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  1. Article: Effects of

    Chen, Ya-Ting / Kuo, Chia-Ling / Wu, Chih-Chung / Liu, Chun-Hung / Hsieh, Shu-Ling

    Animals : an open access journal from MDPI

    2023  Volume 13, Issue 7

    Abstract: ... Panax ... ...

    Abstract Panax notoginseng
    Language English
    Publishing date 2023-03-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani13071131
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Effectiveness and Safety of Lower Dose of Rivaroxaban for Cancer-Related Venous Thromboembolism: A Retrospective Cohort Study.

    Chang, Chia-Ling / Lin, Yi-Jei / Pan, Chia-Chia / Kuo, Chun-Nan

    The Annals of pharmacotherapy

    2022  Volume 56, Issue 12, Page(s) 1308–1314

    Abstract: Background: Primary and recurrent venous thromboembolism (VTE) commonly occur in patients with cancer. However, because of the National Health Insurance regulations, available dosage forms, and clinical conditions, the prescribed dose of rivaroxaban may ...

    Abstract Background: Primary and recurrent venous thromboembolism (VTE) commonly occur in patients with cancer. However, because of the National Health Insurance regulations, available dosage forms, and clinical conditions, the prescribed dose of rivaroxaban may not be consistent with its recommended dose.
    Objective: To evaluate the 6-month recurrence rate of VTE and safety of rivaroxaban for patients with cancer.
    Methods: Patients with new cancer diagnosis or recurrence from 2014 to 2018 who initiated rivaroxaban for VTE from January 2015 to January 2019 were included. We set the rivaroxaban initiation date as the index date and followed up the patients for 180 days. We collected information regarding the starting and maintenance dose/frequency and the treatment duration. The efficacy outcome was the recurrence of VTE within 180 days. The safety outcome included the major bleeding rate and clinically relevant nonmajor bleeding (CRNMB) rate.
    Results: Approximately, 46.2% of the 65 included patients received a standard starting dose, and 45% of patients received a maintenance dose above 15 mg (median: 23.9 and 13.1 mg per day, respectively). Two-thirds of the patients stopped treatment within 180 days. Recurrent VTE occurred in 2 (3.1%) patients within 6 months. The major bleeding rate was 7.7%, and the CRNMB rate was 3.1%.
    Conclusion and relevance: The 6-month recurrence rate of VTE and safety profile were similar between the lower and standard dose of rivaroxaban. This result may be applied to the institutions with dosage availability limited by formulary regulation and patients who cannot use full dose because of clinical considerations.
    MeSH term(s) Anticoagulants/therapeutic use ; Factor Xa Inhibitors/adverse effects ; Hemorrhage/drug therapy ; Humans ; Neoplasms/complications ; Neoplasms/drug therapy ; Recurrence ; Retrospective Studies ; Rivaroxaban/adverse effects ; Treatment Outcome ; Venous Thromboembolism/etiology
    Chemical Substances Anticoagulants ; Factor Xa Inhibitors ; Rivaroxaban (9NDF7JZ4M3)
    Language English
    Publishing date 2022-04-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1101370-9
    ISSN 1542-6270 ; 1060-0280
    ISSN (online) 1542-6270
    ISSN 1060-0280
    DOI 10.1177/10600280221084418
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Response to Comment on "ApoE e4e4 Genotype and Mortality With COVID-19 in UK Biobank" by Kuo et al.

    Kuo, Chia-Ling / Melzer, David

    The journals of gerontology. Series A, Biological sciences and medical sciences

    2020  Volume 75, Issue 11, Page(s) 2235–2236

    MeSH term(s) Apolipoproteins E/genetics ; Betacoronavirus ; Biological Specimen Banks ; COVID-19 ; Coronavirus Infections ; Genotype ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; United Kingdom
    Chemical Substances Apolipoproteins E
    Keywords covid19
    Language English
    Publishing date 2020-07-30
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1223643-3
    ISSN 1758-535X ; 1079-5006
    ISSN (online) 1758-535X
    ISSN 1079-5006
    DOI 10.1093/gerona/glaa198
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Comparison of electronic versus mechanical torque-limiting devices for dental implants: An in vitro study.

    Faraj, Mohaad A / Bidra, Avinash S / Taylor, Thomas D / Kuo, Chia-Ling

    Journal of prosthodontics : official journal of the American College of Prosthodontists

    2023  

    Abstract: Purpose: To determine the accuracy of new electronic torque-limiting devices (ET) when compared to new and used conventional-style beam-type (BT) mechanical torque-limiting devices and hand-piece style (HS) mechanical torque-limiting devices. The ... ...

    Abstract Purpose: To determine the accuracy of new electronic torque-limiting devices (ET) when compared to new and used conventional-style beam-type (BT) mechanical torque-limiting devices and hand-piece style (HS) mechanical torque-limiting devices. The secondary purpose was to compare any difference in accuracy between new and used mechanical torque-limiting devices, and any difference in accuracy when used on a straight versus an angled screw channel abutment.
    Materials and methods: A total of five torque-limiting devices were used to obtain 2000 readings under standardized conditions. An implant analog was fastened into a digital torque meter, to which an abutment was connected. Pre-determined torque values of 15 Ncm and 35 Ncm were applied, and actual torque values were recorded. A straight and an angled abutment were used to record 1000 readings each using the five torque-limiting devices. An overall Kruskal-Wallis test was applied to compare the median deviation among devices followed by a pairwise comparison ( = 0.05).
    Results: For a target torque value of 15 Ncm on a straight abutment, the electronic device (ET) was statistically more accurate than the beam type (BT) new (p < 0.001) and used (p < 0.048) devices but less accurate than the hand-piece style (HS) used device (p < 0.001). On an angled abutment for a target value of 15 Ncm, the electronic device (ET) was statistically more accurate than hand-piece style (HS) new and used devices (p < 0.001). For a target torque value of 35 Ncm on a straight abutment, the ET was statistically more accurate than the HS new device (p < 0.001) but less accurate than the BT new device (p < 0.001). On an angled abutment for a target value of 35 Ncm, the electronic device (ET) was statistically less accurate than the beam-type (BT) new device (p < 0.001), the beam-type (BT) used device (p = 0.001), and the hand-piece style (HS) used device (p < 0.001). The electronic device (ET) was the only device accurate within the ISO standard of accuracy of 6% for each of the target torque value/abutment design combinations. There was no statistically significant difference related to the type of abutment used (angled vs. straight).
    Conclusions: Electronic torque limiting devices (ET) are an acceptable method for delivering torque for implant restorations for straight and angled abutments at 15 Ncm and 35 Ncm torque values. Conventional style beam-type (BT) mechanical torque-limiting devices are a simple, predictable, validated, and inexpensive tool for delivering accurate torque at 15 Ncm and 35 Ncm torque values. The hand-piece style (HS) mechanical torque-limiting devices are predictable to deliver 15 Ncm torque values.
    Language English
    Publishing date 2023-08-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1197213-0
    ISSN 1532-849X ; 1059-941X
    ISSN (online) 1532-849X
    ISSN 1059-941X
    DOI 10.1111/jopr.13752
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Effects of Panax notoginseng Water Extract on Immune Responses and Digestive Enzymes in White Shrimp Litopenaeus vannamei

    Chen, Ya-Ting / Kuo, Chia-Ling / Wu, Zhizhong / Liu, Chun-Hung / Hsieh, Shu-Ling

    Animals. 2023 Mar. 23, v. 13, no. 7

    2023  

    Abstract: Panax notoginseng (Burk) F. H. Chen is a traditional Chinese herbal medicine commonly used in clinical applications. This study examined the effects of the Panax notoginseng water extract (PNWE) on the immune responses and digestive enzyme activity of ... ...

    Abstract Panax notoginseng (Burk) F. H. Chen is a traditional Chinese herbal medicine commonly used in clinical applications. This study examined the effects of the Panax notoginseng water extract (PNWE) on the immune responses and digestive enzyme activity of Litopenaeus vannamei (L. vannamei). The PNWE (50, 100, and 200 μg (g shrimp)⁻¹) was injected into L. vannamei to analyze the immune response parameters, including the total haemocyte count (THC), granular haemocytes (GC), semi-granular haemocytes (SGC), hialin haemocyte (HC), the respiratory burst (RB), the phagocytic ratio (PR), the phagocytic index (PI), and phenoloxidase (PO). We evaluated the activity of the intestinal digestive enzymes (trypsin, chymotrypsin, amylase, and lipase), the histopathology, and the intestine Vibrio numbers. The results showed that different concentrations of the PNWE significantly increased THC, GC, SGC, PO and RB activity, the PR, and the PI of L. vannamei while reducing the HC. In addition, the PNWE also significantly increased the chymotrypsin, trypsin, and amylase activity of L. vannamei. Furthermore, 50 µg (g shrimp)⁻¹ of PNWE regulated the lipase activity. Additionally, different concentrations of the PNWE significantly reduced the Vibrio numbers in the intestine without damaging the hepatopancreas and intestine tissues. These results indicate that the PNWE improves the immune responses of L. vannamei by increasing the haemocyte count and regulating intestinal digestive enzymes.
    Keywords Litopenaeus vannamei ; Oriental traditional medicine ; Panax notoginseng ; Vibrio ; amylases ; carboxylic ester hydrolases ; chymotrypsin ; enzyme activity ; hemocytes ; hepatopancreas ; histopathology ; immune response ; intestines ; monophenol monooxygenase ; respiratory burst ; shrimp ; trypsin
    Language English
    Dates of publication 2023-0323
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani13071131
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Intranasal corticosteroids reduced acute rhinosinusitis in children with allergic rhinitis: A nested case-control study.

    Lin, Chia-Ling / Lee, Kuo-Huang / Huang, Wan-Ting / Hsieh, Ling-Chin / Wang, Chuang-Ming

    Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi

    2023  Volume 57, Issue 1, Page(s) 175–183

    Abstract: Background: Children with allergic rhinitis (AR) have substantially more acute rhinosinusitis than children without AR. We evaluated whether intranasal corticosteroids (INCS), second-generation antihistamines (SGH), and/or intranasal antihistamines (INH) ...

    Abstract Background: Children with allergic rhinitis (AR) have substantially more acute rhinosinusitis than children without AR. We evaluated whether intranasal corticosteroids (INCS), second-generation antihistamines (SGH), and/or intranasal antihistamines (INH) for AR affect acute rhinosinusitis in children with AR aged 2-18 years.
    Methods: By using the National Health Research Institutes Database 2005 of Taiwan, a cohort of patients with AR aged 2-18 years treated with AR medications between 2002 and 2018 was made, within which a nested case-control study was performed. Risk settings for acute rhinosinusitis cases matched controls for age, sex, and comorbidities. Current users of INCS, INH, and/or SGH were compared with remote and recent users of any AR medications and current users of INCS with and without SGH were compared with current users of SGH.
    Results: Current users of SGH and/or INCS had a higher risk of acute rhinosinusitis than remote users of AR drugs, and current users of SGH had a higher risk of acute rhinosinusitis than recent users; however, no difference in the risk of acute rhinosinusitis was found between current users of INCS and recent users of AR drugs. Current users of INCS with and without SGH had a lower risk of acute rhinosinusitis than current users of SGH alone.
    Conclusions: Treatment of INCS with and without SGH diminished the risk of acute rhinosinusitis compared with treatment using SGH alone. Adequate INCS treatment for patients with AR is important to reduce the incidence of acute rhinosinusitis.
    MeSH term(s) Child ; Humans ; Case-Control Studies ; Rhinosinusitis ; Rhinitis, Allergic/drug therapy ; Adrenal Cortex Hormones/therapeutic use ; Histamine Antagonists/therapeutic use
    Chemical Substances Adrenal Cortex Hormones ; Histamine Antagonists
    Language English
    Publishing date 2023-12-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 1497590-7
    ISSN 1995-9133 ; 1684-1182 ; 0253-2662
    ISSN (online) 1995-9133
    ISSN 1684-1182 ; 0253-2662
    DOI 10.1016/j.jmii.2023.11.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Polygenic scores for cardiovascular risk factors improve estimation of clinical outcomes in CCB treatment compared to pharmacogenetic variants alone.

    Türkmen, Deniz / Bowden, Jack / Masoli, Jane A H / Delgado, João / Kuo, Chia-Ling / Melzer, David / Pilling, Luke C

    The pharmacogenomics journal

    2024  Volume 24, Issue 3, Page(s) 12

    Abstract: Pharmacogenetic variants are associated with clinical outcomes during Calcium Channel Blocker (CCB) treatment, yet whether the effects are modified by genetically predicted clinical risk factors is unknown. We analyzed 32,000 UK Biobank participants ... ...

    Abstract Pharmacogenetic variants are associated with clinical outcomes during Calcium Channel Blocker (CCB) treatment, yet whether the effects are modified by genetically predicted clinical risk factors is unknown. We analyzed 32,000 UK Biobank participants treated with dihydropiridine CCBs (mean 5.9 years), including 23 pharmacogenetic variants, and calculated polygenic scores for systolic and diastolic blood pressures, body fat mass, and other patient characteristics. Outcomes included treatment discontinuation and heart failure. Pharmacogenetic variant rs10898815-A (NUMA1) increased discontinuation rates, highest in those with high polygenic scores for fat mass. The RYR3 variant rs877087 T-allele alone modestly increased heart failure risks versus non-carriers (HR:1.13, p = 0.02); in patients with high polygenic scores for fat mass, lean mass, and lipoprotein A, risks were substantially elevated (HR:1.55, p = 4 × 10
    MeSH term(s) Humans ; Calcium Channel Blockers/therapeutic use ; Antihypertensive Agents/therapeutic use ; Hypertension/drug therapy ; Pharmacogenomic Variants ; Cardiovascular Diseases/chemically induced ; Risk Factors ; Heart Failure/drug therapy ; Heart Disease Risk Factors ; Lipoprotein(a)/therapeutic use
    Chemical Substances Calcium Channel Blockers ; Antihypertensive Agents ; Lipoprotein(a)
    Language English
    Publishing date 2024-04-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2106831-8
    ISSN 1473-1150 ; 1470-269X
    ISSN (online) 1473-1150
    ISSN 1470-269X
    DOI 10.1038/s41397-024-00333-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Proteomic aging clock (PAC) predicts age-related outcomes in middle-aged and older adults.

    Kuo, Chia-Ling / Chen, Zhiduo / Liu, Peiran / Pilling, Luke C / Atkins, Janice L / Fortinsky, Richard H / Kuchel, George A / Diniz, Breno S

    medRxiv : the preprint server for health sciences

    2024  

    Abstract: Beyond mere prognostication, optimal biomarkers of aging provide insights into qualitative and quantitative features of biological aging and might, therefore, offer useful information for the testing and, ultimately, clinical use of gerotherapeutics. We ... ...

    Abstract Beyond mere prognostication, optimal biomarkers of aging provide insights into qualitative and quantitative features of biological aging and might, therefore, offer useful information for the testing and, ultimately, clinical use of gerotherapeutics. We aimed to develop a proteomic aging clock (PAC) for all-cause mortality risk as a proxy of biological age. Data were from the UK Biobank Pharma Proteomics Project, including 53,021 participants aged between 39 and 70 years and 2,923 plasma proteins assessed using the Olink Explore 3072 assay®. The Spearman correlation between PAC proteomic age and chronological age was 0.77. A total of 10.9% of the participants died during a mean follow-up of 13.3 years, with the mean age at death 70.1 years. We developed a proteomic aging clock (PAC) for all-cause mortality risk as a surrogate of BA using a combination of least absolute shrinkage and selection operator (LASSO) penalized Cox regression and Gompertz proportional hazards models. PAC showed robust age-adjusted associations and predictions for all-cause mortality and the onset of various diseases in general and disease-free participants. The proteins associated with PAC were enriched in several processes related to the hallmarks of biological aging. Our results expand previous findings by showing that age acceleration, based on PAC, strongly predicts all-cause mortality and several incident disease outcomes. Particularly, it facilitates the evaluation of risk for multiple conditions in a disease-free population, thereby, contributing to the prevention of initial diseases, which vary among individuals and may subsequently lead to additional comorbidities.
    Language English
    Publishing date 2024-04-21
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.12.19.23300228
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Retrospective evaluation of the success rate and factors associated with the stability of alveolar ridge orthodontic miniscrews: Pilot study.

    Abu Arqub, Sarah / Greene, Renee / Greene, Sara / Laing, Kolbe / Kuo, Chia-Ling / Godoy, Lucas Da Cunha / Uribe, Flavio

    Journal of the World federation of orthodontists

    2024  

    Abstract: Background: An uncommon location for placing miniscrews, used to provide anchorage control in various tooth movements, is the alveolar ridge. This study aimed to provide an evaluation of the success rate of alveolar ridge miniscrews and examine ... ...

    Abstract Background: An uncommon location for placing miniscrews, used to provide anchorage control in various tooth movements, is the alveolar ridge. This study aimed to provide an evaluation of the success rate of alveolar ridge miniscrews and examine variables that might impact their success.
    Methods: Charts for 295 patients who had miniscrews were screened. Twenty patients (5 male and 15 female: average age = 38.15 ± 15.10 years) with a total of 50 alveolar ridge miniscrews were analyzed. A customized data form was used to collect patients' and miniscrews' related variables. Kaplan-Meier estimator was used for the survival function, whereas Cox proportional hazards regression models were used to associate collected variables with alveolar ridge miniscrew survival.
    Results: In total, 31 (62.0%) miniscrews were stable and 19 (38.0%) failed. The survival time for those that failed was 6.03 ± 7.08 months. The follow-up period for those that survived was 35.84 ± 19.47 months. Male gender versus female (hazard ratio [HR] 2.46; 95% confidence interval [CI] 1.35-4.48; P = 0.003), and if the miniscrew was a replacement versus non-replacement (HR 0.27; 95% CI 0.07-0.99; P = 0.048) influenced the survival. Additionally, miniscrews that were used for both indirect and direct or indirect anchorage alone plus those with evidence of splinting showed a 100% survival rate, which led to an HR 0 (P < 0.001). When the previously mentioned variables were modeled, none seemed to have a significant effect on failure except for splinting and type of anchorage (P < 0.001), because none of the splinted miniscrews failed.
    Conclusions: The failure rate of alveolar ridge miniscrews was (38.0%) over 6.03 ± 7.08 months. The survival rate was (62.0%) over 35.84 ± 19.47 months. The evidence of splinting and the type of anchorage had a significant effect on survival probability.
    Language English
    Publishing date 2024-04-19
    Publishing country United States
    Document type Journal Article
    ISSN 2212-4438
    ISSN (online) 2212-4438
    DOI 10.1016/j.ejwf.2024.02.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Prevalence of likely retro-odontoid pseudotumor in patients receiving dental CBCT examinations.

    Fryc, Gosia Anna / Godoy, Lucas da Cunha / Kuo, Chia-Ling / Lurie, Alan G

    Oral surgery, oral medicine, oral pathology and oral radiology

    2023  Volume 137, Issue 3, Page(s) 301–309

    Abstract: Objectives: We calculated the prevalence of unsuspected retro-odontoid pseudotumor (ROP) as detected in cone beam computed tomography (CBCT) examinations. Additionally, we examined patient age, sex, and presence and severity of cervical osteoarthritis ( ... ...

    Abstract Objectives: We calculated the prevalence of unsuspected retro-odontoid pseudotumor (ROP) as detected in cone beam computed tomography (CBCT) examinations. Additionally, we examined patient age, sex, and presence and severity of cervical osteoarthritis (OA) as potential risk factors for ROP.
    Study design: We retrospectively analyzed de-identified CBCT scans of 455 patients from the Division of Oral and Maxillofacial Radiology at the University of Connecticut School of Dental Medicine. Identification of likely ROP was completed through a likelihood scoring scale (1-4) due to the lack of magnetic resonance images. Severity of cervical OA was determined using 5 osteoarthritic features. An ordinal logistic regression model was used to link potential risk factors to ROP.
    Results: In total, 18 patients (3.9%) were classified with probable (11 patients [2.4%]) or definite (7 patients [1.5%]) likely ROP. Older age and the presence and severity of OA were significantly associated with higher ROP scores (P < .001). There was no significant association of ROP likelihood and patient sex (P = .637). An increase of 1 year of age increased the chance of a patient having a higher ROP likelihood score (P < .001). The age-adjusted chance of having a more severe ROP increased with moderate to severe OA (P ≤ .017).
    Conclusions: Prevalence of likely ROP increases with age and OA but is not associated with sex. Individuals with moderate or severe OA are more likely to have ROP.
    MeSH term(s) Humans ; Prevalence ; Odontoid Process ; Retrospective Studies ; Spiral Cone-Beam Computed Tomography ; Cone-Beam Computed Tomography
    Language English
    Publishing date 2023-11-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2650843-6
    ISSN 2212-4411 ; 2212-4403
    ISSN (online) 2212-4411
    ISSN 2212-4403
    DOI 10.1016/j.oooo.2023.11.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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