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Article ; Online: Small habitat matrix: How does it work?

Ng, Casey Keat-Chuan / Payne, John / Oram, Felicity

2020 Volume 50, Issue 3, Page(s) 601–614

Abstract: We present herein our perspective of a novel Small Habitats Matrix (SHM) concept showing how small habitats on private lands are untapped but can be valuable for mitigating ecological degradation. Grounded by the realities in Sabah, Malaysian Borneo, we ... ...

Abstract	We present herein our perspective of a novel Small Habitats Matrix (SHM) concept showing how small habitats on private lands are untapped but can be valuable for mitigating ecological degradation. Grounded by the realities in Sabah, Malaysian Borneo, we model a discontinuous "stepping stones" linkage that includes both terrestrial and aquatic habitats to illustrate exactly how the SHM can be deployed. Taken together, the SHM is expected to optimize the meta-population vitality in monoculture landscapes for aerial, arboreal, terrestrial and aquatic wildlife communities. We also provide the tangible cost estimates and discuss how such a concept is both economically affordable and plausible to complement global conservation initiatives. By proposing a practical approach to conservation in the rapidly developing tropics, we present a perspective from "ground zero" that reaches out to fellow scientists, funders, activists and pro-environmental land owners who often ask, "What more can we do?"
MeSH term(s)	Animals ; Animals, Wild ; Biodiversity ; Borneo ; Conservation of Natural Resources ; Ecosystem
Language	English
Publishing date	2020-09-11
Publishing country	Sweden
Document type	Journal Article
ZDB-ID	120759-3
ISSN	1654-7209 ; 0044-7447
ISSN (online)	1654-7209
ISSN	0044-7447
DOI	10.1007/s13280-020-01384-y
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Article: The ins and outs of ABCA.

Oram, John F

Journal of lipid research

2008 Volume 49, Issue 6, Page(s) 1150–1151

MeSH term(s)	ATP Binding Cassette Transporter 1 ; ATP-Binding Cassette Transporters/metabolism ; Animals ; CHO Cells ; Cricetinae ; Cricetulus ; Endocytosis ; Humans ; Protein Transport
Chemical Substances	ATP Binding Cassette Transporter 1 ; ATP-Binding Cassette Transporters
Language	English
Publishing date	2008-03-28
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	80154-9
ISSN	1539-7262 ; 0022-2275
ISSN (online)	1539-7262
ISSN	0022-2275
DOI	10.1194/jlr.E800006-JLR200
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Zs.A 175: Show issues

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Article ; Online: Islet autoantibodies as precision diagnostic tools to characterize heterogeneity in type 1 diabetes: a systematic review.

Communications medicine

2024 Volume 4, Issue 1, Page(s) 66

Abstract: Background: Islet autoantibodies form the foundation for type 1 diabetes (T1D) diagnosis and staging, but heterogeneity exists in T1D development and presentation. We hypothesized that autoantibodies can identify heterogeneity before, at, and after T1D ... ...

Abstract	Background: Islet autoantibodies form the foundation for type 1 diabetes (T1D) diagnosis and staging, but heterogeneity exists in T1D development and presentation. We hypothesized that autoantibodies can identify heterogeneity before, at, and after T1D diagnosis, and in response to disease-modifying therapies. Methods: We systematically reviewed PubMed and EMBASE databases (6/14/2022) assessing 10 years of original research examining relationships between autoantibodies and heterogeneity before, at, after diagnosis, and in response to disease-modifying therapies in individuals at-risk or within 1 year of T1D diagnosis. A critical appraisal checklist tool for cohort studies was modified and used for risk of bias assessment. Results: Here we show that 152 studies that met extraction criteria most commonly characterized heterogeneity before diagnosis (91/152). Autoantibody type/target was most frequently examined, followed by autoantibody number. Recurring themes included correlations of autoantibody number, type, and titers with progression, differing phenotypes based on order of autoantibody seroconversion, and interactions with age and genetics. Only 44% specifically described autoantibody assay standardization program participation. Conclusions: Current evidence most strongly supports the application of autoantibody features to more precisely define T1D before diagnosis. Our findings support continued use of pre-clinical staging paradigms based on autoantibody number and suggest that additional autoantibody features, particularly in relation to age and genetic risk, could offer more precise stratification. To improve reproducibility and applicability of autoantibody-based precision medicine in T1D, we propose a methods checklist for islet autoantibody-based manuscripts which includes use of precision medicine MeSH terms and participation in autoantibody standardization workshops.
Language	English
Publishing date	2024-04-06
Publishing country	England
Document type	Journal Article
ISSN	2730-664X
ISSN (online)	2730-664X
DOI	10.1038/s43856-024-00478-y
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Article: The ins and outs of ABCA

Oram, John F

Journal of lipid research JLR. 2008 June, v. 49, no. 6

2008

Language	English
Dates of publication	2008-06
Size	p. 1150-1151.
Publishing place	American Society for Biochemistry and Molecular Biology
Document type	Article
ZDB-ID	80154-9
ISSN	1539-7262 ; 0022-2275
ISSN (online)	1539-7262
ISSN	0022-2275
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Disease-modifying therapies and features linked to treatment response in type 1 diabetes prevention: a systematic review.

Felton, Jamie L / Griffin, Kurt J / Oram, Richard A / Speake, Cate / Long, S Alice / Onengut-Gumuscu, Suna / Rich, Stephen S / Monaco, Gabriela S F / Evans-Molina, Carmella / DiMeglio, Linda A / Ismail, Heba M / Steck, Andrea K / Dabelea, Dana / Johnson, Randi K / Urazbayeva, Marzhan / Gitelman, Stephen / Wentworth, John M / Redondo, Maria J / Sims, Emily K

Communications medicine

2023 Volume 3, Issue 1, Page(s) 130

Abstract: Background: Type 1 diabetes (T1D) results from immune-mediated destruction of insulin-producing beta cells. Prevention efforts have focused on immune modulation and supporting beta cell health before or around diagnosis; however, heterogeneity in ... ...

Abstract	Background: Type 1 diabetes (T1D) results from immune-mediated destruction of insulin-producing beta cells. Prevention efforts have focused on immune modulation and supporting beta cell health before or around diagnosis; however, heterogeneity in disease progression and therapy response has limited translation to clinical practice, highlighting the need for precision medicine approaches to T1D disease modification. Methods: To understand the state of knowledge in this area, we performed a systematic review of randomized-controlled trials with ≥50 participants cataloged in PubMed or Embase from the past 25 years testing T1D disease-modifying therapies and/or identifying features linked to treatment response, analyzing bias using a Cochrane-risk-of-bias instrument. Results: We identify and summarize 75 manuscripts, 15 describing 11 prevention trials for individuals with increased risk for T1D, and 60 describing treatments aimed at preventing beta cell loss at disease onset. Seventeen interventions, mostly immunotherapies, show benefit compared to placebo (only two prior to T1D onset). Fifty-seven studies employ precision analyses to assess features linked to treatment response. Age, beta cell function measures, and immune phenotypes are most frequently tested. However, analyses are typically not prespecified, with inconsistent methods of reporting, and tend to report positive findings. Conclusions: While the quality of prevention and intervention trials is overall high, the low quality of precision analyses makes it difficult to draw meaningful conclusions that inform clinical practice. To facilitate precision medicine approaches to T1D prevention, considerations for future precision studies include the incorporation of uniform outcome measures, reproducible biomarkers, and prespecified, fully powered precision analyses into future trial design.
Language	English
Publishing date	2023-10-05
Publishing country	England
Document type	Journal Article
ISSN	2730-664X
ISSN (online)	2730-664X
DOI	10.1038/s43856-023-00357-y
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Article: ABCA1 as a New Therapeutic Target for Treating Cardiovascular Disease.

Oram, John F.

Drug news & perspectives

2003 Volume 15, Issue 1, Page(s) 24–28

Abstract: Atherosclerotic cardiovascular disease remains the leading cause of morbidity and mortality in western societies. Although cholesterol is a major cardiovascular disease risk factor, therapeutic interventions to lower plasma cholesterol levels have had ... ...

Abstract	Atherosclerotic cardiovascular disease remains the leading cause of morbidity and mortality in western societies. Although cholesterol is a major cardiovascular disease risk factor, therapeutic interventions to lower plasma cholesterol levels have had limited success in reducing coronary events, underscoring the need for other treatment strategies. A promising therapeutic target is an ATP binding cassette transporter called ABCA1, a cell membrane protein that is the gatekeeper for secretion of excess cholesterol from macrophages into the high-density lipoprotein (HDL) metabolic pathway. Mutations in ABCA1 cause Tangier disease, a severe HDL-deficiency syndrome characterized by accumulation of cholesterol in tissue macrophages and prevalent atherosclerosis. Thus, ABCA1-activating drugs have the potential to mobilize cholesterol from macrophages of atherosclerotic lesions, making them powerful agents for preventing and reversing cardiovascular disease. (c) 2002 Prous Science. All rights reserved.
Language	English
Publishing date	2003-03-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	885125-6
ISSN	2013-0139 ; 0214-0934
ISSN (online)	2013-0139
ISSN	0214-0934
DOI	10.1358/dnp.2002.15.1.840027
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Zs.A 2393: Show issues

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Article: ATP-binding cassette transporter A1 and cholesterol trafficking.

Oram, John F

Current opinion in lipidology

2003 Volume 13, Issue 4, Page(s) 373–381

Abstract: Purpose of review: Two hallmarks of cardiovascular disease are the presence of sterol-laden macrophages in the artery wall and reduced plasma HDL levels. A cell membrane protein named ATP-binding cassette transporter A1 (ABCA1) mediates secretion of ... ...

Abstract	Purpose of review: Two hallmarks of cardiovascular disease are the presence of sterol-laden macrophages in the artery wall and reduced plasma HDL levels. A cell membrane protein named ATP-binding cassette transporter A1 (ABCA1) mediates secretion of excess cholesterol from cells into the HDL metabolic pathway. The discovery of ABCA1 in 1999 triggered a deluge of studies conducted to characterize the properties of this important transporter. The present review summarizes the more recent of those studies and evaluates their implications for the role of ABCA1 in cholesterol transport, HDL metabolism, and atherogenesis. Recent findings: Cell culture experiments have shown that ABCA1 transports cholesterol, phospholipids, and other lipophilic molecules across the plasma membrane, where they are picked up by apolipoproteins containing little or no lipids, but the mechanisms involved are still unclear. It is now apparent that factors in addition to sterols modulate ABCA1 expression by diverse transcriptional and post-transcriptional processes. Studies in humans and mice with ABCA1 mutations revealed that the relative activity of ABCA1 determines plasma HDL levels and influences susceptibility to cardiovascular disease. Mouse models are beginning to provide insights into the function of ABCA1 in vivo but are also raising new questions regarding the contribution of ABCA1 to total cholesterol flux. Summary: Recent studies underscore the critical role of ABCA1 in clearing excess cholesterol from macrophages and generating HDL particles, implicating ABCA1 as an attractive new therapeutic target for treating cardiovascular disease.
MeSH term(s)	ATP Binding Cassette Transporter 1 ; ATP-Binding Cassette Transporters/genetics ; ATP-Binding Cassette Transporters/metabolism ; Animals ; Biological Transport ; Cholesterol/metabolism ; Gene Expression Regulation ; Humans ; Tangier Disease/genetics ; Tangier Disease/metabolism
Chemical Substances	ABCA1 protein, human ; ATP Binding Cassette Transporter 1 ; ATP-Binding Cassette Transporters ; Cholesterol (97C5T2UQ7J)
Language	English
Publishing date	2003-03-06
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Review
ZDB-ID	1045394-5
ISSN	1473-6535 ; 0957-9672
ISSN (online)	1473-6535
ISSN	0957-9672
DOI	10.1097/00041433-200208000-00004
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Zs.A 3010: Show issues

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Article ; Online: HDL apolipoproteins and ABCA1: partners in the removal of excess cellular cholesterol.

Oram, John F

Arteriosclerosis, thrombosis, and vascular biology

2003 Volume 23, Issue 5, Page(s) 720–727

Abstract: It is widely believed that HDL protects against atherosclerosis by removing excess cholesterol from arterial cells. Lipid-poor HDL apolipoproteins promote efflux of cholesterol, phospholipids, and other lipophilic molecules from cells by an active ... ...

Abstract	It is widely believed that HDL protects against atherosclerosis by removing excess cholesterol from arterial cells. Lipid-poor HDL apolipoproteins promote efflux of cholesterol, phospholipids, and other lipophilic molecules from cells by an active process mediated by a cell-membrane transporter called the ATP binding cassette transporter A-1 (ABCA1). ABCA1 either directly or indirectly translocates phospholipids and cholesterol to the cell surface, where they appear to form lipid domains that interact with amphipathic alpha-helixes in apolipoproteins. This interaction solubilizes these lipids and generates nascent HDL particles that dissociate from the cell. Binding of apolipoproteins to ABCA1 may also enhance the activity of this lipid-transport pathway. Thus, the apolipoprotein/ABCA1 pathway efficiently clears cells of excess cholesterol that would otherwise accumulate as intracellular lipid droplets. ABCA1 expression is highly induced by cholesterol loading of cells and is also modulated by sterol-independent mechanisms at both the transcriptional and posttranslational level. Studies of human disease and animal models have shown that both an increased availability of apolipoproteins and an enhanced macrophage ABCA1 activity are atheroprotective. These findings implicate the apolipoprotein/ABCA1 pathway as an important therapeutic target for treating cardiovascular disease.
MeSH term(s)	ATP Binding Cassette Transporter 1 ; ATP-Binding Cassette Transporters/chemistry ; ATP-Binding Cassette Transporters/physiology ; Amino Acid Sequence ; Biological Transport ; CD36 Antigens/physiology ; Cell Membrane/metabolism ; Cholesterol/metabolism ; Gene Expression Regulation ; Humans ; Lipoproteins, HDL/physiology ; Membrane Proteins ; Models, Molecular ; Molecular Sequence Data ; Phospholipids/metabolism ; Protein Binding ; Receptors, Immunologic ; Receptors, Lipoprotein ; Receptors, Scavenger ; Scavenger Receptors, Class B
Chemical Substances	ABCA1 protein, human ; ATP Binding Cassette Transporter 1 ; CD36 Antigens ; Lipoproteins, HDL ; Membrane Proteins ; Phospholipids ; Receptors, Immunologic ; Receptors, Lipoprotein ; Receptors, Scavenger ; Scarb1 protein, mouse ; Scavenger Receptors, Class B ; Cholesterol (97C5T2UQ7J)
Language	English
Publishing date	2003-05-01
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Review
ZDB-ID	1221433-4
ISSN	1524-4636 ; 1079-5642
ISSN (online)	1524-4636
ISSN	1079-5642
DOI	10.1161/01.ATV.0000054662.44688.9A
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Article: The cholesterol mobilizing transporter ABCA1 as a new therapeutic target for cardiovascular disease.

Oram, John F

Trends in cardiovascular medicine

2002 Volume 12, Issue 4, Page(s) 170–175

Abstract: Atherosclerotic cardiovascular disease remains the leading cause of morbidity and mortality in Western societies. A hallmark of the developing atherosclerotic lesion is the appearance of cholesterol-laden macrophages in the artery wall. A cell membrane ... ...

Abstract	Atherosclerotic cardiovascular disease remains the leading cause of morbidity and mortality in Western societies. A hallmark of the developing atherosclerotic lesion is the appearance of cholesterol-laden macrophages in the artery wall. A cell membrane transporter called ABCA1 mediates the removal of excess cholesterol from macrophages into the lipoprotein pathway. This makes ABCA1 a promising new therapeutic target for reducing cholesterol deposits in tissues, eliminating excess cholesterol from the body, and preventing cardiovascular disease.
MeSH term(s)	ATP Binding Cassette Transporter 1 ; ATP-Binding Cassette Transporters/genetics ; ATP-Binding Cassette Transporters/metabolism ; Biological Transport/physiology ; Cardiovascular Diseases/therapy ; Cholesterol/metabolism ; Humans ; Macrophages/metabolism ; Models, Biological
Chemical Substances	ABCA1 protein, human ; ATP Binding Cassette Transporter 1 ; ATP-Binding Cassette Transporters ; Cholesterol (97C5T2UQ7J)
Language	English
Publishing date	2002-06-09
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Review
ZDB-ID	1097434-9
ISSN	1873-2615 ; 1050-1738
ISSN (online)	1873-2615
ISSN	1050-1738
DOI	10.1016/s1050-1738(02)00159-7
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Zs.A 3419: Show issues

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Article: Molecular basis of cholesterol homeostasis: lessons from Tangier disease and ABCA1.

Oram, John F

Trends in molecular medicine

2002 Volume 8, Issue 4, Page(s) 168–173

Abstract: High-density lipoproteins (HDLs) play a role in transporting cholesterol from peripheral tissues to the liver for elimination from the body. Two hallmarks of cardiovascular disease are the presence of sterol-laden macrophages in the artery wall and ... ...

Abstract	High-density lipoproteins (HDLs) play a role in transporting cholesterol from peripheral tissues to the liver for elimination from the body. Two hallmarks of cardiovascular disease are the presence of sterol-laden macrophages in the artery wall and reduced plasma HDL levels. A cell-membrane protein called ABCA1 mediates the secretion of excess cholesterol from cells into the HDL metabolic pathway. Mutations in ABCA1 cause Tangier disease, a severe HDL deficiency syndrome characterized by accumulation of cholesterol in tissue macrophages and prevalent atherosclerosis. Because of its ability to deplete macrophages of cholesterol and to raise plasma HDL levels, ABCA1 has become a promising therapeutic target for preventing cardiovascular disease.
MeSH term(s)	ATP Binding Cassette Transporter 1 ; ATP-Binding Cassette Transporters/genetics ; ATP-Binding Cassette Transporters/metabolism ; Biological Transport/physiology ; Cholesterol/metabolism ; Homeostasis ; Humans ; Lipoproteins, HDL/metabolism ; Liver/metabolism ; Macrophages/metabolism ; Models, Biological ; Receptors, Cytoplasmic and Nuclear/metabolism ; Tangier Disease/genetics ; Tangier Disease/metabolism
Chemical Substances	ABCA1 protein, human ; ATP Binding Cassette Transporter 1 ; ATP-Binding Cassette Transporters ; Lipoproteins, HDL ; Receptors, Cytoplasmic and Nuclear ; Cholesterol (97C5T2UQ7J)
Language	English
Publishing date	2002-04-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Review
ZDB-ID	2036490-8
ISSN	1471-499X ; 1471-4914
ISSN (online)	1471-499X
ISSN	1471-4914
DOI	10.1016/s1471-4914(02)02289-x
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