Chu / Lin, Chung-Saint / Hsiao, Yun-Ting / Huang, Ya-Ling / Yen, Feng-Lin / Lee, Yi-Chen / Tsai, Yung-Hsiang

    Biology

    2023  Volume 12, Issue 11

    Abstract: In this study, ...

    Abstract In this study,
    Language English
    Publishing date 2023-10-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology12111383
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  10. Article ; Online: Nursing Students’ Perceptions of Menstrual Distress during Clinical Practice

    Ya-Lin Fu / Chia-Ling Yang / Shu-Chuan Yu / Yun-Hsuan Lin / Hsiao-Pei Hsu / Chiu-Mieh Huang

    International Journal of Environmental Research and Public Health, Vol 18, Iss 3160, p

    A Q-Methodology Study

    2021  Volume 3160

    Abstract: This study aimed to explore the cluster patterns of female nursing students’ perceptions of the effects of menstrual distress during clinical practice. This study adopted the Q-methodology study design. We recruited female nursing students from a college ...

    Abstract This study aimed to explore the cluster patterns of female nursing students’ perceptions of the effects of menstrual distress during clinical practice. This study adopted the Q-methodology study design. We recruited female nursing students from a college in northern Taiwan. Forty-seven Q-statements were constructed to explore participants’ experiences of the impact of menstrual distress on clinical learning. In total, 58 participants subjectively ranked Q-statements concerning menstrual distress experiences during clinical practice and were classified. After Q-sorting, the subjective ranking process PQ Method (version 2.35, Schmolck, Emmendingen, Germany) was employed for factor analysis. Four patterns of shared perspectives, accounting for 46.6% of the total variance, were identified: (a) influencing clinical learning and making good use of painkillers; (b) responsible attitudes and diversified relief of discomfort; (c) seeking peer support and effect on mood; (d) negative impact on learning ability and conservative self-care. Clinical practice is a major component of nursing education; menstrual distress affects female nursing students’ clinical learning and performance. The exploration of clustering different nursing students’ perceptions may facilitate customized strategies to enable more appropriate assistance.
    Keywords clinical practice ; menstrual distress ; nursing students ; Q-methodology ; northern Taiwan ; Medicine ; R
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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