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Article ; Online: Pattern regulation in a regenerating jellyfish.

Sinigaglia, Chiara / Peron, Sophie / Eichelbrenner, Jeanne / Chevalier, Sandra / Steger, Julia / Barreau, Carine / Houliston, Evelyn / Leclère, Lucas

eLife

2020 Volume 9

Abstract: Jellyfish, with their tetraradial symmetry, offer a novel paradigm for addressing patterning mechanisms during regeneration. Here we show that an interplay between mechanical forces, cell migration and proliferation allows jellyfish fragments to regain ... ...

Abstract	Jellyfish, with their tetraradial symmetry, offer a novel paradigm for addressing patterning mechanisms during regeneration. Here we show that an interplay between mechanical forces, cell migration and proliferation allows jellyfish fragments to regain shape and functionality rapidly, notably by efficient restoration of the central feeding organ (manubrium). Fragmentation first triggers actomyosin-powered remodeling that restores body umbrella shape, causing radial smooth muscle fibers to converge around 'hubs' which serve as positional landmarks. Stabilization of these hubs, and associated expression of
MeSH term(s)	Animals ; Body Patterning/physiology ; Cell Movement ; Hydrozoa/cytology ; Hydrozoa/metabolism ; Hydrozoa/physiology ; Regeneration/physiology ; Wnt Proteins/metabolism ; Wnt Signaling Pathway
Chemical Substances	Wnt Proteins
Language	English
Publishing date	2020-09-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.54868
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Article ; Online: Relation between auditory difficulties and bortezomib-induced peripheral neuropathy in multiple myeloma: a single-center cross-sectional study.

Giraudet, Fabrice / Selvy, Marie / Kerckhove, Nicolas / Pereira, Bruno / Barreau, Fantine / Nguyen, Daniel / Busserolles, Jérôme / Cabrespine, Aurélie / Chaleteix, Carine / Soubrier, Martin / Bay, Jacques-Olivier / Lemal, Richard / Balayssac, David

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

2022 Volume 279, Issue 4, Page(s) 2197–2201

Abstract: Purpose: Bortezomib is a neurotoxic drug used in multiple myeloma and responsible for chemotherapy-induced peripheral neuropathy (CIPN). In a previous cross-sectional study, CIPN prevalence was about 26.9% in 67 patients. A second data analysis was ... ...

Abstract	Purpose: Bortezomib is a neurotoxic drug used in multiple myeloma and responsible for chemotherapy-induced peripheral neuropathy (CIPN). In a previous cross-sectional study, CIPN prevalence was about 26.9% in 67 patients. A second data analysis was performed to explore the relation between CIPN and auditory difficulties. Methods: Based on 66 multiple myeloma patients from a single center, auditory difficulties were assessed with a self-questionnaire and compared to sensory CIPN (QLQ-CIPN20 questionnaire), patients' characteristics and anticancer treatments. Results: The prevalence of auditory difficulties was about 42.4% (95% CI [30.6-55.2]) of the 66 patients analyzed and was higher in patients with CIPN than without (82.4% vs. 28.6%, p < 0.001). Auditory difficulties were not related to the characteristics of patients and treatments. The severity of auditory difficulties were correlated to CIPN severity (spearman's coefficient: 0.49, p = 0.009). Odds-ratio of auditory difficulties (multivariable analysis adjusted for sensory CIPN, recreation or professional noise exposure, gender, age, and treatments) was significantly associated with CIPN (18.7, 95% CI [3.0-117.1], p = 0.002). Conclusion: This relation between CIPN and auditory difficulties raises concerns about hearing safety in multiple myeloma patients treated by bortezomib. Trial registration number: NCT03344328.
MeSH term(s)	Antineoplastic Agents/adverse effects ; Bortezomib/adverse effects ; Cross-Sectional Studies ; Humans ; Multiple Myeloma/chemically induced ; Multiple Myeloma/drug therapy ; Peripheral Nervous System Diseases/chemically induced ; Peripheral Nervous System Diseases/drug therapy ; Peripheral Nervous System Diseases/epidemiology ; Quality of Life
Chemical Substances	Antineoplastic Agents ; Bortezomib (69G8BD63PP)
Language	English
Publishing date	2022-01-31
Publishing country	Germany
Document type	Clinical Study ; Journal Article
ZDB-ID	1017359-6
ISSN	1434-4726 ; 0937-4477
ISSN (online)	1434-4726
ISSN	0937-4477
DOI	10.1007/s00405-021-07234-1
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Article ; Online: Pattern regulation in a regenerating jellyfish

Chiara Sinigaglia / Sophie Peron / Jeanne Eichelbrenner / Sandra Chevalier / Julia Steger / Carine Barreau / Evelyn Houliston / Lucas Leclère

eLife, Vol

2020 Volume 9

Abstract	Jellyfish, with their tetraradial symmetry, offer a novel paradigm for addressing patterning mechanisms during regeneration. Here we show that an interplay between mechanical forces, cell migration and proliferation allows jellyfish fragments to regain shape and functionality rapidly, notably by efficient restoration of the central feeding organ (manubrium). Fragmentation first triggers actomyosin-powered remodeling that restores body umbrella shape, causing radial smooth muscle fibers to converge around ‘hubs’ which serve as positional landmarks. Stabilization of these hubs, and associated expression of Wnt6, depends on the configuration of the adjoining muscle fiber ‘spokes’. Stabilized hubs presage the site of the manubrium blastema, whose growth is Wnt/β-catenin dependent and fueled by both cell proliferation and long-range cell recruitment. Manubrium morphogenesis is modulated by its connections with the gastrovascular canal system. We conclude that body patterning in regenerating jellyfish emerges mainly from local interactions, triggered and directed by the remodeling process.
Keywords	Clytia hemisphaerica ; Cnidaria ; jellyfish ; Hydrozoa ; regeneration ; medusa ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2020-09-01T00:00:00Z
Publisher	eLife Sciences Publications Ltd
Document type	Article ; Online
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Article: Prevalence of Chemotherapy-Induced Peripheral Neuropathy in Multiple Myeloma Patients and its Impact on Quality of Life: A Single Center Cross-Sectional Study.

Selvy, Marie / Kerckhove, Nicolas / Pereira, Bruno / Barreau, Fantine / Nguyen, Daniel / Busserolles, Jérôme / Giraudet, Fabrice / Cabrespine, Aurélie / Chaleteix, Carine / Soubrier, Martin / Bay, Jacques-Olivier / Lemal, Richard / Balayssac, David

Frontiers in pharmacology

2021 Volume 12, Page(s) 637593

Abstract: Bortezomib is a pivotal drug for the management of multiple myeloma. However, bortezomib is a neurotoxic anticancer drug responsible for chemotherapy-induced peripheral neuropathy (CIPN). CIPN is associated with psychological distress and a decrease of ... ...

Abstract	Bortezomib is a pivotal drug for the management of multiple myeloma. However, bortezomib is a neurotoxic anticancer drug responsible for chemotherapy-induced peripheral neuropathy (CIPN). CIPN is associated with psychological distress and a decrease of health-related quality of life (HRQoL), but little is known regarding bortezomib-related CIPN. This single center, cross-sectional study assessed the prevalence and severity of sensory/motor CIPN, neuropathic pain and ongoing pain medications, anxiety, depression, and HRQoL, in multiple myeloma patients after the end of bortezomib treatment. Paper questionnaires were sent to patients to record the scores of sensory and motor CIPNs (QLQ-CIPN20), neuropathic pain (visual analogue scale and DN4 interview), anxiety and depression (HADS), the scores of HRQoL (QLQ-C30 and QLQ-MY20) and ongoing pain medications. Oncological data were recorded using chemotherapy prescription software and patient medical records. The prevalence of sensory CIPN was 26.9% (95% CI 16.7; 39.1) among the 67 patients analyzed and for a mean time of 2.9 ± 2.8 years since the last bortezomib administration. The proportion of sensory CIPN was higher among patients treated by intravenous and subcutaneous routes than intravenous or subcutaneous routes (
Language	English
Publishing date	2021-04-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2021.637593
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Article ; Online: An improved whole life cycle culture protocol for the hydrozoan genetic model

Lechable, Marion / Jan, Alexandre / Duchene, Axel / Uveira, Julie / Weissbourd, Brandon / Gissat, Loann / Collet, Sophie / Gilletta, Laurent / Chevalier, Sandra / Leclère, Lucas / Peron, Sophie / Barreau, Carine / Lasbleiz, Régis / Houliston, Evelyn / Momose, Tsuyoshi

Biology open

2020 Volume 9, Issue 11

Abstract: The jellyfish ... ...

Abstract	The jellyfish species
MeSH term(s)	Animals ; Genetic Association Studies ; Humans ; Hydrozoa/genetics ; Hydrozoa/growth & development ; Larva ; Life Cycle Stages/genetics ; Metamorphosis, Biological ; Models, Animal ; Models, Genetic
Language	English
Publishing date	2020-11-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2632264-X
ISSN	2046-6390 ; 2046-6390
ISSN (online)	2046-6390
ISSN	2046-6390
DOI	10.1242/bio.051268
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Article ; Online: An improved whole life cycle culture protocol for the hydrozoan genetic model Clytia hemisphaerica

Marion Lechable / Alexandre Jan / Axel Duchene / Julie Uveira / Brandon Weissbourd / Loann Gissat / Sophie Collet / Laurent Gilletta / Sandra Chevalier / Lucas Leclère / Sophie Peron / Carine Barreau / Régis Lasbleiz / Evelyn Houliston / Tsuyoshi Momose

Biology Open, Vol 9, Iss

2020 Volume 11

Abstract: The jellyfish species Clytia hemisphaerica (Cnidaria, Hydrozoa) has emerged as a new experimental model animal in the last decade. Favorable characteristics include a fully transparent body suitable for microscopy, daily gamete production and a ... ...

Abstract	The jellyfish species Clytia hemisphaerica (Cnidaria, Hydrozoa) has emerged as a new experimental model animal in the last decade. Favorable characteristics include a fully transparent body suitable for microscopy, daily gamete production and a relatively short life cycle. Furthermore, whole genome sequence assembly and efficient gene editing techniques using CRISPR/Cas9 have opened new possibilities for genetic studies. The quasi-immortal vegetatively-growing polyp colony stage provides a practical means to maintain mutant strains. In the context of developing Clytia as a genetic model, we report here an improved whole life cycle culture method including an aquarium tank system designed for culture of the tiny jellyfish form. We have compared different feeding regimes using Artemia larvae as food and demonstrate that the stage-dependent feeding control is the key for rapid and reliable medusa and polyp rearing. Metamorphosis of the planula larvae into a polyp colony can be induced efficiently using a new synthetic peptide. The optimized procedures detailed here make it practical to generate genetically modified Clytia strains and to maintain their whole life cycle in the laboratory. This article has an associated First Person interview with the two first authors of the paper.
Keywords	animal culture ; cnidarian ; developmental biology ; genetics ; jellyfish ; Science ; Q ; Biology (General) ; QH301-705.5
Subject code	590
Language	English
Publishing date	2020-11-01T00:00:00Z
Publisher	The Company of Biologists
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Identification of jellyfish neuropeptides that act directly as oocyte maturation-inducing hormones.

Takeda, Noriyo / Kon, Yota / Quiroga Artigas, Gonzalo / Lapébie, Pascal / Barreau, Carine / Koizumi, Osamu / Kishimoto, Takeo / Tachibana, Kazunori / Houliston, Evelyn / Deguchi, Ryusaku

Development (Cambridge, England)

2018 Volume 145, Issue 2

Abstract: Oocyte meiotic maturation is crucial for sexually reproducing animals, and its core cytoplasmic regulators are highly conserved between species. By contrast, the few known maturation-inducing hormones (MIHs) that act on oocytes to initiate this process ... ...

Abstract	Oocyte meiotic maturation is crucial for sexually reproducing animals, and its core cytoplasmic regulators are highly conserved between species. By contrast, the few known maturation-inducing hormones (MIHs) that act on oocytes to initiate this process are highly variable in their molecular nature. Using the hydrozoan jellyfish species
MeSH term(s)	Amino Acid Sequence ; Animals ; Darkness ; Female ; Gene Expression Profiling ; Gonadal Steroid Hormones/genetics ; Gonadal Steroid Hormones/pharmacology ; Gonadal Steroid Hormones/physiology ; Hydrozoa/genetics ; Hydrozoa/growth & development ; Hydrozoa/physiology ; Light ; Male ; Neuropeptides/genetics ; Neuropeptides/pharmacology ; Neuropeptides/physiology ; Neurosecretory Systems/cytology ; Oligopeptides/genetics ; Oligopeptides/pharmacology ; Oligopeptides/physiology ; Oocytes/drug effects ; Oocytes/growth & development ; Oogenesis/drug effects ; Oogenesis/genetics ; Oogenesis/physiology ; Species Specificity
Chemical Substances	Gonadal Steroid Hormones ; Neuropeptides ; Oligopeptides
Language	English
Publishing date	2018-01-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	90607-4
ISSN	1477-9129 ; 0950-1991
ISSN (online)	1477-9129
ISSN	0950-1991
DOI	10.1242/dev.156786
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Article: Comet and cup genes in Drosophila spermatogenesis: the first demonstration of post-meiotic transcription.

Barreau, Carine / Benson, Elizabeth / White-Cooper, Helen

Biochemical Society transactions

2008 Volume 36, Issue Pt 3, Page(s) 540–542

Abstract: Post-meiotic transcription is widespread in mammalian spermatogenesis, but is generally believed to be absent from Drosophila spermatogenesis. Genes required during meiosis, in early spermatids or later in spermiogenesis are typically transcribed in ... ...

Abstract	Post-meiotic transcription is widespread in mammalian spermatogenesis, but is generally believed to be absent from Drosophila spermatogenesis. Genes required during meiosis, in early spermatids or later in spermiogenesis are typically transcribed in primary spermatocytes in Drosophila. Their mRNAs are then stored in the cytoplasm until the protein product is needed. Recently, using in situ hybridization, we identified 17 Drosophila genes, collectively named 'comets' and 'cups', whose mRNAs are most abundant in, and localize to the distal ends of, elongating spermatids. Using a single-cyst quantitative RT-PCR (reverse transcription-PCR) assay, we confirmed this unusual expression pattern and conclusively demonstrate the existence of post-meiotic transcription in Drosophila spermatids. We found that transcription of comets and cups occurs just before protamines can be detected in spermatid nuclei.
MeSH term(s)	Animals ; Chromatin/metabolism ; Drosophila Proteins/genetics ; Drosophila melanogaster/cytology ; Drosophila melanogaster/genetics ; Gene Expression Regulation ; Genes, Insect ; In Situ Hybridization ; Male ; Meiosis/genetics ; Models, Biological ; Spermatogenesis/genetics ; Testis/metabolism ; Time Factors ; Transcription, Genetic
Chemical Substances	Chromatin ; Drosophila Proteins ; cup protein, Drosophila
Language	English
Publishing date	2008-05-15
Publishing country	England
Document type	Journal Article
ZDB-ID	184237-7
ISSN	1470-8752 ; 0300-5127
ISSN (online)	1470-8752
ISSN	0300-5127
DOI	10.1042/BST0360540
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Article ; Online: Tethering of proteins to RNAs by bacteriophage proteins.

Keryer-Bibens, Cecile / Barreau, Carine / Osborne, H Beverley

Biology of the cell

2008 Volume 100, Issue 2, Page(s) 125–138

Abstract: Many steps in the control of gene expression are dependent on RNA-binding proteins, most of which are bi-functional, in as much as they both bind to RNA and interact with other protein partners in a functional complex. A powerful approach to study the ... ...

Abstract	Many steps in the control of gene expression are dependent on RNA-binding proteins, most of which are bi-functional, in as much as they both bind to RNA and interact with other protein partners in a functional complex. A powerful approach to study the functional properties of these proteins in vivo, independently of their RNA-binding ability, is to attach or tether them to specifically engineered reporter mRNAs whose fate can be easily followed. Two tethering systems have been mainly used in eukaryotic cells, namely the MS2 coat protein system and the lambda N-B box system. In this review, we firstly describe several studies in which these tethering systems have been used and provide an overview of these applications. We next describe the major features of these two systems, and, finally, we highlight a number of points that should be considered when designing experiments using this approach.
MeSH term(s)	Bacteriophages/metabolism ; Capsid Proteins/metabolism ; Protein Binding ; RNA/metabolism ; RNA-Binding Proteins/metabolism ; Viral Proteins/metabolism
Chemical Substances	Capsid Proteins ; RNA-Binding Proteins ; Viral Proteins ; RNA (63231-63-0)
Language	English
Publishing date	2008-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	245745-3
ISSN	1768-322X ; 0399-0311 ; 0248-4900
ISSN (online)	1768-322X
ISSN	0399-0311 ; 0248-4900
DOI	10.1042/BC20070067
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Zs.A 758: Show issues

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Article ; Online: Covid-19 and blood groups: ABO antibody levels may also matter.

Deleers, Marie / Breiman, Adrien / Daubie, Valéry / Maggetto, Carine / Barreau, Isabelle / Besse, Tatiana / Clémenceau, Béatrice / Ruvoën-Clouet, Nathalie / Fils, Jean-François / Maillart, Evelyne / Doyen, Virginie / Mahadeb, Bhavna / Jani, Jacques C / Van der Linden, Philippe / Cannie, Mieke M / Hayef, Nabil / Corazza, Francis / Le Pendu, Jacques / El Kenz, Hanane

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

2020 Volume 104, Page(s) 242–249

Abstract: Background: Susceptibility to Covid-19 has been found to be associated with the ABO blood group, with O type individuals being at a lower risk. However, the underlying mechanism has not been elucidated. Here, we aimed to test the hypothesis that Covid- ... ...

Abstract	Background: Susceptibility to Covid-19 has been found to be associated with the ABO blood group, with O type individuals being at a lower risk. However, the underlying mechanism has not been elucidated. Here, we aimed to test the hypothesis that Covid-19 patients might have lower levels of ABO antibodies than non-infected individuals as they could offer some degree of protection. Methods: After showing that the viral spike protein harbors the ABO glycan epitopes when produced by cells expressing the relevant glycosyltransferases, like upper respiratory tract epithelial cells, we enrolled 290 patients with Covid-19 and 276 asymptomatic controls to compare their levels of natural ABO blood group antibodies. Results: We found significantly lower IgM anti-A + anti-B agglutination scores in blood group O patients (76.93 vs 88.29, P-value = 0.034) and lower levels of anti-B (24.93 vs 30.40, P-value = 0.028) and anti-A antibodies (28.56 vs 36.50, P-value = 0.048) in blood group A and blood group B patients, respectively, compared to controls. Conclusion: In this study, we showed that ABO antibody levels are significantly lower in Covid-19 patients compared to controls. These findings could indicate that patients with low levels of ABO antibodies are at higher risk of being infected.
MeSH term(s)	ABO Blood-Group System/immunology ; Adult ; Aged ; Aged, 80 and over ; Antibodies/blood ; COVID-19/blood ; COVID-19/virology ; Disease Susceptibility ; Epithelial Cells/immunology ; Epitopes/immunology ; Female ; Galactosyltransferases ; Humans ; Immunoglobulin M/immunology ; Male ; Middle Aged ; Polysaccharides/immunology ; Risk ; SARS-CoV-2/immunology ; Spike Glycoprotein, Coronavirus/immunology ; Young Adult
Chemical Substances	ABO Blood-Group System ; Antibodies ; Epitopes ; Immunoglobulin M ; Polysaccharides ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; ABO protein, human (EC 2.4.1.-) ; Galactosyltransferases (EC 2.4.1.-)
Language	English
Publishing date	2020-12-14
Publishing country	Canada
Document type	Journal Article
ZDB-ID	1331197-9
ISSN	1878-3511 ; 1201-9712
ISSN (online)	1878-3511
ISSN	1201-9712
DOI	10.1016/j.ijid.2020.12.025
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