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  1. Article ; Online: Immune Response to Chikungunya Virus: Sex as a Biological Variable and Implications for Natural Delivery via the Mosquito.

    Taylor, Meagan / Rayner, Jonathan O

    Viruses

    2023  Volume 15, Issue 9

    Abstract: Chikungunya virus (CHIKV) is a mosquito-borne virus with significant public health implications around the world. Climate change, as well as rapid urbanization, threatens to expand the population range ... ...

    Abstract Chikungunya virus (CHIKV) is a mosquito-borne virus with significant public health implications around the world. Climate change, as well as rapid urbanization, threatens to expand the population range of
    MeSH term(s) Animals ; Female ; Male ; Chikungunya virus ; Mosquito Vectors ; Aedes ; Chikungunya Fever/epidemiology ; Immunity ; Mammals
    Language English
    Publishing date 2023-09-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15091869
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Ticks of Alabama: the fauna and spatial distribution of medically important species across the state.

    Kerr, Skyler M / Rayner, Jonathan O / Wood, R Ryan / Schultze, Steven / McCreadie, John

    Journal of vector ecology : journal of the Society for Vector Ecology

    2022  Volume 47, Issue 1, Page(s) 38–50

    Abstract: The last statewide survey of hard ticks in Alabama was in 1972. To address this deficit, we examined the distribution of the medically important species across the state, ...

    Abstract The last statewide survey of hard ticks in Alabama was in 1972. To address this deficit, we examined the distribution of the medically important species across the state,
    MeSH term(s) Alabama ; Animals ; Deer ; Ixodes ; Ixodidae
    Language English
    Publishing date 2022-04-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2212806-2
    ISSN 1948-7134 ; 1081-1710
    ISSN (online) 1948-7134
    ISSN 1081-1710
    DOI 10.52707/1081-1710-47.1.38
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Statewide survey of medically important ticks on white-tailed deer,

    Kerr, Skyler M / Rayner, Jonathan O / Wood, R Ryan / McCreadie, John

    Journal of vector ecology : journal of the Society for Vector Ecology

    2022  Volume 47, Issue 2, Page(s) 210–216

    Abstract: A statewide survey of the tick fauna found on deer, using harvested deer heads as the sample unit, was conducted during the Alabama hunting seasons of 2019-2020 and 2020-2021. Four species of ticks: ...

    Abstract A statewide survey of the tick fauna found on deer, using harvested deer heads as the sample unit, was conducted during the Alabama hunting seasons of 2019-2020 and 2020-2021. Four species of ticks:
    MeSH term(s) Animals ; Deer ; Tick Infestations/epidemiology ; Tick Infestations/veterinary ; Alabama/epidemiology ; Ixodes
    Language English
    Publishing date 2022-10-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2212806-2
    ISSN 1948-7134 ; 1081-1710
    ISSN (online) 1948-7134
    ISSN 1081-1710
    DOI 10.52707/1081-1710-47.2.210
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Real-time tracking of bioluminescent influenza A virus infection in mice.

    Kim, Jin H / Bryant, Hannah / Fiedler, Edward / Cao, TuAnh / Rayner, Jonathan O

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 3152

    Abstract: Despite the availability of vaccines and antiviral therapies, seasonal influenza infections cause 400,000 human deaths on average per year. Low vaccine coverage and the occurrence of drug-resistant viral strains highlight the need for new and improved ... ...

    Abstract Despite the availability of vaccines and antiviral therapies, seasonal influenza infections cause 400,000 human deaths on average per year. Low vaccine coverage and the occurrence of drug-resistant viral strains highlight the need for new and improved countermeasures. While influenza A virus (IAV) engineered to express a reporter gene may serve as a valuable tool for real-time tracking of viral infection, reporter gene insertion into IAV typically attenuates viral pathogenicity, hindering its application to research. Here, we demonstrate that lethal or even sublethal doses of bioluminescent IAV carrying the NanoLuc gene in the C-terminus of PB2 can be tracked in real-time in live mice without compromising pathogenicity. Real-time tracking of this bioluminescent IAV enables spatiotemporal viral replication tracking in animals that will facilitate the development of countermeasures by enhancing the interpretation of clinical signs and prognosis while also allowing less animal usage.
    MeSH term(s) Animals ; Dogs ; Female ; Genes, Reporter ; HEK293 Cells ; Humans ; Influenza A virus/physiology ; Luminescent Measurements ; Madin Darby Canine Kidney Cells ; Mice ; Orthomyxoviridae Infections/genetics ; Orthomyxoviridae Infections/metabolism
    Language English
    Publishing date 2022-02-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-06667-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Tick-Borne Pathogens Associated with Medically Important Ticks in Alabama: A Four-Year Survey.

    Wood, Raphael Ryan / Roberts, Rosemary W / Kerr, Skyler M / Wasden, Madeline / Hammer, Thelma G / McCreadie, John W / Rayner, Jonathan O

    Vector borne and zoonotic diseases (Larchmont, N.Y.)

    2022  Volume 23, Issue 2, Page(s) 57–62

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Humans ; Animals ; United States ; Ticks ; Alabama/epidemiology ; Tick-Borne Diseases/epidemiology ; Tick-Borne Diseases/veterinary ; Ehrlichiosis/epidemiology ; Ehrlichiosis/veterinary
    Language English
    Publishing date 2022-12-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 2047199-3
    ISSN 1557-7759 ; 1530-3667
    ISSN (online) 1557-7759
    ISSN 1530-3667
    DOI 10.1089/vbz.2022.0038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Real-time tracking of bioluminescent influenza A virus infection in mice

    Jin H. Kim / Hannah Bryant / Edward Fiedler / TuAnh Cao / Jonathan O. Rayner

    Scientific Reports, Vol 12, Iss 1, Pp 1-

    2022  Volume 17

    Abstract: Abstract Despite the availability of vaccines and antiviral therapies, seasonal influenza infections cause 400,000 human deaths on average per year. Low vaccine coverage and the occurrence of drug-resistant viral strains highlight the need for new and ... ...

    Abstract Abstract Despite the availability of vaccines and antiviral therapies, seasonal influenza infections cause 400,000 human deaths on average per year. Low vaccine coverage and the occurrence of drug-resistant viral strains highlight the need for new and improved countermeasures. While influenza A virus (IAV) engineered to express a reporter gene may serve as a valuable tool for real-time tracking of viral infection, reporter gene insertion into IAV typically attenuates viral pathogenicity, hindering its application to research. Here, we demonstrate that lethal or even sublethal doses of bioluminescent IAV carrying the NanoLuc gene in the C-terminus of PB2 can be tracked in real-time in live mice without compromising pathogenicity. Real-time tracking of this bioluminescent IAV enables spatiotemporal viral replication tracking in animals that will facilitate the development of countermeasures by enhancing the interpretation of clinical signs and prognosis while also allowing less animal usage.
    Keywords Medicine ; R ; Science ; Q
    Subject code 570
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Evaluation of DNA-Launched Virus-Like Particle Vaccines in an Immune Competent Mouse Model of Chikungunya Virus Infection.

    Rayner, Jonathan O / Kim, Jin Hyun / Roberts, Rosemary W / Wood, Raphael Ryan / Fouty, Brian / Solodushko, Victor

    Vaccines

    2021  Volume 9, Issue 4

    Abstract: Chikungunya virus (CHIKV) infection can result in chronic and debilitating arthralgia affecting humans in tropical and subtropical regions around the world, yet there are no licensed vaccines to prevent infection. DNA launched virus like particle (VLP) ... ...

    Abstract Chikungunya virus (CHIKV) infection can result in chronic and debilitating arthralgia affecting humans in tropical and subtropical regions around the world, yet there are no licensed vaccines to prevent infection. DNA launched virus like particle (VLP) vaccines represent a potentially safer alternative to traditional live-attenuated vaccines; however, fully characterized immunocompetent mouse models which appropriately include both male and female animals for preclinical evaluation of these, and other, vaccine platforms are lacking. Utilizing virus stocks engineered to express mutations reported to enhance CHIKV virulence in mice, infection of male and female immunocompetent mice was evaluated, and the resulting model utilized to assess the efficacy of candidate DNA launched CHIKV VLP vaccines. Results demonstrate the potential utility of DNA launched VLP vaccines in comparison to a live attenuated CHIKV vaccine and identify gender differences in viral RNA loads that impact interpretation of vaccine efficacy and may have important implications for future CHIKV vaccine development.
    Language English
    Publishing date 2021-04-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines9040345
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Statewide survey of medically important ticks on white-tailed deer, Odocoileus virginianus Zimmerman, in Alabama, U.S.A

    Kerr, Skyler M. / Rayner, Jonathan O. / Wood, R. Ryan / McCreadie, John

    Journal of Vector Ecology. 2022 Oct. 18, v. 47, no. 2 p.210-216

    2022  

    Abstract: A statewide survey of the tick fauna found on deer, using harvested deer heads as the sample unit, was conducted during the Alabama hunting seasons of 2019-2020 and 2020-2021. Four species of ticks: Ixodes scapularis (n= 936, % of catch 69.1%), Amblyomma ...

    Abstract A statewide survey of the tick fauna found on deer, using harvested deer heads as the sample unit, was conducted during the Alabama hunting seasons of 2019-2020 and 2020-2021. Four species of ticks: Ixodes scapularis (n= 936, % of catch 69.1%), Amblyomma americanum (315, 23.2%), Dermacentor albipictus (97, 7.1%), and Amblyomma maculatum (6, 0.4%) were taken from 151 deer heads harvested from 21 deer processing centers (n = 4-17 heads/processor). A total of 87.7% (prevalence) of deer heads had one or more ticks. We used two standard numerical descriptors of tick numbers, abundance, and relative abundance. No significant stepwise regressions (p > 0.05) were found between tick abundance (all ticks, I. scapularis, A. americanum) and the predictor variables of latitude, deer density, season, and year. In addition, the correlation between the abundance of I. scapularis and A. americanum was not significant (p > 0.5). In contrast, the relative abundance of both I. scapularis and A. americanum showed a significant (P < 0.05) relationship with latitude, with the relative abundance of I. scapularis increasing on deer with increased latitude and A. americanum showing the opposite pattern.
    Keywords Amblyomma americanum ; Amblyomma maculatum ; Dermacentor albipictus ; Ixodes scapularis ; Odocoileus virginianus ; deer ; fauna ; latitude ; surveys ; ticks ; Alabama ; White-tailed deer
    Language English
    Dates of publication 2022-1018
    Size p. 210-216.
    Publishing place Society for Vector Ecology
    Document type Article ; Online
    ZDB-ID 2212806-2
    ISSN 1948-7134 ; 1081-1710
    ISSN (online) 1948-7134
    ISSN 1081-1710
    DOI 10.52707/1081-1710-47.2.210
    Database NAL-Catalogue (AGRICOLA)

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  9. Article: Ticks of Alabama: the fauna and spatial distribution of medically important species across the state

    Kerr, Skyler M. / Rayner, Jonathan O. / Wood, R. Ryan / Schultze, Steven / McCreadie, John

    Journal of vector ecology. 2022 Mar. 24, v. 47, no. 1

    2022  

    Abstract: The last statewide survey of hard ticks in Alabama was in 1972. To address this deficit, we examined the distribution of the medically important species across the state, Ixodes scapularis (Say), Dermacentor variabilis (Say), Amblyomma americanum (L.), ... ...

    Abstract The last statewide survey of hard ticks in Alabama was in 1972. To address this deficit, we examined the distribution of the medically important species across the state, Ixodes scapularis (Say), Dermacentor variabilis (Say), Amblyomma americanum (L.), and A. maculatum (Koch), between April, 2018 and February, 2021. Collections primarily involved dragging (April to July) and examination of harvested deer (November to February). A total of 2,927 ticks was collected from 110 sites; three species, I. scapularis, A. americanum, and D. variabilis, represented 91.70% of all ticks collected. Amblyomma americanum and D. variabilis were the most common species encountered in drags; I. scapularis dominated deer collections. Dermacentor variabilis was never found on deer, whereas D. albipictus was only found on deer. Stepwise regression (AIC) of drag data was linked to several site variables. Results suggest a linear response along a south (low abundance) to north (high abundance) gradient, in addition to increased abundance at sites with lower temperatures and greater precipitation and canopy cover.
    Keywords Amblyomma americanum ; Dermacentor variabilis ; Ixodes scapularis ; canopy ; deer ; fauna ; surveys ; Alabama
    Language English
    Dates of publication 2022-0324
    Size p. 38-50.
    Publishing place Society for Vector Ecology
    Document type Article
    ZDB-ID 2212806-2
    ISSN 1948-7134 ; 1081-1710
    ISSN (online) 1948-7134
    ISSN 1081-1710
    DOI 10.52707/1081-1710-47.1.38
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Evaluation of DNA-Launched Virus-Like Particle Vaccines in an Immune Competent Mouse Model of Chikungunya Virus Infection

    Jonathan O. Rayner / Jin Hyun Kim / Rosemary W. Roberts / Raphael Ryan Wood / Brian Fouty / Victor Solodushko

    Vaccines, Vol 9, Iss 345, p

    2021  Volume 345

    Abstract: Chikungunya virus (CHIKV) infection can result in chronic and debilitating arthralgia affecting humans in tropical and subtropical regions around the world, yet there are no licensed vaccines to prevent infection. DNA launched virus like particle (VLP) ... ...

    Abstract Chikungunya virus (CHIKV) infection can result in chronic and debilitating arthralgia affecting humans in tropical and subtropical regions around the world, yet there are no licensed vaccines to prevent infection. DNA launched virus like particle (VLP) vaccines represent a potentially safer alternative to traditional live-attenuated vaccines; however, fully characterized immunocompetent mouse models which appropriately include both male and female animals for preclinical evaluation of these, and other, vaccine platforms are lacking. Utilizing virus stocks engineered to express mutations reported to enhance CHIKV virulence in mice, infection of male and female immunocompetent mice was evaluated, and the resulting model utilized to assess the efficacy of candidate DNA launched CHIKV VLP vaccines. Results demonstrate the potential utility of DNA launched VLP vaccines in comparison to a live attenuated CHIKV vaccine and identify gender differences in viral RNA loads that impact interpretation of vaccine efficacy and may have important implications for future CHIKV vaccine development.
    Keywords chikungunya virus ; immune competent ; mouse model ; DNA vaccine ; virus-like particle ; Medicine ; R
    Subject code 570
    Language English
    Publishing date 2021-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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