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  1. Article ; Online: Laparoscopic mesh measurement.

    Lauder, Chris I W / Strickland, Andrew / Maddern, Guy J

    Annals of the Royal College of Surgeons of England

    2010  Volume 92, Issue 3, Page(s) 262–263

    MeSH term(s) Hernia, Ventral/surgery ; Humans ; Laparoscopy/methods ; Surgical Mesh
    Language English
    Publishing date 2010-04-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 80044-2
    ISSN 1478-7083 ; 0035-8843
    ISSN (online) 1478-7083
    ISSN 0035-8843
    DOI 10.1308/rcsann.2010.92.3.262
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  2. Article ; Online: Use of a modified chitosan-dextran gel to prevent peritoneal adhesions in a porcine hemicolectomy model.

    Lauder, Chris I W / Strickland, Andrew / Maddern, Guy J

    The Journal of surgical research

    2012  Volume 176, Issue 2, Page(s) 448–454

    Abstract: Background: The prevention of peritoneal adhesions following abdominal surgery remains an ongoing challenge, with the ideal product for adhesion reduction still elusive. This study examines the outcome of application of a modified chitosan-dextran (CD) ... ...

    Abstract Background: The prevention of peritoneal adhesions following abdominal surgery remains an ongoing challenge, with the ideal product for adhesion reduction still elusive. This study examines the outcome of application of a modified chitosan-dextran (CD) gel within the intraperitoneal cavity of a porcine model to assess its effect on adhesion formation. This is a unique synthetic gel, its active ingredients being succinyl chitosan and dextran aldehyde.
    Materials and methods: Twenty female domestic pigs were randomized to undergo surgery alone or to receive CD gel at the time of surgery. The surgical procedures comprised of laparotomy and ileocaecal resection with ileo-colic anastomosis. At postoperative d 21, a laparoscopy was performed, and adhesions graded using a predetermined adhesion measurement score. Adhesiolysis was then performed and CD gel applied to all animals. After a further 21 d animals were euthanized and adhesions graded using the same scoring regimen.
    Results: Adhesions involving the wound were significantly reduced following application of the gel at the time of open surgery (P = 0.01). Following adhesiolysis and further application of the gel, a decrease in adhesion scores involving the bowel was noted (P = 0.03). No significant adverse outcomes were observed with application of the gel, specifically no anastomotic leak occurred.
    Conclusions: Chitosan-dextran gel is a well tolerated hydrogel with beneficial properties, which has been designed in an effort to reduce postoperative peritoneal adhesion formation. The observed reduction of adhesion scores following the application of the gel is encouraging and should stimulate further development of this product. The lack of adverse outcomes following application of CD gel is reassuring when used around a bowel anastomosis.
    MeSH term(s) Anastomosis, Surgical/adverse effects ; Anastomosis, Surgical/methods ; Animals ; Biocompatible Materials/pharmacology ; Cecum/surgery ; Chitosan/pharmacology ; Colectomy/adverse effects ; Colectomy/methods ; Dextrans/pharmacology ; Disease Models, Animal ; Female ; Hydrogels/pharmacology ; Ileum/surgery ; Laparotomy/adverse effects ; Laparotomy/methods ; Peritoneum/pathology ; Peritoneum/surgery ; Surgical Wound Infection/pathology ; Sus scrofa ; Tissue Adhesions/pathology ; Tissue Adhesions/prevention & control ; Treatment Outcome
    Chemical Substances Biocompatible Materials ; Dextrans ; Hydrogels ; Chitosan (9012-76-4)
    Language English
    Publishing date 2012-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80170-7
    ISSN 1095-8673 ; 0022-4804
    ISSN (online) 1095-8673
    ISSN 0022-4804
    DOI 10.1016/j.jss.2011.10.029
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  3. Article ; Online: A novel technique for biliary T-tube fixation.

    Lauder, Chris I W / Strickland, Andrew / Maddern, Guy J

    Annals of the Royal College of Surgeons of England

    2010  Volume 92, Issue 2, Page(s) 169

    MeSH term(s) Bile Ducts/surgery ; Drainage/instrumentation ; Humans ; Postoperative Care/instrumentation ; Suture Techniques
    Language English
    Publishing date 2010-04-06
    Publishing country England
    Document type Journal Article ; Technical Report
    ZDB-ID 80044-2
    ISSN 1478-7083 ; 0035-8843
    ISSN (online) 1478-7083
    ISSN 0035-8843
    DOI 10.1308/rcsann.2010.92.2.169a
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  4. Article ; Online: Abdominal adhesion prevention, time to change our everyday practice?

    Lauder, Chris I W / Strickland, Andrew / Maddern, Guy J

    ANZ journal of surgery

    2010  Volume 80, Issue 5, Page(s) 306–307

    MeSH term(s) Abdomen/surgery ; Humans ; Postoperative Complications ; Practice Patterns, Physicians' ; Tissue Adhesions/etiology ; Tissue Adhesions/pathology ; Tissue Adhesions/prevention & control
    Language English
    Publishing date 2010-05
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2050749-5
    ISSN 1445-2197 ; 1445-1433 ; 0004-8682
    ISSN (online) 1445-2197
    ISSN 1445-1433 ; 0004-8682
    DOI 10.1111/j.1445-2197.2010.05273.x
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    Zs.A 180: Show issues Location:
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  5. Article ; Online: Characterization of projections of longitudinal muscle motor neurons in human colon.

    Humenick, Adam / Chen, Bao Nan / Lauder, Chris I W / Wattchow, David A / Zagorodnyuk, Vladimir P / Dinning, Phil G / Spencer, Nick J / Costa, Marcello / Brookes, Simon J H

    Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society

    2019  Volume 31, Issue 10, Page(s) e13685

    Abstract: Background: The enteric nervous system contains inhibitory and excitatory motor neurons which modulate smooth muscle contractility. Cell bodies of longitudinal muscle motor neurons have not been identified in human intestine.: Methods: We used ... ...

    Abstract Background: The enteric nervous system contains inhibitory and excitatory motor neurons which modulate smooth muscle contractility. Cell bodies of longitudinal muscle motor neurons have not been identified in human intestine.
    Methods: We used retrograde tracing ex vivo with DiI, with multiple labeling immunohistochemistry, to characterize motor neurons innervating tenial and inter-tenial longitudinal muscle of human colon.
    Key results: The most abundant immunohistochemical markers in the tertiary plexus were vesicular acetylcholine transporter, nitric oxide synthase (NOS), and vasoactive intestinal polypeptide (VIP). Of retrogradely traced motor neurons innervating inter-tenial longitudinal muscle, 95% were located within 6mm oral or anal to the DiI application site. Excitatory motor neuron cell bodies, immunoreactive for choline acetyltransferase (ChAT), were clustered aborally, whereas NOS-immunoreactive cell bodies were distributed either side of the DiI application site. Motor neurons had small cell bodies, averaging 438 + 18µm
    Conclusions and inferences: Tenial and inter-tenial motor neurons innervating the longitudinal muscle have short projections. Inhibitory motor neurons have less polarized projections than cholinergic excitatory motor neurons. Longitudinal and circular muscle layers are innervated by distinct local populations of excitatory and inhibitory motor neurons. A population of human enteric neurons that contribute significantly to colonic motility has been characterized.
    MeSH term(s) Aged ; Cell Size ; Choline O-Acetyltransferase/metabolism ; Colon/innervation ; Colon/metabolism ; Colon/pathology ; Enteric Nervous System/cytology ; Enteric Nervous System/metabolism ; Female ; Fluorescent Dyes ; Gastrointestinal Motility ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Motor Neurons/cytology ; Motor Neurons/metabolism ; Muscle, Smooth/innervation ; Muscle, Smooth/metabolism ; Muscle, Smooth/pathology ; Neuroanatomical Tract-Tracing Techniques ; Nitric Oxide Synthase/metabolism
    Chemical Substances Fluorescent Dyes ; Nitric Oxide Synthase (EC 1.14.13.39) ; Choline O-Acetyltransferase (EC 2.3.1.6)
    Language English
    Publishing date 2019-07-29
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1186328-6
    ISSN 1365-2982 ; 1350-1925
    ISSN (online) 1365-2982
    ISSN 1350-1925
    DOI 10.1111/nmo.13685
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    Zs.A 2979: Show issues Location:
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  6. Article ; Online: Use of a modified chitosan-dextran gel to prevent peritoneal adhesions in a rat model.

    Lauder, Chris I W / Garcea, Giuseppe / Strickland, Andrew / Maddern, Guy J

    The Journal of surgical research

    2011  Volume 171, Issue 2, Page(s) 877–882

    Abstract: Background: Intra-abdominal adhesions are a major cause of morbidity and a significant drain on healthcare resources. Numerous anti-adhesion products have reached clinical use but none has been wholly satisfactory. This study examines the application of ...

    Abstract Background: Intra-abdominal adhesions are a major cause of morbidity and a significant drain on healthcare resources. Numerous anti-adhesion products have reached clinical use but none has been wholly satisfactory. This study examines the application of a modified chitosan-dextran (CD) gel to the intraperitoneal cavity to reduce adhesion formation. This is a unique synthetic gel, its active ingredients being succinyl chitosan and dextran aldehyde.
    Materials and methods: Eighty adult male Wistar albino rats were randomized to undergo surgery alone or to receive CD gel at the time of surgery. Control groups using modified dextran only gel were also included. The surgical procedures comprised of laparotomy and either cecal abrasion or anastomotic simulation by enterotomy of the cecum with primary closure. At postoperative d 21 rats were euthanized by CO2 inhalation, and adhesions graded by an investigator blinded to the treatment groups, using a predetermined adhesion measurement score.
    Results: Adhesions were significantly reduced in the cecal abrasion group with median adhesion scores for the treatment group of 0 versus 3 in the control group (P<0.001, Fisher's exact test). Further reduction in adhesion formation was noted in the enterotomy group with median scores of 2 versus 5 for treatment and control groups respectively (P=0.003, Fisher's exact test).
    Conclusions: Chitosan-dextran gel appears to significantly reduce the formation of intra-abdominal adhesions without adversely affecting wound healing. This is a noteworthy advancement in the safe prevention of post operative, intra-abdominal adhesions.
    MeSH term(s) Animals ; Anticoagulants/pharmacology ; Biocompatible Materials/pharmacology ; Cecum/surgery ; Chitosan/pharmacology ; Dextrans/pharmacology ; Disease Models, Animal ; Gels/pharmacology ; Laparotomy ; Male ; Peritoneal Cavity/pathology ; Peritoneal Cavity/surgery ; Peritoneum/drug effects ; Peritoneum/pathology ; Peritoneum/surgery ; Rats ; Rats, Wistar ; Tissue Adhesions/pathology ; Tissue Adhesions/prevention & control ; Wound Healing/physiology
    Chemical Substances Anticoagulants ; Biocompatible Materials ; Dextrans ; Gels ; Chitosan (9012-76-4)
    Language English
    Publishing date 2011-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80170-7
    ISSN 1095-8673 ; 0022-4804
    ISSN (online) 1095-8673
    ISSN 0022-4804
    DOI 10.1016/j.jss.2010.06.028
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  7. Article ; Online: Abdominal adhesion prevention: still a sticky subject?

    Lauder, Chris I W / Garcea, Giuseppe / Strickland, Andrew / Maddern, Guy J

    Digestive surgery

    2010  Volume 27, Issue 5, Page(s) 347–358

    Abstract: Background: Adhesion formation remains an almost inevitable consequence of abdominal procedures, potentially resulting in significant morbidity and mortality. There is an ongoing need to evaluate current understanding of adhesion formation and products ... ...

    Abstract Background: Adhesion formation remains an almost inevitable consequence of abdominal procedures, potentially resulting in significant morbidity and mortality. There is an ongoing need to evaluate current understanding of adhesion formation and products aimed at prevention. Failure to keep up to date with adhesion treatment may subject clinicians to a greater medico-legal risk.
    Design: Review of published studies exploring the problem of peritoneal adhesion formation. This encompasses the underlying processes of adhesion formation combined with general approaches to reduce formation. An overview of products trialled to prevent formation in both the animal model and clinical setting describes products of scientific interest and commercial success.
    Results: Advances in surgical technique, such as laparoscopic surgery, can help minimize the probability of adhesion formation. Currently barrier products, whilst reducing adhesion formation, have not been shown to reduce the risk of readmission with complications related to adhesions. Hybrid products may improve upon this situation.
    Conclusions: No single approach has been wholly satisfactory in reducing adhesions. Research into the processes driving adhesion formation is providing exciting new targets for therapeutic agents. It would seem plausible that with many promising avenues of research a revolutionary agent to reduce the incidence of adhesional small bowel obstruction may result.
    MeSH term(s) Abdomen/surgery ; Animals ; Digestive System Surgical Procedures/methods ; Humans ; Peritoneum/pathology ; Peritoneum/surgery ; Tissue Adhesions/epidemiology ; Tissue Adhesions/physiopathology ; Tissue Adhesions/prevention & control
    Language English
    Publishing date 2010
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 605888-7
    ISSN 1421-9883 ; 0253-4886
    ISSN (online) 1421-9883
    ISSN 0253-4886
    DOI 10.1159/000314805
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  8. Article: Abdominal Adhesion Prevention: Still a Sticky Subject

    Lauder, Chris I.W. / Garcea, Giuseppe / Strickland, Andrew / Maddern, Guy J.

    Digestive Surgery

    2010  Volume 27, Issue 5, Page(s) 347–358

    Abstract: Background: Adhesion formation remains an almost inevitable consequence of abdominal procedures, potentially resulting in significant morbidity and mortality. There is an ongoing need to evaluate current understanding of adhesion formation and products ... ...

    Institution University of Adelaide Discipline of Surgery, The Queen Elizabeth Hospital, Woodville, S.A., Australia
    Abstract Background: Adhesion formation remains an almost inevitable consequence of abdominal procedures, potentially resulting in significant morbidity and mortality. There is an ongoing need to evaluate current understanding of adhesion formation and products aimed at prevention. Failure to keep up to date with adhesion treatment may subject clinicians to a greater medico-legal risk. Design: Review of published studies exploring the problem of peritoneal adhesion formation. This encompasses the underlying processes of adhesion formation combined with general approaches to reduce formation. An overview of products trialled to prevent formation in both the animal model and clinical setting describes products of scientific interest and commercial success. Results: Advances in surgical technique, such as laparoscopic surgery, can help minimize the probability of adhesion formation. Currently barrier products, whilst reducing adhesion formation, have not been shown to reduce the risk of readmission with complications related to adhesions. Hybrid products may improve upon this situation. Conclusions: No single approach has been wholly satisfactory in reducing adhesions. Research into the processes driving adhesion formation is providing exciting new targets for therapeutic agents. It would seem plausible that with many promising avenues of research a revolutionary agent to reduce the incidence of adhesional small bowel obstruction may result.
    Keywords Adhesions ; Peritoneum ; Adhesion barrier ; Adhesion prevention ; Abdominal surgery
    Language English
    Publishing date 2010-09-16
    Publisher S. Karger AG
    Publishing place Basel, Switzerland
    Document type Article
    Note Review
    ZDB-ID 605888-7
    ISSN 1421-9883 ; 0253-4886
    ISSN (online) 1421-9883
    ISSN 0253-4886
    DOI 10.1159/000314805
    Database Karger publisher's database

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