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  1. Article ; Online: COVID-19 in Children.

    Kalyanaraman, Meena / Anderson, Michael R

    Pediatric clinics of North America

    2022  Volume 69, Issue 3, Page(s) 547–571

    Abstract: Coronavirus disease 2019 (COVID-19) is an ongoing pandemic caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus. More than 5 million children have been infected in the United States. Risk factors for more severe disease ... ...

    Abstract Coronavirus disease 2019 (COVID-19) is an ongoing pandemic caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus. More than 5 million children have been infected in the United States. Risk factors for more severe disease progression include obesity, pulmonary disease, gastrointestinal disorders, and neurologic comorbidities. Children with COVID-19 are admitted to the pediatric intensive care unit because of severe acute COVID-19 illness or COVID-19-associated multisystem inflammatory syndrome in children. The delta surge of 2021 was responsible for an increased disease burden in children and points to the key role of vaccinating children against this sometimes-deadly disease.
    MeSH term(s) COVID-19/complications ; COVID-19/epidemiology ; Child ; Humans ; Intensive Care Units, Pediatric ; Pandemics ; SARS-CoV-2 ; Systemic Inflammatory Response Syndrome ; United States/epidemiology
    Language English
    Publishing date 2022-02-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 215711-1
    ISSN 1557-8240 ; 0031-3955
    ISSN (online) 1557-8240
    ISSN 0031-3955
    DOI 10.1016/j.pcl.2022.01.013
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  2. Article ; Online: ARDS in an ex-premature infant with bronchopulmonary dysplasia and COVID-19.

    Kalyanaraman, Meena / McQueen, Derrick / Morparia, Kavita / Bergel, Maria

    Pediatric pulmonology

    2020  Volume 55, Issue 10, Page(s) 2506–2507

    Keywords covid19
    Language English
    Publishing date 2020-08-06
    Publishing country United States
    Document type Letter
    ZDB-ID 632784-9
    ISSN 1099-0496 ; 8755-6863
    ISSN (online) 1099-0496
    ISSN 8755-6863
    DOI 10.1002/ppul.24989
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  3. Article ; Online: Purulent pericarditis secondary to influenza and community-acquired methicillin-resistant Staphylococcus aureus co-infection.

    Morparia, Kavita / Peshkovsky, Courtney / Kalyanaraman, Meena

    Cardiology in the young

    2018  Volume 28, Issue 12, Page(s) 1481–1483

    Abstract: Purulent pericarditis occurs rarely in the current antibiotic era. We describe clinical and echocardiographic features of purulent pericarditis in a previously healthy child with influenza and community-acquired methicillin-resistant Staphylococcus ... ...

    Abstract Purulent pericarditis occurs rarely in the current antibiotic era. We describe clinical and echocardiographic features of purulent pericarditis in a previously healthy child with influenza and community-acquired methicillin-resistant Staphylococcus aureus co-infection. The child was already on appropriate antibiotics and had a very subtle clinical presentation, with prominent abdominal symptoms. Timely surgical drainage led to complete recovery.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Child, Preschool ; Community-Acquired Infections ; Humans ; Influenza B virus ; Influenza, Human/complications ; Male ; Methicillin-Resistant Staphylococcus aureus ; Pericarditis/diagnostic imaging ; Pericarditis/drug therapy ; Pericarditis/microbiology ; Rifampin/therapeutic use ; Staphylococcal Infections/complications ; Staphylococcus aureus ; Vancomycin/therapeutic use
    Chemical Substances Anti-Bacterial Agents ; Vancomycin (6Q205EH1VU) ; Rifampin (VJT6J7R4TR)
    Language English
    Publishing date 2018-09-17
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1078466-4
    ISSN 1467-1107 ; 1047-9511
    ISSN (online) 1467-1107
    ISSN 1047-9511
    DOI 10.1017/S1047951118001580
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  5. Article ; Online: ARDS in an ex‐premature infant with bronchopulmonary dysplasia and COVID‐19

    Kalyanaraman, Meena / McQueen, Derrick / Morparia, Kavita / Bergel, Maria

    Pediatric Pulmonology ; ISSN 8755-6863 1099-0496

    2020  

    Keywords Pediatrics, Perinatology, and Child Health ; Pulmonary and Respiratory Medicine ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    DOI 10.1002/ppul.24989
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Abdominal Imaging Findings in Critically Ill Children With Multisystem Inflammatory Syndrome Associated With COVID-19.

    Morparia, Kavita / Park, Min Jung / Kalyanaraman, Meena / McQueen, Derrick / Bergel, Maria / Phatak, Tej

    The Pediatric infectious disease journal

    2020  Volume 40, Issue 2, Page(s) e82–e83

    Abstract: We report findings on abdominal imaging in critically ill children admitted with MIS-C. On sonography, hepatomegaly, nephromegaly, gallbladder wall edema, ascites, intestinal inflammation and mesenteric lymphadenopathy were seen, while CT showed fluid- ... ...

    Abstract We report findings on abdominal imaging in critically ill children admitted with MIS-C. On sonography, hepatomegaly, nephromegaly, gallbladder wall edema, ascites, intestinal inflammation and mesenteric lymphadenopathy were seen, while CT showed fluid-filled small bowel loops, mural thickening of the terminal ileum, diffuse lymphadenopathy, and moderate ascites.
    MeSH term(s) Abdomen/diagnostic imaging ; Adolescent ; Ascites/diagnostic imaging ; COVID-19/diagnostic imaging ; COVID-19/physiopathology ; COVID-19/therapy ; Child ; Child, Preschool ; Critical Illness ; Female ; Gallbladder Diseases/diagnostic imaging ; Hepatomegaly/diagnostic imaging ; Humans ; Ileum/diagnostic imaging ; Infant ; Inflammation/diagnostic imaging ; Inflammation/drug therapy ; Inflammation/physiopathology ; Intestine, Small/diagnostic imaging ; Kidney Diseases/diagnostic imaging ; Lymphadenopathy/diagnostic imaging ; Male ; Mesenteric Lymphadenitis/diagnostic imaging ; Mucocutaneous Lymph Node Syndrome/diagnostic imaging ; SARS-CoV-2 ; Ultrasonography
    Language English
    Publishing date 2020-12-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392481-6
    ISSN 1532-0987 ; 0891-3668
    ISSN (online) 1532-0987
    ISSN 0891-3668
    DOI 10.1097/INF.0000000000002967
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    Zs.A 1852: Show issues Location:
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  7. Article ; Online: Thromboelastography profiles in critically ill children with multisystem inflammatory syndrome.

    Morparia, Kavita / Spinella, Philip C / McQueen, Derrick / Kalyanaraman, Meena / Bergel, Maria / Lin, John / Narang, Shalu / Saini, Arun

    Pediatric blood & cancer

    2021  Volume 69, Issue 5, Page(s) e29426

    Abstract: Objectives: To describe critically ill children's coagulation profile with the multisystem inflammatory syndrome (MIS-C) related to coronavirus.: Study design: Single-center, observational study at a tertiary, pediatric intensive care unit (PICU) in ... ...

    Abstract Objectives: To describe critically ill children's coagulation profile with the multisystem inflammatory syndrome (MIS-C) related to coronavirus.
    Study design: Single-center, observational study at a tertiary, pediatric intensive care unit (PICU) in children aged 1 month to 18 years.
    Measurements and main results: Sixteen children, with a median age of 5.4 years (interquartile range [IQR] 2.1, 11.75), 56% female, admission Pediatric Logistic Organ Dysfunction-2 (PELOD-2) score of 3.5 (IQR 2, 5), and median PICU length of stay 3 days (IQR 1.5, 4), met criteria of MIS-C. All patients received acetylsalicylic acid (80-100 mg/kg) and none received anticoagulation. Sixty-three percent (10/16) of children had out-of-normal range values on thromboelastography (TEG) (44% [7/16] with hypercoagulability and 19% [3/16] with hypocoagulability). Of those with hypercoagulability, 19% (3/16) had rapid clot formation, and 25% (4/16) had increased clot strength. In 69% (11/16) of children, there was impaired fibrinolysis (0% lysis at 30 minutes) on TEG. Seventy-five percent (12/16) of children had out-of-normal range value on standard coagulation assays (37.5% [6/16] with hypocoagulability and 37.5% [6/16] with hypercoagulability). TEG-G (clot strength as measured by TEG) value (ρ -.553, p = .033) and platelet count (ρ -.840, p < .0001) were correlated with admission PELOD-2 score. TEG-G value (ρ -.506, p = .04) and platelet count (ρ -.539, p = .03) were correlated with the duration of intensive care unit stay.
    Conclusions: Coagulation abnormalities are frequent in children with MIS-C. TEG parameter and platelet count are correlated with the severity of multiorgan dysfunction and the duration of intensive care stay. Multicenter studies are needed to confirm the clinical implications of these coagulation abnormalities.
    MeSH term(s) Blood Coagulation Disorders/etiology ; Blood Coagulation Tests ; Child ; Child, Preschool ; Critical Illness ; Female ; Humans ; Male ; Thrombelastography ; Thrombophilia
    Language English
    Publishing date 2021-12-22
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 2131448-2
    ISSN 1545-5017 ; 1545-5009
    ISSN (online) 1545-5017
    ISSN 1545-5009
    DOI 10.1002/pbc.29426
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    Zs.A 1131: Show issues Location:
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  8. Article ; Online: Posttraumatic Stress among Pediatric Critical Care Physicians in the United States in Association with Coronavirus Disease 2019 Patient Care Experiences.

    Kalyanaraman, Meena / Sankar, Ashwini / Timpo, Edem / McQueen, Derrick / Morparia, Kavita / Bergel, Maria / Rosenblatt, Joshua

    Journal of intensive care medicine

    2021  Volume 37, Issue 4, Page(s) 510–517

    Abstract: Posttraumatic stress among pediatric critical care physicians in the United States in association with coronavirus disease 2019 patient care experiences. Our objective was to assess the prevalence of posttraumatic stress (PTS) and its association with ... ...

    Abstract Posttraumatic stress among pediatric critical care physicians in the United States in association with coronavirus disease 2019 patient care experiences. Our objective was to assess the prevalence of posttraumatic stress (PTS) and its association with COVID-19 patient care experiences among pediatric critical care physicians. Our study was a cross-sectional study of pediatric critical care physicians in the United States. We measured PTS which included posttraumatic stress disorder (PTSD) and subthreshold posttraumatic stress disorder (SubPTSD) using validated PTSD Checklist- 5 survey tool. Association of PTS with COVID-19 patient care experiences was analyzed using regression analysis. Prevalence of PTS was noted in 120 among 294 pediatric critical care physicians (41%; 95% CI, 35-47%). The predominant symptoms were that of hyperarousal and feelings of negative cognition and mood. Among our physicians with PTS, 19% had PTSD and 81% had SubPTSD. Demographic and practice characteristics were not significant for increased PTS on regression analysis. Posttraumatic stress was significantly associated with physicians testing positive or taking time off for COVID-19 illness, self-isolation, fear of infecting their loved ones, families scared of being infected, feeling helpless, patients expressing fears of dying, having pre-existing depression, anxiety, or insomnia, working beyond comfort level of training and having thoughts of quitting (p < 0.05). Thoughts of quitting was associated with the highest significant increase in PTS scores (coefficient:11.643; 95% CI:8.551,14.735; P < 0.01) followed by feeling of helplessness (coefficient:11.055; 95% CI: 8.484,13.624; P < 0.01) and need for additional medications for depression, anxiety and insomnia (coefficient: 10.980; 95% CI: 4.970, 16.990; P < 0.01). Posttraumatic stress is high in pediatric critical care physicians and is associated with various COVID-19 patient care experiences. Thoughts of quitting was associated with highest increase in posttraumatic stress score which could have major implications for the workforce in the future. Subthreshold posttraumatic stress disorder should be recognized, and mental health issues of pediatric critical care physicians addressed.
    MeSH term(s) COVID-19/epidemiology ; Child ; Critical Care ; Cross-Sectional Studies ; Depression/epidemiology ; Depression/etiology ; Humans ; Physicians/psychology ; Stress Disorders, Post-Traumatic/diagnosis ; Stress Disorders, Post-Traumatic/epidemiology ; Stress Disorders, Post-Traumatic/psychology ; United States/epidemiology
    Language English
    Publishing date 2021-11-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632828-3
    ISSN 1525-1489 ; 0885-0666
    ISSN (online) 1525-1489
    ISSN 0885-0666
    DOI 10.1177/08850666211059385
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    Zs.A 2158: Show issues Location:
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  9. Article ; Online: Burnout and Psychological Distress Among Pediatric Critical Care Physicians in the United States.

    Shenoi, Asha N / Kalyanaraman, Meena / Pillai, Aravind / Raghava, Preethi S / Day, Scottie

    Critical care medicine

    2017  

    Abstract: Objectives: To estimate the prevalence of physician burnout, psychological distress, and its association with selected personal and practice characteristics among pediatric critical care physicians and to evaluate the relationship between burnout and ... ...

    Abstract Objectives: To estimate the prevalence of physician burnout, psychological distress, and its association with selected personal and practice characteristics among pediatric critical care physicians and to evaluate the relationship between burnout and psychological distress.
    Design: Cross-sectional, online survey.
    Setting: Pediatric critical care practices in the United States.
    Subjects: Pediatric critical care physicians.
    Interventions: None.
    Measurement and main results: A nonrandom sample of 253 physicians completed an online survey consisting of personal and practice characteristics, the Maslach Burnout Inventory, and the General Health Questionnaire. Nearly half of the participants (49%; 95% CI, 43-55%; n = 124) scored high burnout in at least one of the three subscales of the Maslach Burnout Inventory and 21% reported severe burnout. The risk of any burnout was about two times more in women physicians (odds ratio, 1.97; 95% CI, 1.2-3.4). Association between other personal or practice characteristics and burnout was not evident in this study, while regular physical exercise appeared to be protective. One third of all participants (30.5%) and 69% of those who experienced severe burnout screened positive for psychological distress. About 90% of the physicians reporting severe burnout have considered leaving their practice.
    Conclusions: Burnout is high among pediatric critical care physicians in the United States. About two thirds of the physicians with severe burnout met the screening criteria for psychological distress that suggests possible common mental disorders. Significant percentages of physicians experiencing burnout and considering to leave the profession has major implications for the critical care workforce.
    Language English
    Publishing date 2017-10-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000002751
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    Zs.A 1261: Show issues Location:
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  10. Article ; Online: The use of extracorporeal membrane oxygenation, high-frequency oscillatory ventilation, and surfactant for the management of intraoperative acute pulmonary hemorrhage in tetralogy of Fallot.

    Nathan, Meena / Kalyanaraman, Meena / Blank, Jonathan / Hardin, Joel T / Starr, Joanne P

    Journal of cardiothoracic and vascular anesthesia

    2011  Volume 25, Issue 2, Page(s) 313–315

    MeSH term(s) Acute Disease ; Blood Loss, Surgical/prevention & control ; Combined Modality Therapy/methods ; Disease Management ; Extracorporeal Membrane Oxygenation/methods ; Female ; High-Frequency Ventilation/methods ; Humans ; Infant ; Intraoperative Complications/diagnostic imaging ; Intraoperative Complications/prevention & control ; Lung/diagnostic imaging ; Pulmonary Surfactants/therapeutic use ; Radiography ; Tetralogy of Fallot/diagnostic imaging ; Tetralogy of Fallot/surgery ; Tetralogy of Fallot/therapy
    Chemical Substances Pulmonary Surfactants
    Language English
    Publishing date 2011-04
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1067317-9
    ISSN 1532-8422 ; 1053-0770
    ISSN (online) 1532-8422
    ISSN 1053-0770
    DOI 10.1053/j.jvca.2010.01.012
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